Peter Smielewski

Summary

Affiliation: University of Cambridge
Country: UK

Publications

  1. doi request reprint ICM+: a versatile software for assessment of CSF dynamics
    Peter Smielewski
    Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK
    Acta Neurochir Suppl 114:75-9. 2012
  2. doi request reprint Cerebral extracellular chemistry and outcome following traumatic brain injury: a microdialysis study of 223 patients
    Ivan Timofeev
    Division of Neurosurgery, Department of Clinical Neurosciences, University of Cambridge, Addenbrooke s Hospital, Cambridge, UK
    Brain 134:484-94. 2011
  3. doi request reprint A comparison study of cerebral autoregulation assessed with transcranial Doppler and cortical laser Doppler flowmetry
    Christian Zweifel
    Academic Neurosurgical Unit, University of Cambridge Clinical School, Cambridge, UK
    Neurol Res 32:425-8. 2010
  4. doi request reprint Transcranial Doppler pulsatility index: what it is and what it isn't
    Nicolas de Riva
    Division of Neurosurgery, Department of Clinical Neurosciences, Addenbrooke s Hospital, University of Cambridge, Hills Road, Box 167, Cambridge, CB2 0QQ, UK
    Neurocrit Care 17:58-66. 2012
  5. doi request reprint Transient changes in brain tissue oxygen in response to modifications of cerebral perfusion pressure: an observational study
    Danila K Radolovich
    Academic Neurosurgical Unit, Department of Clinical Neuroscience, University of Cambridge, Cambridge CB2 2QQ, UK
    Anesth Analg 110:165-73. 2010
  6. ncbi request reprint Intersubject variability and reproducibility of 15O PET studies
    Jonathan P Coles
    The Division of Anaesthesia, University of Cambridge, Addenbrooke s Hospital, Cambridge, UK
    J Cereb Blood Flow Metab 26:48-57. 2006
  7. doi request reprint Critical closing pressure during intracranial pressure plateau waves
    Georgios V Varsos
    Division of Neurosurgery, Department of Clinical Neurosciences, Addenbrooke s Hospital, University of Cambridge, Hills Road, Cambridge CB2 0QQ, UK
    Neurocrit Care 18:341-8. 2013
  8. ncbi request reprint Reliability of the blood flow velocity pulsatility index for assessment of intracranial and cerebral perfusion pressures in head-injured patients
    Christian Zweifel
    Academic Neurosurgical Unit, University of Cambridge Clinical School, Department of Clinical Neurosciences, Addenbrooke s Hospital, Cambridge, United Kingdom
    Neurosurgery 71:853-61. 2012
  9. doi request reprint Monitoring cerebral autoregulation after head injury. Which component of transcranial Doppler flow velocity is optimal?
    Karol P Budohoski
    Division of Neurosurgery, Department of Clinical Neurosciences, Addenbrooke s Hospital, University of Cambridge, Hills Road, Cambridge CB2 0QQ, UK
    Neurocrit Care 17:211-8. 2012
  10. pmc Critical closing pressure determined with a model of cerebrovascular impedance
    Georgios V Varsos
    Neurosurgical Unit, Department of Clinical Neurosciences, Division of Neurosurgery, Addenbrooke s Hospital, Cambridge, UK
    J Cereb Blood Flow Metab 33:235-43. 2013

Detail Information

Publications60

  1. doi request reprint ICM+: a versatile software for assessment of CSF dynamics
    Peter Smielewski
    Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK
    Acta Neurochir Suppl 114:75-9. 2012
    ..and analysis of their dependency on primary modalities. A collected database of cases and signals forms a powerful reference tool in the investigation and understanding of the complex pathophysiology of hydrocephalus...
  2. doi request reprint Cerebral extracellular chemistry and outcome following traumatic brain injury: a microdialysis study of 223 patients
    Ivan Timofeev
    Division of Neurosurgery, Department of Clinical Neurosciences, University of Cambridge, Addenbrooke s Hospital, Cambridge, UK
    Brain 134:484-94. 2011
    ..Whether treatment-related improvement in biochemistry translates into better outcome remains to be established...
