Fiona E Smith
Affiliation: University of Newcastle
- Quantitative lithium magnetic resonance spectroscopy in the normal human brain on a 3 T clinical scannerFiona E Smith
Newcastle Magnetic Resonance Centre, Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, United Kingdom
Magn Reson Med 66:945-9. 2011..71 ± 0.1 mM, with no significant difference between gray and white matter. Mean serum concentration was 0.9 ± 0.16 mM, giving a mean brain/serum ratio of 0.78 ± 0.26...
- Comparison of magnetocardiography and electrocardiography: a study of automatic measurement of dispersion of ventricular repolarizationFiona E Smith
Medical Physics Department, Freeman Hospital Unit, University of Newcastle upon Tyne, High Heaton, Newcastle upon Tyne NE7 7DN, UK
Europace 8:887-93. 2006..For this study, magnetocardiography and electrocardiography were compared from automatic measurements of dispersion of ventricular repolarization...
- Comparison of magnetocardiography and electrocardiographyFiona E Smith
Medical Physics Department, Freeman Hospital Unit, Newcastle upon Tyne, UK
Anadolu Kardiyol Derg 7:20-2. 2007..Automated techniques were developed for the measurement of cardiac repolarisation using magnetocardiography...
- Effects of raising muscle glycogen synthesis rate on skeletal muscle ATP turnover rate in type 2 diabetesEe L Lim
Institute of Cellular Medicine, Newcastle Magnetic Resonance Centre, Newcastle University, Newcastle upon Tyne, United Kingdom
Am J Physiol Endocrinol Metab 301:E1155-62. 2011..In type 2 diabetes, skeletal muscle ATP turnover rates reflect the rate of glucose uptake and glycogen synthesis, rather than any primary mitochondrial defect...
- Errors in repolarization measurement using magnetocardiographyFiona E Smith
Regional Medical Physics Department, Freeman Hospital, Newcastle upon Tyne, UK
Pacing Clin Electrophysiol 25:1223-9. 2002..The errors detected demonstrate the importance of a standard presentation for repolarization measurement in the MCG...
- Effect of vildagliptin on hepatic steatosisMavin Macauley
Newcastle Magnetic Resonance Centre M M, K G H, F E S, P E T, A A M, R T, Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne NE4 5PL, United Kingdom Novartis Pharma AG A S, CH 4056 Basel, Switzerland and Novartis Pharmaceutical J E F, East Hanover, New Jersey 07936
J Clin Endocrinol Metab 100:1578-85. 2015..Although dipeptidyl-peptidase-4 inhibitors exert their major action via an incretin mechanism, a favorable effect of vildagliptin on lipid metabolism remains unexplained...
- Hepatic cholesteryl ester accumulation in lysosomal acid lipase deficiency: non-invasive identification and treatment monitoring by magnetic resonancePeter E Thelwall
Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, UK
J Hepatol 59:543-9. 2013..Secondly, we used MR spectroscopy to monitor the effects of an enzyme replacement therapy (ERT), sebelipase alfa (a recombinant human lysosomal acid lipase), on hepatic TG and CE content in the preclinical model...
- Diurnal variation in skeletal muscle and liver glycogen in humans with normal health and Type 2 diabetesMavin Macauley
Newcastle Magnetic Resonance Centre, Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, NE4 5PL, U K
Clin Sci (Lond) 128:707-13. 2015..0001). In early Type 2 diabetes, the major physiological mechanism for skeletal muscle postprandial glycogen storage is completely inactive. This is directly related to insulin resistance, although liver glycogen storage is normal. ..
- Noninvasive in vivo magnetic resonance measures of glutathione synthesis in human and rat liver as an oxidative stress biomarkerJohn T Skamarauskas
Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, UK Newcastle Magnetic Resonance Center, Newcastle University, Newcastle upon Tyne, UK
Hepatology 59:2321-30. 2014....
- Inhibition of lipolysis in Type 2 diabetes normalizes glucose disposal without change in muscle glycogen synthesis ratesEe L Lim
Newcastle Magnetic Resonance Centre, Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne NE4 5PL, UK
Clin Sci (Lond) 121:169-77. 2011..ATP turnover rate in muscle exhibits no relationship to the acute metabolic effect of insulin...
- Magnetic resonance quantification of water and metabolites in the brain of cirrhotics following induced hyperammonaemiaHanan Mardini
Liver Unit and Institute of Cellular Medicine, Freeman Hospital and Newcastle University, Newcastle upon Tyne, UK
J Hepatol 54:1154-60. 2011....
- Extraocular muscle atrophy and central nervous system involvement in chronic progressive external ophthalmoplegiaCynthia Yu-Wai-Man
Department of Ophthalmology, Royal Victoria Infirmary, Newcastle upon Tyne, United Kingdom
PLoS ONE 8:e75048. 2013..The aim of this magnetic resonance imaging (MRI) study was to investigate whether the ophthalmoplegia in CPEO is primarily myopathic in origin or whether there is evidence of contributory supranuclear pathway dysfunction...
- Comparison of automatic repolarization measurement techniques in the normal magnetocardiogramFiona E Smith
Regional Medical Physics Department, Freeman Hospital, Newcastle upon Tyne, The United Kingdom
Pacing Clin Electrophysiol 26:2096-102. 2003..25 Hz, -5.5 (5.3) ms for 0.5 Hz, and -17.1 (7.8) ms for 1 Hz. Automatic measurements of repolarization (QT) in the MCG differ between techniques and are influenced by filtering. These effects should be considered when comparing results...