Vasanta Subramanian

Summary

Affiliation: University of Bath
Country: UK

Publications

  1. ncbi request reprint A new role for angiogenin in neurite growth and pathfinding: implications for amyotrophic lateral sclerosis
    Vasanta Subramanian
    Department of Biology and Biochemistry, University of Bath, Bath BA2 7AY, UK
    Hum Mol Genet 16:1445-53. 2007
  2. ncbi request reprint Human angiogenin is a neuroprotective factor and amyotrophic lateral sclerosis associated angiogenin variants affect neurite extension/pathfinding and survival of motor neurons
    Vasanta Subramanian
    Department of Biology and Biochemistry, University of Bath, Bath BA2 7AY, UK
    Hum Mol Genet 17:130-49. 2008
  3. pmc Ribonuclease A homologues of the zebrafish: polymorphism, crystal structures of two representatives and their evolutionary implications
    Konstantina Kazakou
    Department of Biology and Biochemistry, University of Bath, Claverton Down, Bath BA2 7AY, UK
    J Mol Biol 380:206-22. 2008
  4. ncbi request reprint Biological and structural features of murine angiogenin-4, an angiogenic protein
    Benedict Crabtree
    Department of Biology and Biochemistry, University of Bath, Claverton Down, Bath BA2 7AY, United Kingdom
    Biochemistry 46:2431-43. 2007
  5. ncbi request reprint Characterization of human angiogenin variants implicated in amyotrophic lateral sclerosis
    Benedict Crabtree
    Department of Biology and Biochemistry, University of Bath, Claverton Down, Bath BA2 7AY, United Kingdom
    Biochemistry 46:11810-8. 2007
  6. pmc Structural and molecular insights into the mechanism of action of human angiogenin-ALS variants in neurons
    Nethaji Thiyagarajan
    Department of Biology and Biochemistry, University of Bath, Claverton Down, Bath BA2 7AY, UK
    Nat Commun 3:1121. 2012
  7. pmc Structure of murine angiogenin: features of the substrate- and cell-binding regions and prospects for inhibitor-binding studies
    Daniel E Holloway
    Department of Biology and Biochemistry, University of Bath, England
    Acta Crystallogr D Biol Crystallogr 61:1568-78. 2005
  8. ncbi request reprint Behavior of endothelial cells on Matrigel and development of a method for a rapid and reproducible in vitro angiogenesis assay
    Benedict Crabtree
    Department of Biology and Biochemistry, University of Bath, Bath, BA2 7AY, UK
    In Vitro Cell Dev Biol Anim 43:87-94. 2007
  9. pmc PA6 Stromal Cell Co-Culture Enhances SH-SY5Y and VSC4.1 Neuroblastoma Differentiation to Mature Phenotypes
    Ross Ferguson
    Department of Biology and Biochemistry, University of Bath, Bath, United Kingdom
    PLoS ONE 11:e0159051. 2016
  10. doi request reprint Dynamic expression of the mouse orthologue of the human amyotropic lateral sclerosis associated gene C9orf72 during central nervous system development and neuronal differentiation
    Ross Ferguson
    Department of Biology and Biochemistry, University of Bath, BA2 7AY, Bath, UK
    J Anat . 2016

Collaborators

  • K Ravi Acharya
  • Keith Brew
  • Robert Shapiro
  • Ross Ferguson
  • Benedict Crabtree
  • Daniel E Holloway
  • Nethaji Thiyagarajan
  • Konstantina Kazakou
  • Stephen H Prior
  • Eleni Serafeimidou-Pouliou
  • Matthew D Baker
  • Peter Wilson
  • Shalini Iyer
  • Tyrone Ferns
  • Gayatri B Chavali
  • Michelle C Hares

