Simon Rousseau

Summary

Affiliation: University of Dundee
Country: UK

Publications

  1. doi request reprint TPL2-mediated activation of ERK1 and ERK2 regulates the processing of pre-TNF alpha in LPS-stimulated macrophages
    Simon Rousseau
    MRC Protein Phosphorylation Unit, College of Life Sciences, University of Dundee, Dow Street, Dundee, DD1 5EH, UK
    J Cell Sci 121:149-54. 2008
  2. ncbi request reprint Integrating the VEGF signals leading to actin-based motility in vascular endothelial cells
    S Rousseau
    Centre de recherche en cancérologie de l Université Laval, L Hôtel Dieu de Québec, 9 rue McMahon, G1R 2J6, Quebec, Canada
    Trends Cardiovasc Med 10:321-7. 2000
  3. pmc Inhibition of SAPK2a/p38 prevents hnRNP A0 phosphorylation by MAPKAP-K2 and its interaction with cytokine mRNAs
    Simon Rousseau
    MRC Protein Phosphorylation Unit, School of Life Sciences, University of Dundee, MSI WTB complex, Dow Street, Dundee DD1 5EH, UK E mail
    EMBO J 21:6505-14. 2002
  4. pmc Nogo-B is a new physiological substrate for MAPKAP-K2
    Simon Rousseau
    MRC Protein Phosphorylation Unit, Faculty of Life Sciences, University of Dundee, MSI WTB complex, Dow Street, Dundee DD1 5EH, Scotland, UK
    Biochem J 391:433-40. 2005
  5. ncbi request reprint CXCL12 and C5a trigger cell migration via a PAK1/2-p38alpha MAPK-MAPKAP-K2-HSP27 pathway
    Simon Rousseau
    MRC Protein Phosphorylation Unit, Faculty of Life Sciences, University of Dundee, CIR Building, Dow Street, Dundee DD1 5EH, United Kingdom
    Cell Signal 18:1897-905. 2006
  6. ncbi request reprint IL-1beta-stimulated activation of ERK1/2 and p38alpha MAPK mediates the transcriptional up-regulation of IL-6, IL-8 and GRO-alpha in HeLa cells
    Huei Ting Yang
    MRC Protein Phosphorylation Unit, College of Life Sciences, University of Dundee, Sir James Black Centre, Dow Street, Dundee, DD1 5EH, United Kingdom
    Cell Signal 20:375-80. 2008
  7. pmc Phosphorylation of the ARE-binding protein DAZAP1 by ERK2 induces its dissociation from DAZ
    Simon Morton
    MRC Protein Phosphorylation Unit, Faculty of Life Sciences, University of Dundee, CIR Building, Dow Street, Dundee DD1 5EH, UK
    Biochem J 399:265-73. 2006
  8. doi request reprint Lipopolysaccharide-induced toll-like receptor 4 signaling enhances the migratory ability of human esophageal cancer cells in a selectin-dependent manner
    Mathieu C Rousseau
    LD McLean Surgical Research Laboratories, Division of Thoracic Surgery, Department of Surgery, McGill University, Montreal, Quebec, Canada
    Surgery 154:69-77. 2013
  9. doi request reprint TH17 cytokines induce human airway smooth muscle cell migration
    Ying Chang
    Meakins Christie Laboratories and Respiratory Division, Department of Medicine McGill University, Montreal, Quebec, Canada
    J Allergy Clin Immunol 127:1046-53.e1-2. 2011
  10. doi request reprint IL-17 promotes p38 MAPK-dependent endothelial activation enhancing neutrophil recruitment to sites of inflammation
    Lucie Roussel
    Meakins Christie Laboratories, University Heath Centre Research Institute, Montreal, Quebec, Canada
    J Immunol 184:4531-7. 2010

