Genomes and Genes
Affiliation: University of Dundee
- Activation of the thiazide-sensitive Na+-Cl- cotransporter by the WNK-regulated kinases SPAK and OSR1Ciaran Richardson
MRC Protein Phosphorylation Unit, MSI WTB complex, University of Dundee, Dow Street, Dundee, DD1 5EH, UK
J Cell Sci 121:675-84. 2008..They also suggest a mechanism by which increased WNK1 overexpression could lead to hypertension and that inhibitors of SPAK/OSR1 might be of use in reducing blood pressure by suppressing phosphorylation and hence activity of NCC...
- The regulation of salt transport and blood pressure by the WNK-SPAK/OSR1 signalling pathwayCiaran Richardson
MRC Protein Phosphorylation Unit, Sir James Black Centre, College of Life Sciences, University of Dundee, Dow Street, Dundee DD1 5EH, UK
J Cell Sci 121:3293-304. 2008..We also discuss unresolved and controversial questions in this field of research...
- Regulation of the NKCC2 ion cotransporter by SPAK-OSR1-dependent and -independent pathwaysCiaran Richardson
MRC Protein Phosphorylation Unit, College of Life Sciences, University of Dundee, Dow Street, Dundee DD1 5EH, UK
J Cell Sci 124:789-800. 2011....
- Role of the WNK-activated SPAK kinase in regulating blood pressureFatema H Rafiqi
University of Dundee, Scotland, UK
EMBO Mol Med 2:63-75. 2010..See accompanying Closeup by Maria Castañeda-Bueno and Gerald Gamba (DOI 10.1002/emmm.200900059)...