I Sayers

Summary

Affiliation: University of Nottingham
Country: UK

Publications

  1. pmc Clonally expanded human airway smooth muscle cells exhibit morphological and functional heterogeneity
    Shailendra R Singh
    Division of Respiratory Medicine, University of Nottingham, Queen s Medical Centre, NG7 2UH Nottingham, United Kingdom
    Respir Res 15:57. 2014
  2. pmc Defining the contribution of SNPs identified in asthma GWAS to clinical variables in asthmatic children
    Asif S Tulah
    Division of Respiratory Medicine, Queen s Medical Centre, University of Nottingham, Nottingham NG7 2UH, United Kingdom
    BMC Med Genet 14:100. 2013
  3. pmc HTR4 gene structure and altered expression in the developing lung
    Emily Hodge
    Division of Respiratory Medicine, University of Nottingham, Queen s Medical Centre, Nottingham NG7 2UH, UK
    Respir Res 14:77. 2013
  4. pmc Leukotriene B4 receptor locus gene characterisation and association studies in asthma
    Asif S Tulah
    Division of Therapeutics and Molecular Medicine, University of Nottingham, Queen s Medical Centre, Nottingham, United Kingdom
    BMC Med Genet 13:110. 2012
  5. doi request reprint A tailored approach to asthma management: Arg(16) holds the key?
    Ian Sayers
    Division of Therapeutics and Molecular Medicine, University of Nottingham, Queen s Medical Centre, Nottingham NG7 2UH, UK
    Clin Sci (Lond) 124:517-9. 2013
  6. pmc uPAR regulates bronchial epithelial repair in vitro and is elevated in asthmatic epithelium
    Ceri E Stewart
    Division of Therapeutics and Molecular Medicine, Nottingham Respiratory Biomedical Research Unit, University Hospital of Nottingham, Nottingham NG7 2UH, UK
    Thorax 67:477-87. 2012
  7. pmc Salmeterol and cytokines modulate inositol-phosphate signalling in human airway smooth muscle cells via regulation at the receptor locus
    Natalie Smith
    Division of Therapeutics and Molecular Medicine, University Hospital of Nottingham, Nottingham, UK
    Respir Res 8:68. 2007
  8. pmc Meta-analysis of genome-wide linkage studies of asthma and related traits
    Samuel Denham
    Division of Therapeutics and Molecular Medicine, University Hospital of Nottingham, Nottingham, UK
    Respir Res 9:38. 2008
  9. pmc The role of ALOX5AP, LTA4H and LTB4R polymorphisms in determining baseline lung function and COPD susceptibility in UK smokers
    Asif S Tulah
    Division of Therapeutics and Molecular Medicine, Nottingham Respiratory Biomedical Research Unit, University of Nottingham, Queen s Medical Centre, Nottingham, UK
    BMC Med Genet 12:173. 2011
  10. pmc Characterisation of urokinase plasminogen activator receptor variants in human airway and peripheral cells
    Ceri E Stewart
    Division of Therapeutics and Molecular Medicine, Nottingham Respiratory Biomedical Research Unit, University of Nottingham, Queen s Medical Centre, Nottingham, NG7 2UH, UK
    BMC Mol Biol 10:75. 2009

