Owen J Sansom

Summary

Affiliation: University of Glasgow
Country: UK

Publications

  1. pmc Deficiency of SPARC suppresses intestinal tumorigenesis in APCMin/+ mice
    Owen J Sansom
    Beatson Institute of Cancer Research, Glasgow, Scotland, UK
    Gut 56:1410-4. 2007
  2. pmc Focal adhesion kinase is required for intestinal regeneration and tumorigenesis downstream of Wnt/c-Myc signaling
    Gabrielle H Ashton
    The Beatson Institute for Cancer Research, Glasgow, UK
    Dev Cell 19:259-69. 2010
  3. pmc Reduced LIMK2 expression in colorectal cancer reflects its role in limiting stem cell proliferation
    Filipe C Lourenco
    Beatson Institute for Cancer Research, Glasgow, UK
    Gut 63:480-93. 2014
  4. pmc Inhibition of CXCR2 profoundly suppresses inflammation-driven and spontaneous tumorigenesis
    Thomas Jamieson
    Beatson Institute of Cancer Research, Glasgow, United Kingdom
    J Clin Invest 122:3127-44. 2012
  5. pmc Cyclin D2-cyclin-dependent kinase 4/6 is required for efficient proliferation and tumorigenesis following Apc loss
    Alicia M Cole
    Beatson Institute of Cancer Research, Glasgow, United Kingdom School of Biosciences, Cardiff, United Kingdom
    Cancer Res 70:8149-58. 2010
  6. pmc Fibroblast growth factor receptor 3 activation plays a causative role in urothelial cancer pathogenesis in cooperation with Pten loss in mice
    Mona Foth
    School of Medicine, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, UK Beatson Institute for Cancer Research, Glasgow, UK
    J Pathol 233:148-58. 2014
  7. pmc Fascin is regulated by slug, promotes progression of pancreatic cancer in mice, and is associated with patient outcomes
    Ang Li
    CRUK Beatson Institute for Cancer Research, College of Medical Veterinary and Life Sciences, University of Glasgow, Glasgow, UK
    Gastroenterology 146:1386-96.e1-17. 2014
  8. doi Luminal iron levels govern intestinal tumorigenesis after Apc loss in vivo
    Sorina Radulescu
    Beatson Institute of Cancer Research, Glasgow, UK
    Cell Rep 2:270-82. 2012
  9. pmc FAK deletion promotes p53-mediated induction of p21, DNA-damage responses and radio-resistance in advanced squamous cancer cells
    Kathryn Graham
    The Beatson Institute for Cancer Research, Garscube Estate, Bearsden, Glasgow, Scotland
    PLoS ONE 6:e27806. 2011
  10. pmc LKB1 haploinsufficiency cooperates with Kras to promote pancreatic cancer through suppression of p21-dependent growth arrest
    Jennifer P Morton
    Beatson Institute for Cancer Research, Garscube Estate, Glasgow, UK
    Gastroenterology 139:586-97, 597.e1-6. 2010

Detail Information

Publications59

  1. pmc Deficiency of SPARC suppresses intestinal tumorigenesis in APCMin/+ mice
    Owen J Sansom
    Beatson Institute of Cancer Research, Glasgow, Scotland, UK
    Gut 56:1410-4. 2007
    ..More recently, it has been shown to be upregulated in human gastric and colorectal cancer. We therefore wished to address the functional importance of SPARC upregulation to intestinal tumorigenesis in vivo...
  2. pmc Focal adhesion kinase is required for intestinal regeneration and tumorigenesis downstream of Wnt/c-Myc signaling
    Gabrielle H Ashton
    The Beatson Institute for Cancer Research, Glasgow, UK
    Dev Cell 19:259-69. 2010
    ..Importantly, this work suggests that FAK inhibitors may suppress tumorigenesis in patients at high risk of developing colorectal cancer...
  3. pmc Reduced LIMK2 expression in colorectal cancer reflects its role in limiting stem cell proliferation
    Filipe C Lourenco
    Beatson Institute for Cancer Research, Glasgow, UK
    Gut 63:480-93. 2014
    ....
