William D Richardson

Summary

Affiliation: University College London
Country: UK

Publications

  1. pmc New Olig1 null mice confirm a non-essential role for Olig1 in oligodendrocyte development
    Joana Paes de Faria
    Wolfson Institute for Biomedical Research and Research Department of Cell and Developmental Biology, University College London, Gower Street, London WC1E 6BT, UK
    BMC Neurosci 15:12. 2014
  2. ncbi request reprint Oligodendrocyte wars
    William D Richardson
    Wolfson Institute for Biomedical Research and Department of Biology, University College London, Gower Street, London WC1E 6BT, UK
    Nat Rev Neurosci 7:11-8. 2006
  3. ncbi request reprint Oligodendrocyte lineage and the motor neuron connection
    W D Richardson
    MRC Laboratory for Molecular Cell Biology and Department of Biology, University College London, London, United Kingdom
    Glia 29:136-42. 2000
  4. pmc NG2-glia as multipotent neural stem cells: fact or fantasy?
    William D Richardson
    Wolfson Institute for Biomedical Research and Research Department of Cell and Developmental Biology, University College London UCL, UK
    Neuron 70:661-73. 2011
  5. doi request reprint An Fgfr3-iCreER(T2) transgenic mouse line for studies of neural stem cells and astrocytes
    Kaylene M Young
    The Wolfson Institute for Biomedical Research, University College London, London WC1E 6BT, United Kingdom
    Glia 58:943-53. 2010
  6. pmc Properties and fate of oligodendrocyte progenitor cells in the corpus callosum, motor cortex, and piriform cortex of the mouse
    Laura E Clarke
    Department of Neuroscience, Physiology, and Pharmacology, University College London, London, WC1E 6BT, United Kingdom
    J Neurosci 32:8173-85. 2012
  7. ncbi request reprint Olig1 and Sox10 interact synergistically to drive myelin basic protein transcription in oligodendrocytes
    HuiLiang Li
    Wolfson Institute for Biomedical Research and Department of Biology, University College London, London WC1E 6BT, United Kingdom
    J Neurosci 27:14375-82. 2007
  8. doi request reprint Cell cycle dynamics of NG2 cells in the postnatal and ageing brain
    Konstantina Psachoulia
    Wolfson Institute for Biomedical Research and Research, Department of Cell and Developmental Biology, University College London, London WC1E 6BT, UK
    Neuron Glia Biol 5:57-67. 2009
  9. pmc Phosphorylation regulates OLIG2 cofactor choice and the motor neuron-oligodendrocyte fate switch
    HuiLiang Li
    Wolfson Institute for Biomedical Research, University College London, London, UK
    Neuron 69:918-29. 2011
  10. pmc Oligodendrocyte dynamics in the healthy adult CNS: evidence for myelin remodeling
    Kaylene M Young
    Wolfson Institute for Biomedical Research and Department of Cell and Developmental Biology, University College London, London WC1E 6BT, UK
    Neuron 77:873-85. 2013

Collaborators

Detail Information

Publications53

  1. pmc New Olig1 null mice confirm a non-essential role for Olig1 in oligodendrocyte development
    Joana Paes de Faria
    Wolfson Institute for Biomedical Research and Research Department of Cell and Developmental Biology, University College London, Gower Street, London WC1E 6BT, UK
    BMC Neurosci 15:12. 2014
    ..However, this was not tested, so the importance of Olig1 for oligodendrocyte development has remained unclear...
  2. ncbi request reprint Oligodendrocyte wars
    William D Richardson
    Wolfson Institute for Biomedical Research and Department of Biology, University College London, Gower Street, London WC1E 6BT, UK
    Nat Rev Neurosci 7:11-8. 2006
    ..How do the different populations compete and what is the outcome of the competition? Do different embryonic origins signify different functional subgroups of oligodendrocyte?..
  3. ncbi request reprint Oligodendrocyte lineage and the motor neuron connection
    W D Richardson
    MRC Laboratory for Molecular Cell Biology and Department of Biology, University College London, London, United Kingdom
    Glia 29:136-42. 2000
    ..We decide in favour of a single embryonic lineage with regional variations along the anterior-posterior neuraxis...
