Mohamed L Seghier

Summary

Affiliation: University College London
Country: UK

Publications

  1. pmc A trade-off between somatosensory and auditory related brain activity during object naming but not reading
    Mohamed L Seghier
    Wellcome Trust Centre for Neuroimaging, Institute of Neurology, UCL, London WC1N 3BG, United Kingdom
    J Neurosci 35:4751-9. 2015
  2. pmc The importance of premotor cortex for supporting speech production after left capsular-putaminal damage
    Mohamed L Seghier
    Wellcome Trust Centre for Neuroimaging, Institute of Neurology, University College London, London, United Kingdom
    J Neurosci 34:14338-48. 2014
  3. pmc Functional Heterogeneity within the Default Network during Semantic Processing and Speech Production
    Mohamed L Seghier
    Wellcome Trust Centre for Neuroimaging, Institute of Neurology, University College London London, UK
    Front Psychol 3:281. 2012
  4. pmc Dissociating frontal regions that co-lateralize with different ventral occipitotemporal regions during word processing
    Mohamed L Seghier
    Wellcome Trust Centre for Neuroimaging, Institute of Neurology, UCL, London, UK
    Brain Lang 126:133-40. 2013
  5. pmc Network discovery with large DCMs
    Mohamed L Seghier
    The Wellcome Trust Centre for Neuroimaging, UCL, 12 Queen Square, London, WC1N 3BG, UK
    Neuroimage 68:181-91. 2013
  6. pmc Where, when and why brain activation differs for bilinguals and monolinguals during picture naming and reading aloud
    Oiwi Parker Jones
    Wellcome Trust Centre for Neuroimaging, Institute of Neurology, University College London, London WC1N 3BG, UK
    Cereb Cortex 22:892-902. 2012
  7. pmc Auditory-motor interactions for the production of native and non-native speech
    Oiwi Parker Jones
    Wellcome Trust Centre for Neuroimaging, University College London, London WC1N 3BG, United Kingdom
    J Neurosci 33:2376-87. 2013
  8. pmc Reading without the left ventral occipito-temporal cortex
    Mohamed L Seghier
    Wellcome Trust Centre for Neuroimaging, Institute of Neurology, UCL, London WC1N 3BG, UK
    Neuropsychologia 50:3621-35. 2012
  9. pmc Predicting language lateralization from gray matter
    Goulven Josse
    Wellcome Trust Centre for Neuroimaging, UCL, London, United Kingdom
    J Neurosci 29:13516-23. 2009
  10. pmc Lateralization is predicted by reduced coupling from the left to right prefrontal cortex during semantic decisions on written words
    Mohamed L Seghier
    Wellcome Trust Centre for Neuroimaging, UCL Institute of Neurology, London WC1N 3BG, UK
    Cereb Cortex 21:1519-31. 2011

