Affiliation: University College London
- Development of a definition for Rapid Progression (RP) of renal function in HIV-positive persons: the D:A:D studyDavid A Kamara
Research Dept, of Infection and Population Health, University College London, London, United Kingdom
BMC Nephrol 15:51. 2014..73 m2 (using Cockcroft Gault) in the Data Collection on Adverse Events of Anti-HIV Drugs (D:A:D) study from 2004 to 2011...
- Higher risk of renal impairment associated with tenofovir use amongst people living with HIV in India: a comparative cohort analysis between Western India and United KingdomSanjay N Pujari
Institute of Infectious Diseases, Pune, India
BMC Infect Dis 14:173. 2014....
- Trends in underlying causes of death in people with HIV from 1999 to 2011 (D:A:D): a multicohort collaborationColette J Smith
Research Department of Infection and Population Health, University College London, London, UK Electronic address
Lancet 384:241-8. 2014..Consequently, the relative importance of other traditionally non-AIDS-related morbidities has increased. We investigated trends over time in all-cause mortality and for specific causes of death in people with HIV from 1999 to 2011...
- Factors associated with specific causes of death amongst HIV-positive individuals in the D:A:D StudyColette Smith
Research Department of Infection and Population Health, UCL, Royal Free Campus, London, UK
AIDS 24:1537-48. 2010..To investigate any emerging trends in causes of death amongst HIV-positive individuals in the current cART era, and to investigate the factors associated with each specific cause of death...
- Estimated average annual rate of change of CD4(+) T-cell counts in patients on combination antiretroviral therapyAmanda Mocroft
Research Department of Infection and Population Health, University College London Medical School, London, UK
Antivir Ther 15:563-70. 2010..Patients receiving combination antiretroviral therapy (cART) might continue treatment with a virologically failing regimen. We sought to identify annual change in CD4(+) T-cell count according to levels of viraemia in patients on cART...
- Outcomes in the first year after initiation of first-line HAART among heterosexual men and women in the UK CHIC StudyTristan J Barber
St Stephen s AIDS Trust Clinical Trials Unit, Chelsea and Westminster NHS Foundation Trust, London, UK
Antivir Ther 16:805-14. 2011..We analysed the influence of gender on use and outcomes of first-line HAART in a UK cohort...
- Data linkage reduces loss to follow-up in an observational HIV cohort studyTeresa Hill
Research Department of Infection and Population Health, UCL Medical School, London, UK
J Clin Epidemiol 63:1101-9. 2010..To ascertain the degree of loss to follow-up in a cohort and to identify its predictors...
- Discordant responses on starting highly active antiretroviral therapy: suboptimal CD4 increases despite early viral suppression in the UK Collaborative HIV Cohort (UK CHIC) StudyR J C Gilson
Centre for Sexual Health and HIV Research, Research Department of Infection and Population Health, University College London, The Mortimer Market Centre, Camden Primary Care Trust, London, UK
HIV Med 11:152-60. 2010..This study was designed to determine the incidence of a discordant response at two time-points, soon after 6 months and at 12 months, and to determine the relationship with clinical outcomes...
- The impact of HIV drug resistance testing on changes to treatmentLoveleen Bansi
Research Department of Infection and Population Health, UCL Medical School, UK
AIDS 25:603-10. 2011..We investigate changes made to therapy after a resistance test result and identify factors associated with switching regimen...
- Determinants of virological failure after successful viral load suppression in first-line highly active antiretroviral therapyAnna M Geretti
Royal Free and University College Medical School, London, UK
Antivir Ther 13:927-36. 2008....
- Lack of association between use of efavirenz and death from suicide: evidence from the D:A:D studyColette Smith
Infection and Population Health, University College London, London, UK
J Int AIDS Soc 17:19512. 2014..We investigated the association between EFV use and completed suicide...
- Predictors and kinetics of occult hepatitis B virus infection in HIV-infected personsGaia Nebbia
Department of Virology, Royal Free Hospital and Royal Free and University College Medical School, London, UK
J Med Virol 79:1464-71. 2007..The intermittent nature of HBV-DNA detection poses a diagnostic challenge, but no association is observed with ALT levels...
- Development and validation of a risk score for chronic kidney disease in HIV infection using prospective cohort data from the D:A:D studyAmanda Mocroft
Department of Infection and Population Health, University College London, London, United Kingdom
PLoS Med 12:e1001809. 2015..The aims of this study were to develop a simple, externally validated, and widely applicable long-term risk score model for CKD in HIV-positive individuals that can guide decision making in clinical practice...