  4. pmc NG2-glia as multipotent neural stem cells: fact or fantasy?
    William D Richardson
    Wolfson Institute for Biomedical Research and Research Department of Cell and Developmental Biology, University College London UCL, UK
    Neuron 70:661-73. 2011
    ..We review these developments, highlighting areas of current interest, contention, and speculation...
  5. doi request reprint An Fgfr3-iCreER(T2) transgenic mouse line for studies of neural stem cells and astrocytes
    Kaylene M Young
    The Wolfson Institute for Biomedical Research, University College London, London WC1E 6BT, United Kingdom
    Glia 58:943-53. 2010
    ..It therefore seems likely that adult-born interneurons integrate into existing circuitry and perform long-term functions in the adult OB...
  6. pmc Properties and fate of oligodendrocyte progenitor cells in the corpus callosum, motor cortex, and piriform cortex of the mouse
    Laura E Clarke
    Department of Neuroscience, Physiology, and Pharmacology, University College London, London, WC1E 6BT, United Kingdom
    J Neurosci 32:8173-85. 2012
    ..These OPCs generated OLs but did not generate neurons in the aPC or elsewhere at any time that we examined...
  7. ncbi request reprint Olig1 and Sox10 interact synergistically to drive myelin basic protein transcription in oligodendrocytes
    HuiLiang Li
    Wolfson Institute for Biomedical Research and Department of Biology, University College London, London WC1E 6BT, United Kingdom
    J Neurosci 27:14375-82. 2007
    ..In contrast, Olig2 does not bind to Sox10 in zebrafish, although both OLIG1 and OLIG2 bind SOX10 in mouse...
  8. doi request reprint Cell cycle dynamics of NG2 cells in the postnatal and ageing brain
    Konstantina Psachoulia
    Wolfson Institute for Biomedical Research and Research, Department of Cell and Developmental Biology, University College London, London WC1E 6BT, UK
    Neuron Glia Biol 5:57-67. 2009
    ..We also report that new oligodendrocytes continue to be formed at a slow rate from NG2 cells even after P240 (8 months of age)...
  9. pmc Phosphorylation regulates OLIG2 cofactor choice and the motor neuron-oligodendrocyte fate switch
    HuiLiang Li
    Wolfson Institute for Biomedical Research, University College London, London, UK
    Neuron 69:918-29. 2011
    ..Wild-type OLIG2 forms stable homodimers, whereas mutant (unphosphorylated) OLIG2(S147A) prefers to form heterodimers with Neurogenin 2 or other bHLH partners, suggesting a molecular basis for the switch...
  10. pmc Oligodendrocyte dynamics in the healthy adult CNS: evidence for myelin remodeling
    Kaylene M Young
    Wolfson Institute for Biomedical Research and Department of Cell and Developmental Biology, University College London, London WC1E 6BT, UK
    Neuron 77:873-85. 2013
    ..The latter would predict that average internode length should decrease with age. Consistent with that, we found that adult-born OLs elaborated much shorter but many more internodes than OLs generated during early postnatal life...
  11. pmc PDGFRA/NG2 glia generate myelinating oligodendrocytes and piriform projection neurons in adult mice
    Leanne E Rivers
    Wolfson Institute for Biomedical Research, University College London, Gower Street, London WC1E 6BT, UK
    Nat Neurosci 11:1392-401. 2008
    ..We found no evidence for astrocyte production in gray or white matter. However, small numbers of projection neurons were generated in the forebrain, especially in the piriform cortex, which is the main target of the olfactory bulb...
  12. ncbi request reprint Competing waves of oligodendrocytes in the forebrain and postnatal elimination of an embryonic lineage
    Nicoletta Kessaris
    Wolfson Institute for Biomedical Research and Department of Biology, University College London, Gower Street, London WC1E 6BT, UK
    Nat Neurosci 9:173-9. 2006
    ..Notably, the embryonic MGE- and AEP-derived population is eliminated during postnatal life, raising questions about the nature and purpose of the competition...