Detail Information

Publications36

  1. pmc A trade-off between somatosensory and auditory related brain activity during object naming but not reading
    Mohamed L Seghier
    Wellcome Trust Centre for Neuroimaging, Institute of Neurology, UCL, London WC1N 3BG, United Kingdom
    J Neurosci 35:4751-9. 2015
    ..In contrast, fast and efficient error-free reading places more consistent demands on both types of feedback, perhaps because of the potential for increased competition between lexical and sublexical codes at the articulatory level. ..
  2. pmc The importance of premotor cortex for supporting speech production after left capsular-putaminal damage
    Mohamed L Seghier
    Wellcome Trust Centre for Neuroimaging, Institute of Neurology, University College London, London, United Kingdom
    J Neurosci 34:14338-48. 2014
    ..The results of our four-pronged approach therefore have clinical implications for predicting which patients are more or less likely to recover their speech after left putaminal damage. ..
  3. pmc Functional Heterogeneity within the Default Network during Semantic Processing and Speech Production
    Mohamed L Seghier
    Wellcome Trust Centre for Neuroimaging, Institute of Neurology, University College London London, UK
    Front Psychol 3:281. 2012
    ..Together these results emphasize that core nodes within the DMN are functionally heterogeneous and differentially sensitive to the type of language processing...
  4. pmc Dissociating frontal regions that co-lateralize with different ventral occipitotemporal regions during word processing
    Mohamed L Seghier
    Wellcome Trust Centre for Neuroimaging, Institute of Neurology, UCL, London, UK
    Brain Lang 126:133-40. 2013
    ..These findings increase the spatial resolution of our understanding of how vOT interacts with other brain areas during semantic categorisation on words...
  5. pmc Network discovery with large DCMs
    Mohamed L Seghier
    The Wellcome Trust Centre for Neuroimaging, UCL, 12 Queen Square, London, WC1N 3BG, UK
    Neuroimage 68:181-91. 2013
    ....
  6. pmc Where, when and why brain activation differs for bilinguals and monolinguals during picture naming and reading aloud
    Oiwi Parker Jones
    Wellcome Trust Centre for Neuroimaging, Institute of Neurology, University College London, London WC1N 3BG, UK
    Cereb Cortex 22:892-902. 2012
    ....
  7. pmc Auditory-motor interactions for the production of native and non-native speech
    Oiwi Parker Jones
    Wellcome Trust Centre for Neuroimaging, University College London, London WC1N 3BG, United Kingdom
    J Neurosci 33:2376-87. 2013
    ..Together, these findings provide a foundation on which to explore auditory-motor interactions during speech production in other human populations, particularly those with speech difficulties...
  8. pmc Reading without the left ventral occipito-temporal cortex
    Mohamed L Seghier
    Wellcome Trust Centre for Neuroimaging, Institute of Neurology, UCL, London WC1N 3BG, UK
    Neuropsychologia 50:3621-35. 2012
    ..Preservation and use of this pathway may explain how patients are still able to read short words accurately when LvOT has been damaged...
  9. pmc Predicting language lateralization from gray matter
    Goulven Josse
    Wellcome Trust Centre for Neuroimaging, UCL, London, United Kingdom
    J Neurosci 29:13516-23. 2009
    ..This is the first demonstration that structural brain scans can be used to predict language lateralization on a voxel-by-voxel basis in the normal healthy brain...
  10. pmc Lateralization is predicted by reduced coupling from the left to right prefrontal cortex during semantic decisions on written words
    Mohamed L Seghier
    Wellcome Trust Centre for Neuroimaging, UCL Institute of Neurology, London WC1N 3BG, UK
    Cereb Cortex 21:1519-31. 2011
    ..These results have theoretical implications for understanding how left and right hemispheres communicate with one another during the processing of lateralized functions...
  11. pmc Multiple routes from occipital to temporal cortices during reading
    Fiona M Richardson
    Wellcome Trust Centre for Neuroimaging, University College London, London WC1N 3BG, United Kingdom
    J Neurosci 31:8239-47. 2011
    ..We discuss these results in terms of cognitive models of reading and propose that efficient reading relies on the integrity of all these pathways...
  12. pmc Explaining left lateralization for words in the ventral occipitotemporal cortex
    Mohamed L Seghier
    Wellcome Trust Centre for Neuroimaging, Institute of Neurology, University College London, London WC1N 3BG, UK
    J Neurosci 31:14745-53. 2011
    ..Moreover, the determinants of lateralization include both visual and semantic factors depending on the subregion tested...