  3. doi request reprint A comparison study of cerebral autoregulation assessed with transcranial Doppler and cortical laser Doppler flowmetry
    Christian Zweifel
    Academic Neurosurgical Unit, University of Cambridge Clinical School, Cambridge, UK
    Neurol Res 32:425-8. 2010
    ....
  4. doi request reprint Transcranial Doppler pulsatility index: what it is and what it isn't
    Nicolas de Riva
    Division of Neurosurgery, Department of Clinical Neurosciences, Addenbrooke s Hospital, University of Cambridge, Hills Road, Box 167, Cambridge, CB2 0QQ, UK
    Neurocrit Care 17:58-66. 2012
    ..We sought to evaluate the relationship between PI and CVR in situations, where CVR increases (mild hypocapnia) and decreases (plateau waves of intracranial pressure-ICP)...
  5. doi request reprint Transient changes in brain tissue oxygen in response to modifications of cerebral perfusion pressure: an observational study
    Danila K Radolovich
    Academic Neurosurgical Unit, Department of Clinical Neuroscience, University of Cambridge, Cambridge CB2 2QQ, UK
    Anesth Analg 110:165-73. 2010
    ..However, only a few of them analyzed fast (few minutes) and transient behavior of PbtO(2) in response to variations (waves) of intracranial pressure (ICP) and cerebral perfusion pressure (CPP)...
  6. ncbi request reprint Intersubject variability and reproducibility of 15O PET studies
    Jonathan P Coles
    The Division of Anaesthesia, University of Cambridge, Addenbrooke s Hospital, Cambridge, UK
    J Cereb Blood Flow Metab 26:48-57. 2006
    ..While ideally each centre should develop its own bank of such data, the figures provided will allow initial generic approximations of sample size for such studies...
  7. doi request reprint Critical closing pressure during intracranial pressure plateau waves
    Georgios V Varsos
    Division of Neurosurgery, Department of Clinical Neurosciences, Addenbrooke s Hospital, University of Cambridge, Hills Road, Cambridge CB2 0QQ, UK
    Neurocrit Care 18:341-8. 2013
    ..The aim of this study is to describe the behavior of CCP and WT during spontaneous increases of ICP, termed plateau waves, in order to quantify ischemic risk...
  8. ncbi request reprint Reliability of the blood flow velocity pulsatility index for assessment of intracranial and cerebral perfusion pressures in head-injured patients
    Christian Zweifel
    Academic Neurosurgical Unit, University of Cambridge Clinical School, Department of Clinical Neurosciences, Addenbrooke s Hospital, Cambridge, United Kingdom
    Neurosurgery 71:853-61. 2012
    ..It has been postulated that the Gosling pulsatility index (PI) assessed with transcranial Doppler (TCD) has a diagnostic value for noninvasive estimation of intracranial pressure (ICP) and cerebral perfusion pressure (CPP)...
  9. doi request reprint Monitoring cerebral autoregulation after head injury. Which component of transcranial Doppler flow velocity is optimal?
    Karol P Budohoski
    Division of Neurosurgery, Department of Clinical Neurosciences, Addenbrooke s Hospital, University of Cambridge, Hills Road, Cambridge CB2 0QQ, UK
    Neurocrit Care 17:211-8. 2012
    ..Systolic and diastolic FV have been explored in other diseases. This study aims to evaluate the systolic, mean and diastolic FV for monitoring autoregulation and predicting outcome after TBI...
  10. pmc Critical closing pressure determined with a model of cerebrovascular impedance
    Georgios V Varsos
    Neurosurgical Unit, Department of Clinical Neurosciences, Division of Neurosurgery, Addenbrooke s Hospital, Cambridge, UK
    J Cereb Blood Flow Metab 33:235-43. 2013
    ....
