Genomes and Genes
Ricky A Sharma
Affiliation: University of Oxford
- Radioembolization of liver metastases from colorectal cancer using yttrium-90 microspheres with concomitant systemic oxaliplatin, fluorouracil, and leucovorin chemotherapyRicky A Sharma
Department of Radiation Oncology and Biology, University of Oxford, Churchill Hospital, Oxford, UK
J Clin Oncol 25:1099-106. 2007..This treatment has not been tested with the radiosensitizing chemotherapy, oxaliplatin, which appears synergistic in the treatment of CRC when combined with fluorouracil and leucovorin (FOLFOX)...
- DNA repair pathways as targets for cancer therapyThomas Helleday
Radiation Oncology and Biology, University of Oxford, Old Road Campus Research Building, off Roosevelt Drive, Headington, Oxford, OX3 7DQ, UK
Nat Rev Cancer 8:193-204. 2008....
- Pharmacokinetics and pharmacodynamics of curcuminRicky A Sharma
Radiation Oncology and Biology, University of Oxford, Churchill Hospital, UK
Adv Exp Med Biol 595:453-70. 2007..With regard to considerable public and scientific interest in the use of phytochemicals derived from dietary components to combat or prevent human diseases, curcumin is currently a leading agent...
- Anatomical basis and histopathological changes resulting from selective internal radiotherapy for liver metastasesLai Mun Wang
Department of Cellular Pathology, Oxford University Hospitals NHS Trust, John Radcliffe Hospital, Oxford, UK
J Clin Pathol 66:205-11. 2013..Knowledge that liver tumours preferentially take their blood supply from the arterial blood supply rather than the portal venous system can be used for local delivery of treatment or for embolisation to cut off the blood supply to tumours...
- XPF protein levels determine sensitivity of malignant melanoma cells to oxaliplatin chemotherapy: suitability as a biomarker for patient selectionStephanie B Hatch
Department of Oncology, Oxford NIHR Biomedical Research Centre, Cancer Research UK Medical Research Council Gray Institute for Radiation Oncology and Biology, University of Oxford, Oxford, Oxfordshire, OX3 7DQ, United Kingdom
Int J Cancer 134:1495-503. 2014..Immunohistochemical detection of XPF appears suitable for development as a tissue biomarker for potentially selecting patients for oxaliplatin treatment in a prospective clinical trial. ..
- Biological and therapeutic relevance of nonreplicative DNA polymerases to cancerJason L Parsons
Cancer Research UK Medical Research Council, Oncology Department, Gray Institute for Radiation Oncology and Biology, University of Oxford, Oxford, United Kingdom
Antioxid Redox Signal 18:851-73. 2013..Furthermore, specialized DNA polymerases warrant examination of their potential use as clinical biomarkers to select for particular cancer therapies, to individualize treatment for patients...
- Liver metastases from colorectal cancer: radioembolization with systemic therapyNils H Nicolay
Cancer Research UK Medical Research Council Gray Institute for Radiation Oncology and Biology, University of Oxford, Old Road Campus Research Building, Oxford, UK
Nat Rev Clin Oncol 6:687-97. 2009....
- Homologous recombination mediates S-phase-dependent radioresistance in cells deficient in DNA polymerase etaNils H Nicolay
Cancer Research UK Medical Research Council Gray Institute for Radiation Oncology and Biology, Oncology Department, Old Road Campus Research Building, University of Oxford, Oxford OX3 7DQ, UK
Carcinogenesis 33:2026-34. 2012..We propose that pol η protein levels in tumours may potentially be used to identify patients who require treatment with chemo-radiotherapy rather than radiotherapy alone for adequate tumour control...
- Reversibility of liver failure secondary to metastatic breast cancer by vinorelbine and cisplatin chemotherapyRicky A Sharma
Department of Oncology, Leicester Royal Infirmary, University Hospitals of Leicester, Leicester, LE1 5WW, UK
Cancer Chemother Pharmacol 52:367-70. 2003..Since treatment with many chemotherapeutic agents is relatively contraindicated, we assessed the safety, tolerability and potential efficacy of combination chemotherapy with vinorelbine and cisplatin (ViP)...
- Poly(ADP-ribose) polymerase is hyperactivated in homologous recombination-defective cellsPonnari Gottipati
Cancer Research UK Medical Research Council, Gray Institute for Radiation Oncology and Biology, University of Oxford, Oxford, United Kingdom
Cancer Res 70:5389-98. 2010..Furthermore, the presence of PAR polymers can be used to identify HR-defective cells that are sensitive to PARP inhibitors, which may be potential biomarkers...
- Clinical Trial of Oral Nelfinavir before and during Radiation Therapy for Advanced Rectal CancerEsme J Hill
Oxford Cancer Imaging Centre and NIHR Oxford Biomedical Research Centre, Department of Oncology, University of Oxford, Oxford, United Kingdom
Clin Cancer Res 22:1922-31. 2016..We conducted an early-phase study to demonstrate the safety of nelfinavir combined with hypofractionated radiotherapy (RT) and to develop biomarkers of tumor perfusion and radiosensitization for this combinatorial approach...
- Biological relevance of DNA polymerase β and translesion synthesis polymerases to cancer and its treatmentNils H Nicolay
Cancer Research UK Medical Research Council Gray Institute, Department of Oncology, University of Oxford, Old Road Campus Research Building, Oxford OX3 7DQ, UK
Curr Mol Pharmacol 5:54-67. 2012..The potential clinical role of new DNA polymerase inhibitors is discussed and how they may be combined with conventional cytotoxic agents...
