Salman Siddiqui

Summary

Affiliation: University of Leicester
Country: UK

Publications

  1. doi request reprint Advances in the management of severe asthma
    Salman Siddiqui
    Department of Infection, Immunity, and Inflammation, Institute for Lung Health, University Hospitals of Leicester NHS Trust, Glenfield Hospital, Leicester, United Kingdom
    Semin Respir Crit Care Med 33:666-84. 2012
  2. pmc Airway hyperresponsiveness is dissociated from airway wall structural remodeling
    Salman Siddiqui
    Institute of Lung Health, Leicester, United Kingdom
    J Allergy Clin Immunol 122:335-41, 341.e1-3. 2008
  3. doi request reprint Mast cell fibroblastoid differentiation mediated by airway smooth muscle in asthma
    Davinder Kaur
    Institute for Lung Health, Department of Infection, Inflammation, and Immunity, University of Leicester, Leicester, United Kingdom
    J Immunol 185:6105-14. 2010
  4. pmc Elevated sputum interleukin-5 and submucosal eosinophilia in obese individuals with severe asthma
    Dhananjay Desai
    1 Institute for Lung Health, NIHR Respiratory Biomedical Research Unit, Department of Infection, Immunity and Inflammation, University of Leicester, Leicester, United Kingdom
    Am J Respir Crit Care Med 188:657-63. 2013
  5. pmc Quantitative analysis of high-resolution computed tomography scans in severe asthma subphenotypes
    Sumit Gupta
    Institute for Lung Health, Department of Infection, Inflammation and Immunity, University of Leicester, Leicester LE3 9QP, UK
    Thorax 65:775-81. 2010
  6. pmc Sputum mediator profiling and relationship to airway wall geometry imaging in severe asthma
    Dhananjay Desai
    Institute for Lung Health, NIHR Respiratory Biomedical Research Unit, Department of Infection, Immunity and Inflammation, University of Leicester, Leicester, UK
    Respir Res 14:17. 2013
  7. pmc Eosinophil protein in airway macrophages: a novel biomarker of eosinophilic inflammation in patients with asthma
    Neeta S Kulkarni
    Institute for Lung Health, Glenfield Hospital, Groby Road, Leicester LE3 9QP, United Kingdom
    J Allergy Clin Immunol 126:61-9.e3. 2010
  8. pmc The role of CT scanning in multidimensional phenotyping of COPD
    Mona Bafadhel
    Department of Infection, Immunity and Inflammation, Institute for Lung Health, University of Leicester, Leicester, England
    Chest 140:634-42. 2011
  9. pmc Expression of the T helper 17-associated cytokines IL-17A and IL-17F in asthma and COPD
    Camille Doe
    Institute for Lung Health, University of Leicester, Clinical Sciences Wing, Glenfield Hospital, Groby Rd, Leicester, LE3 9QP, England
    Chest 138:1140-7. 2010
  10. pmc Qualitative analysis of high-resolution CT scans in severe asthma
    Sumit Gupta
    Institute for Lung Health, University of Leicester, Leicester, UK
    Chest 136:1521-8. 2009

Collaborators

  • Sumit Gupta
  • Sherif Gonem
  • Ian D Pavord
  • Pranab Haldar
  • Richard May
  • Omar S Usmani
  • Glenn Cruse
  • Neeta S Kulkarni
  • Sudha Visvanathan
  • Dhananjay Desai
  • Christopher E Brightling
  • Peter Bradding
  • Mona Bafadhel
  • Christopher Brightling
  • Camille Doe
  • Davinder Kaur
  • Ruth Saunders
  • Christopher Newby
  • Lucy Woodman
  • Ruth Green
  • Amisha Singapuri
  • Joanne Woods
  • Ian K Anderson
  • Carolina Walker
  • Andrew J Wardlaw
  • Fay Hollins
  • Amanda Sutcliffe
  • Shironjit K Saha
  • Joshua Agbetile
  • Beverley Hargadon
  • Will Monteiro
  • Chris E Brightling
  • Harsukh Parmar
  • Radhika Kajekar
  • William Monteiro
  • Ana R Sousa
  • Sachil Shah
  • Fiona A Symon
  • James Entwisle
  • Richard P Marshall
  • Athula Herath
  • Dhiraj D Vara
  • Vimal Raj
  • James J Entwisle
  • Imran Umar
  • J Vimal Raj
  • Paul Rugman
  • Vijay Mistry
  • Margaret McCormick
  • Matthew A Sleeman
  • Andrew Wardlaw
  • Angela Morgan
  • Deborah Parker
  • Phillip Monk
  • Mike A Berry