Detail Information

Publications10

  1. ncbi request reprint A new role for angiogenin in neurite growth and pathfinding: implications for amyotrophic lateral sclerosis
    Vasanta Subramanian
    Department of Biology and Biochemistry, University of Bath, Bath BA2 7AY, UK
    Hum Mol Genet 16:1445-53. 2007
    ..Our findings clearly show that ANG plays an important role in neurite pathfinding and this has implications for ALS...
  2. ncbi request reprint Human angiogenin is a neuroprotective factor and amyotrophic lateral sclerosis associated angiogenin variants affect neurite extension/pathfinding and survival of motor neurons
    Vasanta Subramanian
    Department of Biology and Biochemistry, University of Bath, Bath BA2 7AY, UK
    Hum Mol Genet 17:130-49. 2008
    ..Our findings show that ANG plays an important role in neurite extension/pathfinding and survival providing a causal link between mutations in hANG and ALS...
  3. pmc Ribonuclease A homologues of the zebrafish: polymorphism, crystal structures of two representatives and their evolutionary implications
    Konstantina Kazakou
    Department of Biology and Biochemistry, University of Bath, Claverton Down, Bath BA2 7AY, UK
    J Mol Biol 380:206-22. 2008
    ....
  4. ncbi request reprint Biological and structural features of murine angiogenin-4, an angiogenic protein
    Benedict Crabtree
    Department of Biology and Biochemistry, University of Bath, Claverton Down, Bath BA2 7AY, United Kingdom
    Biochemistry 46:2431-43. 2007
    ..In the putative cell-binding segment, the replacement of Lys59 with Asn (its counterpart at position 61 of hAng) does not abrogate enzymatic activity but abolishes angiogenic activity, the reason for which is unclear...
  5. ncbi request reprint Characterization of human angiogenin variants implicated in amyotrophic lateral sclerosis
    Benedict Crabtree
    Department of Biology and Biochemistry, University of Bath, Claverton Down, Bath BA2 7AY, United Kingdom
    Biochemistry 46:11810-8. 2007
    ..Our studies on the biochemical and structural features of these ANG variants now form the basis for further investigations to determine their role(s) in ALS...
  6. pmc Structural and molecular insights into the mechanism of action of human angiogenin-ALS variants in neurons
    Nethaji Thiyagarajan
    Department of Biology and Biochemistry, University of Bath, Claverton Down, Bath BA2 7AY, UK
    Nat Commun 3:1121. 2012
    ..Our structure-function studies on these ANG-ALS variants are the first to provide insights into the cellular and molecular mechanisms underlying their role in ALS...
  7. pmc Structure of murine angiogenin: features of the substrate- and cell-binding regions and prospects for inhibitor-binding studies
    Daniel E Holloway
    Department of Biology and Biochemistry, University of Bath, England
    Acta Crystallogr D Biol Crystallogr 61:1568-78. 2005
    ..These features represent considerable advantages over crystalline hAng and bAng...
  8. ncbi request reprint Behavior of endothelial cells on Matrigel and development of a method for a rapid and reproducible in vitro angiogenesis assay
    Benedict Crabtree
    Department of Biology and Biochemistry, University of Bath, Bath, BA2 7AY, UK
    In Vitro Cell Dev Biol Anim 43:87-94. 2007
    ..We also describe the differential behavior of normal and transformed endothelial cells cultured in Matrigel...
  9. pmc PA6 Stromal Cell Co-Culture Enhances SH-SY5Y and VSC4.1 Neuroblastoma Differentiation to Mature Phenotypes
    Ross Ferguson
    Department of Biology and Biochemistry, University of Bath, Bath, United Kingdom
    PLoS ONE 11:e0159051. 2016
    ..The co-culture system additionally cuts short the time taken to produce a more mature phenotype. We also show the application of this system to study proteins implicated in motor neuron disease...
  10. doi request reprint Dynamic expression of the mouse orthologue of the human amyotropic lateral sclerosis associated gene C9orf72 during central nervous system development and neuronal differentiation
    Ross Ferguson
    Department of Biology and Biochemistry, University of Bath, BA2 7AY, Bath, UK
    J Anat . 2016
    ..Our findings have implications for interpreting the pathophysiology caused by the repeat expansions in C9orf72 in mouse models...