  13. pmc NG2 glia generate new oligodendrocytes but few astrocytes in a murine experimental autoimmune encephalomyelitis model of demyelinating disease
    Richa B Tripathi
    Wolfson Institute for Biomedical Research and Research Department of Cell and Developmental Biology, University College London, London WC1E 6BT, UK
    J Neurosci 30:16383-90. 2010
    ..PDGFRA/NG2 cells generated very few GFAP(+)-reactive astrocytes (1-2% of all YFP(+) cells) or NeuN(+) neurons (<0.02%). Thus, PDGFRA/NG2 cells act predominantly as a reservoir of new oligodendrocytes in the demyelinated spinal cord...
  14. ncbi request reprint A subset of oligodendrocytes generated from radial glia in the dorsal spinal cord
    Matthew Fogarty
    The Wolfson Institute for Biomedical Research and Department of Biology, University College London UCL, London, UK
    Development 132:1951-9. 2005
    ..Dbx-expressing precursors also generate astrocytes and interneurons, but do not contribute to the ependymal layer of the postnatal spinal cord...
  15. pmc Conditional deletion of neurogenin-3 using Nkx2.1iCre results in a mouse model for the central control of feeding, activity and obesity
    Neal Anthwal
    Division of Developmental Neurobiology, MRC National Institute for Medical Research, London, NW7 1AA, UK
    Dis Model Mech 6:1133-45. 2013
    ....
  16. ncbi request reprint Subventricular zone stem cells are heterogeneous with respect to their embryonic origins and neurogenic fates in the adult olfactory bulb
    Kaylene M Young
    Wolfson Institute for Biomedical Research and Department of Biology, University College London, London WC1E 6BT, United Kingdom
    J Neurosci 27:8286-96. 2007
    ..This could have important implications for the design of endogenous stem cell-based therapies in the future...
  17. ncbi request reprint Stabilization of the retinal vascular network by reciprocal feedback between blood vessels and astrocytes
    Heloise West
    The Wolfson Institute for Biomedical Research, University College London, Gower Street, London WC1E 6BT, UK
    Development 132:1855-62. 2005
    ....
  18. pmc Transcription factor positive regulatory domain 4 (PRDM4) recruits protein arginine methyltransferase 5 (PRMT5) to mediate histone arginine methylation and control neural stem cell proliferation and differentiation
    Alexandra Chittka
    Wolfson Institute for Biomedical Research and Research Department of Cell and Developmental Biology, University College London, London, WC1E 6BT, United Kingdom
    J Biol Chem 287:42995-3006. 2012
    ..Our findings provide evidence that histone arginine methylation regulates NSC differentiation...
  19. pmc Dorsally and ventrally derived oligodendrocytes have similar electrical properties but myelinate preferred tracts
    Richa B Tripathi
    Wolfson Institute for Biomedical Research, Research Department of Cell and Developmental Biology, University College London, London WC1E 6BT, United Kingdom
    J Neurosci 31:6809-19. 2011
    ..Thus, dOLPs are electrically similar to vOLPs but appear to outcompete them for dorsal axons...
  20. ncbi request reprint A screen for mutations in zebrafish that affect myelin gene expression in Schwann cells and oligodendrocytes
    Natalia Kazakova
    Department of Anatomy and Developmental Biology, University College London, Gower Street, London WC1E 6BT, UK
    Dev Biol 297:1-13. 2006
    ..Timed application of the RA synthesis inhibitor DEAB to wild type embryos showed that RA signalling is required at least 48 h before the onset of myelin protein synthesis in both CNS and PNS...
  21. pmc Neural crest origins of the neck and shoulder
    Toshiyuki Matsuoka
    Wolfson Institute for Biomedical Research, University College London, Gower Street, London WC1E 6BT, UK
    Nature 436:347-55. 2005
    ..This has allowed us to trace the whereabouts of the cleithrum, the major shoulder bone of extinct land vertebrate ancestors, which seems to survive as the scapular spine in living mammals...
  22. pmc Specification of CNS glia from neural stem cells in the embryonic neuroepithelium
    Nicoletta Kessaris
    Wolfson Institute for Biomedical Research and Department of Biology, University College London, Gower Street, London WC1E 6BT, UK
    Philos Trans R Soc Lond B Biol Sci 363:71-85. 2008
    ..This review focuses on the different extracellular signals and intracellular responses that influence glial generation and the choice between oligodendrocyte and astrocyte fates...