  13. pmc Comparing language outcomes in monolingual and bilingual stroke patients
    Thomas M H Hope
    1 Wellcome Trust Centre for Neuroimaging, University College London, UK
    Brain 138:1070-83. 2015
    ..Both patient groups appeared to be sensitive to damage in the same sets of regions, though the bilinguals were more sensitive than the monolinguals. media-1vid1 10.1093/brain/awv020_video_abstract awv020_video_abstract. ..
  14. pmc The main sources of intersubject variability in neuronal activation for reading aloud
    Ferath Kherif
    Wellcome Trust Centre for Neuroimaging, Institute of Neurology, London, UK
    J Cogn Neurosci 21:654-68. 2009
    ..We therefore conclude that, of the variables tested, age and reading strategy were the most prominent source of variability in activation for reading familiar words aloud...
  15. pmc Functional subdivisions in the left angular gyrus where the semantic system meets and diverges from the default network
    Mohamed L Seghier
    Wellcome Trust Centre for Neuroimaging, Institute of Neurology, University College London, London WC1N 3BG, United Kingdom
    J Neurosci 30:16809-17. 2010
    ..Our findings provide a framework for reporting and interpreting AG activations with greater definition...
  16. pmc The left superior temporal gyrus is a shared substrate for auditory short-term memory and speech comprehension: evidence from 210 patients with stroke
    Alexander P Leff
    Wellcome Trust Centre for Neuroimaging, Institute of Neurology, UCL, 12 Queen Square, London WC1N 3BG, UK
    Brain 132:3401-10. 2009
    ..The method applied here will be particularly useful for modelling structure-function relationships within other complex cognitive domains...
  17. pmc Regional and hemispheric determinants of language laterality: implications for preoperative fMRI
    Mohamed L Seghier
    Wellcome Trust Centre for Neuroimaging, Institute of Neurology, UCL, London, UK
    Hum Brain Mapp 32:1602-14. 2011
    ..We therefore highlight the importance of investigating within hemisphere regional variations in fMRI activation, prior to neuro-surgical intervention, to determine how each hemisphere and each region contributes to language processing...
  18. pmc Verbal and non-verbal intelligence changes in the teenage brain
    Sue Ramsden
    Wellcome Trust Centre for Neuroimaging, University College London, London WC1N 3BG, UK
    Nature 479:113-6. 2011
    ..This would be encouraging to those whose intellectual potential may improve, and would be a warning that early achievers may not maintain their potential...
  19. pmc The angular gyrus: multiple functions and multiple subdivisions
    Mohamed L Seghier
    Wellcome Trust Centre for Neuroimaging, Institute of Neurology, UCL, London, UK
    Neuroscientist 19:43-61. 2013
    ..Several interesting questions that warrant further investigations are finally emphasized...
  20. pmc Reading aloud boosts connectivity through the putamen
    Mohamed L Seghier
    Wellcome Trust Centre for Neuroimaging, Institute of Neurology, UCL, London WC1N 3BG, UK
    Cereb Cortex 20:570-82. 2010
    ..We conclude that the putamen plays a special role in reading but this is likely to vary with individual reading preferences and strategies...
  21. pmc The influence of reading ability on subsequent changes in verbal IQ in the teenage years
    Sue Ramsden
    Wellcome Trust Centre for Neuroimaging, UCL, London WC1N 3BG, UK
    Dev Cogn Neurosci 6:30-9. 2013
    ..Our finding that reading in the early teenage years can predict a significant proportion of the variance in subsequent VIQ change has implications for targeted education in both home and school environments. ..
  22. pmc Lesion identification using unified segmentation-normalisation models and fuzzy clustering
    Mohamed L Seghier
    Wellcome Trust Centre for Neuroimaging, Institute of Neurology, UCL, London UK
    Neuroimage 41:1253-66. 2008
    ..From a clinical perspective, our method should help to compute the total volume of lesion or to trace precisely lesion boundaries that might be pertinent for surgical or diagnostic purposes...
  23. pmc The PLORAS Database: A data repository for Predicting Language Outcome and Recovery After Stroke
    Mohamed L Seghier
    Wellcome Trust Centre for Neuroimaging, Institute of Neurology, UCL, London, UK
    Neuroimage 124:1208-12. 2016
    ..Data will be made available for sharing, subject to: funding, ethical approval and patient consent. ..
  24. pmc Dissociating the semantic function of two neighbouring subregions in the left lateral anterior temporal lobe
    Ana Sanjuan
    Wellcome Trust Centre for Neuroimaging, University College London, London WC1N 3BG, United Kingdom Neuropsychology and Functional Imaging Group, Departamento de Psicologia Basica, Clinica y Psicobiologia, Universitat Jaume I, Castellon, Spain Electronic address