  11. doi request reprint Cerebrospinal compensation of pulsating cerebral blood volume in hydrocephalus
    Dong Joo Kim
    Academic Neurosurgical Unit, Addenbrooke s Hosptal, University of Cambridge, Cambridge CB2 2QQ, UK
    Neurol Res 32:587-92. 2010
    ..The method was verified using clinical recordings performed during infusion studies in a group of patients diagnosed with hydrocephalus...
  12. ncbi request reprint Effect of cerebral perfusion pressure augmentation on regional oxygenation and metabolism after head injury
    Andrew J Johnston
    University Department of Anaesthetics, Addenbrooke s Hospital, Cambridge, UK
    Crit Care Med 33:189-95; discussion 255-7. 2005
    ....
  13. pmc Changes in cerebral compartmental compliances during mild hypocapnia in patients with traumatic brain injury
    Emmanuel Carrera
    Academic Neurosurgery Unit, Department of Clinical Neurosciences, University of Cambridge, Cambridge, United Kingdom
    J Neurotrauma 28:889-96. 2011
    ..Further studies are needed to determine whether monitoring of arterial and CSF compartment compliances may detect and prevent an adverse ischemic event during hyperventilation...
  14. doi request reprint Continuous determination of optimal cerebral perfusion pressure in traumatic brain injury
    Marcel J H Aries
    Division of Neurosurgery, Department of Clinical Neurosciences, University of Cambridge, and Neurosciences Critical Care Unit, Addenbrooke s Hospital, Cambridge, UK
    Crit Care Med 40:2456-63. 2012
    ..We then validated the CPPopt algorithm by determining the association between outcome and the deviation of actual CPP from CPPopt...
  15. doi request reprint Time constant of the cerebral arterial bed
    Magdalena Kasprowicz
    Addenbrooke s Hospital, Cambridge, UK
    Acta Neurochir Suppl 114:17-21. 2012
    ..62, p = 0.001). In controls, τ was independent of age. Further study during cerebrovascular reactivity tests is needed to establish the usefulness of τ for quantitative estimation of haemodynamics in cerebrovascular disease...
  16. pmc Cerebral autoregulation after subarachnoid hemorrhage: comparison of three methods
    Karol P Budohoski
    Division of Neurosurgery, Department of Clinical Neurosciences, Addenbrooke s Hospital, University of Cambridge, Cambridge, UK
    J Cereb Blood Flow Metab 33:449-56. 2013
    ..Combining all three indices had 100% specificity for predicting DCI. While multiple colinearities exist between the assessed methods, multimodal monitoring of cerebral autoregulation can aid in predicting DCI...
  17. ncbi request reprint The relationship between cerebral blood flow autoregulation and cerebrovascular pressure reactivity after traumatic brain injury
    Karol P Budohoski
    Division of Neurosurgery, Department of Clinical Neurosciences, Addenbrooke s Hospital, University of Cambridge, Cambridge, UK
    Neurosurgery 71:652-60; discussion 660-1. 2012
    ..From a practical point of view, PRx can be monitored continuously, whereas Mx can only be monitored in short periods when transcranial Doppler probes can be applied...
  18. doi request reprint Continuous monitoring of cerebrovascular reactivity using pulse waveform of intracranial pressure
    Marcel J H Aries
    Academic Neurosurgery Unit, Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK
    Neurocrit Care 17:67-76. 2012
    ....
  19. doi request reprint Reactivity of brain tissue oxygen to change in cerebral perfusion pressure in head injured patients
    Danila K Radolovich
    Academic Neurosurgical Unit, Department of Clinical Neuroscience, University of Cambridge, Addenbrooke s Hospital, P O Box 167, Cambridge, CB2 2QQ, UK
    Neurocrit Care 10:274-9. 2009
    ..We aimed to compare similar indices describing interaction between changes in intracranial pressure (ICP), arterial blood pressure (ABP), and brain tissue oxygen to verify their clinical utility in patients after traumatic brain injury...