  23. ncbi request reprint A dynamic switch in the replication timing of key regulator genes in embryonic stem cells upon neural induction
    Pascale Perry
    Lymphocyte Development Group, MRC Clinical Sciences Centre, Imperial College School of Medicine, Hammersmith Hospital, London, UK
    Cell Cycle 3:1645-50. 2004
    ..These results show that loss of pluripotency (and lineage choice) is associated with extensive and predictable changes in the replication timing of key regulator genes...
  24. doi request reprint Motor skill learning requires active central myelination
    Ian A McKenzie
    The Wolfson Institute for Biomedical Research, University College London, Gower Street, London WC1E 6BT, UK
    Science 346:318-22. 2014
    ..This prevented the mice from mastering the complex wheel. Thus, generation of new OLs and myelin is important for learning motor skills. ..
  25. doi request reprint Expression of Tbx2 and Tbx3 in the developing hypothalamic-pituitary axis
    Marco Pontecorvi
    Wolfson Institute for Biomedical Research and Department of Biology, University College London, Gower Street, London WC1E 6BT, UK
    Gene Expr Patterns 8:411-7. 2008
    ....
  26. ncbi request reprint Platelet-derived growth factor regulates oligodendrocyte progenitor numbers in adult CNS and their response following CNS demyelination
    Rachel H Woodruff
    Wolfson Institute for Biomedical Research and Department of Biology, University College London, London WC1E 6BT, UK
    Mol Cell Neurosci 25:252-62. 2004
    ..Nevertheless, our experiments show that it is possible to increase OPC population density in demyelinated areas by artificially increasing the supply of PDGF...
  27. ncbi request reprint Oligodendrocyte population dynamics and the role of PDGF in vivo
    A R Calver
    MRC Laboratory for Molecular Cell Biology and Department of Biology, University College London, United Kingdom
    Neuron 20:869-82. 1998
    ..Therefore, cell survival controls override proliferation controls for determining the final number and distribution of mature oligodendrocytes...
  28. pmc Rapid production of new oligodendrocytes is required in the earliest stages of motor-skill learning
    Lin Xiao
    Wolfson Institute for Biomedical Research, University College London, London, UK
    Nat Neurosci 19:1210-7. 2016
    ..We concluded that new oligodendrocytes contribute to both early and late stages of motor skill learning. ..
  29. pmc Endogenous GABA controls oligodendrocyte lineage cell number, myelination, and CNS internode length
    Nicola B Hamilton
    Department of Neuroscience, Pharmacology and Physiology, University College London, London, WC1E 6BT, United Kingdom
    Glia . 2016
    ..These results imply that, during development, GABA can act as a local environmental cue to control myelination and thus influence the conduction velocity of action potentials within the CNS. GLIA 2016...
  30. ncbi request reprint A regulatory network involving Foxn4, Mash1 and delta-like 4/Notch1 generates V2a and V2b spinal interneurons from a common progenitor pool
    Marta G del Barrio
    Wolfson Institute for Biomedical Research and Department of Biology, University College London, Gower Street, London WC1E 6BT, UK
    Development 134:3427-36. 2007
    ....
  31. ncbi request reprint Cooperation between sonic hedgehog and fibroblast growth factor/MAPK signalling pathways in neocortical precursors
    Nicoletta Kessaris
    Wolfson Institute for Biomedical Research and Department of Biology, University College London, Gower Street, London WC1E 6BT, UK
    Development 131:1289-98. 2004
    ..Stimulating the MAPK pathway with a retrovirus encoding constitutively active RAS shows that the requirement for MAPK is cell-autonomous, i.e. MAPK is needed together with SHH signalling in the cells that become OLPs...
  32. ncbi request reprint Receptor tyrosine phosphatase zeta/beta in astrocyte progenitors in the developing chick spinal cord
    Anna Ivanova
    Wolfson Institute for Biomedical Research, Department of Biology, University College London, Gower Street, London WC1E 6BT, UK
    Gene Expr Patterns 4:161-6. 2004
    ....
