Natalia Savelyeva

Summary

Affiliation: University of Southampton
Country: UK

Publications

  1. ncbi request reprint Engineering DNA vaccines that include plant virus coat proteins
    Natalia Savelyeva
    Molecular Immunology Group, Cancer Sciences Division, Southampton University Hospitals Trust, Tremona Road, Southampton, SO16 6YD, UK
    Biotechnol Genet Eng Rev 20:101-14. 2003
  2. pmc Inhibition of a vaccine-induced anti-tumor B cell response by soluble protein antigen in the absence of continuing T cell help
    Natalia Savelyeva
    Molecular Immunology Group, Cancer Sciences Division, Southampton University Hospitals Trust, Southampton, Hampshire SO16 6YD, United Kingdom
    Proc Natl Acad Sci U S A 102:10987-92. 2005
  3. doi request reprint High-affinity memory B cells induced by conjugate vaccines against weak tumor antigens are vulnerable to nonconjugated antigen
    Natalia Savelyeva
    Genetic Vaccine Group, Cancer Sciences Division, School of Medicine, University of Southampton, Southampton, United Kingdom
    Blood 118:650-9. 2011
  4. pmc DNA vaccines to attack cancer
    Freda K Stevenson
    Molecular Immunology Group, Tenovus Laboratory, Cancer Sciences Division, Southampton University Hospitals Trust, Southampton SO16 6YD, UK
    Proc Natl Acad Sci U S A 101:14646-52. 2004
  5. doi request reprint Bystander stimulation of activated CD4+ T cells of unrelated specificity following a booster vaccination with tetanus toxoid
    Gianfranco Di Genova
    Cancer Sciences Division, University of Southampton School of Medicine, Southampton, UK
    Eur J Immunol 40:976-85. 2010
  6. pmc A plant-expressed conjugate vaccine breaks CD4(+) tolerance and induces potent immunity against metastatic Her2(+) breast cancer
    Warayut Chotprakaikiat
    Cancer Sciences Unit, Faculty of Medicine, University of Southampton, Southampton, UK
    Oncoimmunology 5:e1166323. 2016
  7. ncbi request reprint Linked CD4 T Cell Help: Broadening Immune Attack Against Cancer by Vaccination
    Natalia Savelyeva
    Cancer Sciences Unit, Faculty of Medicine, University of Southampton, Tremona Road, Southampton, SO16 6YD, UK
    Curr Top Microbiol Immunol . 2016
  8. pmc Plant virus particles carrying tumour antigen activate TLR7 and Induce high levels of protective antibody
    Jantipa Jobsri
    Cancer Sciences Unit, Faculty of Medicine, University of Southampton, Southampton, United Kingdom
    PLoS ONE 10:e0118096. 2015
  9. doi request reprint DNA fusion vaccine designs to induce tumor-lytic CD8+ T-cell attack via the immunodominant cysteine-containing epitope of NY-ESO 1
    Juan Campos-Perez
    Genetic Vaccine Group, Cancer Sciences Unit, Faculty of Medicine, University of Southampton, Southampton, United Kingdom
    Int J Cancer 133:1400-7. 2013
  10. pmc Gene expression analysis of TIL rich HPV-driven head and neck tumors reveals a distinct B-cell signature when compared to HPV independent tumors
    Oliver Wood
    Faculty of Medicine, University of Southampton and University Hospital Southampton, Southampton, UK
    Oncotarget . 2016