- Sexual behaviour, recreational drug use and hepatitis C co-infection in HIV-diagnosed men who have sex with men in the United Kingdom: results from the ASTRA studyMarina Daskalopoulou
University College London Royal Free Hospital, London, UK
J Int AIDS Soc 17:19630. 2014..We explore associations between self-reported sexual behaviours and drug use with cumulative HCV prevalence, as well as new HCV diagnosis...
- A clinically useful risk-score for chronic kidney disease in HIV infectionAmanda Mocroft
Department of Infection and Population Health, University College London, London, UK
J Int AIDS Soc 17:19514. 2014..Development of a simple, widely applicable risk score for chronic kidney disease (CKD) allows comparisons of risks or benefits of starting potentially nephrotoxic antiretrovirals (ARVs) as part of a treatment regimen...
- The effect of transmitted HIV-1 drug resistance on pre-therapy viral loadLinda Harrison
HIV and Infections Group, MRC Clinical Trials Unit, London, UK
AIDS 24:1917-22. 2010..Reduced replication capacity of viruses expressing drug resistant mutations implies that patients with transmitted drug resistance (TDR) could have lower HIV RNA viral load than those infected with wild-type virus...
- Predictors of advanced chronic kidney disease and end-stage renal disease in HIV-positive personsLene Ryom
aCopenhagen HIV Programme, University of Copenhagen, Faculty of Health and Medical Sciences and Epidemiklinikken M5132, Copenhagen University Hospital Rigshospitalet, Copenhagen, Denmark bResearch Department of Infection and Population Health, UCL, London, UK cDivision of Nephrology, Mount Sinai School of Medicine, New York, USA dAcademic Medical Center, University of Amsterdam, and Stichting HIV Monitoring, The Netherlands eClinic for Infectious Diseases and Hospital Hygiene, Kantonsspital Aarau, Switzerland fService de médecine interne et maladies infectieuses, Hôpital Saint André, CHU de Bordeaux gNephrology Department, Public Health Department, CHU Nice, France hICAP Columbia University and Harlem Hospital, New York, USA iKirby Institute, Sydney, Australia
AIDS 28:187-99. 2014..Whilst several antiretroviral drugs have been associated with moderate chronic kidney disease (CKD), their contribution to advanced CKD and end-stage renal disease (ESRD) remain unknown...
- Responses to switching to maraviroc-based antiretroviral therapy in treated patients with suppressed plasma HIV-1-RNA loadPaola Vitiello
UCL Medical School, London, UK
Intervirology 55:172-8. 2012..The aim of this study was to evaluate patients on suppressive ART switching to an MVC-containing regimen (MVC-CR), and test the hypothesis that the switch may have an impact on T cell activation...
- Factors influencing lopinavir and atazanavir plasma concentrationWolfgang Stöhr
MRC Clinical Trials Unit, London, UK
J Antimicrob Chemother 65:129-37. 2010..The aim of this study was to evaluate which demographic factors and concomitant drugs are associated with lopinavir and atazanavir plasma concentration...
- Late diagnosis in the HAART era: proposed common definitions and associations with mortalityCaroline A Sabin
Research Department of Infection and Population Health, UCL Medical School, London, UK
AIDS 24:723-7. 2010....
- Cytomegalovirus glycoprotein-B vaccine with MF59 adjuvant in transplant recipients: a phase 2 randomised placebo-controlled trialPaul D Griffiths
Centre for Virology, UCL Medical School, London, UK
Lancet 377:1256-63. 2011..Values of viral load correlate with development of end-organ disease and are moderated by pre-existing natural immunity. Our aim was to determine whether vaccine-induced immunity could do likewise...
- Rate of viral load failure over time in people on ART in the UK Collaborative HIV Cohort (CHIC) studyJemma O'Connor
Department of Infection and Population Health, UCL, London, UK
J Int AIDS Soc 17:19527. 2014..It is unclear whether those who have maintained VL suppression for several years will be able to continue to do so, or if rates of VL failure - due to poor adherence, ART interruption and/or resistance - remain at appreciable levels...
- Socio-economic factors and virological suppression among people diagnosed with HIV in the United Kingdom: results from the ASTRA studyLisa Burch
Department of Infection and Population Health, University College London, London, UK
J Int AIDS Soc 17:19533. 2014..The impact of socio-economic factors on virological suppression has been little studied...
