Cyril M Sanders

Summary

Affiliation: University of Sheffield
Country: UK

Publications

  1. ncbi request reprint High-specific-activity probes and a high-resolution in-gel photo cross-linking assay for protein-DNA complexes
    Sandrine Castella
    Institute for Cancer Studies, University of Sheffield, Beech Hill Rd, Sheffield S10 2RX, UK
    Anal Biochem 359:203-9. 2006
  2. pmc Common determinants in DNA melting and helicase-catalysed DNA unwinding by papillomavirus replication protein E1
    Sandrine Castella
    Institute for Cancer Studies, University of Sheffield, Beech Hill Road, Sheffield S10 2RX, UK
    Nucleic Acids Res 34:3008-19. 2006
  3. pmc Characterization of an unusual bipolar helicase encoded by bacteriophage T5
    Io Nam Wong
    Department of Oncology, Institute for Cancer Studies
    Nucleic Acids Res 41:4587-600. 2013
  4. pmc Transcription activator structure reveals redox control of a replication initiation reaction
    Cyril M Sanders
    Institute for Cancer Studies, University of Sheffield, Beech Hill Rd, Sheffield, S10 2RX, UK
    Nucleic Acids Res 35:3504-15. 2007
  5. pmc A DNA-binding activity in BPV initiator protein E1 required for melting duplex ori DNA but not processive helicase activity initiated on partially single-stranded DNA
    Cyril M Sanders
    Institute for Cancer Studies, University of Sheffield, Beech Hill Rd, Sheffield, S10 2RX, UK
    Nucleic Acids Res 36:1891-9. 2008
  6. ncbi request reprint Human Pif1 helicase is a G-quadruplex DNA-binding protein with G-quadruplex DNA-unwinding activity
    Cyril M Sanders
    Institute for Cancer Studies, University of Sheffield, UK
    Biochem J 430:119-28. 2010
  7. pmc Papillomavirus E1 helicase assembly maintains an asymmetric state in the absence of DNA and nucleotide cofactors
    Cyril M Sanders
    Institute for Cancer Studies, University of Sheffield, Beech Hill Road, Sheffield, S10 2RX, UK
    Nucleic Acids Res 35:6451-7. 2007
  8. pmc Role of ATP hydrolysis in the DNA translocase activity of the bovine papillomavirus (BPV-1) E1 helicase
    Sandrine Castella
    Institute for Cancer Studies, University of Sheffield, Beech Hill Road, Sheffield S10 2RX, UK
    Nucleic Acids Res 34:3731-41. 2006
  9. pmc Human Pif1 helicase unwinds synthetic DNA structures resembling stalled DNA replication forks
    Tresa George
    Institute for Cancer Studies, University of Sheffield, Beech Hill Road, Sheffield S10 2RX, UK
    Nucleic Acids Res 37:6491-502. 2009

Collaborators

Detail Information

Publications9

  1. ncbi request reprint High-specific-activity probes and a high-resolution in-gel photo cross-linking assay for protein-DNA complexes
    Sandrine Castella
    Institute for Cancer Studies, University of Sheffield, Beech Hill Rd, Sheffield S10 2RX, UK
    Anal Biochem 359:203-9. 2006
    ..These approaches should be widely applicable to the study of protein-DNA complexes...
  2. pmc Common determinants in DNA melting and helicase-catalysed DNA unwinding by papillomavirus replication protein E1
    Sandrine Castella
    Institute for Cancer Studies, University of Sheffield, Beech Hill Road, Sheffield S10 2RX, UK
    Nucleic Acids Res 34:3008-19. 2006
    ..One possible mechanism is that with the DNA locked in the loop/PS1betaH DNA binding site, ATP-dependent conformational changes draw the DNA inwards in a twisting motion to promote unwinding...
  3. pmc Characterization of an unusual bipolar helicase encoded by bacteriophage T5
    Io Nam Wong
    Department of Oncology, Institute for Cancer Studies
    Nucleic Acids Res 41:4587-600. 2013
    ....
  4. pmc Transcription activator structure reveals redox control of a replication initiation reaction
    Cyril M Sanders
    Institute for Cancer Studies, University of Sheffield, Beech Hill Rd, Sheffield, S10 2RX, UK
    Nucleic Acids Res 35:3504-15. 2007
    ..Our data demonstrate that as well as a mechanism for regulating DNA binding, redox reactions can control replication by modulating the tertiary structure of critical protein factors using a specific redox sensor...
  5. pmc A DNA-binding activity in BPV initiator protein E1 required for melting duplex ori DNA but not processive helicase activity initiated on partially single-stranded DNA
    Cyril M Sanders
    Institute for Cancer Studies, University of Sheffield, Beech Hill Rd, Sheffield, S10 2RX, UK
    Nucleic Acids Res 36:1891-9. 2008
    ..New insights into the mechanism of ori melting are elaborated, suggesting the coordinated involvement of rigid and flexible DNA-binding components in E1...
  6. ncbi request reprint Human Pif1 helicase is a G-quadruplex DNA-binding protein with G-quadruplex DNA-unwinding activity
    Cyril M Sanders
    Institute for Cancer Studies, University of Sheffield, UK
    Biochem J 430:119-28. 2010
    ..Human Pif1 could therefore have a role in processing G4 structures that arise in the single-stranded nucleic acid intermediates formed during DNA replication and gene expression...
  7. pmc Papillomavirus E1 helicase assembly maintains an asymmetric state in the absence of DNA and nucleotide cofactors
    Cyril M Sanders
    Institute for Cancer Studies, University of Sheffield, Beech Hill Road, Sheffield, S10 2RX, UK
    Nucleic Acids Res 35:6451-7. 2007
    ..Since a single ATP hydrolysis event would affect the whole hexamer, such events may simply serve to rectify the direction of the wave's motion...
  8. pmc Role of ATP hydrolysis in the DNA translocase activity of the bovine papillomavirus (BPV-1) E1 helicase
    Sandrine Castella
    Institute for Cancer Studies, University of Sheffield, Beech Hill Road, Sheffield S10 2RX, UK
    Nucleic Acids Res 34:3731-41. 2006
    ..This reciprocal change in protein-protein and protein-DNA affinities could be part of a mechanism for tethering the protein to its substrate while unidirectional movement along DNA proceeds...
  9. pmc Human Pif1 helicase unwinds synthetic DNA structures resembling stalled DNA replication forks
    Tresa George
    Institute for Cancer Studies, University of Sheffield, Beech Hill Road, Sheffield S10 2RX, UK
    Nucleic Acids Res 37:6491-502. 2009
    ..The result of hPif1 helicase action at stalled DNA replication forks would generate free 3' ends and ssDNA that could potentially be used to assist replication restart in conjunction with its strand annealing activity...