  20. doi request reprint Impairment of cerebral autoregulation predicts delayed cerebral ischemia after subarachnoid hemorrhage: a prospective observational study
    Karol P Budohoski
    Department of Clinical Neurosciences, Addenbrooke s Hospital, University of Cambridge, UK
    Stroke 43:3230-7. 2012
    ..We tested the hypothesis that early autoregulatory failure, detected using near-infrared spectroscopy-based index, TOxa and transcranial Doppler-based index, Sxa, can predict DCI...
  21. doi request reprint Critical closing pressure: comparison of three methods
    Jorge A López-Magaña
    Department of Clinical Neurosciences, Neurosurgery Unit, Addenbrooke s Hospital, University of Cambridge, Cambridge, UK
    J Cereb Blood Flow Metab 29:987-93. 2009
    ..However, predictions of CCP using TCD waveform analysis show substantial differences from values of CCP recorded during cardiac arrest...
  22. ncbi request reprint Responses of posttraumatic pericontusional cerebral blood flow and blood volume to an increase in cerebral perfusion pressure
    Luzius A Steiner
    Wolfson Brain Imaging Centre, University Department of Anesthesia, Academic Neurosurgery, Addenbrooke s Hospital, Cambridge, UK
    J Cereb Blood Flow Metab 23:1371-7. 2003
    ..Pericontusional oedema on computed tomography was associated with lower absolute values of CBF and CBV but did not differ from nonoedematous tissue in the relative response to CPP elevation...
  23. doi request reprint Critical thresholds for transcranial Doppler indices of cerebral autoregulation in traumatic brain injury
    Enrico Sorrentino
    Department of Academic Neurosurgery, Addenbrooke s Hospital, Hills Rd, Cambridge, CB2 OQQ, UK
    Neurocrit Care 14:188-93. 2011
    ..Transcranial Doppler-derived indices of cerebral autoregulation are related to outcome after TBI. We analyzed our retrospective material to identify thresholds discriminative of outcome for these indices...
  24. doi request reprint Continuous assessment of cerebral autoregulation with near-infrared spectroscopy in adults after subarachnoid hemorrhage
    Christian Zweifel
    Academic Neurosurgical Unit, University of Cambridge Clinical School, Cambridge, UK
    Stroke 41:1963-8. 2010
    ..In this study, we compared near-infrared spectroscopy-based indices of cerebral autoregulation (TOx) with Mx in patients with subarachnoid hemorrhage...
  25. doi request reprint Non-invasively estimated ICP pulse amplitude strongly correlates with outcome after TBI
    Karol P Budohoski
    Department of Clinical Neurosciences, Addenbrooke s Hospital, Cambridge, UK
    Acta Neurochir Suppl 114:121-5. 2012
    ....
  26. ncbi request reprint Effect of hyperoxia on regional oxygenation and metabolism after severe traumatic brain injury: preliminary findings
    Jurgens Nortje
    University Division of Anaesthesia, University of Cambridge, Addenbrooke s Hospital, Cambridge, UK
    Crit Care Med 36:273-81. 2008
    ..To determine the effect of normobaric hyperoxia on cerebral metabolism in patients with severe traumatic brain injury...
  27. doi request reprint "Optimal cerebral perfusion pressure" in poor grade patients after subarachnoid hemorrhage
    Philippe Bijlenga
    Academic Neurosurgical Unit, Department of Neurosurgery, Addenbrooke s Hospital, University of Cambridge, Cambridge, CB2 0QQ, UK
    Neurocrit Care 13:17-23. 2010
    ..The study investigates the association between vasospasm, PRx, and CPPopt in poor grade patients (WFNS 4&5) after subarachnoid hemorrhage (SAH)...
  28. doi request reprint What shapes pulse amplitude of intracranial pressure?
