Robert C Read

Summary

Affiliation: University of Sheffield
Country: UK

Publications

  1. pmc Adjunctive rifampicin to reduce early mortality from Staphylococcus aureus bacteraemia (ARREST): study protocol for a randomised controlled trial
    Guy Thwaites
    Department of Infectious Diseases Centre for Clinical Infection and Diagnostics Research, Kings College London Guy s and St, Thomas Hospitals NHS Foundation Trust, London, England, United Kingdom
    Trials 13:241. 2012
  2. ncbi request reprint Toll receptors and sepsis
    R C Read
    Division of Genomic Medicine, University of Sheffield School of Medicine and Biomedical Sciences, Sheffield, United Kingdom
    Curr Opin Crit Care 7:371-5. 2001
  3. ncbi request reprint A functional polymorphism of toll-like receptor 4 is not associated with likelihood or severity of meningococcal disease
    R C Read
    Division of Genomic Medicine, Royal Hallamshire Hospital, University of Sheffield, Sheffield S10 2RX, United Kingdom
    J Infect Dis 184:640-2. 2001
  4. ncbi request reprint Effective nasal influenza vaccine delivery using chitosan
    Robert C Read
    Academic Unit of Infection and Immunity, Division of Genomic Medicine, University of Sheffield Medical School, Beech Hill Road, Sheffield S10 2RX, UK
    Vaccine 23:4367-74. 2005
  5. doi request reprint Professional challenges and opportunities in clinical microbiology and infectious diseases in Europe
    Robert C Read
    Department of Infection and Immunity, School of Medicine, University of Sheffield, Sheffield, UK
    Lancet Infect Dis 11:408-15. 2011
  6. ncbi request reprint Evidence-based medicine: empiric antibiotic therapy in community-acquired pneumonia
    R C Read
    Division of Molecular and Genetic Medicine, University of Sheffield Medical School, UK
    J Infect 39:171-8. 1999
  7. ncbi request reprint Infection in acute exacerbations of chronic bronchitis: a clinical perspective
    R C Read
    University of Sheffield Medical School, Royal Hallamshire Hospital, UK
    Respir Med 93:845-50. 1999
  8. pmc Monocytes regulate the mechanism of T-cell death by inducing Fas-mediated apoptosis during bacterial infection
    Marc Daigneault
    Department of Infection and Immunity, University of Sheffield Medical School, Sheffield, United Kingdom
    PLoS Pathog 8:e1002814. 2012
  9. pmc Cooperative role for tetraspanins in adhesin-mediated attachment of bacterial species to human epithelial cells
    Luke R Green
    Department of Infection and Immunity, University of Sheffield Medical School, Beech Hill Rd, Sheffield S10 2RX, United Kingdom
    Infect Immun 79:2241-9. 2011
  10. ncbi request reprint Proinflammatory activation of Toll-like receptor-2 during exposure of penicillin-resistant Streptococcus pneumoniae to beta-lactam antibiotics
    Lisa J Moore
    Division of Genomic Medicine, University of Sheffield Medical School, Beech Hill Road, Sheffield S10 2RX, UK
    J Antimicrob Chemother 59:35-42. 2007

Detail Information

Publications75

  1. pmc Adjunctive rifampicin to reduce early mortality from Staphylococcus aureus bacteraemia (ARREST): study protocol for a randomised controlled trial
    Guy Thwaites
    Department of Infectious Diseases Centre for Clinical Infection and Diagnostics Research, Kings College London Guy s and St, Thomas Hospitals NHS Foundation Trust, London, England, United Kingdom
    Trials 13:241. 2012
    ..Our aim is to determine whether adjunctive rifampicin reduces all-cause mortality within 14 days and bacteriological failure or death within 12 weeks from randomisation...