Collaborators

Detail Information

Publications20

  1. pmc Clonally expanded human airway smooth muscle cells exhibit morphological and functional heterogeneity
    Shailendra R Singh
    Division of Respiratory Medicine, University of Nottingham, Queen s Medical Centre, NG7 2UH Nottingham, United Kingdom
    Respir Res 15:57. 2014
    ....
  2. pmc Defining the contribution of SNPs identified in asthma GWAS to clinical variables in asthmatic children
    Asif S Tulah
    Division of Respiratory Medicine, Queen s Medical Centre, University of Nottingham, Nottingham NG7 2UH, United Kingdom
    BMC Med Genet 14:100. 2013
    ....
  3. pmc HTR4 gene structure and altered expression in the developing lung
    Emily Hodge
    Division of Respiratory Medicine, University of Nottingham, Queen s Medical Centre, Nottingham NG7 2UH, UK
    Respir Res 14:77. 2013
    ....
  4. pmc Leukotriene B4 receptor locus gene characterisation and association studies in asthma
    Asif S Tulah
    Division of Therapeutics and Molecular Medicine, University of Nottingham, Queen s Medical Centre, Nottingham, United Kingdom
    BMC Med Genet 13:110. 2012
    ..The aim of this study was to characterise the genes for the two pivotal LTB4 receptors, LTB4R1 and LTB4R2 in lung tissue and determine if polymorphisms spanning these genes are associated with asthma and disease severity...
  5. doi request reprint A tailored approach to asthma management: Arg(16) holds the key?
    Ian Sayers
    Division of Therapeutics and Molecular Medicine, University of Nottingham, Queen s Medical Centre, Nottingham NG7 2UH, UK
    Clin Sci (Lond) 124:517-9. 2013
    ....
  6. pmc uPAR regulates bronchial epithelial repair in vitro and is elevated in asthmatic epithelium
    Ceri E Stewart
    Division of Therapeutics and Molecular Medicine, Nottingham Respiratory Biomedical Research Unit, University Hospital of Nottingham, Nottingham NG7 2UH, UK
    Thorax 67:477-87. 2012
    ..uPAR expression in the lung epithelium of normal subjects and patients with asthma was investigated and the contribution of uPAR to epithelial wound repair in vitro was studied using primary bronchial epithelial cells (NHBECs)...
  7. pmc Salmeterol and cytokines modulate inositol-phosphate signalling in human airway smooth muscle cells via regulation at the receptor locus
    Natalie Smith
    Division of Therapeutics and Molecular Medicine, University Hospital of Nottingham, Nottingham, UK
    Respir Res 8:68. 2007
    ..The aim of the current study was to clarify the effect of proinflammatory cytokines and asthma medication on primary human airway smooth muscle (ASM) inositol phosphate (IPx) signalling and define the regulatory loci involved...
  8. pmc Meta-analysis of genome-wide linkage studies of asthma and related traits
    Samuel Denham
    Division of Therapeutics and Molecular Medicine, University Hospital of Nottingham, Nottingham, UK
    Respir Res 9:38. 2008
    ....
  9. pmc The role of ALOX5AP, LTA4H and LTB4R polymorphisms in determining baseline lung function and COPD susceptibility in UK smokers
    Asif S Tulah
    Division of Therapeutics and Molecular Medicine, Nottingham Respiratory Biomedical Research Unit, University of Nottingham, Queen s Medical Centre, Nottingham, UK
    BMC Med Genet 12:173. 2011
    ..The aim of the current study was to see if these SNPs and those spanning the receptor genes for LTB4 (LTB4R1 and LTB4R2) influence baseline lung function and COPD susceptibility/severity in smokers...
  10. pmc Characterisation of urokinase plasminogen activator receptor variants in human airway and peripheral cells
    Ceri E Stewart
    Division of Therapeutics and Molecular Medicine, Nottingham Respiratory Biomedical Research Unit, University of Nottingham, Queen s Medical Centre, Nottingham, NG7 2UH, UK
    BMC Mol Biol 10:75. 2009
    ....
  11. pmc PLAUR polymorphisms and lung function in UK smokers
    Ceri E Stewart
    Division of Therapeutics and Molecular Medicine, Nottingham Respiratory Biomedical Research Unit, University Hospital of Nottingham, Nottingham, UK
    BMC Med Genet 10:112. 2009
    ..In the current study we tested the hypothesis that PLAUR single nucleotide polymorphisms (SNPs) determine baseline lung function and contribute to the development of Chronic Obstructive Pulmonary Disease (COPD) in smokers...
  12. pmc Pharmacogenetic characterization of indacaterol, a novel beta 2-adrenoceptor agonist
    I Sayers
    Division of Therapeutics and Molecular Medicine, University Hospital of Nottingham, Nottingham, UK
    Br J Pharmacol 158:277-86. 2009
    ..The aim of this study was to investigate the comparative pharmacology of indacaterol in recombinant cells expressing the common polymorphic variants of the human beta(2)-adrenoceptor and in human primary airway smooth muscle (ASM) cells...
  13. doi request reprint Leukotriene pathway genetics and pharmacogenetics in allergy
    N P Duroudier
    Division of Therapeutics and Molecular Medicine, University of Nottingham, Nottingham, UK
    Allergy 64:823-39. 2009
    ..The aim of this review was to summarize the recent advances in the knowledge of these important mediators, focusing on genetic and pharmacogenetic aspects in the context of allergic phenotypes...
  14. pmc Genes associated with polymorphic variants predicting lung function are differentially expressed during human lung development
    S Miller
    Division of Respiratory Medicine, Queen s Medical Centre, University of Nottingham, Nottingham, NG7 2UH, UK
    Respir Res 17:95. 2016
    ....
  15. doi request reprint The secretory tailpiece isoform of IgE is not associated with allergy
    A Aslam
    School of Pharmacy, Centre for Biomolecular Sciences, University of Nottingham, Nottingham NG7 2RD, UK
    Allergy 63:942-3. 2008
  16. ncbi request reprint Genome-wide association study to identify genetic determinants of severe asthma
    Y I Wan
    Therapeutics and Molecular Medicine, University of Nottingham, Nottingham, UK
    Thorax 67:762-8. 2012
    ..The genetic basis for developing asthma has been extensively studied. However, association studies to date have mostly focused on mild to moderate disease and genetic risk factors for severe asthma remain unclear...
  17. ncbi request reprint Pharmacogenetics and asthma: false hope or new dawn?
    I P Hall
    Division of Therapeutics and Molecular Medicine, University Hospital of Nottingham, Nottingham, NG7 2UH, UK
    Eur Respir J 29:1239-45. 2007
    ..In addition, there is a shortage of well-designed, adequately powered clinical studies in this area. This series summarises the current state of knowledge and identifies areas for further research...
  18. doi request reprint The challenge of measuring IL-33 in serum using commercial ELISA: lessons from asthma
    M E Ketelaar
    Division of Respiratory Medicine, University of Nottingham, Nottingham, UK
    Clin Exp Allergy 46:884-7. 2016
    ..Reliable methods are required to study the association of IL-33 with disease, especially considering the complex nature of serum samples...
  19. doi request reprint Airway and peripheral urokinase plasminogen activator receptor is elevated in asthma, and identifies a severe, nonatopic subset of patients
    M A Portelli
    Division of Respiratory Medicine, Queen s Medical Centre, University of Nottingham, Nottingham, UK
    Allergy . 2016
    ..Preliminary studies have identified uPAR elevation in asthma; however, a definitive study regarding which clinical features of asthma uPAR may be driving is currently lacking...
  20. doi request reprint Translating Lung Function Genome-Wide Association Study (GWAS) Findings: New Insights for Lung Biology
    A K Kheirallah
    Division of Respiratory Medicine, University of Nottingham, Nottingham, United Kingdom
    Adv Genet 93:57-145. 2016
    ..Herein, we review state-of-the-art in silico, in vivo, and in vitro approaches that may be used to accelerate functional translation of genetic findings...