Detail Information

Publications24

  1. doi request reprint Advances in the management of severe asthma
    Salman Siddiqui
    Department of Infection, Immunity, and Inflammation, Institute for Lung Health, University Hospitals of Leicester NHS Trust, Glenfield Hospital, Leicester, United Kingdom
    Semin Respir Crit Care Med 33:666-84. 2012
    ....
  2. pmc Airway hyperresponsiveness is dissociated from airway wall structural remodeling
    Salman Siddiqui
    Institute of Lung Health, Leicester, United Kingdom
    J Allergy Clin Immunol 122:335-41, 341.e1-3. 2008
    ..However, it is not known whether other features of structural remodeling including increased airway smooth muscle (ASM) mass, matrix deposition, and glandular hyperplasia are also present in EB...
  3. doi request reprint Mast cell fibroblastoid differentiation mediated by airway smooth muscle in asthma
    Davinder Kaur
    Institute for Lung Health, Department of Infection, Inflammation, and Immunity, University of Leicester, Leicester, United Kingdom
    J Immunol 185:6105-14. 2010
    ....
  4. pmc Elevated sputum interleukin-5 and submucosal eosinophilia in obese individuals with severe asthma
    Dhananjay Desai
    1 Institute for Lung Health, NIHR Respiratory Biomedical Research Unit, Department of Infection, Immunity and Inflammation, University of Leicester, Leicester, United Kingdom
    Am J Respir Crit Care Med 188:657-63. 2013
    ..The relationship between airway inflammation and obesity in severe asthma is poorly understood...
  5. pmc Quantitative analysis of high-resolution computed tomography scans in severe asthma subphenotypes
    Sumit Gupta
    Institute for Lung Health, Department of Infection, Inflammation and Immunity, University of Leicester, Leicester LE3 9QP, UK
    Thorax 65:775-81. 2010
    ..The aim of this study was to assess whether airway remodelling is restricted to specific subphenotypes of severe asthma...
  6. pmc Sputum mediator profiling and relationship to airway wall geometry imaging in severe asthma
    Dhananjay Desai
    Institute for Lung Health, NIHR Respiratory Biomedical Research Unit, Department of Infection, Immunity and Inflammation, University of Leicester, Leicester, UK
    Respir Res 14:17. 2013
    ..We sought to define sputum mediator profiles in severe asthmatics categorised by CT-determined airway geometry and sputum differential cell counts...
  7. pmc Eosinophil protein in airway macrophages: a novel biomarker of eosinophilic inflammation in patients with asthma
    Neeta S Kulkarni
    Institute for Lung Health, Glenfield Hospital, Groby Road, Leicester LE3 9QP, United Kingdom
    J Allergy Clin Immunol 126:61-9.e3. 2010
    ....
  8. pmc The role of CT scanning in multidimensional phenotyping of COPD
    Mona Bafadhel
    Department of Infection, Immunity and Inflammation, Institute for Lung Health, University of Leicester, Leicester, England
    Chest 140:634-42. 2011
    ..CT imaging is emerging as an important, noninvasive tool in phenotyping COPD. However, the use of CT imaging in defining the disease heterogeneity above lung function is not fully known...
  9. pmc Expression of the T helper 17-associated cytokines IL-17A and IL-17F in asthma and COPD
    Camille Doe
    Institute for Lung Health, University of Leicester, Clinical Sciences Wing, Glenfield Hospital, Groby Rd, Leicester, LE3 9QP, England
    Chest 138:1140-7. 2010
    ..The T helper (Th) 17 cytokines IL-17A and IL-17F have been implicated in the development of neutrophilic airway inflammation, but their expression in asthma and COPD is uncertain...
  10. pmc Qualitative analysis of high-resolution CT scans in severe asthma
    Sumit Gupta
    Institute for Lung Health, University of Leicester, Leicester, UK
    Chest 136:1521-8. 2009
    ..We sought to describe the HRCT scan abnormalities of a large severe asthma cohort and to determine the utility of clinical features to direct the use of HRCT scanning in this group of patients...
  11. pmc Mast cells promote airway smooth muscle cell differentiation via autocrine up-regulation of TGF-beta 1
    Lucy Woodman
    Institute for Lung Health, Department of Infection, Inflammation and Immunity, University of Leicester, Leicester, United Kingdom
    J Immunol 181:5001-7. 2008
    ....
  12. pmc Airway wall expression of OX40/OX40L and interleukin-4 in asthma
    Salman Siddiqui
    Institute of Lung Health, Department of Infection, Inflammation and Immunity, University of Leicester, Leicester, LE3 9QP, England
    Chest 137:797-804. 2010
    ..We sought to examine OX40/OX40L and interleukin (IL)-4 expression in asthma across severities...
  13. doi request reprint Evidence for phenotype-driven treatment in asthmatic patients
    Sherif Gonem
    Department of Infection, Immunity and Inflammation, Institute for Lung Health, University of Leicester, Leicester, UK
    Curr Opin Allergy Clin Immunol 11:381-5. 2011
    ..This review summarizes the current state of knowledge on phenotype-driven treatment of asthma...