  2. ncbi request reprint Toll receptors and sepsis
    R C Read
    Division of Genomic Medicine, University of Sheffield School of Medicine and Biomedical Sciences, Sheffield, United Kingdom
    Curr Opin Crit Care 7:371-5. 2001
    ..Human polymorphisms of Toll-like receptor genes have been discovered and are associated with hyporesponsiveness to bacterial components...
  3. ncbi request reprint A functional polymorphism of toll-like receptor 4 is not associated with likelihood or severity of meningococcal disease
    R C Read
    Division of Genomic Medicine, Royal Hallamshire Hospital, University of Sheffield, Sheffield S10 2RX, United Kingdom
    J Infect Dis 184:640-2. 2001
    ..Therefore, this functional TLR4 polymorphism does not influence susceptibility to or severity of meningococcal disease...
  4. ncbi request reprint Effective nasal influenza vaccine delivery using chitosan
    Robert C Read
    Academic Unit of Infection and Immunity, Division of Genomic Medicine, University of Sheffield Medical School, Beech Hill Road, Sheffield S10 2RX, UK
    Vaccine 23:4367-74. 2005
    ..These data show that nasal immunisation with chitosan plus trivalent inactivated influenza is a potentially effective, easily-administered form of vaccination...
  5. doi request reprint Professional challenges and opportunities in clinical microbiology and infectious diseases in Europe
    Robert C Read
    Department of Infection and Immunity, School of Medicine, University of Sheffield, Sheffield, UK
    Lancet Infect Dis 11:408-15. 2011
    ..The recently formed European Centre for Disease Prevention and Control in Stockholm, Sweden, will increase demands in areas of surveillance of infectious diseases and antimicrobial resistance on both specialties...
  6. ncbi request reprint Evidence-based medicine: empiric antibiotic therapy in community-acquired pneumonia
    R C Read
    Division of Molecular and Genetic Medicine, University of Sheffield Medical School, UK
    J Infect 39:171-8. 1999
    ..A number of studies have shown that it is possible to stratify patients according to severity of illness, to in-patient or out-patient management protocols. These have been validated and refined...
  7. ncbi request reprint Infection in acute exacerbations of chronic bronchitis: a clinical perspective
    R C Read
    University of Sheffield Medical School, Royal Hallamshire Hospital, UK
    Respir Med 93:845-50. 1999
    ..From a clinical perspective, appropriate drugs include those that are stable to beta-lactamases, are bactericidal against causative pathogens, penetrate diseased lung tissue in high concentrations and have a good safety profile...
  8. pmc Monocytes regulate the mechanism of T-cell death by inducing Fas-mediated apoptosis during bacterial infection
    Marc Daigneault
    Department of Infection and Immunity, University of Sheffield Medical School, Sheffield, United Kingdom
    PLoS Pathog 8:e1002814. 2012
    ..These changes were associated with enhanced bacterial clearance in the lung and reduced levels of invasive pneumococcal disease...
  9. pmc Cooperative role for tetraspanins in adhesin-mediated attachment of bacterial species to human epithelial cells
    Luke R Green
    Department of Infection and Immunity, University of Sheffield Medical School, Beech Hill Rd, Sheffield S10 2RX, United Kingdom
    Infect Immun 79:2241-9. 2011
    ..These data suggest that tetraspanins are required for optimal function of epithelial adhesion platforms containing specific receptors for Neisseria meningitidis and potentially for multiple species of bacteria...
  10. ncbi request reprint Proinflammatory activation of Toll-like receptor-2 during exposure of penicillin-resistant Streptococcus pneumoniae to beta-lactam antibiotics
    Lisa J Moore
    Division of Genomic Medicine, University of Sheffield Medical School, Beech Hill Road, Sheffield S10 2RX, UK
    J Antimicrob Chemother 59:35-42. 2007
    ..06 mg/L) and a high-level PRSP clinical isolate (159; MIC 16 mg/L) following exposure to penicillin and cefotaxime...