    Emmanuel Carrera
    Academic Neurosurgical Unit, Department of Clinical Neurosciences, Addenbrooke s Hospital, University of Cambridge, Cambridge CB2 2QQ, United Kingdom
    J Neurotrauma 27:317-24. 2010
    ..Further clinical studies will reveal whether AMP(ICP) is a better indicator of clinical severity and outcome than mICP in TBI and NPH patients...
  29. pmc Cerebral vasospasm affects arterial critical closing pressure
    Georgios V Varsos
    Division of Neurosurgery, Department of Clinical Neurosciences, Addenbrooke s Hospital, University of Cambridge, Cambridge, UK
    J Cereb Blood Flow Metab 35:285-91. 2015
    ..As ICP remained unchanged during CVS, reduced CrCP most probably reflects a lower wall tension in dilated small vessels distal to spasm. ..
  30. doi request reprint Clinical relevance of cerebral autoregulation following subarachnoid haemorrhage
    Karol P Budohoski
    Division of Neurosurgery, Department of Clinical Neurosciences, Addenbrooke s Hospital, University of Cambridge, Hills Road, Cambridge CB2 0QQ, UK
    Nat Rev Neurol 9:152-63. 2013
    ..Better understanding of cerebral autoregulation following SAH could reveal mechanisms of blood-flow regulation that could be therapeutically targeted to improve patient outcome...
  31. doi request reprint Index of cerebrospinal compensatory reserve in hydrocephalus
    Dong Joo Kim
    Academic Neurosurgical Unit, Addenbrooke s Hospital, University of Cambridge, Cambridge, England
    Neurosurgery 64:494-501; discussion 501-2. 2009
    ..We explore how RAP varies with different forms of physiological or nonphysiological intracranial volume loads in adult hydrocephalus, with and without a functioning cerebrospinal fluid (CSF) shunt...
  32. ncbi request reprint Defining ischemic burden after traumatic brain injury using 15O PET imaging of cerebral physiology
    Jonathan P Coles
    The Division of Anesthesia, and The Wolfson Brain Imaging Center, University of Cambridge, Addenbrooke s Hospital, Cambridge, UK
    J Cereb Blood Flow Metab 24:191-201. 2004
    ..We conclude that this technique is a valid and useful tool for quantifying ischemic burden after traumatic brain injury...
  33. ncbi request reprint Hyperventilation following head injury: effect on ischemic burden and cerebral oxidative metabolism
    Jonathan P Coles
    Division of Anaesthesia, University of Cambridge, Addenbrooke s Hospital, Cambridge, UK
    Crit Care Med 35:568-78. 2007
    ..To determine whether hyperventilation exacerbates cerebral ischemia and compromises oxygen metabolism (CMRO2) following closed head injury...
  34. doi request reprint A synopsis of brain pressures: which? when? are they all useful?
    Marek Czosnyka
    Academic Neurosurgery Unit, Department of Neurosciences, University of Cambridge, Box 167, Addenbrooke s Hospital, Cambridge CB2 2QQ, UK
    Neurol Res 29:672-9. 2007
    ....
  35. doi request reprint Intraspinal pressure and spinal cord perfusion pressure after spinal cord injury: an observational study
    Georgios V Varsos
    Division of Neurosurgery, Department of Clinical Neurosciences, Addenbrooke s Hospital, University of Cambridge, Cambridge
    J Neurosurg Spine 23:763-71. 2015
    ..It was hypothesized that the waveform analysis method used to assess ICP could be similarly applied to ISP...
  36. doi request reprint The monitoring of relative changes in compartmental compliances of brain
    Dong Joo Kim
    Academic Neurosurgical Unit, Addenbrooke s Hospital, University of Cambridge, Cambridge, UK Department of Engineering, University of Cambridge, Cambridge, UK
    Physiol Meas 30:647-59. 2009
    ..Plateau waves affect the balance between vascular and CSF compartments, which is reflected by the inverse change of compliance of the cerebral arterial bed and global compliance of the CSF space...