  14. pmc Quantitative computed tomography-derived clusters: redefining airway remodeling in asthmatic patients
    Sumit Gupta
    Department of Infection, Inflammation and Immunity, Institute for Lung Health, University of Leicester, Leicester, United Kingdom Radiology Department, Glenfield Hospital, University Hospitals of Leicester NHS Trust, Leicester, United Kingdom Electronic address
    J Allergy Clin Immunol 133:729-38.e18. 2014
    ..Computed tomography (CT)-assessed proximal airway remodeling and air trapping in asthmatic patients might provide new insights into underlying disease mechanisms...
  15. pmc Fibrocyte localization to the airway smooth muscle is a feature of asthma
    Ruth Saunders
    Institute for Lung Health, Department of Infection, Immunity and Inflammation, University of Leicester, Leicester, United Kingdom
    J Allergy Clin Immunol 123:376-84. 2009
    ..Airway smooth muscle (ASM) hyperplasia is a hallmark of asthma that is associated with disease severity and persistent airflow obstruction...
  16. pmc Increased sputum and bronchial biopsy IL-13 expression in severe asthma
    Shironjit K Saha
    Institute for Lung Health, Clinical Sciences Wing, University Hospitals of Leicester, Leicester, United Kingdom
    J Allergy Clin Immunol 121:685-91. 2008
    ..The importance of IL-13 in the asthma paradigm is supported by increased expression in human subjects, particularly in patients with mild-to-moderate asthma. However, the role of IL-13 in severe asthma needs to be further defined...
  17. doi request reprint Characterization of acinar airspace involvement in asthmatic patients by using inert gas washout and hyperpolarized (3)helium magnetic resonance
    Sherif Gonem
    Institute for Lung Health, Department of Infection, Immunity and Inflammation, University of Leicester, Leicester, United Kingdom
    J Allergy Clin Immunol 137:417-25. 2016
    ..The multiple-breath inert gas washout parameter acinar ventilation heterogeneity (Sacin) is thought to be a marker of acinar airway involvement but has not been validated by using quantitative imaging techniques in asthmatic patients...
  18. doi request reprint Lung function decline and variable airway inflammatory pattern: longitudinal analysis of severe asthma
    Christopher Newby
    Department of Health Sciences, University of Leicester, Leicester, United Kingdom
    J Allergy Clin Immunol 134:287-94. 2014
    ..In addition, sputum eosinophilia has been shown to be associated with severe exacerbations and airflow limitation...
  19. doi request reprint Can inhaled corticosteroids prevent asthma exacerbations?
    Dhananjay Desai
    Department of Infection, Inflammation and Immunity, Institute of Lung Health, University of Leicester, Leicester, UK
    Curr Opin Pulm Med 17:16-22. 2011
    ..asthma exacerbations occur unpredictably, are a cause of morbidity and mortality, and contribute significantly to increased healthcare costs. Inhaled corticosteroids reduce exacerbations and improve quality of life...
  20. pmc Lung clearance index in adults with non-cystic fibrosis bronchiectasis
    Sherif Gonem
    Institute for Lung Health, University of Leicester, Leicester, UK
    Respir Res 15:59. 2014
    ....
  21. doi request reprint Validation of a photoacoustic gas analyser for the measurement of functional residual capacity using multiple-breath inert gas washout
    Sherif Gonem
    Institute for Lung Health, University of Leicester, Leicester, UK
    Respiration 87:462-8. 2014
    ..The respiratory mass spectrometer is the current gold-standard technique for performing multiple-breath inert gas washout (MBW), but is expensive and lacks portability. A number of alternative techniques have recently been described...
  22. doi request reprint Imaging advances in asthma
    Carolina Walker
    University of Leicester, Institute for Lung Health, Department of Infection, Inflammation and Immunity, Leicester, UK
    Expert Opin Med Diagn 5:453-65. 2011
    ....
  23. doi request reprint Small airways, big challenge: measuring the unseen?
    Salman Siddiqui
    Institute for Lung Health, Department of Infection, Immunity and Inflammation, University of Leicester and Glenfield Hospital, Leicester, UK
    Nat Med 18:1619-21. 2012
    ..This approach may be used as a biomarker to identify the small-airway lesion in chronic obstructive pulmonary disease, at an individual level in the clinic (pages 1711-1715)...
  24. ncbi request reprint Vascular remodeling is a feature of asthma and nonasthmatic eosinophilic bronchitis
    Salman Siddiqui
    Institute of Lung Health, University of Leicester, Leicester, United Kingdom
    J Allergy Clin Immunol 120:813-9. 2007
    ..Increased vascularity and expression of vascular endothelial growth factor (VEGF) are recognized features of the asthmatic airway. The association of vascular remodeling with airway hyperresponsiveness (AHR) is unclear...