  11. doi request reprint Severity of meningococcal disease associated with genomic bacterial load
    Tom Darton
    Department of Infection and Immunity, University of Sheffield, Sheffield, United Kingdom
    Clin Infect Dis 48:587-94. 2009
    ..Diagnostic polymerase chain reaction (PCR) detection of Neisseria meningitidis has enabled accurate quantification of the bacterial load in patients with meningococcal disease...
  12. pmc NsrR: a key regulator circumventing Salmonella enterica serovar Typhimurium oxidative and nitrosative stress in vitro and in IFN-gamma-stimulated J774.2 macrophages
    Nicola J Gilberthorpe
    Department of Molecular Biology and Biotechnology, University of Sheffield, Sheffield S10 2TN, UK
    Microbiology 153:1756-71. 2007
    ....
  13. pmc Correlation of group C meningococcal conjugate vaccine response with B- and T-lymphocyte activity
    James B Wing
    Department of Infection and Immunity, University of Sheffield Medical School, Sheffield, United Kingdom
    PLoS ONE 7:e31160. 2012
    ..This suggests that the processes underlying the more rapid loss of antibody levels are independent of defects in either initial T- or B-cell activation...
  14. pmc Bacterial nitric oxide detoxification prevents host cell S-nitrosothiol formation: a novel mechanism of bacterial pathogenesis
    Jay R Laver
    Department of Infection and Immunity, Medical School, The University of Sheffield, Royal Hallamshire Hospital, Beech Hill Rd, Sheffield, South Yorkshire, UK
    FASEB J 24:286-95. 2010
    ..coli. In each case, this effect was shown to be dependent on bacterial NO detoxification genes, which act to prevent SNO formation through the removal of NO. This may represent a novel mechanism of host cell injury by bacteria...
  15. pmc Peroxynitrite toxicity in Escherichia coli K12 elicits expression of oxidative stress responses and protein nitration and nitrosylation
    Samantha McLean
    Departments of Molecular Biology and Biotechnology, University of Sheffield, Firth Court, Western Bank, Sheffield S10 2TN, UK
    J Biol Chem 285:20724-31. 2010
    ..Thus, the cellular responses to peroxynitrite and hydrogen peroxide are distinct...
  16. pmc Functional T-cell deficiency in adolescents who experience serogroup C meningococcal disease despite receiving the meningococcal serogroup C conjugate vaccine
    Rachel A Foster
    Department of Infection and Immunity, University of Sheffield Medical School, Beech Hill Rd, Sheffield S10 2RX, United Kingdom
    Clin Vaccine Immunol 17:1104-10. 2010
    ..0385). There was a relative defect of T-cell responsiveness to T-cell-dependent antigen stimulation in MCC vaccine failures, which was manifested in reduced T-cell help to B cells...
  17. ncbi request reprint The hmp gene encoding the NO-inducible flavohaemoglobin in Escherichia coli confers a protective advantage in resisting killing within macrophages, but not in vitro: links with swarming motility
    Tania M Stevanin
    The University of Sheffield, Division of Genomic Medicine, Beech Hill Road, Sheffield, S10 2RX, UK
    Gene 398:62-8. 2007
    ..The lack of swarming motility of the hmp mutant and its aflagellate state suggest that Hmp synthesis is a metabolic burden in the absence of NO-related stresses...
  18. ncbi request reprint Metabolism of nitric oxide by Neisseria meningitidis modifies release of NO-regulated cytokines and chemokines by human macrophages
    Tania M Stevanin
    Academic Unit of Infection and Immunity, School of Medicine and Biomedical Sciences, University of Sheffield, Royal Hallamshire Hospital, Sheffield, S10 2RX, UK
    Microbes Infect 9:981-7. 2007
    ..Addition of SNAP to cultures infected with wild-type mimicked the effect observed in cultures infected with the norB mutant. In conclusion, NorB-catalysed removal of NO modifies cellular release of NO-regulated cytokines and chemokines...