- Characteristics of Epstein-Barr viraemia in adult liver transplant patients: a retrospective cohort studyNeil Halliday
Department of Virology, Royal Free London NHS Foundation Trust, London, UK
Transpl Int 27:838-46. 2014..001) but shortened with ganciclovir exposure (P = 0.06). Younger patients were more likely to have high peak viral loads (P = 0.07). No clinical signs or symptoms or adverse outcomes were associated with EBV reactivation. ..
- Clinical epidemiology of HIV-associated end-stage renal failure in the UKLoveleen Bansi
University College London Medical School, London, UK
AIDS 23:2517-21. 2009..To describe the clinical epidemiology of HIV-associated end-stage renal failure (HIV/ESRF) from 1998 to 2007 in the United Kingdom...
- The associations between age and the development of laboratory abnormalities and treatment discontinuation for reasons other than virological failure in the first year of highly active antiretroviral therapyC A Sabin
Department of Primary Care and Population Science, Royal Free and UC Medical School, London, UK
HIV Med 10:35-43. 2009....
- Acetyl-l-carnitine: a pathogenesis based treatment for HIV-associated antiretroviral toxic neuropathyAndrew M Hart
Blond McIndoe Centre, Royal Free and University College Medical School, London, UK
AIDS 18:1549-60. 2004..ALCAR enhances neurotrophic support of sensory neurons and promotes energy metabolism, potentially causing nerve regeneration and symptom relief...
- Decreasing cost effectiveness of testing for latent TB in HIV in a low TB incidence areaSantino Capocci
Department of HIV and Thoracic Medicine, Royal Free London NHS Foundation Trust, London, UK
Eur Respir J 46:165-74. 2015..Both UK testing regimens missed cases but are cost-effective compared with no testing. Using recent data, they all became more expensive, suggesting that alternative or more targeted TB testing strategies must be considered...
- Injection Drug Use and Hepatitis C as Risk Factors for Mortality in HIV-Infected Individuals: The Antiretroviral Therapy Cohort CollaborationMargaret T May
School of Social and Community Medicine, University of Bristol, Bristol, United Kingdom Schools of Medicine and Public Health, Yale University, New Haven, CT VA Connecticut Healthcare System, West Haven, CT Stichting HIV Monitoring, Amsterdam, the Netherlands Research Department of Infection and Population Health, University College London, London, United Kingdom Fédération des Maladies Infectieuses, Centre Hospitalo Universitaire Pellegrin, Bordeaux, France INSERM U943 and UPMC UMR S 943, Paris, France Department of Internal Medicine, University Hospital Bonn, Bonn, Germany Department of Infectious Diseases, Ramon y Cajal Hospital, IRYCIS, Madrid, Spain Atlanta Veterans Affairs Medical Center, Decatur, GA Clinic of Infectious Diseases and Tropical Medicine, San Paolo Hospital, University of Milan, Milan, Italy Fundació de la Lluita contra la Sida, Hospital Universitari Germans Trias i Pujol, Universitat Autonoma de Barcelona, Badalona, Spain Division of Infectious Diseases, University of Calgary, Calgary, Alberta, Canada Department of Infectious Diseases, Cantonal Hospital St Gallen, Gallen, Department of Evolutionary Genetics
J Acquir Immune Defic Syndr 69:348-54. 2015..The extent to which higher rates of hepatitis C (HCV) infection in IDU explain survival differences is unclear...
- Will antiretroviral therapy reduce HIV-related liver risk?Joanna Allen
aDepartment of Infectious Diseases and HIV Medicine bResearch Department of Infection and Population Health, UCL, Royal Free Campus, London, United Kingdom
Curr Opin HIV AIDS 9:48-53. 2014..This article reviews the positive and potential negative impact of cART on liver-related morbidity and mortality...
- Impact of UK academic foundation programmes on aspirations to pursue a career in academiaOliver T A Lyons
Academic Department of Surgery, St Thomas Hospital, London, UK
Med Educ 44:996-1005. 2010..This study aimed to determine the role played by academic foundation programmes in influencing junior doctors' desire to pursue a career in academic medicine...