  37. doi request reprint Effect of hyper- and hypocapnia on cerebral arterial compliance in normal subjects
    Emmanuel Carrera
    Department of Clinical Neurosciences, Addenbrooke s Hospital, University of Cambridge, Cambridge, United Kingdom
    J Neuroimaging 21:121-5. 2011
    ..However, the effects of changes in PaCO2 on cerebral arterial compliance (Ca) are unknown...
  38. ncbi request reprint Diffusion limited oxygen delivery following head injury
    David K Menon
    Division of Anaesthesia, and The Wolfson Brain Imaging Centre, University of Cambridge, Addenbrooke s Hospital, Cambridge, UK
    Crit Care Med 32:1384-90. 2004
    ..To use a range of techniques to explore diffusion limitation as a mechanism of cellular hypoxia in the setting of head injury...
  39. doi request reprint A noninvasive estimation of cerebral perfusion pressure using critical closing pressure
    Georgios V Varsos
    Division of Neurosurgery, Department of Clinical Neurosciences, Addenbrooke s Hospital, University of Cambridge, United Kingdom
    J Neurosurg 123:638-48. 2015
    ..Based on critical closing pressure (CrCP), the authors introduce a novel method for a noninvasive estimator of CPP (eCPP)...
  40. pmc Comparison of frequency and time domain methods of assessment of cerebral autoregulation in traumatic brain injury
    Xiuyun Liu
    Division of Neurosurgery, Department of Clinical Neurosciences, Addenbrooke s Hospital, University of Cambridge, Cambridge, UK
    J Cereb Blood Flow Metab 35:248-56. 2015
    ..05). Only ARI_a, ARI_c, Mx_a, Mx_c, and phase_c were significantly correlated with patients' outcome, with Mx_c showing the strongest association...
  41. doi request reprint Bilateral failure of cerebral autoregulation is related to unfavorable outcome after subarachnoid hemorrhage
    Karol P Budohoski
    Division of Neurosurgery, Department of Clinical Neurosciences, Addenbrooke s Hospital, University of Cambridge, Hills Road, CB2 0QQ, Cambridge, UK
    Neurocrit Care 22:65-73. 2015
    ..The extent of hemodynamic disturbances following subarachnoid hemorrhage (SAH) varies. We aim to determine the prognostic implications of unilateral and bilateral autoregulatory failure on delayed cerebral ischemia (DCI) and outcome...
  42. doi request reprint Cessation of diastolic cerebral blood flow velocity: the role of critical closing pressure
    Georgios V Varsos
    Division of Neurosurgery, Department of Clinical Neurosciences, University of Cambridge Biomedical Campus, Cambridge, CB20QQ, UK
    Neurocrit Care 20:40-8. 2014
    ..Further reductions in CPP can cause cessation of CBF during diastole. We hypothesized that zero diastolic flow velocity (FV) occurs when diastolic blood pressure becomes less than the critical closing pressure (CrCP)...
  43. ncbi request reprint Integrated image analysis solutions for PET datasets in damaged brain
    Peter Smielewski
    Wolfson Brain Imaging Centre, Department of Neurosurgery, University of Cambridge, UK
    J Clin Monit Comput 17:427-40. 2002
    ..To present an integrated imaging solution for analysis of such datasets and report on its use in practice...
  44. ncbi request reprint Predictive value of initial computerized tomography scan, intracranial pressure, and state of autoregulation in patients with traumatic brain injury
    Magdalena Hiler
    Academic Neurosurgical Unit, Department of Clinical Neuroscience, University of Cambridge, Addenbrooke s NHS Trust, Cambridge, United Kingdom
    J Neurosurg 104:731-7. 2006
    ....
  45. doi request reprint Near infrared spectroscopy as possible non-invasive monitor of slow vasogenic ICP waves
    Ruwan Alwis Weerakkody
    University of Cambridge, Cambridge, UK
    Acta Neurochir Suppl 114:181-5. 2012
    ..Correlating changes in Hb and HbO(2) may be of use as a method of non-invasive detection of vasogenic ICP waves...