Collaborators

  • James G Martin
  • Qutayba Hamid
  • Jacques Huot
  • Matthias Gaestel
  • Nurlan Dauletbaev
  • Simon Law
  • Parameswaran Nair
  • Sakae Tanaka
  • Ana Cuenda
  • Simon Morton
  • Angel R Nebreda
  • P Cohen
  • Christopher G Proud
  • J S Arthur
  • P Moreau
  • Anne O'Garra
  • Yu Yao
  • Lucie Roussel
  • Dao Nguyen
  • Huei Ting Yang
  • Julie Berube
  • Mathieu C Rousseau
  • Rich Y C Hsu
  • Elyse MacFadden-Murphy
  • Manon Ruffin
  • Shantelle L LaFayette
  • Guy Martel
  • Toby K McGovern
  • Samuel M Chekabab
  • Gabriella Wojewodka
  • Francois Houle
  • Michela Zago
  • Lorenzo E Ferri
  • Betty Giannias
  • David H Eidelman
  • Carlos H F Chan
  • Jonathan D Spicer
  • Ying Chang
  • Maria Buxade
  • Nick Morrice
  • Nguyen Thu Ngan Trinh
  • Martin Yvon Desrosiers
  • Emilie Maillé
  • Claudia Bilodeau
  • Trevor Beaudoin
  • Geoffrey A McKay
  • Emmanuelle Brochiero
  • Michael O'Sullivan
  • Soroor Farahnak
  • Nobuaki Hirota
  • Yishan Luo
  • Benoit Allard
  • Richard J Silverman
  • Yoichiro Hamamoto
  • Madison Goldberger
  • Jim Gruber
  • Larry C Lands
  • Juan B De Sanctis
  • Danuta Radzioch
  • Andrea Benedetti
  • Heather G Ahlgren
  • Elias Matouk
  • Joanie Bernier
  • Jennifer Landry
  • Jared A Sheridan
  • Rushika M Perera
  • Sergio Di Marco
  • Carolyn J Baglole
  • Simon C Chow
  • Imed Eddine Gallouzi
  • Angela Rico De Souza
  • Braedon McDonald
  • Laila Al-Alwan
  • Andrew J Halayko
  • Paul Andre Risse
  • Ron Olivenstein
  • Lorenzo Ferri
  • Carlos Chan
  • Mark Peggie
  • S Giroux
  • Jenny Bain
  • Natalia Shpiro
  • Rodolfo Marquez
  • Josep L Parra
  • Enric Espel
  • Mario Luc
  • Sébastien Mongrain
  • Christopher E Turner
  • M Tremblay
  • L Jeannotte

