Alan J Robinson

Summary

Affiliation: University of Cambridge
Country: UK

Publications

  1. pmc Mitochondrial carriers in the cytoplasmic state have a common substrate binding site
    Alan J Robinson
    Dunn Human Nutrition Unit, Medical Research Council, Hills Road, Cambridge CB2 2XY, United Kingdom
    Proc Natl Acad Sci U S A 103:2617-22. 2006
  2. pmc The mechanism of transport by mitochondrial carriers based on analysis of symmetry
    Alan J Robinson
    Medical Research Council, Dunn Human Nutrition Unit, Hills Road, Cambridge CB2 0XY, United Kingdom
    Proc Natl Acad Sci U S A 105:17766-71. 2008
  3. ncbi request reprint The conserved substrate binding site of mitochondrial carriers
    Edmund R S Kunji
    The Medical Research Council, Dunn Human Nutrition Unit, CB2 2XY, Cambridge, UK
    Biochim Biophys Acta 1757:1237-48. 2006
  4. doi request reprint Coupling of proton and substrate translocation in the transport cycle of mitochondrial carriers
    Edmund R S Kunji
    The Medical Research Council, Mitochondrial Biology Unit, Hills Road, Cambridge CB2 0XY, United Kingdom
    Curr Opin Struct Biol 20:440-7. 2010
  5. pmc Metabolic flexibility of mitochondrial respiratory chain disorders predicted by computer modelling
    Łukasz P Zieliński
    MRC Mitochondrial Biology Unit, Cambridge Biomedical Campus, Hills Road, Cambridge, CB2 0XY, UK University of Cambridge School of Clinical Medicine, Cambridge Biomedical Campus, Hills Road, Cambridge, CB2 0SP, UK
    Mitochondrion 31:45-55. 2016
  6. pmc MitoMiner: a data warehouse for mitochondrial proteomics data
    Anthony C Smith
    Medical Research Council Mitochondrial Biology Unit, Wellcome Trust MRC Building, Hills Road, Cambridge CB2 0XY, UK
    Nucleic Acids Res 40:D1160-7. 2012
  7. doi request reprint Mitochondrial carrier homolog 2 (MTCH2): the recruitment and evolution of a mitochondrial carrier protein to a critical player in apoptosis
    Alan J Robinson
    The Medical Research Council, Mitochondrial Biology Unit, Cambridge, UK
    Exp Cell Res 318:1316-23. 2012
  8. pmc The mimivirus genome encodes a mitochondrial carrier that transports dATP and dTTP
    Magnus Monné
    Dunn Human Nutrition Unit, Medical Research Council, Hills Road, Cambridge CB2 2XY, United Kingdom
    J Virol 81:3181-6. 2007
  9. pmc Complex I within oxidatively stressed bovine heart mitochondria is glutathionylated on Cys-531 and Cys-704 of the 75-kDa subunit: potential role of CYS residues in decreasing oxidative damage
    Thomas R Hurd
    Medical Research Council Dunn Human Nutrition Unit, Wellcome Trust MRC Building, Hills Road, Cambridge CB2 0XY, United Kingdom
    J Biol Chem 283:24801-15. 2008
  10. pmc The AAA+ protein ATAD3 has displacement loop binding properties and is involved in mitochondrial nucleoid organization
    Jiuya He
    Medical Research Council Dunn Human Nutrition Unit, Wellcome Trust Medical Research Council Building, Cambridge CB2 OXY, England, UK
    J Cell Biol 176:141-6. 2007

Collaborators

  • Edmund R S Kunji
  • M P Murphy
  • F Palmieri
  • Anthony C Smith
  • Łukasz P Zieliński
  • Ian M Fearnley
  • Thomas R Hurd
  • Anna R Cappello
  • Magnus Monné
  • Jiuya He
  • Italo Stipani
  • Rosita Curcio
  • Anna Rita Cappello
  • Alexander G Smith
  • James A Blackshaw
  • Aleksandra Filipovska
  • Tracy A Prime
  • Stephanie Brown
  • Raquel Requejo
  • Christoph Boes
  • Lucia Daddabbo
  • Hiroshi Sembongi
  • Anna Ludovico
  • Johannes N Spelbrink
  • Andrew B Clippingdale
  • John E Walker
  • Aurelio Reyes
  • Michael Harbour
  • Miriam Di Re
  • Stefanie Reichelt
  • Chih Chieh Mao
  • Caroline Granycome
  • Daniela V Miniero
  • Michael E Harbour
  • Ian J Holt
  • Daniela Valeria Miniero