  19. doi request reprint The tumor necrosis factor polymorphism TNF (-308) is associated with susceptibility to meningococcal sepsis, but not with lethality
    Robert C Read
    Section of Infection, Inflammation and Immunity, University of Sheffield Medical School, Sheffield, United Kingdom
    Crit Care Med 37:1237-43. 2009
    ..Controls were derived from 1280 northern English blood donors...
  20. ncbi request reprint Induction of pro-inflammatory cytokine release by human macrophages during exposure of Streptococcus pneumoniae to penicillin is influenced by minimum inhibitory concentration ratio
    Lisa J Moore
    Division of Genomic Medicine, University of Sheffield School of Medicine and Biomedical Sciences, Beech Hill Road, Sheffield S10 2RX, UK
    Int J Antimicrob Agents 26:188-96. 2005
    ..Bacteria exposed to concentrations of penicillin that cause lysis (MIC) or no lysis with morphological changes (sub-MIC) induce differential patterns of pro-inflammatory cytokine expression by human macrophages...
  21. ncbi request reprint The glycopeptide vancomycin does not enhance toll-like receptor 2 (TLR2) activation by Streptococcus pneumoniae
    Lisa J Moore
    Division of Genomic Medicine, University of Sheffield School of Medicine and Biomedical Sciences, Beech Hill Road, Sheffield S10 2RX, UK
    J Antimicrob Chemother 54:76-8. 2004
    ..The aim of this study was to compare the activation of human TLR2 pathways after exposure of S. pneumoniae to faropenem, cefotaxime and vancomycin...
  22. ncbi request reprint Nitric oxide levels regulate macrophage commitment to apoptosis or necrosis during pneumococcal infection
    Helen M Marriott
    Division of Genomic Medicine, University of Sheffield School of Medicine and Biomedical Sciences, Sheffield, UK
    FASEB J 18:1126-8. 2004
    ..These results illustrate important roles for NO in the integration of host defense and regulation of inflammation in human macrophages...
  23. pmc Proteomic evaluation and validation of cathepsin D regulated proteins in macrophages exposed to Streptococcus pneumoniae
    Martin A Bewley
    Medical School, University of Sheffield, Sheffield, UK
    Mol Cell Proteomics 10:M111.008193. 2011
    ..These findings demonstrate that cathepsin D regulates multiple proteins controlling the mitochondrial pathway of macrophage apoptosis or competing death processes, facilitating intracellular bacterial killing...
  24. doi request reprint Nitrosothiols in bacterial pathogens and pathogenesis
    Jay R Laver
    Department of Infection and Immunity, The University of Sheffield, Sheffield, United Kingdom
    Antioxid Redox Signal 18:309-22. 2013
    ..These processes play well-characterized roles in eukaryotic cells, including a variety of pathologies and in relation to chronic conditions. We know little of the roles of these processes in pathogenic and other bacteria...
  25. ncbi request reprint Genetic polymorphism of the binding domain of surfactant protein-A2 increases susceptibility to meningococcal disease
    Dominic L Jack
    Academic Unit of Infection and Immunity, Division of Genomic Medicine, University of Sheffield, Sheffield, S10 2RX, United Kingdom
    Clin Infect Dis 43:1426-33. 2006
    ..Variation in the genes of the surfactant proteins affects the expression and function of these molecules...
  26. doi request reprint Bacterial genomic detection within cerebrospinal fluid of patients with meningococcal disease is influenced by microbial and host characteristics
    Tom C Darton
    Department of Infection and Immunity, University of Sheffield, Sheffield, UK
    Clin Infect Dis 53:463-7. 2011
    ..Plasma and CSF genomic bacterial loads of non-B N. meningitidis serogroups correlated significantly. Serogroup B-infected patients with genotype TNF2 (-308A) had significantly higher CSF bacterial loads...
