Elizabeth J Robertson

Summary

Affiliation: University of Oxford
Country: UK

Publications

  1. doi Dose-dependent Nodal/Smad signals pattern the early mouse embryo
    Elizabeth J Robertson
    Sir William Dunn School of Pathology, University of Oxford, South Parks Road, Oxford OX1 3RE, UK Electronic address
    Semin Cell Dev Biol 32:73-9. 2014
  2. ncbi Blimp1 regulates development of the posterior forelimb, caudal pharyngeal arches, heart and sensory vibrissae in mice
    Elizabeth J Robertson
    Sir William Dunn School of Pathology, University of Oxford, South Parks Road, Oxford OX1 3RE, UK
    Development 134:4335-45. 2007
  3. doi Ventral closure, headfold fusion and definitive endoderm migration defects in mouse embryos lacking the fibronectin leucine-rich transmembrane protein FLRT3
    Silvia Maretto
    Sir William Dunn School of Pathology, University of Oxford, South Parks Road, Oxford, OX1 3RE, UK
    Dev Biol 318:184-93. 2008
  4. pmc Lhx1 functions together with Otx2, Foxa2, and Ldb1 to govern anterior mesendoderm, node, and midline development
    Ita Costello
    The Sir William Dunn School of Pathology, University of Oxford, Oxford OX1 3RE, United Kingdom
    Genes Dev 29:2108-22. 2015
  5. pmc The T-box transcription factor Eomesodermin acts upstream of Mesp1 to specify cardiac mesoderm during mouse gastrulation
    Ita Costello
    Sir William Dunn School of Pathology, University of Oxford, South Parks Road, Oxford OX1 3RE, UK
    Nat Cell Biol 13:1084-91. 2011
  6. pmc Blimp-1/Prdm1 alternative promoter usage during mouse development and plasma cell differentiation
    Marc A J Morgan
    University of Oxford, Sir William Dunn School of Pathology, South Parks Road, Oxford OX1 3RE, United Kingdom
    Mol Cell Biol 29:5813-27. 2009
  7. doi Pivotal roles for eomesodermin during axis formation, epithelium-to-mesenchyme transition and endoderm specification in the mouse
    Sebastian J Arnold
    Sir William Dunn School of Pathology, University of Oxford, South Parks Road, Oxford OX1 3RE, UK
    Development 135:501-11. 2008
  8. pmc Alternative splicing regulates Prdm1/Blimp-1 DNA binding activities and corepressor interactions
    Marc A J Morgan
    Sir William Dunn School of Pathology, University of Oxford, Oxford, United Kingdom
    Mol Cell Biol 32:3403-13. 2012
  9. pmc Blimp1/Prdm1 governs terminal differentiation of endovascular trophoblast giant cells and defines multipotent progenitors in the developing placenta
    Arne Mould
    Sir William Dunn School of Pathology, University of Oxford, Oxford, United Kingdom
    Genes Dev 26:2063-74. 2012
  10. pmc The transcriptional repressor Blimp1/Prdm1 regulates postnatal reprogramming of intestinal enterocytes
    James Harper
    Sir William Dunn School of Pathology, University of Oxford, Oxford OX1 3RE, United Kingdom
    Proc Natl Acad Sci U S A 108:10585-90. 2011