  33. ncbi request reprint Fgfr3 expression by astrocytes and their precursors: evidence that astrocytes and oligodendrocytes originate in distinct neuroepithelial domains
    Nigel P Pringle
    Wolfson Institute for Biomedical Research and Department of Biology, University College London, Gower Street, London WC1E 6BT, UK
    Development 130:93-102. 2003
    ..In addition, we found that mice with a targeted deletion in the Fgfr3 locus strongly upregulate Gfap in grey matter (protoplasmic) astrocytes, implying that signalling through Fgfr3 normally represses Gfap expression in vivo...
  34. pmc Regulation of oligodendrocyte development and myelination by glucose and lactate
    Johanne E Rinholm
    Department of Neuroscience, Physiology, and Pharmacology, University College London, London WC1E 6BT, UK
    J Neurosci 31:538-48. 2011
    ....
  35. ncbi request reprint A human YAC transgene rescues craniofacial and neural tube development in PDGFRalpha knockout mice and uncovers a role for PDGFRalpha in prenatal lung growth
    T Sun
    Wolfson Institute for Biomedical Research and Department of Biology, The Cruciform Building, University College London, Gower Street, London WC1E 6BT, UK
    Development 127:4519-29. 2000
    ..In addition, we found that the YAC transgene did not prolong survival of Patch mutant mice, indicating that genetic defects outside the PDGFRalpha locus contribute to the early embryonic lethality of Patch mice...
  36. ncbi request reprint Defective oligodendrocyte development and severe hypomyelination in PDGF-A knockout mice
    M Fruttiger
    MRC Laboratory for Molecular Cell Biology and Department of Biology, University College London, Gower Street, London WC1E 6BT, UK
    Development 126:457-67. 1999
    ..We also provide evidence that myelin proteolipid protein (PLP/DM-20)-positive cells in the late embryonic brainstem are non-dividing cells, presumably immature oligodendrocytes, and not proliferating precursors...
  37. ncbi request reprint Platelet-derived growth factor is constitutively secreted from neuronal cell bodies but not from axons
    M Fruttiger
    Wolfson Institute for Biomedical Research and Department of Biology, University College London, UK
    Curr Biol 10:1283-6. 2000
    ..We conclude that PDGF is constitutively secreted from neuronal cell bodies in vivo, but not from axons in white-matter tracts...
  38. doi request reprint The evolution of Olig genes and their roles in myelination
    HuiLiang Li
    Wolfson Institute for Biomedical Research and Research, Department of Cell and Developmental Biology, University College London, UK
    Neuron Glia Biol 4:129-35. 2008
    ....
  39. pmc Two-tier transcriptional control of oligodendrocyte differentiation
    HuiLiang Li
    Wolfson Institute for Biomedical Research, and Research Department of Cell and Developmental Biology, University College London, Gower Street, London WC1E 6BT, United Kingdom
    Curr Opin Neurobiol 19:479-85. 2009
    ..This 'two-pronged' approach creates a fail-safe system of genetic control to ensure orderly and unambiguous expression of the myelination program during development and during repair of demyelinated lesions...
  40. ncbi request reprint Roles for p53 and p73 during oligodendrocyte development
    Nathalie Billon
    MRC Laboratory for Molecular Cell Biology and Cell Biology Unit, University College London, London WC1E 6BT, UK
    Development 131:1211-20. 2004
    ..This is the first evidence for a role of p73 in the differentiation of a normal mammalian cell...
  41. ncbi request reprint Hedgehog-dependent oligodendrocyte lineage specification in the telencephalon
    N Tekki-Kessaris
    Wolfson Institute for Biomedical Research, The Cruciform Building, University College London, Gower Street, London WC1E 6AE, UK
    Development 128:2545-54. 2001
    ..Overall, the data are consistent with the idea that OLPs in the telencephalon, possibly even some of those in the cortex, develop under the influence of SHH in the ventral forebrain...
  42. ncbi request reprint Pax6 influences the time and site of origin of glial precursors in the ventral neural tube
    T Sun
    Department of Biology, University College London, Gower Street, London, WC1E 6BT
    Mol Cell Neurosci 12:228-39. 1998
    ..OLs developed normally in explants of Isl1(-/-) spinal cords, which lack MNs, arguing against feedback control and suggesting that the neuron-glia switch is an intrinsic developmental program in a specific subset of neural precursors...
