Affiliation: University College London
- Diffusion tensor imaging of post mortem multiple sclerosis brainKlaus Schmierer
Institute of Neurology, University College London, NMR Research Unit, Box 117, Queen Square, London WC1N 3BG, UK
Neuroimage 35:467-77. 2007..70, p<0.001) and (ii) MD (r=-0.66, p<0.001). In conclusion, this study suggests that FA and MD are affected by myelin content and - to a lesser degree - axonal count in post mortem MS brain...
- Progressive change in primary progressive multiple sclerosis normal-appearing white matter: a serial diffusion magnetic resonance imaging studyKlaus Schmierer
Klinik fur Neurologie, Charite, Humboldt Universitat Berlin, Germany
Mult Scler 10:182-7. 2004..Our preliminary findings suggest that the processes causing structural damage in NAWM and lesions in patients with PPMS are partially linked and that changes of water diffusion in NAWM depicted by DW-MRI are clinically relevant...
- Quantitative magnetic resonance of postmortem multiple sclerosis brain before and after fixationKlaus Schmierer
NMR Research Unit, Institute of Neurology, University College London, Queen Square, London, UK
Magn Reson Med 59:268-77. 2008..01) whereas postfixation T(2) (r = 0.92; P < 0.01), T(1) (r = 0.89; P < 0.01), and f(B) (r = -0.86; P < 0.01) were superior. All diffusivity measures (except for D(ax) in unfixed tissue) were predictors of myelin content...
- Correlates of disability in multiple sclerosis detected by transcranial magnetic stimulationK Schmierer
Department of Neurology, Unit for Motor Disturbances and Cortex Function, Charite, Humboldt University, Berlin, Germany
Neurology 59:1218-24. 2002..To study the usefulness of corticospinally mediated excitatory responses and transcallosal inhibition (TI) elicited by transcranial magnetic stimulation (TMS) as a surrogate marker of disability in patients with different courses of MS...
- Paraneoplastic stiff-person syndrome: no tumor progression over 5 yearsK Schmierer
Department of Neurology, Charite, Humboldt University, Berlin, Germany
Neurology 58:148. 2002
- Quantitative magnetization transfer imaging in postmortem multiple sclerosis brainKlaus Schmierer
Department of Brain Repair and Rehabilitation, Institute of Neurology, University College London, London, United Kingdom
J Magn Reson Imaging 26:41-51. 2007....
- High field (9.4 Tesla) magnetic resonance imaging of cortical grey matter lesions in multiple sclerosisKlaus Schmierer
UCL Institute of Neurology, Department of Neuroinflammation, NMR Research Unit, London, UK
Brain 133:858-67. 2010....
- Effects of formalin fixation on magnetic resonance indices in multiple sclerosis cortical gray matterKlaus Schmierer
UCL Institute of Neurology, Department of Neuroinflammation, NMR Research Unit, London, United Kingdom
J Magn Reson Imaging 32:1054-60. 2010..Fixation induces tissue alterations that may confound inference of in vivo observations from MRI/histology correlation studies...
- Magnetization transfer ratio and myelin in postmortem multiple sclerosis brainKlaus Schmierer
Department of Neuroinflammation, MS NMR Research Unit, University College London, United Kingdom
Ann Neurol 56:407-15. 2004..MTR was significantly higher in remyelinated than demyelinated lesions (means: 30.0 [standard deviation, 2.9] vs 23.8 [standard deviation, 4.3], p = 0.008). In conclusion, MTR is affected by myelin content in MS white matter...
- Imaging cadavers: cold FLAIR and noninvasive brain thermometry using CSF diffusionPaul S Tofts
Institute of Neurology, Queen Square, University College London, UK
Magn Reson Med 59:190-5. 2008..Thus, FLAIR imaging can be optimized for cadaveric brains at low and unknown temperatures, thereby improving value for autopsy purposes and facilitating comparisons with in vivo imaging...