- A Method to Estimate the Size and Characteristics of HIV-positive Populations Using an Individual-based Stochastic Simulation ModelFumiyo Nakagawa
From the aResearch Department of Infection and Population Health, UCL, London, United Kingdom bStichting HIV Monitoring, Amsterdam, The Netherlands cInserm, centre Inserm U897, Bordeaux, France dDepartment of Infectious Disease Epidemiology, Imperial College London, London, United Kingdom eDepartment of Microbiology, Tumor and Cell Biology, Karolinska Institute, Stockholm, Sweden fDepartment of Clinical Microbiology, Karolinska University Hospital, Stockholm, Sweden gEuropean Centre for Disease Prevention and Control ECDC, Stockholm, Sweden hCEEISCAT, Generalitat de Catalunya, Barcelona, Spain iWHO Regional Office for Europe, Copenhagen, Denmark jInstitute of Clinical Trials and Methodology, UCL, London, United Kingdom kDivision of Infectious Diseases and Hospital Epidemiology, University Hospital Zurich, Zurich, Switzerland lResearch Department of Primary Care and Population Health, UCL, London, United Kingdom mCHIP Department of Infectious Diseases, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark nDepartment of Hygiene, Epidemiology and Medical Statistics, University of Athens Medical School, Athens, Greece oUCL Institute of Child Health, UCL, London
Epidemiology 27:247-56. 2016..We demonstrate that our method can be applied to settings with less data, however plausibility ranges for estimates will be wider to reflect greater uncertainty of the data used to fit the model. ..
- Evaluation of sequencing of HCV core/E1, NS5A and NS5B as a genotype predictive tool in comparison with commercial assays targeting 5'UTRAdele L McCormick
Department of Virology, Royal Free London NHS Foundation Trust, London, UK Electronic address
J Clin Virol 66:56-9. 2015..Hepatitis C virus (HCV) genotyping is required for tailoring the dose and duration of antiviral therapy, predicting virological response rates, and selecting future treatment options...
- Smoking and life expectancy among HIV-infected individuals on antiretroviral therapy in Europe and North AmericaMarie Helleberg
aDepartment of Infectious Diseases, Copenhagen University Hospital, Rigshospitalet bFaculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark cSchool of Social and Community Medicine, University of Bristol, Bristol, UK dUniversité Bordeaux, ISPED, Centre INSERM U897 Epidemiologie Biostatistique, Bordeaux, France eDepartment of Global Health, Academisch Medisch Centrum bij de universiteit van Amsterdam, and Stichting HIV Monitoring, Amsterdam, The Netherlands fDepartment of Internal Medicine, University of Cologne and German Centre for Infection Research DZIF, Cologne, Germany gSorbonne Universités, UPMC Univ Paris 06 hINSERM, UMR_S 1136, Institut Pierre Louis d Epidémiologie et de Santé Publique, Paris, France iClinic of Infectious Diseases and Tropical Medicine, San Paolo Hospital, University of Milan, Milan, Italy jService des maladies infectieuses, CHUV, Lausanne, Switzerland kResearch Department of Infection and Population Health, University College London, London, UK lYale University, New Haven mVA Connecticut Healthcare System, West Haven, Connecticut, USA nDivision of Infectious Diseases, University of Calgary, Calgary, USA
AIDS 29:221-9. 2015..Cardiovascular disease and non-AIDS malignancies have become major causes of death among HIV-infected individuals. The relative impact of lifestyle and HIV-related factors are debated...
- Fibroblast growth factor 23 and soluble klotho in children with chronic kidney diseaseMandy Wan
Renal Unit, Great Ormond Street Hospital for Children NHS Foundation Trust, London, UK
Nephrol Dial Transplant 28:153-61. 2013..There are scarce data on the levels of its essential co-receptor klotho, and longitudinal changes in FGF23 levels are also unknown...
- Reconstitution of herpes simplex virus-specific T cell immunity in HIV-infected patients receiving highly active antiretroviral therapyMeghna Ramaswamy
Department of Virology, Royal Free Hospital and Royal Free and University College Medical School, North Middlesex University Hospital, London, UK
J Infect Dis 195:410-5. 2007..6/month (95% confidence interval, 1.2-9.9 [P=.01]) and 21.3/100 CD4 cells/mm(3) gained (95% confidence interval, 13.8-28.7 [P<.0001]). Responses were correlated with LTNP status and CD4 cell count...
- Prospective monitoring of Epstein-Barr virus DNA in adult renal transplant recipients during the early posttransplant period: role of mycophenolate mofetilMichael V Holmes
Centre for Virology, Royal Free Campus, UCL Medical School, London, United Kingdom
Transplantation 87:852-6. 2009..Epstein-Barr virus (EBV) is associated with posttransplant lymphoproliferative disease. We monitored the incidence of EBV viraemia in adult renal transplant recipients and investigated the association with clinical parameters...