Genomes and Genes
E M Santos
Affiliation: University of Exeter
- Identifying health impacts of exposure to copper using transcriptomics and metabolomics in a fish modelEduarda M Santos
School of Biosciences, University of Exeter, Exeter, Devon EX4 4PS, United Kingdom
Environ Sci Technol 44:820-6. 2010....
- Population bottlenecks, genetic diversity and breeding ability of the three-spined stickleback (Gasterosteus aculeatus) from three polluted English RiversEduarda M Santos
Biosciences, College of Life and Environmental Sciences, University of Exeter, Exeter, UK Electronic address
Aquat Toxicol 142:264-71. 2013....
- Follicle-stimulating hormone and its alpha and beta subunits in rainbow trout (Oncorhynchus mykiss): purification, characterization, development of specific radioimmunoassays, and their seasonal plasma and pituitary concentrations in femalesE M Santos
School of Biological Sciences, Hatherly Laboratories, University of Exeter, Exeter EX4 4PS, United Kingdom
Biol Reprod 65:288-94. 2001..The presence of free GTHalpha2 subunit in the plasma similarly occurs in mammals, but its functional significance in fish has yet to be established...
- Molecular basis of sex and reproductive status in breeding zebrafishE M Santos
School of Biosciences, University of Exeter, Exeter, UK
Physiol Genomics 30:111-22. 2007..In summary, we have identified molecular processes associated with (gonadal) sex specificity in breeding zebrafish and established a strong relationship between individual ovarian transcriptomes and reproductive status in females...
- Gonadal transcriptome responses and physiological consequences of exposure to oestrogen in breeding zebrafish (Danio rerio)Eduarda M Santos
School of Biosciences, University of Exeter, Prince of Wales Road, Exeter, UK
Aquat Toxicol 83:134-42. 2007..The molecular mechanisms mediating some of these effects were identified and included those impacting processes central to gametogenesis in both males and females...
- Mechanisms of toxicity of di(2-ethylhexyl) phthalate on the reproductive health of male zebrafishTamsyn M Uren-Webster
Hatherly Laboratories, School of Biosciences, University of Exeter, Exeter, Devon EX4 4PS, UK
Aquat Toxicol 99:360-9. 2010....
- Hepatic transcriptomic and metabolomic responses in the stickleback (Gasterosteus aculeatus) exposed to environmentally relevant concentrations of dibenzanthraceneTim D Williams
School of Biosciences, The University of Birmingham, Birmingham, B15 2TT, UK
Environ Sci Technol 43:6341-8. 2009..Metabolic pathways were identified where both gene expression and metabolite concentrations were altered in response to DbA...
- ELISAs for detecting vitellogenin in the fathead minnow (Pimephales promelas)-a critical analysis. Response to Mylchreest et al., Comp Biochem Physiol C 134: 251-257, 2003Charles R Tyler
School of Biological and Chemical Sciences, University of Exeter, Exeter EX4 4PS, United Kingdom
Comp Biochem Physiol C Toxicol Pharmacol 138:531-2; author reply 533-6. 2004
- Gene expression profiling for understanding chemical causation of biological effects for complex mixtures: a case study on estrogensAmy L Filby
School of Biosciences, The Hatherly Laboratories, University of Exeter, Prince of Wales Road, Exeter, EX4 4PS, UK
Environ Sci Technol 41:8187-94. 2007....
- Sexually dimorphic gene expression in the brains of mature zebrafishEduarda M Santos
School of Biosciences, University of Exeter, Prince of Wales Road, Exeter, EX4 4PS, UK
Comp Biochem Physiol A Mol Integr Physiol 149:314-24. 2008..We have demonstrated the existence of dimorphic patterns of gene expression in the brain of a sexually mature, non-mammalian, vertebrate model, with implications for studies into reproduction and chemical disruption of brain function...
- Variability in measures of reproductive success in laboratory-kept colonies of zebrafish and implications for studies addressing population-level effects of environmental chemicalsGregory C Paull
Environmental and Molecular Fish Biology Group, School of Biosciences, Hatherly Laboratories, University of Exeter, Prince of Wales Road, Exeter EX4 4PS, United Kingdom
Aquat Toxicol 87:115-26. 2008..These data demonstrate the need for high levels of replication when testing for effects of EDCs on reproductive output in the zebrafish model in an environmentally relevant ('6 x 6') breeding matrix...
- Bisphenol A causes reproductive toxicity, decreases dnmt1 transcription, and reduces global DNA methylation in breeding zebrafish (Danio rerio)L V Laing
a Biosciences, College of Life and Environmental Sciences, Geoffrey Pope Building, University of Exeter, Exeter, EX4 4QD, United Kingdom
Epigenetics 11:526-38. 2016..These findings provide evidence of the mechanisms of action of BPA in a model vertebrate and advocate for its reduction in the environment. ..
- Accounting for differences in estrogenic responses in rainbow trout (Oncorhynchus mykiss: Salmonidae) and roach (Rutilus rutilus: Cyprinidae) exposed to effluents from wastewater treatment worksC R Tyler
Environmental and Molecular Fish Biology Group, Department of Biological Sciences, University of Exeter, Exeter, United Kingdom
Environ Sci Technol 39:2599-607. 2005..The nature of the estrogenic contaminants is detailed in an accompanying paper...
- Effects of aqueous exposure to silver nanoparticles of different sizes in rainbow troutTessa M Scown
Ecotoxicology and Aquatic Biology Research Group, Hatherly Laboratories, School of Biosciences, University of Exeter, Exeter EX4 4PS, UK
Toxicol Sci 115:521-34. 2010..However, exposure to N(10) particles was found to induce expression of cyp1a2 in the gills, suggesting a possible increase in oxidative metabolism in this tissue...
- Global transcriptome profiling reveals molecular mechanisms of metal tolerance in a chronically exposed wild population of brown troutT M Uren Webster
Biosciences, College of Life and Environmental Sciences, Geoffrey Pope Building, University of Exeter, Exeter, EX4 4QD
Environ Sci Technol 47:8869-77. 2013....