  27. pmc A cardinal role for cathepsin d in co-ordinating the host-mediated apoptosis of macrophages and killing of pneumococci
    Martin A Bewley
    Medical School, University of Sheffield, Sheffield, United Kingdom
    PLoS Pathog 7:e1001262. 2011
    ..These findings establish an unexpected role for a cathepsin D-mediated lysosomal pathway of apoptosis in pulmonary host defense and underscore the importance of apoptosis-associated microbial killing to macrophage function...
  28. pmc Inhibition of macrophage apoptosis by Neisseria meningitidis requires nitric oxide detoxification mechanisms
    Anne J Tunbridge
    Division of Genomic Medicine, F Floor, University of Sheffield, Beech Hill Road, Sheffield S10 2RX, United Kingdom
    Infect Immun 74:729-33. 2006
    ..We demonstrate that N. meningitidis prevents macrophage apoptosis via genes encoding nitric oxide detoxification and a porin, PorB...
  29. doi request reprint Age-related loss of CpG methylation in the tumour necrosis factor promoter
    Isobel R Gowers
    Department of Infection and Immunity, Medical School, University of Sheffield, Sheffield S10 2RX, United Kingdom
    Cytokine 56:792-7. 2011
    ..Ageing is also associated with changes in the immune system including higher systemic levels of pro-inflammatory cytokines. Methylation of DNA is an important regulator of gene expression and changes with age...
  30. pmc Dynamic changes in Mcl-1 expression regulate macrophage viability or commitment to apoptosis during bacterial clearance
    Helen M Marriott
    Division of Genomic Medicine, University of Sheffield, Sheffield, United Kingdom
    J Clin Invest 115:359-68. 2005
    ..Mcl-1 transgenic mice clear pneumococci from the lung less efficiently than nontransgenic mice. Dynamic changes in Mcl-1 expression determine macrophage viability as well as antibacterial host defense...
  31. pmc Distinct cell death programs in monocytes regulate innate responses following challenge with common causes of invasive bacterial disease
    Steve J Webster
    Department of Infection and Immunity, Medical School, University of Sheffield, Sheffield, United Kingdom
    J Immunol 185:2968-79. 2010
    ..coli and K. pneumoniae or bacterial stimulation of cell metabolism. In this regard, the fate of monocytes following bacterial challenge more closely resembles neutrophils than macrophages...
  32. doi request reprint Kinetics of immune responses to nasal challenge with meningococcal polysaccharide one year after serogroup-C glycoconjugate vaccination
    James B Wing
    Department of Infection and Immunity, University of Sheffield Medical School, Sheffield, UK
    Clin Infect Dis 52:1317-23. 2011
    ....
  33. doi request reprint B-cell-T-cell activation and interaction in common variable immunodeficiency
    Nima Rezaei
    Department of Infection and Immunity, The University of Sheffield, Sheffield, UK
    Hum Immunol 71:355-62. 2010
    ..In conclusion, this sample of CVID patients exhibits a defect of T-cell "help" to B cells, and/or B-cell response to T-cell help...
  34. pmc Distinct roles for tetraspanins CD9, CD63 and CD81 in the formation of multinucleated giant cells
    Varadarajan Parthasarathy
    Department of Molecular Biology and Biotechnology, University of Sheffield, UK
    Immunology 127:237-48. 2009
    ..Our findings indicate that the tetraspanins CD9, CD63 and CD81 are all involved in MGC formation, but play distinct roles...
  35. pmc Nitric oxide in chemostat-cultured Escherichia coli is sensed by Fnr and other global regulators: unaltered methionine biosynthesis indicates lack of S nitrosation
    Steven T Pullan
    Department of Molecular Biology and Biotechnology, University of Sheffield, Sheffield S10 2TN, UK
    J Bacteriol 189:1845-55. 2007
    ....
  36. pmc Nitric oxide detoxification systems enhance survival of Neisseria meningitidis in human macrophages and in nasopharyngeal mucosa
    Tania M Stevanin
    Infection and Immunity, Division of Genomic Medicine, Sheffield University School of Medicine and Biomedical Science, Beech Hill Road, Sheffield S10 2RX, United Kingdom
    Infect Immun 73:3322-9. 2005
    ..meningitidis. These findings indicate that the meningococcus requires active NO detoxification systems for optimal survival during experimental nasopharyngeal colonization and processing by human phagocytic cells...