  4. pmc Inhibition of CXCR2 profoundly suppresses inflammation-driven and spontaneous tumorigenesis
    Thomas Jamieson
    Beatson Institute of Cancer Research, Glasgow, United Kingdom
    J Clin Invest 122:3127-44. 2012
    ..Similar leukocyte populations were also found in human intestinal adenomas, which suggests that CXCR2 antagonists may have therapeutic and prophylactic potential in the treatment of cancer...
  5. pmc Cyclin D2-cyclin-dependent kinase 4/6 is required for efficient proliferation and tumorigenesis following Apc loss
    Alicia M Cole
    Beatson Institute of Cancer Research, Glasgow, United Kingdom School of Biosciences, Cardiff, United Kingdom
    Cancer Res 70:8149-58. 2010
    ....
  6. pmc Fibroblast growth factor receptor 3 activation plays a causative role in urothelial cancer pathogenesis in cooperation with Pten loss in mice
    Mona Foth
    School of Medicine, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, UK Beatson Institute for Cancer Research, Glasgow, UK
    J Pathol 233:148-58. 2014
    ..Given the wide availability of inhibitors specific to FGF signalling pathways, our model may open the avenue for FGFR3-targeted translation in urothelial disease...
  7. pmc Fascin is regulated by slug, promotes progression of pancreatic cancer in mice, and is associated with patient outcomes
    Ang Li
    CRUK Beatson Institute for Cancer Research, College of Medical Veterinary and Life Sciences, University of Glasgow, Glasgow, UK
    Gastroenterology 146:1386-96.e1-17. 2014
    ..The actin-bundling protein fascin has been identified as a biomarker of invasive and advanced PDAC and regulates cell migration and invasion in vitro. We investigated fascin expression and its role in PDAC progression in mice...
  8. doi Luminal iron levels govern intestinal tumorigenesis after Apc loss in vivo
    Sorina Radulescu
    Beatson Institute of Cancer Research, Glasgow, UK
    Cell Rep 2:270-82. 2012
    ..Taken together, our data definitively delineate iron as a potent modifier of intestinal tumorigenesis and have important implications for dietary iron supplementation in patients at high risk of colorectal cancer...
  9. pmc FAK deletion promotes p53-mediated induction of p21, DNA-damage responses and radio-resistance in advanced squamous cancer cells
    Kathryn Graham
    The Beatson Institute for Cancer Research, Garscube Estate, Bearsden, Glasgow, Scotland
    PLoS ONE 6:e27806. 2011
    ..We suggest that there should be caution when considering inhibiting FAK in combination with radiation, as this may not always be clinically advantageous...
  10. pmc LKB1 haploinsufficiency cooperates with Kras to promote pancreatic cancer through suppression of p21-dependent growth arrest
    Jennifer P Morton
    Beatson Institute for Cancer Research, Garscube Estate, Glasgow, UK
    Gastroenterology 139:586-97, 597.e1-6. 2010
    ..In this study, we aimed to investigate the impact of LKB1 down-regulation for pancreatic cancer in mouse and human and to elucidate the mechanism by which Lkb1 deregulation contributes to this disease...
  11. pmc E-cadherin can limit the transforming properties of activating β-catenin mutations
    David J Huels
    Cancer Research UK Beatson Institute, Glasgow, UK
    EMBO J 34:2321-33. 2015
    ..Thus, there is a threshold of β-catenin that is required to drive transformation, and E-cadherin can act as a buffer to sequester mutated β-catenin...
  12. doi Advanced intravital subcellular imaging reveals vital three-dimensional signalling events driving cancer cell behaviour and drug responses in live tissue
    Max Nobis
    The Beatson Institute for Cancer Research, Glasgow, UK
    FEBS J 280:5177-97. 2013
    ..Furthermore, we offer a prospective view of how imaging applications may be integrated further with the aim of understanding disease in a more physiological and functional manner within the framework of the drug discovery process...