  46. doi request reprint Increased blood glucose is related to disturbed cerebrovascular pressure reactivity after traumatic brain injury
    Joseph Donnelly
    Division of Neurosurgery, Department of Clinical Neurosciences, University of Cambridge, Cambridge Biomedical Campus, Box 167, Cambridge, CB2 0QQ, UK
    Neurocrit Care 22:20-5. 2015
    ..Increased blood glucose and impaired pressure reactivity (PRx) after traumatic brain injury (TBI) are both known to correlate with unfavorable patient outcome. However, the relationship between these two variables is unknown...
  47. doi request reprint Relationship of vascular wall tension and autoregulation following traumatic brain injury
    Georgios V Varsos
    Division of Neurosurgery, Department of Clinical Neurosciences, Addenbrooke s Hospital, University of Cambridge, Hills Road, Cambridge, CB2 0QQ, UK
    Neurocrit Care 21:266-74. 2014
    ..In this study, we investigated the association of WT and CrCP with autoregulation and outcome of a large group of patients after traumatic brain injury (TBI)...
  48. pmc Complexity of intracranial pressure correlates with outcome after traumatic brain injury
    Cheng Wei Lu
    Division of Neurosurgery, Department of Clinical Neurosciences, University of Cambridge, Cambridge CB0 2QQ, UK
    Brain 135:2399-408. 2012
    ..0001). The results of this study suggest that complexity of intracranial pressure assessed by multiscale entropy was significantly associated with outcome in patients with brain injury...
  49. doi request reprint Vasospasm shortens cerebral arterial time constant
    Magdalena Kasprowicz
    Academic Neurosurgery Unit, Addenbrooke s Hospital, Cambridge CB20QQ, Box167, UK
    Neurocrit Care 16:213-8. 2012
    ..We investigate the pattern of changes in τ following subarachnoid hemorrhage (SAH), with specific emphasis on the temporal profile of changes in relation to the development of cerebral vasospasm...
  50. pmc Continuous Multimodality Monitoring in Children after Traumatic Brain Injury-Preliminary Experience
    Adam M H Young
    Division of Academic Neurosurgery, Department of Clinical Neurosciences, Addenbrooke s Hospital, University of Cambridge, Cambridge, United Kingdom
    PLoS ONE 11:e0148817. 2016
    ..Multimodality monitoring is regularly employed in adult traumatic brain injury (TBI) patients where it provides physiologic and therapeutic insight into this heterogeneous condition. Pediatric studies are less frequent...
  51. doi request reprint Clinical and Physiological Events That Contribute to the Success Rate of Finding "Optimal" Cerebral Perfusion Pressure in Severe Brain Trauma Patients
    Corien S A Weersink
    1Division of Neurosurgery, Department of Clinical Neurosciences, Addenbrooke s Hospital, University of Cambridge, Cambridge, United Kingdom 2Department of Neurosurgery, University of Groningen, University Medical Centre Groningen, Groningen, The Netherlands 3Department of Critical Care, University of Groningen, University Medical Centre Groningen, Groningen, The Netherlands 4Department of Intensive Care, Neurocritical Care Unit, Hospital Sao Joao, Porto, Portugal
    Crit Care Med 43:1952-63. 2015
    ..The aim of this study is to investigate the relation between the absence of the optimal cerebral perfusion pressure curve and physiological variables, clinical factors, and interventions...
  52. doi request reprint Monitoring of spinal cord perfusion pressure in acute spinal cord injury: initial findings of the injured spinal cord pressure evaluation study*
    Melissa C Werndle
    1Academic Neurosurgery Unit, St George s, University of London, London, United Kingdom 2Department of Neurosurgery, University of Cambridge, Addenbrooke s Hospital, Cambridge, United Kingdom 3National Spinal Injuries Centre, Stoke Mandeville Hospital, Stoke Mandeville, United Kingdom 4Department of Anaesthesia, St George s Hospital, London, United Kingdom
    Crit Care Med 42:646-55. 2014
    ..To develop a technique for continuously monitoring intraspinal pressure at the injury site (intraspinal pressure) after traumatic spinal cord injury...