Collaborators

Detail Information

Publications24

  1. doi Dose-dependent Nodal/Smad signals pattern the early mouse embryo
    Elizabeth J Robertson
    Sir William Dunn School of Pathology, University of Oxford, South Parks Road, Oxford OX1 3RE, UK Electronic address
    Semin Cell Dev Biol 32:73-9. 2014
    ....
  2. ncbi Blimp1 regulates development of the posterior forelimb, caudal pharyngeal arches, heart and sensory vibrissae in mice
    Elizabeth J Robertson
    Sir William Dunn School of Pathology, University of Oxford, South Parks Road, Oxford OX1 3RE, UK
    Development 134:4335-45. 2007
    ..Collectively, the present experiments demonstrate that Blimp1 requirements in diverse cell types are exquisitely dose dependent...
  3. doi Ventral closure, headfold fusion and definitive endoderm migration defects in mouse embryos lacking the fibronectin leucine-rich transmembrane protein FLRT3
    Silvia Maretto
    Sir William Dunn School of Pathology, University of Oxford, South Parks Road, Oxford, OX1 3RE, UK
    Dev Biol 318:184-93. 2008
    ..Surprisingly, the mutation has no effect on FGF signalling. Collectively these experiments demonstrate that FLRT3 plays a key role in controlling cell adhesion and tissue morphogenesis in the developing mouse embryo...
  4. pmc Lhx1 functions together with Otx2, Foxa2, and Ldb1 to govern anterior mesendoderm, node, and midline development
    Ita Costello
    The Sir William Dunn School of Pathology, University of Oxford, Oxford OX1 3RE, United Kingdom
    Genes Dev 29:2108-22. 2015
    ..These partnerships cooperatively regulate development of the anterior mesendoderm, node, and midline cell populations responsible for establishment of the left-right body axis and head formation. ..
  5. pmc The T-box transcription factor Eomesodermin acts upstream of Mesp1 to specify cardiac mesoderm during mouse gastrulation
    Ita Costello
    Sir William Dunn School of Pathology, University of Oxford, South Parks Road, Oxford OX1 3RE, UK
    Nat Cell Biol 13:1084-91. 2011
    ..Collectively, our experiments demonstrate that Eomes governs discrete context-dependent transcriptional programmes that sequentially specify cardiac and definitive endoderm progenitors during gastrulation...
  6. pmc Blimp-1/Prdm1 alternative promoter usage during mouse development and plasma cell differentiation
    Marc A J Morgan
    University of Oxford, Sir William Dunn School of Pathology, South Parks Road, Oxford OX1 3RE, United Kingdom
    Mol Cell Biol 29:5813-27. 2009
    ..Collectively, these experiments provide insight into the organization of the Prdm1 gene and demonstrate that NF-kappaB is a key mediator of Prdm1 expression...
  7. doi Pivotal roles for eomesodermin during axis formation, epithelium-to-mesenchyme transition and endoderm specification in the mouse
    Sebastian J Arnold
    Sir William Dunn School of Pathology, University of Oxford, South Parks Road, Oxford OX1 3RE, UK
    Development 135:501-11. 2008
    ..Collectively, our experiments establish that Eomes is a key regulator of anteroposterior axis formation, EMT and definitive endoderm specification in the mouse...
  8. pmc Alternative splicing regulates Prdm1/Blimp-1 DNA binding activities and corepressor interactions
    Marc A J Morgan
    Sir William Dunn School of Pathology, University of Oxford, Oxford, United Kingdom
    Mol Cell Biol 32:3403-13. 2012
    ..We propose that developmentally regulated alternative splicing is influenced by chromatin structure at the locus and fine-tunes Blimp-1's functional capabilities...
  9. pmc Blimp1/Prdm1 governs terminal differentiation of endovascular trophoblast giant cells and defines multipotent progenitors in the developing placenta
    Arne Mould
    Sir William Dunn School of Pathology, University of Oxford, Oxford, United Kingdom
    Genes Dev 26:2063-74. 2012
    ..In sum, the transcriptional repressor Blimp1/Prdm1 is required for terminal differentiation of SpA-TGCs and defines a lineage-restricted progenitor cell population contributing to placental growth and morphogenesis...
  10. pmc The transcriptional repressor Blimp1/Prdm1 regulates postnatal reprogramming of intestinal enterocytes
    James Harper
    Sir William Dunn School of Pathology, University of Oxford, Oxford OX1 3RE, United Kingdom
    Proc Natl Acad Sci U S A 108:10585-90. 2011
    ..In contrast, those required for processing maternal milk were markedly reduced. Thus, we conclude Blimp1 governs the developmental switch responsible for postnatal intestinal maturation...
  11. pmc The PR/SET domain zinc finger protein Prdm4 regulates gene expression in embryonic stem cells but plays a nonessential role in the developing mouse embryo
    Debora Bogani
    Sir William Dunn School of Pathology, University of Oxford, Oxford, United Kingdom
    Mol Cell Biol 33:3936-50. 2013