Detail Information

Publications12

  1. pmc Mitochondrial carriers in the cytoplasmic state have a common substrate binding site
    Alan J Robinson
    Dunn Human Nutrition Unit, Medical Research Council, Hills Road, Cambridge CB2 2XY, United Kingdom
    Proc Natl Acad Sci U S A 103:2617-22. 2006
    ..It enables the substrate specificity of uncharacterized mitochondrial carriers to be predicted...
  2. pmc The mechanism of transport by mitochondrial carriers based on analysis of symmetry
    Alan J Robinson
    Medical Research Council, Dunn Human Nutrition Unit, Hills Road, Cambridge CB2 0XY, United Kingdom
    Proc Natl Acad Sci U S A 105:17766-71. 2008
    ..The interaction energies of the networks allow members of the transporter family to be classified as strict exchangers or uniporters...
  3. ncbi request reprint The conserved substrate binding site of mitochondrial carriers
    Edmund R S Kunji
    The Medical Research Council, Dunn Human Nutrition Unit, CB2 2XY, Cambridge, UK
    Biochim Biophys Acta 1757:1237-48. 2006
    ..The trigger for the translocation event is likely to be the substrate-induced perturbation of the salt bridge network at the bottom of the cavity...
  4. doi request reprint Coupling of proton and substrate translocation in the transport cycle of mitochondrial carriers
    Edmund R S Kunji
    The Medical Research Council, Mitochondrial Biology Unit, Hills Road, Cambridge CB2 0XY, United Kingdom
    Curr Opin Struct Biol 20:440-7. 2010
    ..In the case of proton-substrate symporters the substrate binding sites contain also negatively charged residues that are proposed to be involved in proton transport...
  5. pmc Metabolic flexibility of mitochondrial respiratory chain disorders predicted by computer modelling
    Łukasz P Zieliński
    MRC Mitochondrial Biology Unit, Cambridge Biomedical Campus, Hills Road, Cambridge, CB2 0XY, UK University of Cambridge School of Clinical Medicine, Cambridge Biomedical Campus, Hills Road, Cambridge, CB2 0SP, UK
    Mitochondrion 31:45-55. 2016
    ..These simulations can enhance understanding of dysfunctional mitochondrial metabolism and suggest new avenues for research into treatment of mitochondrial disease and other areas of mitochondrial dysfunction...
  6. pmc MitoMiner: a data warehouse for mitochondrial proteomics data
    Anthony C Smith
    Medical Research Council Mitochondrial Biology Unit, Wellcome Trust MRC Building, Hills Road, Cambridge CB2 0XY, UK
    Nucleic Acids Res 40:D1160-7. 2012
    ....
  7. doi request reprint Mitochondrial carrier homolog 2 (MTCH2): the recruitment and evolution of a mitochondrial carrier protein to a critical player in apoptosis
    Alan J Robinson
    The Medical Research Council, Mitochondrial Biology Unit, Cambridge, UK
    Exp Cell Res 318:1316-23. 2012
    ....
  8. pmc The mimivirus genome encodes a mitochondrial carrier that transports dATP and dTTP
    Magnus Monné
    Dunn Human Nutrition Unit, Medical Research Council, Hills Road, Cambridge CB2 2XY, United Kingdom
    J Virol 81:3181-6. 2007
    ..As the 1.2-Mb double-stranded DNA mimivirus genome is rich in A and T residues, we speculate that the virus is using this protein to target the host mitochondria as a source of deoxynucleotides for its replication...
  9. pmc Complex I within oxidatively stressed bovine heart mitochondria is glutathionylated on Cys-531 and Cys-704 of the 75-kDa subunit: potential role of CYS residues in decreasing oxidative damage
    Thomas R Hurd
    Medical Research Council Dunn Human Nutrition Unit, Wellcome Trust MRC Building, Hills Road, Cambridge CB2 0XY, United Kingdom
    J Biol Chem 283:24801-15. 2008
    ....
  10. pmc The AAA+ protein ATAD3 has displacement loop binding properties and is involved in mitochondrial nucleoid organization
    Jiuya He
    Medical Research Council Dunn Human Nutrition Unit, Wellcome Trust Medical Research Council Building, Cambridge CB2 OXY, England, UK
    J Cell Biol 176:141-6. 2007
    ..These results suggest that mitochondrial D-loops serve to recruit ATAD3p for the purpose of forming or segregating mitochondrial nucleoids...
  11. ncbi request reprint Functional and structural role of amino acid residues in the odd-numbered transmembrane alpha-helices of the bovine mitochondrial oxoglutarate carrier
    Anna R Cappello
    Department of Pharmaco Biology, Laboratory of Biochemistry and Molecular Biology, University of Bari, Via E Orabona 4, 70125 Bari, Italy
    J Mol Biol 369:400-12. 2007
    ..Residues G32, A35, Q40, G130, G133, A134, G230, and S237 are potentially engaged in inter-helical interactions and they may be involved in the movements of the alpha-helices during translocation...
  12. ncbi request reprint Functional and structural role of amino acid residues in the even-numbered transmembrane alpha-helices of the bovine mitochondrial oxoglutarate carrier
    Anna Rita Cappello
    Department of Pharmaco Biology, Laboratory of Biochemistry and Molecular Biology, University of Bari, Via E Orabona 4, 70125 Bari, Italy
    J Mol Biol 363:51-62. 2006
    ..The third cluster is at the midpoint of the membrane and consists of residues that are proposed to be involved in substrate binding...