  13. doi Intravital FLIM-FRET imaging reveals dasatinib-induced spatial control of src in pancreatic cancer
    Max Nobis
    The Beatson Institute for Cancer Research, Glasgow Section of Dermatology, School of Medicine, University of Glasgow, Glasgow, UK
    Cancer Res 73:4674-86. 2013
    ..We propose that using FLIM-FRET in this capacity could provide a useful preclinical tool in animal models before clinical translation...
  14. pmc Activated mutant NRas(Q61K) drives aberrant melanocyte signaling, survival, and invasiveness via a Rac1-dependent mechanism
    Ang Li
    The Beatson Institute for Cancer Research, Garscube Estate, Glasgow, UK
    J Invest Dermatol 132:2610-21. 2012
    ....
  15. pmc K-Ras and β-catenin mutations cooperate with Fgfr3 mutations in mice to promote tumorigenesis in the skin and lung, but not in the bladder
    Imran Ahmad
    The Beatson Institute for Cancer Research, Glasgow, G61 1BD, UK
    Dis Model Mech 4:548-55. 2011
    ..These results indicate that activation of FGFR3 can cooperate with other mutations to drive tumorigenesis in a context-dependent manner, and support the hypothesis that activation of FGFR3 signaling contributes to human cancer...
  16. pmc Targeting the LOX/hypoxia axis reverses many of the features that make pancreatic cancer deadly: inhibition of LOX abrogates metastasis and enhances drug efficacy
    Bryan W Miller
    Cancer Research UK Beatson Institute Garscube Estate, Glasgow, UK
    EMBO Mol Med 7:1063-76. 2015
    ..Therefore, LOX inhibition is able to reverse many of the features that make PDAC inherently refractory to conventional therapies and targeting LOX could improve outcome in surgically resectable disease. ..
  17. pmc CXCR2 inhibition suppresses acute and chronic pancreatic inflammation
    Colin W Steele
    Cancer Research UK Beatson Institute, Glasgow, UK
    J Pathol 237:85-97. 2015
    ..CXCR2 may therefore be a viable therapeutic target in the treatment of pancreatitis...
  18. doi Activation of Wnt signalling promotes development of dysplasia in Barrett's oesophagus
    Lisa H Moyes
    University Department of Surgery, Royal Infirmary, Glasgow, UK
    J Pathol 228:99-112. 2012
    ..Based on these results in human tissues and a mouse model, we conclude that abnormal activation of Wnt signalling likely plays only a minor role in initiation of Barrett's metaplasia but a more critical role in progression to dysplasia...
  19. doi p53 mutation and loss have different effects on tumourigenesis in a novel mouse model of pleomorphic rhabdomyosarcoma
    Brendan Doyle
    Beatson Institute for Cancer Research, Garscube Estate, Switchback Road, Glasgow, G61 1BD, UK
    J Pathol 222:129-37. 2010
    ..These data demonstrate that mutant p53 can co-operate with activated, mutant KRas to influence tumourigenesis and metastatic potential, over and above simple loss of normal protein function...
  20. doi Methods to assess Myc function in intestinal homeostasis, regeneration, and tumorigenesis
    David J Huels
    Beatson Institute for Cancer Research, Glasgow, UK
    Methods Mol Biol 1012:237-48. 2013
    ..Cancer Cell 14:447-457, 2008). In this chapter we will provide an overview of our current laboratory protocols to characterize c-Myc function in intestinal homeostasis, regeneration, and tumorigenesis in vivo and in vitro...
  21. pmc Loss of Apc allows phenotypic manifestation of the transforming properties of an endogenous K-ras oncogene in vivo
    Owen J Sansom
    Beatson Institute for Cancer Research, Glasgow G61 1BD, United Kingdom
    Proc Natl Acad Sci U S A 103:14122-7. 2006
    ..These data imply a window of opportunity for anti-K-ras therapies after tumor initiation in preventing tumor growth and invasion...
  22. ncbi Cyclin D1 is not an immediate target of beta-catenin following Apc loss in the intestine
    Owen J Sansom
    School of Biosciences, University of Cardiff, Museum P O Box 911, Cardiff CF103US, Wales, United Kingdom
    J Biol Chem 280:28463-7. 2005
    ..Taken together, this argues that cyclin D1 up-regulation in intestinal neoplasia is important for tumor progression rather than initiation...