    Neuropsychologia 76:153-62. 2015
    ..We discuss the implications of these novel findings for cognitive models of semantic processing and left anterior temporal lobe function...
  25. pmc Distinguishing the effect of lesion load from tract disconnection in the arcuate and uncinate fasciculi
    Thomas M H Hope
    Wellcome Trust Centre for Neuroimaging, Institute of Neurology, University College London, London, UK Electronic address
    Neuroimage 125:1169-73. 2016
    ....
  26. doi request reprint Gradual lesion expansion and brain shrinkage years after stroke
    Mohamed L Seghier
    From the Wellcome Trust Centre for Neuroimaging, Institute of Neurology, UCL, London, UK
    Stroke 45:877-9. 2014
    ..Here, we aimed to quantify the extent of lesion volume change and brain atrophy in the chronic poststroke brain using magnetic resonance imaging...
  27. pmc Explaining function with anatomy: language lateralization and corpus callosum size
    Goulven Josse
    Wellcome Trust Centre for Neuroimaging, UCL, London WC1N 3BG, UK
    J Neurosci 28:14132-9. 2008
    ..We discuss the complex interhemispheric processes that might underlie this effect...
  28. pmc Predicting language outcome and recovery after stroke: the PLORAS system
    Cathy J Price
    Wellcome Trust Center for Neuroimaging, Institute of Neurology, University College London, 12 Queen Square, London WC1N 3BG, UK
    Nat Rev Neurol 6:202-10. 2010
    ..The outputs of this system are the longitudinal language outcomes of corresponding patients in the database. This approach will provide the patient with a range of probable recovery patterns over a variety of language measures...
  29. pmc Dissociating functional brain networks by decoding the between-subject variability
    Mohamed L Seghier
    Wellcome Trust Centre for Neuroimaging, Wellcome Department of Imaging Neuroscience, Institute of Neurology, UCL, 12 Queen Square, London WC1N 3BG, UK
    Neuroimage 45:349-59. 2009
    ....
  30. pmc Ten problems and solutions when predicting individual outcome from lesion site after stroke
    Cathy J Price
    Wellcome Trust Centre for Neuroimaging, Institute of Neurology, UCL, UK Electronic address
    Neuroimage . 2016
    ..This will entail integrating the results of lesion analyses with those from functional imaging (fMRI, MEG), transcranial magnetic stimulation (TMS) and diffusor tensor imaging (DTI) studies of healthy participants and patients...
  31. pmc Visualising inter-subject variability in fMRI using threshold-weighted overlap maps
    Mohamed L Seghier
    Wellcome Trust Centre for Neuroimaging, Institute of Neurology, UCL, London UK
    Sci Rep 6:20170. 2016
    ..In particular, we emphasize that functional overlap maps can be particularly useful when it comes to explaining typical (or atypical) compensatory mechanisms used by patients following brain damage. ..
  32. pmc Laterality index in functional MRI: methodological issues
    Mohamed L Seghier
    Wellcome Trust Centre for Neuroimaging, Institute of Neurology, UCL London, UK
    Magn Reson Imaging 26:594-601. 2008
    ..Although these factors are common to a range of fMRI domains, they are discussed here in the context of fMRI of the language system...
  33. pmc Can fully automated detection of corticospinal tract damage be used in stroke patients?
    Nancy Kou
    Sobell Department of Motor Neuroscience, UCL Institute of Neurology, London, UK
    Neurology 80:2242-5. 2013
    ....
  34. pmc Microbleed detection using automated segmentation (MIDAS): a new method applicable to standard clinical MR images
    Mohamed L Seghier
    Wellcome Trust Centre for Neuroimaging, University College London Institute of Neurology, London, United Kingdom
    PLoS ONE 6:e17547. 2011
    ..Cerebral microbleeds, visible on gradient-recalled echo (GRE) T2* MRI, have generated increasing interest as an imaging marker of small vessel diseases, with relevance for intracerebral bleeding risk or brain dysfunction...
  35. doi request reprint The role of functional magnetic resonance imaging in the study of brain development, injury, and recovery in the newborn
    Mohamed L Seghier
    Wellcome Trust Centre for Neuroimaging, UCL Institute of Neurology, London, United Kingdom
    Semin Perinatol 34:79-86. 2010
    ....
  36. pmc Detecting subject-specific activations using fuzzy clustering
    Mohamed L Seghier
    Wellcome Trust Centre for Neuroimaging, Institute of Neurology, 12 Queen Square, London WC1N 3BG, UK
    Neuroimage 36:594-605. 2007
    ..The advantage of using FCP is that it searches all voxels systematically and can identify atypical activation patterns in a quantitative and unsupervised manner...