Detail Information

Publications25

  1. doi request reprint TPL2-mediated activation of ERK1 and ERK2 regulates the processing of pre-TNF alpha in LPS-stimulated macrophages
    Simon Rousseau
    MRC Protein Phosphorylation Unit, College of Life Sciences, University of Dundee, Dow Street, Dundee, DD1 5EH, UK
    J Cell Sci 121:149-54. 2008
    ....
  2. ncbi request reprint Integrating the VEGF signals leading to actin-based motility in vascular endothelial cells
    S Rousseau
    Centre de recherche en cancérologie de l Université Laval, L Hôtel Dieu de Québec, 9 rue McMahon, G1R 2J6, Quebec, Canada
    Trends Cardiovasc Med 10:321-7. 2000
    ..In particular, the role of the VEGF receptors involved in initiating the coordinated signals that leads to actin-based motility is discussed...
  3. pmc Inhibition of SAPK2a/p38 prevents hnRNP A0 phosphorylation by MAPKAP-K2 and its interaction with cytokine mRNAs
    Simon Rousseau
    MRC Protein Phosphorylation Unit, School of Life Sciences, University of Dundee, MSI WTB complex, Dow Street, Dundee DD1 5EH, UK E mail
    EMBO J 21:6505-14. 2002
    ..Our data suggest that LPS-induced binding of hnRNP A0 to AREs may contribute to the post-transcriptional regulation of specific mRNAs...
  4. pmc Nogo-B is a new physiological substrate for MAPKAP-K2
    Simon Rousseau
    MRC Protein Phosphorylation Unit, Faculty of Life Sciences, University of Dundee, MSI WTB complex, Dow Street, Dundee DD1 5EH, Scotland, UK
    Biochem J 391:433-40. 2005
    ..The anisomycin-induced phosphorylation of Ser107 in HeLa cells can be prevented by 'knockdown' of MAPKAP-K2 using siRNA (small interfering RNA). Taken together, our results identify Nogo-B as a new physiological substrate of MAPKAP-K2...
  5. ncbi request reprint CXCL12 and C5a trigger cell migration via a PAK1/2-p38alpha MAPK-MAPKAP-K2-HSP27 pathway
    Simon Rousseau
    MRC Protein Phosphorylation Unit, Faculty of Life Sciences, University of Dundee, CIR Building, Dow Street, Dundee DD1 5EH, United Kingdom
    Cell Signal 18:1897-905. 2006
    ..These results demonstrate a general and essential role of the PAK-p38alpha MAPK-MAPKAP-K2-HSP27 signalling pathway in mediating the effects of chemotactic stimuli on cell migration...
  6. ncbi request reprint IL-1beta-stimulated activation of ERK1/2 and p38alpha MAPK mediates the transcriptional up-regulation of IL-6, IL-8 and GRO-alpha in HeLa cells
    Huei Ting Yang
    MRC Protein Phosphorylation Unit, College of Life Sciences, University of Dundee, Sir James Black Centre, Dow Street, Dundee, DD1 5EH, United Kingdom
    Cell Signal 20:375-80. 2008
    ....
  7. pmc Phosphorylation of the ARE-binding protein DAZAP1 by ERK2 induces its dissociation from DAZ
    Simon Morton
    MRC Protein Phosphorylation Unit, Faculty of Life Sciences, University of Dundee, CIR Building, Dow Street, Dundee DD1 5EH, UK
    Biochem J 399:265-73. 2006
    ....
  8. doi request reprint Lipopolysaccharide-induced toll-like receptor 4 signaling enhances the migratory ability of human esophageal cancer cells in a selectin-dependent manner
    Mathieu C Rousseau
    LD McLean Surgical Research Laboratories, Division of Thoracic Surgery, Department of Surgery, McGill University, Montreal, Quebec, Canada
    Surgery 154:69-77. 2013
    ..We investigated the direct impact of LPS on the migratory ability of esophageal cancer cells via the LPS receptor toll-like receptor 4 (TLR4)...
  9. doi request reprint TH17 cytokines induce human airway smooth muscle cell migration
    Ying Chang
    Meakins Christie Laboratories and Respiratory Division, Department of Medicine McGill University, Montreal, Quebec, Canada
    J Allergy Clin Immunol 127:1046-53.e1-2. 2011
    ..T(H)17 cells and T(H)17-associated cytokines are involved in the pathogenesis of asthma and might also contribute to airway remodeling...
  10. doi request reprint IL-17 promotes p38 MAPK-dependent endothelial activation enhancing neutrophil recruitment to sites of inflammation
    Lucie Roussel
    Meakins Christie Laboratories, University Heath Centre Research Institute, Montreal, Quebec, Canada
    J Immunol 184:4531-7. 2010
    ..Therefore, preventing neutrophil recruitment by blocking the action of IL-17 on endothelial cells may prove to be highly beneficial in diseases in which neutrophilic inflammation plays a key role...
  11. doi request reprint DAZAP1 interacts via its RNA-recognition motifs with the C-termini of other RNA-binding proteins
    Huei Ting Yang
    MRC Protein Phosphorylation Unit, Sir James Black Centre, University of Dundee, Dow Street, Dundee, DD1 5EH, United Kingdom
    Biochem Biophys Res Commun 380:705-9. 2009
    ..The results suggest that DAZAP1 is a component of complexes that are crucial for the degradation and silencing of mRNA...
  12. pmc Aryl hydrocarbon receptor-dependent retention of nuclear HuR suppresses cigarette smoke-induced cyclooxygenase-2 expression independent of DNA-binding
    Michela Zago
    Department of Medicine, McGill University, Montreal, Quebec, Canada
    PLoS ONE 8:e74953. 2013
    ..These findings open the possibility that a DRE-independent AhR pathway may be exploited therapeutically as an anti-inflammatory target. ..
  13. pmc Extracellular signal-regulated kinase mediates phosphorylation of tropomyosin-1 to promote cytoskeleton remodeling in response to oxidative stress: impact on membrane blebbing
    Francois Houle
    Le Centre de Recherche en Cancérologie de l Université Laval, L Hôtel Dieu de Québec, Quebec G1R 2J6, Canada
    Mol Biol Cell 14:1418-32. 2003
    ....
  14. ncbi request reprint p38 MAP-kinases pathway regulation, function and role in human diseases
    Ana Cuenda
    MRC Protein Phosphorylation Unit, College of Life Sciences, University of Dundee, Dundee DD1 5EH, Scotland, UK