  43. ncbi request reprint Determination of neuroepithelial cell fate: induction of the oligodendrocyte lineage by ventral midline cells and sonic hedgehog
    N P Pringle
    MRC Laboratory for Molecular Cell Biology and Department of Biology, University College London, Gower Street, London, WC1E 6BT, United Kingdom
    Dev Biol 177:30-42. 1996
    ....
  44. ncbi request reprint Control of progenitor cell number by mitogen supply and demand
    P van Heyningen
    Wolfson Institute for Biomedical Research and Department of Biology, University College London, Gower Street, WC1E 6AE, London, UK
    Curr Biol 11:232-41. 2001
    ..The cells might simply consume the available PDGF or they might secrete autocrine inhibitors, or both...
  45. ncbi request reprint Ventral neurogenesis and the neuron-glial switch
    N Kessaris
    Wolfson Institute for Biomedical Research and Department of Biology, University College London, Gower Street, WC1E 6AE, London, United Kingdom
    Neuron 31:677-80. 2001
    ..We review these studies and discuss the nature of the ventral neuron-oligodendrocyte switch...
  46. doi request reprint Evolution of the CNS myelin gene regulatory program
    HuiLiang Li
    Wolfson Institute for Biomedical Research, University College London, Gower Street, London WC1E 6BT, UK Electronic address
    Brain Res 1641:111-21. 2016
    ..This article is part of a Special Issue entitled SI: Myelin Evolution. ..
  47. ncbi request reprint Oligodendrocyte development in the spinal cord and telencephalon: common themes and new perspectives
    R H Woodruff
    Wolfson Institute for Biomedical Research, The Cruciform Building, University College London, Gower Street, WC1E 6AU, London, UK
    Int J Dev Neurosci 19:379-85. 2001
    ....
  48. ncbi request reprint The generation of adipocytes by the neural crest
    Nathalie Billon
    Institut de Recherche, Signalisation, Biologie du Developpement et Cancer, CNRS UMR 6543, Centre de Biochimie, Faculte des Sciences, université Nice Sophia Antipolis, Nice, France
    Development 134:2283-92. 2007
    ..Finally, we mapped NC derivatives in vivo using Cre-mediated recombination in transgenic mice and demonstrated that a subset of adipocytes originates from the NC during normal development...
  49. ncbi request reprint An 'oligarchy' rules neural development
    David H Rowitch
    Dana Farber Cancer Institute and Harvard Medical School, 44 Binney Street, Boston, MA 02115, USA
    Trends Neurosci 25:417-22. 2002
    ..These findings alter our views of how the oligodendrocyte lineage is generated and raise further questions about the underlying developmental relationships between neurons and glia...
  50. ncbi request reprint SoxD proteins influence multiple stages of oligodendrocyte development and modulate SoxE protein function
    C Claus Stolt
    Institut fur Biochemie, Emil Fischer Zentrum, Universitat Erlangen, D 91054 Erlangen, Germany
    Dev Cell 11:697-709. 2006
    ..Our studies reveal a complex regulatory network between different groups of Sox proteins that is essential for proper progression of oligodendrocyte development...
  51. ncbi request reprint The marginal zone/layer I as a novel niche for neurogenesis and gliogenesis in developing cerebral cortex
    Marcos R Costa
    National Research Center for Environment and Health, Institute for Stem Cell Research, 85764 Neuherberg Munich, Germany
    J Neurosci 27:11376-88. 2007
    ....
  52. ncbi request reprint Neural crest origin of perivascular mesenchyme in the adult thymus
    Susanna M Müller
    Institute for Immunology, University of Ulm, Ulm, Germany
    J Immunol 180:5344-51. 2008
    ....
  53. pmc Early forebrain wiring: genetic dissection using conditional Celsr3 mutant mice
    Libing Zhou
    Developmental Neurobiology, Universite Catholique de Louvain, 1200 Bruxelles, Belgique
    Science 320:946-9. 2008
    ..These observations provide in vivo evidence that Celsr3-mediated interactions between axons and guidepost cells govern axonal tract formation in mammals...