  23. ncbi Myc deletion rescues Apc deficiency in the small intestine
    Owen J Sansom
    The Beatson Institute, Garscube Estate, Glasgow G61 1BD, UK
    Nature 446:676-9. 2007
    ..Array analysis revealed that Myc is required for the majority of Wnt target gene activation following Apc loss. These data establish Myc as the critical mediator of the early stages of neoplasia following Apc loss...
  24. pmc Inducible progenitor-derived Wingless regulates adult midgut regeneration in Drosophila
    Julia B Cordero
    Wnt Signaling and Colorectal Cancer Group, The Beatson Institute for Cancer Research, Cancer Research UK, Glasgow, UK
    EMBO J 31:3901-17. 2012
    ..Therefore, fine-tuning Wnt results in optimal balance between the ability to respond to stress without negatively affecting organismal viability...
  25. pmc Actomyosin-mediated cellular tension drives increased tissue stiffness and β-catenin activation to induce epidermal hyperplasia and tumor growth
    Michael S Samuel
    Beatson Institute for Cancer Research, Glasgow, UK
    Cancer Cell 19:776-91. 2011
    ..Tumor number, growth, and progression were increased by ROCK activation, while ROCK blockade was inhibitory, implicating actomyosin-mediated cellular tension and consequent collagen deposition as significant tumor promoters...
  26. pmc Cell lineage tracing reveals a biliary origin of intrahepatic cholangiocarcinoma
    Rachel V Guest
    Authors Affiliations MRC Centre for Regenerative Medicine Human Genetics Unit, University of Edinburgh Department of Surgery and Transplantation Medicine, Royal Infirmary of Edinburgh, Edinburgh and Beatson Institute for Cancer Research, Glasgow, Scotland, United Kingdom
    Cancer Res 74:1005-10. 2014
    ..These data prove that in the context of chronic inflammation and p53 loss, frequent occurrences in human disease, biliary epithelia are a target of transformation and an origin of intrahepatic cholangiocarcinoma...
  27. pmc Exploring molecular genetics of bladder cancer: lessons learned from mouse models
    Imran Ahmad
    Beatson Institute for Cancer Research, Garscube Estate, Switchback Road, Bearsden, Glasgow, G61 1BD, UK
    Dis Model Mech 5:323-32. 2012
    ..We also highlight recent studies supporting a role for dysregulated Wnt signalling in UCC and the development of mouse models that recapitulate this dysregulation...
  28. doi The right time, the right place: will targeting human cancer-associated mutations to the mouse provide the perfect preclinical model?
    Karen Blyth
    The Beatson Institute for Cancer Research, Switchback Road, Glasgow, G61 1BD, UK
    Curr Opin Genet Dev 22:28-35. 2012
    ....
  29. doi Wnt/Myc interactions in intestinal cancer: partners in crime
    Kevin Myant
    Beatson Institute for Cancer Research, Garscube Estate, Switchback Road, Glasgow, Scotland G61 1BD, UK
    Exp Cell Res 317:2725-31. 2011
    ..Moreover, understanding these additional control mechanisms may allow targeting of c-MYC during colorectal carcinogenesis...
  30. pmc p21 loss blocks senescence following Apc loss and provokes tumourigenesis in the renal but not the intestinal epithelium
    Alicia M Cole
    Beatson Institute of Cancer Research, Glasgow, UK
    EMBO Mol Med 2:472-86. 2010
    ..However, in CRC, escape from senescence is likely to only be a barrier in cancers initiated by other mutations...
  31. pmc Targeting mTOR dependency in pancreatic cancer
    Douglas C Morran
    CRUK Beatson Institute, Glasgow, UK
    Gut 63:1481-9. 2014
    ..Pancreatic cancer is a leading cause of cancer-related death in the Western world. Current chemotherapy regimens have modest survival benefit. Thus, novel, effective therapies are required for treatment of this disease...