    Biochim Biophys Acta 1773:1358-75. 2007
    ..Here we focus on these emergent roles of p38MAPKs and their implication in different pathologies...
  15. doi request reprint Quorum-sensing inhibition abrogates the deleterious impact of Pseudomonas aeruginosa on airway epithelial repair
    Manon Ruffin
    Centre de recherche du Centre hospitalier de l Université de Montréal CRCHUM, Montreal, Quebec, Canada Département de Médecine, Universite de Montreal, Montreal, Quebec, Canada
    FASEB J 30:3011-25. 2016
    ..LaFayette, S. L., McKay, G. A., Trinh, N. T. N., Beaudoin, T., Desrosiers, M.-Y., Rousseau, S., Nguyen, D., Brochiero, E. Quorum-sensing inhibition abrogates the deleterious impact of Pseudomonas aeruginosa on airway epithelial repair. ..
  16. doi request reprint Decreasing SMPD1 activity in BEAS-2B bronchial airway epithelial cells results in increased NRF2 activity, cytokine synthesis and neutrophil recruitment
    Elyse MacFadden-Murphy
    Meakins Christie Laboratories, Department of Medicine, McGill University, McGill University Health Centre Research Institute, Montreal, Quebec, Canada
    Biochem Biophys Res Commun . 2016
    ..This can result in a chronic inflammatory state that impairs host defence similar to scenarios observe in other chronic inflammatory lung disease such as Chronic Obstructive Pulmonary Disease or Cystic Fibrosis...
  17. pmc SAPK2/p38-dependent F-actin reorganization regulates early membrane blebbing during stress-induced apoptosis
    J Huot
    Centre de recherche en cancérologie de l Université Laval, L Hôtel Dieu de Québec, Quebec, G1R 2J6, Canada
    J Cell Biol 143:1361-73. 1998
    ..We conclude that the HSP27-dependent actin polymerization-generating activity of SAPK2 associated with a misassembly of the focal adhesions is responsible for induction of membrane blebbing by stressing agents...
  18. doi request reprint LPS-induced TLR4 signaling in human colorectal cancer cells increases beta1 integrin-mediated cell adhesion and liver metastasis
    Rich Y C Hsu
    LD McLean Surgical Research Laboratories, Department of Surgery, McGill University, Montreal, Quebec, Canada
    Cancer Res 71:1989-98. 2011
    ..Our findings suggest that inhibiting LPS-induced TLR4 signaling could improve therapeutic outcomes by preventing cancer metastasis during the perioperative period of CRC resection...
  19. ncbi request reprint Embryonic death of Mek1-deficient mice reveals a role for this kinase in angiogenesis in the labyrinthine region of the placenta
    S Giroux
    Centre de recherche en cancérologie de l Université Laval, Centre Hospitalier Universitaire de Quebec, Pavillon L Hotel Dieu de Quebec, 9, a rue McMahon, Quebec, Canada, G1R 2J6
    Curr Biol 9:369-72. 1999
    ..They also suggest that mek1 function is required for normal response to angiogenic signals that might promote vascularization of the labyrinthine region of the placenta...
  20. doi request reprint Exposure of airway epithelial cells to Pseudomonas aeruginosa biofilm-derived quorum sensing molecules decrease the activity of the anti-oxidant response element bound by NRF2
    Lucie Roussel
    The Meakins Christie Laboratories at the Research Institute of the McGill University Health Centre, Montreal, Quebec, Canada
    Biochem Biophys Res Commun . 2017
    ..Increasing NRF2 activity may thus be a promising strategy to potentiate anti-biofilm activity in cystic fibrosis lung disease...
  21. pmc Staphylococcus aureus Inhibits IL-8 Responses Induced by Pseudomonas aeruginosa in Airway Epithelial Cells
    Samuel M Chekabab
    Research Institute of the McGill University Health Centre, Montreal, Quebec, Canada Meakins Christie Laboratories, McGill University, Montreal, Quebec, Canada
    PLoS ONE 10:e0137753. 2015
    ..These findings show a novel direct anti-inflammatory effect of SA on airway epithelial cells, highlighting its potential to modulate inflammatory responses in the setting of polymicrobial infections. ..
  22. pmc Rhinovirus Load Is High despite Preserved Interferon-β Response in Cystic Fibrosis Bronchial Epithelial Cells
    Nurlan Dauletbaev
    Research Institute of McGill University Health Centre, Montreal, Quebec, Canada
    PLoS ONE 10:e0143129. 2015
    ..High HRV load in CF airway epithelial cells appears to be due to deficiencies manifesting early during HRV infection, and may not be related to interferon-β...
  23. doi request reprint Neutrophils mediate airway hyperresponsiveness after chlorine-induced airway injury in the mouse
    Toby K McGovern
    Meakins Christie Laboratories, Department of Medicine, McGill University, Montreal, Quebec, Canada
    Am J Respir Cell Mol Biol 52:513-22. 2015
    ..Our data suggest the ability of neutrophils to promote Cl2-induced AHR is dependent on increases in oxidative stress and occupation of luminal space in large airways. ..
  24. pmc Candidate markers associated with the probability of future pulmonary exacerbations in cystic fibrosis patients
    Gabriella Wojewodka
    Department of Human Genetics, McGill University, Montreal, Quebec, Canada
    PLoS ONE 9:e88567. 2014
    ..The assessments able to predict a future PE or a recurrent PE are limited. We hypothesized that combining clinical, molecular and patient reported data could identify patients who are at risk of PE...
  25. ncbi request reprint The Mnks are novel components in the control of TNF alpha biosynthesis and phosphorylate and regulate hnRNP A1
    Maria Buxade
    Departament de Fisiologia, Universitat de Barcelona, Spain
    Immunity 23:177-89. 2005
    ..Moreover, Mnk-mediated phosphorylation decreases binding of hnRNP A1 to TNFalpha-ARE in vitro or TNFalpha-mRNA in vivo. Therefore, Mnks are novel players in cytokine regulation and potential new targets for anti-inflammatory therapy...