  37. pmc Adult survivors of invasive pneumococcal disease exhibit defective B cell function
    Tom C Darton
    Department of Infection and Immunity, University of Sheffield Medical School, Sheffield, South Yorkshire, UK
    Clin Infect Dis 52:1133-6. 2011
    ..The defect is not overcome by CD4(+) T cell assistance and may explain the relatively poor response to pneumococcal vaccination in survivors of invasive pneumococcal disease...
  38. pmc Contact dependent suppression of CD4 T cell activation and proliferation by B cells activated through IgD cross-linking
    Lorena Preciado-Llanes
    Department of Infection and Immunity, School of Medicine and Biomedical Sciences, The University of Sheffield, Sheffield, S102RX, United Kingdom
    Immunology . 2014
    ..This is the first evidence of IgD activated B cells mediating inhibition of activation and proliferation of CD4 T cells in humans. This article is protected by copyright. All rights reserved...
  39. pmc Pneumolysin activates macrophage lysosomal membrane permeabilization and executes apoptosis by distinct mechanisms without membrane pore formation
    Martin A Bewley
    Department of Infection and Immunity, University of Sheffield Medical School, Sheffield, United Kingdom
    MBio 5:e01710-14. 2014
    ..This dual response to pneumolysin is critical for an effective immune response to S. pneumoniae...
  40. ncbi request reprint Genetic variation in pro-inflammatory cytokines and meningococcal sepsis
    Alice Deasy
    Department of Infection and Immunity, Sheffield School of Medicine and Biomedical Science, Royal Hallamshire Hospital, Sheffield, UK
    Curr Opin Infect Dis 23:255-8. 2010
    ....
  41. doi request reprint Challenges for development of meningococcal vaccines in infants and children
    Alice Deasy
    Infection and Immunity Department, University of Sheffield Medical School, Beech Hill Road, Sheffield, S10 2RX, UK
    Expert Rev Vaccines 10:335-43. 2011
    ..It will then go on to consider strategies for optimizing the protection of infants against meningococcal disease...
  42. ncbi request reprint Mannose-binding lectin enhances phagocytosis and killing of Neisseria meningitidis by human macrophages
    Dominic L Jack
    University of Sheffield Medical School, Beech Hill Road, Sheffield, UK, S10 2RX
    J Leukoc Biol 77:328-36. 2005
    ..These results suggest that MBL could modify disease susceptibility by modulating macrophage interactions with mucosal organisms at the site of initial acquisition...
  43. ncbi request reprint A lipopolysaccharide-deficient mutant of Neisseria meningitidis elicits attenuated cytokine release by human macrophages and signals via toll-like receptor (TLR) 2 but not via TLR4/MD2
    A C Pridmore
    Division of Molecular and Genetic Medicine, Royal Hallamshire Hospital, University of Sheffield, Sheffield, United Kingdom
    J Infect Dis 183:89-96. 2001
    ..These findings have implications for future therapeutic strategies against meningococcal disease on the basis of the blockade of TLRs and the modulation of LPS activity...
  44. pmc Inability to sustain intraphagolysosomal killing of Staphylococcus aureus predisposes to bacterial persistence in macrophages
    Jamil Jubrail
    Department of Infection and Immunity, University of Sheffield, Sheffield, UK
    Cell Microbiol 18:80-96. 2016
    ..We show that cycles of lysis and reuptake maintain a pool of viable intracellular bacteria over time when killing is overwhelmed and demonstrate intracellular persistence in alveolar macrophages in the lungs in a murine model...