  32. pmc Next-generation sequencing of advanced prostate cancer treated with androgen-deprivation therapy
    Prabhakar Rajan
    Institute of Cancer Sciences, College of Medical, Veterinary and Life Sciences, University of Glasgow, Cancer Research UK Beatson Institute, Glasgow, UK Cancer Research UK Beatson Institute, The Beatson Institute for Cancer Research, Glasgow, UK Electronic address
    Eur Urol 66:32-9. 2014
    ..Many patients develop castration resistance (castration-resistant PCa [CRPC]) after approximately 2-3 yr, with a poor prognosis. The molecular mechanisms underlying CRPC progression are unclear...
  33. ncbi More, More, More: Downregulation of a MK5-FoxO3a-mir34b/c Pathway Further Increases c-Myc Levels in Colorectal Cancer
    Kevin Myant
    Beatson Institute of Cancer Research, Switchback Road, Glasgow G61 1BD, UK
    Mol Cell 41:369-70. 2011
    ..In this issue of Molecular Cell, Kress and colleagues (Kress et al., 2011) identify an exciting new pathway that downregulates c-Myc translation which is lost in aggressive colorectal cancer...
  34. pmc p53-mediated transcriptional regulation and activation of the actin cytoskeleton regulatory RhoC to LIMK2 signaling pathway promotes cell survival
    Daniel R Croft
    The Beatson Institute for Cancer Research, Garscube Estate, Glasgow, UK
    Cell Res 21:666-82. 2011
    ....
  35. doi Advances in mouse models of prostate cancer
    Imran Ahmad
    The Beatson Institute for Cancer Research, Glasgow, UK
    Expert Rev Mol Med 10:e16. 2008
    ..Compound mutational models will also develop further, with double and triple knock-in or knockout systems adding to our knowledge of the interaction between different signalling cascades...
  36. ncbi Inducible Cre-mediated control of gene expression in the murine gastrointestinal tract: effect of loss of beta-catenin
    Heather Ireland
    Department of Oncology, Cancer Research UK, Cambridge Institute of Medical Research, Wellcome Trust MRC Building, Addenbrooke s Hospital, Hills Road, Cambridge CB2 2XY, UK
    Gastroenterology 126:1236-46. 2004
    ....
  37. ncbi Deficiency of Mbd2 suppresses intestinal tumorigenesis
    Owen J Sansom
    Cardiff School of Biosciences, Cardiff University, Cardiff, Wales, UK
    Nat Genet 34:145-7. 2003
    ..As Mbd2-deficient mice are viable and fertile, their resistance to intestinal cancer may be of therapeutic relevance...
  38. pmc Loss of Apc in vivo immediately perturbs Wnt signaling, differentiation, and migration
    Owen J Sansom
    School of Biosciences, University of Cardiff, Cardiff CF10 3US, Wales
    Genes Dev 18:1385-90. 2004
    ..Critically, for the first time we confirm a series of Wnt target molecules in an in vivo setting and also identify a series of new candidate targets within the same setting...
  39. ncbi Inactivation of Apc perturbs mammary development, but only directly results in acanthoma in the context of Tcf-1 deficiency
    Ronald C J Gallagher
    Department of Biomedical Sciences, University of Edinburgh, Medical School, Teviot Place, Edinburgh EH8 9AG, UK
    Oncogene 21:6446-57. 2002
    ..However, additional deficiency of Tcf-1 completely blocks normal mammary development and results in acanthoma...
  40. ncbi Mutations in Apc and p53 synergize to promote mammary neoplasia
    Valerie Meniel
    School of Biological Sciences, Cardiff University, Cardiff, United Kingdom
    Cancer Res 65:410-6. 2005
    ..We therefore show clear synergy between these two mutations in mammary gland neoplasia and present data to suggest that at least one mechanism for this acceleration is the p53-dependent loss of Apc-deficient cells...
  41. ncbi Enhanced CpG mutability and tumorigenesis in MBD4-deficient mice
    Catherine B Millar
    Wellcome Trust Centre for Cell Biology, The King s Buildings, Edinburgh University, Edinburgh EH9 3JR, UK
    Science 297:403-5. 2002
    ..On a cancer-susceptible Apc(Min/+) background, Mbd4-/- mice showed accelerated tumor formation with CpG --> TpG mutations in the Apc gene. Thus MBD4 suppresses CpG mutability and tumorigenesis in vivo...