  53. doi request reprint Doppler Non-invasive Monitoring of ICP in an Animal Model of Acute Intracranial Hypertension
    Chiara Robba
    Neurocritical Care Unit, Addenbrooke s Hospital, Cambridge University, Cambridge University Hospitals Trust, Box 1, Hills Road, Cambridge, CB2 0QQ, UK
    Neurocrit Care 23:419-26. 2015
    ..Non-invasive techniques for monitoring ICP (nICP) have been developed. The aim of this study was to compare three different methods of transcranial Doppler (TCD) assessment of nICP in an animal model of acute intracranial hypertension...
  54. doi request reprint Magnetic field interactions in adjustable hydrocephalus shunts
    Andrea Lavinio
    United Kingdom Shunt Evaluation Laboratory, University of Cambridge, Cambridge, United Kingdom
    J Neurosurg Pediatr 2:222-8. 2008
    ..Shunt valves can also generate considerable imaging artifacts. The purpose of this study was to determine the magnetic field safety and MR imaging compatibility of 5 adjustable models of hydrocephalus shunts...
  55. pmc Consensus statement from the 2014 International Microdialysis Forum
    Peter J Hutchinson
    Division of Neurosurgery, Department of Clinical Neurosciences, University of Cambridge, Box 167, Cambridge Biomedical Campus, Cambridge, CB2 0QQ, UK
    Intensive Care Med 41:1517-28. 2015
    ....
  56. doi request reprint Model-based indices describing cerebrovascular dynamics
    Georgios V Varsos
    Neurosurgical Unit, Department of Clinical Neurosciences, Addenbrooke s Hospital, University of Cambridge, Cambridge, UK
    Neurocrit Care 20:142-57. 2014
    ..This potentially "early warning" indicator may then prove to be important for the therapeutic management of the patient. ..
  57. doi request reprint Use of drains versus no drains after burr-hole evacuation of chronic subdural haematoma: a randomised controlled trial
    Thomas Santarius
    Department of Neurosurgery, Addenbrooke s Hospital, University of Cambridge, Cambridge, UK
    Lancet 374:1067-73. 2009
    ..It recurs after surgical evacuation in 5-30% of patients. Drains might reduce recurrence but are not used routinely. Our aim was to investigate the effect of drains on recurrence rates and clinical outcomes...
  58. pmc Principles of cerebral hemodynamics when intracranial pressure is raised: lessons from the peripheral circulation
    Mi Ok Kim
    aAustralian School of Advanced Medicine, Macquarie University bSt Vincent s Clinic cUniversity of New South Wales dVictor Chang Cardiac Research Institute, Sydney, Australia eAcademic Neurosurgical Unit, Addenbrooke s Hospital, Cambridge University, Cambridge, UK
    J Hypertens 33:1233-41. 2015
    ..Pulsatile arterial hemodynamics in the brain have been studied before, but are still inadequately understood, especially during changes of intracranial pressure (ICP) after head injury...
  59. ncbi request reprint Limbic hypometabolism in Alzheimer's disease and mild cognitive impairment
    Peter J Nestor
    University of Cambridge, Neurology Unit, Cambridge, United Kingdom
    Ann Neurol 54:343-51. 2003
    ..The amnesia of very early AD reflects severe but localized limbic dysfunction...
  60. ncbi request reprint Assessment of cerebrovascular autoregulation in head-injured patients: a validation study
    Luzius A Steiner
    Wolfson Brain Imaging Centre, Addenbrooke s Hospital, Cambridge, UK
    Stroke 34:2404-9. 2003
    ..Cerebrovascular autoregulation is frequently measured in head-injured patients. We attempted to validate 4 bedside methods used for assessment of autoregulation...