- Ubiquitin ligase ARF-BP1/Mule modulates base excision repairJason L Parsons
Gray Institute for Radiation Oncology and Biology, University of Oxford, Oxford, UK
EMBO J 28:3207-15. 2009..Our findings provide a novel mechanism regulating steady-state levels of BER proteins...
- Targeting base excision repair to improve cancer therapiesRicky A Sharma
Radiation Oncology and Biology, University of Oxford, Churchill Hospital, Oxford OX3 7LJ, UK
Mol Aspects Med 28:345-74. 2007..It is anticipated that the application of this knowledge will translate into the development of novel effective therapies for improving existing treatments such as radiation therapy and oxaliplatin chemotherapy...
- Cancer prevention and delay are as important as cureAndreas J Gescher
Cancer Biomarkers and Prevention Group, Department of Oncology, University of Leicester, Leicester, LE2 7LX, UK
Lancet Oncol 4:72-3. 2003
- Consumption of the putative chemopreventive agent curcumin by cancer patients: assessment of curcumin levels in the colorectum and their pharmacodynamic consequencesGiuseppe Garcea
Department of Oncology, RKCSB, LRI, University of Leicester, Leicester, LE2 7LX, United Kingdom
Cancer Epidemiol Biomarkers Prev 14:120-5. 2005..The results suggest that a daily dose of 3.6 g curcumin achieves pharmacologically efficacious levels in the colorectum with negligible distribution of curcumin outside the gut...
- Recommendations for radioembolization of hepatic malignancies using yttrium-90 microsphere brachytherapy: a consensus panel report from the radioembolization brachytherapy oncology consortiumAndrew Kennedy
Wake Radiology Oncology, Cary, NC, USA
Int J Radiat Oncol Biol Phys 68:13-23. 2007..To standardize the indications, techniques, multimodality treatment approaches, and dosimetry to be used for yttrium-90 (Y90) microsphere hepatic brachytherapy...
- Biological relevance of adduct detection to the chemoprevention of cancerRicky A Sharma
Cancer Biomarkers and Prevention Group, Oncology Department, University of Leicester, Leicester Royal Infirmary, Leicester, United Kingdom
Clin Cancer Res 10:4901-12. 2004..We do not administer antihypertensive drugs to patients in clinical trials without checking their blood pressure, so why should we give antioxidants without checking that they have decreased oxidant status...
- Phase I clinical trial of oral curcumin: biomarkers of systemic activity and complianceRicky A Sharma
Oncology Department, University of Leicester, Leicester, United Kingdom
Clin Cancer Res 10:6847-54. 2004..PGE(2) production in blood and target tissue may indicate biological activity. Levels of curcumin and its metabolites in the urine can be used to assess general compliance...
- Angiogenesis and the immune response as targets for the prevention and treatment of colorectal cancer (review)Ricky A Sharma
University Department of Oncology, Leicester Royal Infirmary, Leicester LE1 5WW, UK
Oncol Rep 10:1625-31. 2003..It is proposed that intervention to prevent or treat colorectal cancer should be targeted at inhibiting inflammation, reducing angiogenesis and stimulating cell mediated immune responses...
- Androgen manipulation alters oxidative DNA adduct levels in androgen-sensitive prostate cancer cells grown in vitro and in vivoSanjeev Pathak
Cancer Biomarkers and Prevention Group, Department of Cancer Studies and Molecular Medicine, University of Leicester, Leicester LE2 7LX, UK
Cancer Lett 261:74-83. 2008..001 by Mann-Whitney Test) in flutamide-treated animals compared to controls. The changes demonstrated suggest that oxidative DNA adducts may serve as biomarkers of the efficacy of androgen manipulation in chemoprevention trials...
- Mechanisms of the self/non-self-survey in the defense against cancer: potential for chemoprevention?Ricky A Sharma
Radiotherapy Department, Royal Marsden Hospital NHS Trust, Downs Road, Sutton SM2 5PT, UK
Crit Rev Oncol Hematol 56:5-22. 2005..Interventional strategies may involve the use of pro-differentiation agents such as retinoids, modifiers of polyamine biosynthesis or inhibitors of cyclooxygenase isozymes...
- Neuron-specific enolase expression in multiple myelomaRicky A Sharma
Department of Radiotherapy, Royal Marsden Hospital, London, UK
Lancet Oncol 7:960. 2006
- Curcumin: preventive and therapeutic properties in laboratory studies and clinical trialsAlexios S Strimpakos
Department of Medicine, Royal Marsden Hospital, London, England
Antioxid Redox Signal 10:511-45. 2008..Despite the breadth of the coverage, particular emphasis is placed on the prevention and treatment of human cancers...
- Chemopreventive efficacy and pharmacokinetics of curcumin in the min/+ mouse, a model of familial adenomatous polyposisSarah Perkins
Cancer Biomarkers and Prevention Group, Department of Oncology, University of Leicester, Leicester, United Kingdom
Cancer Epidemiol Biomarkers Prev 11:535-40. 2002..6 g of curcumin is required for efficacy in humans. A clear advantage of curcumin over nonsteroidal anti-inflammatory drugs is its ability to decrease intestinal bleeding linked to adenoma maturation...