  42. ncbi Analyzing tumor suppressor activities in the murine small intestine
    Alan R Clarke
    Cardiff School of Biosciences, Cardiff University, Cardiff, CF10 3US, UK
    Oncol Res 13:333-7. 2003
    ..Finally, we have analyzed mice mutant for Mbd4 and show that this gene functions in vivo as a tumor suppressor...
  43. ncbi PPARdelta status and Apc-mediated tumourigenesis in the mouse intestine
    Karen R Reed
    Cardiff School of Biosciences, Cardiff University, Museum Avenue, Cardiff CF103US, UK
    Oncogene 23:8992-6. 2004
    ..Our data suggest that PPARdelta is not directly regulated by beta-catenin, and that inhibition of PPARdelta activity is unlikely to be an appropriate strategy for the chemoprevention or chemotherapy of intestinal malignancies...
  44. pmc Rapid loss of intestinal crypts upon conditional deletion of the Wnt/Tcf-4 target gene c-Myc
    Vanesa Muncan
    Hubrecht Laboratory, Nederlands Institute for Developmental Biology, Uppsalalaan 8, 3584 CT Utrecht, The Netherlands
    Mol Cell Biol 26:8418-26. 2006
    ..c-Myc appears essential for crypt progenitor cells to provide the necessary biosynthetic capacity to successfully progress through the cell cycle...
  45. ncbi Aspirin activates the NF-kappaB signalling pathway and induces apoptosis in intestinal neoplasia in two in vivo models of human colorectal cancer
    Lesley A Stark
    Division of Oncology, School of Clinical and Molecular Medicine, University of Edinburgh, Colon Cancer Genetics Group, MRC Human Genetics Unit, Western General Hospital, Crewe Road, Edinburgh EH4 2XU, UK
    Carcinogenesis 28:968-76. 2007
    ..These data have considerable relevance to cancer prevention and therapy...
  46. ncbi Apc deficiency predisposes to renal carcinoma in the mouse
    Owen J Sansom
    Cardiff School of Biosciences, Cardiff University, Wales CF10 3US, UK
    Oncogene 24:8205-10. 2005
    ..Compared to other murine models of kidney neoplasia, this represents particularly rapid onset of disease, and so implicates an important role for Apc in suppressing renal carcinoma...
  47. pmc A limited role for p53 in modulating the immediate phenotype of Apc loss in the intestine
    Karen R Reed
    Cardiff School of Biosciences, Cardiff University, Cardiff, CF10 3US, UK
    BMC Cancer 8:162. 2008
    ..Although p53-dependent regulation of Wnt signalling activity is known to occur, the importance of these regulatory mechanisms during the early stages of intestinal neoplasia has not been demonstrated...
  48. pmc PPARdelta status and mismatch repair mediated neoplasia in the mouse intestine
    Karen R Reed
    Cardiff School of Biosciences, Cardiff University, Museum Avenue, Cardiff CF103US, UK
    BMC Cancer 6:113. 2006
    ..To further investigate the PPARdelta dependency of intestinal tumourigenesis, we have analysed the consequences of PPARdelta deficiency upon intestinal neoplasia occurring in mice with impaired mismatch DNA repair...
  49. pmc The pro-apoptotic K-Ras 4A proto-oncoprotein does not affect tumorigenesis in the ApcMin/+ mouse small intestine
    Charles E Patek
    Sir Alastair Currie Cancer Research UK Laboratories, Molecular Medicine Centre, The University of Edinburgh, Western General Hospital, Crewe Road, Edinburgh, EH4 2XU, UK
    BMC Gastroenterol 8:24. 2008
    ..By this means tumorigenesis in the small intestine was compared between ApcMin/+, K-ras+/+ and ApcMin/+, K-rastmDelta4A/tmDelta4A mice that can, and cannot, express the K-ras 4A proto-oncoprotein respectively...