    ..Collectively, these results strongly suggest that Prdm4 functions redundantly with other transcriptional partners to cooperatively regulate gene expression in the embryo and adult animal. ..
  12. ncbi Dose-dependent Smad1, Smad5 and Smad8 signaling in the early mouse embryo
    Sebastian J Arnold
    Wellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, Oxford OX3 7BN, UK
    Dev Biol 296:104-18. 2006
    ..These experiments demonstrate for the first time that Smad1 and Smad5 function cooperatively to govern BMP target gene expression in the early mammalian embryo...
  13. pmc Smad4-dependent pathways control basement membrane deposition and endodermal cell migration at early stages of mouse development
    Ita Costello
    Sir William Dunn School of Pathology, University of Oxford, Oxford, UK
    BMC Dev Biol 9:54. 2009
    ....
  14. doi Making a commitment: cell lineage allocation and axis patterning in the early mouse embryo
    Sebastian J Arnold
    Sir William Dunn School of Pathology, University of Oxford, South Parks Road, Oxford, OX1 3RE, UK
    Nat Rev Mol Cell Biol 10:91-103. 2009
    ..Relevant studies in lower vertebrates indicate the conservation and divergence of regulatory mechanisms for cell lineage allocation and axis patterning...
  15. pmc Blimp1/Prdm1 Functions in Opposition to Irf1 to Maintain Neonatal Tolerance during Postnatal Intestinal Maturation
    Arne W Mould
    Sir William Dunn School of Pathology, University of Oxford, Oxford, United Kingdom
    PLoS Genet 11:e1005375. 2015
    ....
  16. pmc Cortical and Clonal Contribution of Tbr2 Expressing Progenitors in the Developing Mouse Brain
    Navneet A Vasistha
    Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, UK
    Cereb Cortex 25:3290-302. 2015
    ..Our study also describes extracortical contributions from Tbr2+ progenitors to the lateral olfactory tract and ventromedial hypothalamic nucleus. ..
  17. pmc Mice develop normally in the absence of Smad4 nucleocytoplasmic shuttling
    Christine A Biondi
    The Wellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, Oxford OX3 7BN, UK
    Biochem J 404:235-45. 2007
    ..The present study clearly demonstrates that Smad4 nucleocytoplasmic shuttling is not required for embryonic development or tissue homoeostasis in normal, healthy adult mice...
  18. doi An expanding job description for Blimp-1/PRDM1
    Elizabeth K Bikoff
    Sir William Dunn School of Pathology, University of Oxford, South Parks Road, Oxford OX1 3RE, UK
    Curr Opin Genet Dev 19:379-85. 2009
    ..Our current understanding of how this single unique species within the family of structurally similar PRDM proteins regulates gene expression patterns and governs developmental programmes in different cell lineages is discussed...
  19. pmc Single-cell RNA-seq reveals cell type-specific transcriptional signatures at the maternal-foetal interface during pregnancy
    Andrew C Nelson
    Sir William Dunn School of Pathology, University of Oxford, South Parks Road, Oxford OX1 3RE, UK
    Nat Commun 7:11414. 2016
    ....
  20. pmc The nonconventional MHC class II molecule DM governs diabetes susceptibility in NOD mice
    Marc A J Morgan
    Sir William Dunn School of Pathology, University of Oxford, Oxford, United Kingdom
    PLoS ONE 8:e56738. 2013
    ..Overall, this striking phenotype establishes that DM-mediated peptide selection plays an essential role in the development of autoimmune diabetes in NOD mice...
  21. ncbi BMP4 substitutes for loss of BMP7 during kidney development
    Leif Oxburgh
    Wellcome Trust Center for Human Genetics, University of Oxford, Roosevelt Drive, Oxford, UK
    Dev Biol 286:637-46. 2005
    ..Thus, we conclude that partially overlapping expression patterns of BMPs serve to modulate strength of BMP signaling rather than create discrete fields of ligands with intrinsically different signaling properties...
  22. pmc The T-box transcription factor Eomes/Tbr2 regulates neurogenesis in the cortical subventricular zone
    Sebastian J Arnold
    Sir William Dunn School of Pathology, University of Oxford, Oxford OX1 3RE, United Kingdom
    Genes Dev 22:2479-84. 2008
    ..Neurogenesis in the adult dentate gyrus but not the subependymal zone is abolished. These studies establish Tbr2 as a key regulator of neurogenesis in the SVZ...
  23. ncbi Making heads and tails of the early mouse embryo
    Elizabeth J Robertson
    Wellcome Trust Centre for Human Genetics, Division of Medical Sciences, University of Oxford, Oxford, UK
    Harvey Lect 101:59-73. 2005
  24. pmc The transcriptional repressor Blimp1 is expressed in rare luminal progenitors and is essential for mammary gland development
    Mohammed I Ahmed
    Sir William Dunn School of Pathology, University of Oxford, Oxford OX1 3RE, UK
    Development 143:1663-73. 2016
    ..Collectively, these results demonstrate that Blimp1 is required to maintain a highly proliferative luminal subset necessary for mammary gland development and homeostasis. ..