Collaborators

Detail Information

Publications11

  1. ncbi request reprint Engineering DNA vaccines that include plant virus coat proteins
    Natalia Savelyeva
    Molecular Immunology Group, Cancer Sciences Division, Southampton University Hospitals Trust, Tremona Road, Southampton, SO16 6YD, UK
    Biotechnol Genet Eng Rev 20:101-14. 2003
  2. pmc Inhibition of a vaccine-induced anti-tumor B cell response by soluble protein antigen in the absence of continuing T cell help
    Natalia Savelyeva
    Molecular Immunology Group, Cancer Sciences Division, Southampton University Hospitals Trust, Southampton, Hampshire SO16 6YD, United Kingdom
    Proc Natl Acad Sci U S A 102:10987-92. 2005
    ..The principles revealed by using a DNA vaccine have implications for all cancer vaccines designed to induce and maintain antibody responses against weak autologous tumor antigens...
  3. doi request reprint High-affinity memory B cells induced by conjugate vaccines against weak tumor antigens are vulnerable to nonconjugated antigen
    Natalia Savelyeva
    Genetic Vaccine Group, Cancer Sciences Division, School of Medicine, University of Southampton, Southampton, United Kingdom
    Blood 118:650-9. 2011
    ..The latter remain, but the majority fail to undergo isotype switch. These findings could apply to other tumor antigens and are relevant for vaccination strategies aimed to induce long-term antibody...
  4. pmc DNA vaccines to attack cancer
    Freda K Stevenson
    Molecular Immunology Group, Tenovus Laboratory, Cancer Sciences Division, Southampton University Hospitals Trust, Southampton SO16 6YD, UK
    Proc Natl Acad Sci U S A 101:14646-52. 2004
    ..Physical methods including electroporation provide increased expression without introducing additional competing antigens. A wide range of cancers can be targeted, and objective assays of response will determine efficacy...
  5. doi request reprint Bystander stimulation of activated CD4+ T cells of unrelated specificity following a booster vaccination with tetanus toxoid
    Gianfranco Di Genova
    Cancer Sciences Division, University of Southampton School of Medicine, Southampton, UK
    Eur J Immunol 40:976-85. 2010
    ..This crosstalk between a stimulated CD4(+) memory T-cell response and CD4(+) T cells activated by an unrelated antigen could be important in human subjects continually buffeted by environmental antigens...
  6. pmc A plant-expressed conjugate vaccine breaks CD4(+) tolerance and induces potent immunity against metastatic Her2(+) breast cancer
    Warayut Chotprakaikiat
    Cancer Sciences Unit, Faculty of Medicine, University of Southampton, Southampton, UK
    Oncoimmunology 5:e1166323. 2016
    ..Hence, our novel Her2-targeting conjugate vaccine combines preclinical efficacy with clinical deliverability, thus setting the scene for therapeutic testing. ..
  7. ncbi request reprint Linked CD4 T Cell Help: Broadening Immune Attack Against Cancer by Vaccination
    Natalia Savelyeva
    Cancer Sciences Unit, Faculty of Medicine, University of Southampton, Tremona Road, Southampton, SO16 6YD, UK
    Curr Top Microbiol Immunol . 2016
    ..Delivery via DNA vaccines has already indicated clinical efficacy. The same principle of linked T cell help has now been transferred to other novel vaccine modalities to further potentiate immunity against cancer targets...
  8. pmc Plant virus particles carrying tumour antigen activate TLR7 and Induce high levels of protective antibody
    Jantipa Jobsri
    Cancer Sciences Unit, Faculty of Medicine, University of Southampton, Southampton, United Kingdom
    PLoS ONE 10:e0118096. 2015
    ..PVP conjugates are a novel cancer vaccine design, offering an attractive molecular form, similar to VLP, and providing T-cell help. In contrast to VLP, they also incorporate a safe "in-built" ssRNA adjuvant. ..
  9. doi request reprint DNA fusion vaccine designs to induce tumor-lytic CD8+ T-cell attack via the immunodominant cysteine-containing epitope of NY-ESO 1
    Juan Campos-Perez
    Genetic Vaccine Group, Cancer Sciences Unit, Faculty of Medicine, University of Southampton, Southampton, United Kingdom
    Int J Cancer 133:1400-7. 2013
    ..These findings encourage clinical exploration of this vaccine strategy to target NY-ESO-1...
  10. pmc Gene expression analysis of TIL rich HPV-driven head and neck tumors reveals a distinct B-cell signature when compared to HPV independent tumors
    Oliver Wood
    Faculty of Medicine, University of Southampton and University Hospital Southampton, Southampton, UK
    Oncotarget . 2016
    ..A B-cell associated signal segregated tumors relative to HPV status. Our data suggests that the role of B-cells in the adaptive immune response to HPV(+) HNSCC requires re-assessment...
  11. pmc The outcome of B-cell receptor signaling in chronic lymphocytic leukemia: proliferation or anergy
    Graham Packham
    Cancer Research UK Centre, Faculty of Medicine, University of Southampton, UK
    Haematologica 99:1138-48. 2014
    ....