  50. doi C-Myc is a critical mediator of the phenotypes of Apc loss in the intestine
    Julie A Wilkins
    Beatson Insitute of Cancer Research, Garscube Estate, Swithback Road, Glasgow, United Kingdom
    Cancer Res 68:4963-6. 2008
    ..The importance of investigating Apc and C-Myc gene function in the correct tissue context is also discussed...
  51. pmc Deficiency of Mbd2 attenuates Wnt signaling
    Toby J Phesse
    Cardiff School of Biosciences, Cardiff University, Cardiff CF10 3US, United Kingdom
    Mol Cell Biol 28:6094-103. 2008
    ..Furthermore, we show that Lect2 is capable of functioning as a Wnt pathway repressor. These results therefore provide a mechanistic basis for the epigenetic control of adenoma formation mediated through Mbd2...
  52. ncbi Efficient deletion of normal Brca2-deficient intestinal epithelium by poly(ADP-ribose) polymerase inhibition models potential prophylactic therapy
    Trevor Hay
    School of Bioscience, Cardiff University, Cardiff, United Kingdom
    Cancer Res 65:10145-8. 2005
    ....
  53. ncbi Heterozygosity for p53 promotes microsatellite instability and tumorigenesis on a Msh2 deficient background
    Neil J Toft
    Department of Pathology, University Medical School, Teviot Place, Edinburgh EH8 9AG, UK
    Oncogene 21:6299-306. 2002
    ..Our results therefore demonstrate a dose sensitive role for p53 in the maintenance of genomic integrity at the nucleotide level...
  54. ncbi Apoptosis and mutation in the murine small intestine: loss of Mlh1- and Pms2-dependent apoptosis leads to increased mutation in vivo
    Owen J Sansom
    School of Biosciences, University of Cardiff, Museum Avenue, P O Box 911, Cardiff, Wales CF10 3US, UK
    DNA Repair (Amst) 2:1029-39. 2003
    ..However, when MMR does mediate apoptosis, perturbation of this response leads to long-term persistence of mutant cells in vivo...
  55. ncbi Identification of potential biomarkers for measuring inhibition of Src kinase activity in colon cancer cells following treatment with dasatinib
    Alan Serrels
    The Beatson Institute for Cancer Research, Garscube Estate, Switchback Road, Glasgow, G61 1BD, United Kingdom
    Mol Cancer Ther 5:3014-22. 2006
    ..Thus, peripheral blood mononuclear cells may provide a useful surrogate tissue for biomarker studies with dasatinib using inhibition of Src Tyr(419) and paxillin Tyr(118) phosphorylation as read-outs of Src activity...
  56. ncbi Mechanisms of disease: methyl-binding domain proteins as potential therapeutic targets in cancer
    Owen J Sansom
    Cardiff School of Biosciences, Cardiff University, Cardiff, UK
    Nat Clin Pract Oncol 4:305-15. 2007
    ..We review the recent work addressing this possibility, and discuss several of the MBD proteins as potentially excellent novel therapeutic targets...
  57. ncbi Mutationally activated K-ras 4A and 4B both mediate lung carcinogenesis
    Charles E Patek
    Sir Alastair Currie Cancer Research UK Laboratories, Molecular Medicine Centre, The University of Edinburgh, Western General Hospital, Edinburgh, UK
    Exp Cell Res 314:1105-14. 2008
    ....
  58. ncbi Brca2 deficiency in the murine small intestine sensitizes to p53-dependent apoptosis and leads to the spontaneous deletion of stem cells
    Trevor Hay
    School of Biosciences, Cardiff University, Museum Avenue, Cardiff CF10 3US, UK
    Oncogene 24:3842-6. 2005
    ..Furthermore, we show that Brca2 deficiency results in the spontaneous deletion of stem cells, thereby protecting the small intestine against tumorigenesis...
  59. ncbi The ability to engage enterocyte apoptosis does not predict long-term crypt survival in p53 and Msh2 deficient mice
    Owen J Sansom
    Cardiff School of Biosciences, University of Cardiff, CF10 3US, UK
    Oncogene 21:5934-9. 2002
    ..We conclude that loss of either p53 or Msh2 dependent apoptosis does not predict long-term crypt survival in vivo, however genetic status clearly can modulate survival for some agents such as cisplatin...