- ADvanced IMage Algebra (ADIMA): a novel method for depicting multiple sclerosis lesion heterogeneity, as demonstrated by quantitative MRIMarios C Yiannakas
Department of Neuroinflammation, University College London, Institute of Neurology, London, UK
Mult Scler 19:732-41. 2013..This may partly reflect pathological heterogeneity in WMLs, which is not apparent on T2w scans...
- Three-dimensional quantitative magnetisation transfer imaging of the human brainMara Cercignani
Department of Neuroinflammation, NMR Research Unit, Institute of Neurology, University College London, London WC1N 3 BG, UK
Neuroimage 27:436-41. 2005..Results were consistent with previous single-slice data, and parametric maps were of good quality. Further investigations are needed to interpret the regional variation of quantitative MT quantities...
- Diagnostic pitfalls in eosinophilic cryptococcal meningoencephalitisPascal Grosse
Department of Neurology, Charite, Campus Virchow Klinikum, Humboldt University Berlin, Germany
Lancet Neurol 2:512. 2003
- Humoral immune response to EBV in multiple sclerosis is associated with disease activity on MRIR A Farrell
Department of Neuroinflammation, Institute of Neurology, UCL, Queen Square, London, UK
Neurology 73:32-8. 2009..Evidence suggests that Epstein-Barr virus (EBV) plays a role in triggering or perpetuating disease activity in multiple sclerosis (MS)...
- Magnetization transfer ratio abnormalities reflect clinically relevant grey matter damage in multiple sclerosisL K Fisniku
NMR Research Unit, Department of Neuroinflammation, Institute of Neurology, University College London, London, UK
Mult Scler 15:668-77. 2009..In multiple sclerosis, grey matter (GM) damage appears more clinically relevant than either white matter damage or lesion load...
- Phosphorylation and compactness of neurofilaments in multiple sclerosis: indicators of axonal pathologyAxel Petzold
Department of Neuroinflammation, Institute of Neurology, Queen Square, London, UK
Exp Neurol 213:326-35. 2008..This study investigated whether neurofilament (NfH) phosphorylation would relate to the dynamics of axonal pathology in multiple sclerosis (MS)...
- Conduction deficits of callosal fibres in early multiple sclerosisK Schmierer
Department of Neurology, Unit for Motor Disturbances and Cortex Function, Humboldt University, Charite Campus Virchow Klinikum, Augustenburger Platz 1, D 13344 Berlin, Germany
J Neurol Neurosurg Psychiatry 68:633-8. 2000..Recently, TI evoked by TMS has been introduced as a new paradigm to test the function of callosal fibres interconnecting both hand associated motor cortices...
- No cerebrocervical venous congestion in patients with multiple sclerosisFlorian Doepp
Department of Neurology, University Hospital Charite, Humboldt University, Berlin, Germany
Ann Neurol 68:173-83. 2010....
- Stereotactic co-registration of magnetic resonance imaging and histopathology in post-mortem multiple sclerosis brainK Schmierer
Department of Neuroinflammation, MS NMR Research Unit, Division of Neuropathology, Institute of Neurology, University College London, London, UK
Neuropathol Appl Neurobiol 29:596-601. 2003..Standard T2-weighted MRI appeared to be the single most useful approach for lesion detection in fresh and fixed specimens...
- High field MRI correlates of myelin content and axonal density in multiple sclerosis--a post-mortem study of the spinal cordJ P Mottershead
Dept of Neuroinflammation, MS NMR Research Unit, Institute of Neurology, UCL, WC1N 3BG, London, UK
J Neurol 250:1293-301. 2003..Further studies are warranted to investigate the potential of new quantitative MR measures to enable a distinction between axonal loss and demyelination and between demyelinated and remyelinated lesions...
- Diffuse cerebral angiomatosisS J Schreiber
Department of Neurology, University Hospital Charite, Berlin, Germany
Neurology 60:1216-8. 2003