  45. doi request reprint Chemiluminescence quantification of NO and its derivatives in liquid samples
    Jay R Laver
    Academic Unit of Infection and Immunity, School of Medicine and Biomedical Sciences, University of Sheffield, Sheffield, United Kingdom
    Methods Enzymol 436:113-27. 2008
    ..They also allow us to distinguish between the various products that may be generated when NO reacts with molecules in complex biological samples such as cell lysates and supernatants...
  46. doi request reprint Methylation status of a single CpG site in the IL6 promoter is related to IL6 messenger RNA levels and rheumatoid arthritis
    Christoper J Nile
    University of Sheffield, and Royal Hallamshire Hospital, Sheffield, UK
    Arthritis Rheum 58:2686-93. 2008
    ..The aims of this study were to compare the DNA methylation status of the IL6 promoter in rheumatoid arthritis (RA) patients and control subjects and to study the effects on gene expression...
  47. ncbi request reprint Penicillin enhances the toll-like receptor 2-mediated proinflammatory activity of Streptococcus pneumoniae
    Lisa J Moore
    Division of Genomic Medicine, University of Sheffield Medical School, Sheffield, United Kingdom
    J Infect Dis 188:1040-8. 2003
    ..pneumoniae releases proinflammatory cell-wall components that activate TLR2 and that this activity is dependent on autolysin, the growth phase of the organism, and the antibiotic concentration...
  48. pmc Mannose-binding lectin is present in human semen and modulates cellular adhesion of Neisseria gonorrhoeae in vitro
    J B Wing
    Academic Unit of Infection and Immunity, University of Sheffield Medical School, Sheffield S10 2RX, UK
    Clin Exp Immunol 157:408-14. 2009
    ..This effect was dose-dependent. This work demonstrates that MBL is present in human semen and modifies cellular responses to N. gonorrhoeae in a concentration-dependent manner...
  49. ncbi request reprint Immune-mediated phagocytosis and killing of Streptococcus pneumoniae are associated with direct and bystander macrophage apoptosis
    D H Dockrell
    Division of Genomic Medicine, University of Sheffield Medical School, Sheffield S10 2RX, United Kingdom
    J Infect Dis 184:713-22. 2001
    ..This response in vivo may regulate the inflammatory response to infection during a successful host response against S. pneumoniae...
  50. pmc Peptides from Tetraspanin CD9 Are Potent Inhibitors of Staphylococcus Aureus Adherence to Keratinocytes
    Jennifer K Ventress
    Department of Infection, Immunity and Cardiovascular Diseases, University of Sheffield Medical School, Sheffield, United Kingdom
    PLoS ONE 11:e0160387. 2016
    ..These potential therapeutics had no effect on keratinocyte viability, migration or proliferation, indicating that they could be a valuable addition to current treatments for skin infection. ..
  51. ncbi request reprint Toll-like receptors in health and disease: complex questions remain
    Ian Sabroe
    Division of Genomic Medicine, University of Sheffield, Royal Hallamshire Hospital, Sheffield, United Kingdom
    J Immunol 171:1630-5. 2003
  52. pmc Activation of toll-like receptor 2 (TLR2) and TLR4/MD2 by Neisseria is independent of capsule and lipooligosaccharide (LOS) sialylation but varies widely among LOS from different strains
    Alison C Pridmore
    Division of Genomic Medicine, Royal Hallamshire Hospital, University of Sheffield, Sheffield S10 2RX, United Kingdom
    Infect Immun 71:3901-8. 2003
    ....
  53. doi request reprint Nasopharyngeal colonization by Neisseria lactamica and induction of protective immunity against Neisseria meningitidis
    Cariad M Evans
    School of Medicine and Biomedical Science, University of Sheffield, Sheffield, United Kingdom
    Clin Infect Dis 52:70-7. 2011
    ..Natural immunity to Neisseria meningitidis may result from nasopharyngeal carriage of closely related commensals, such as Neisseria lactamica...
  54. pmc Characterisation of receptor binding by the chemotaxis inhibitory protein of Staphylococcus aureus and the effects of the host immune response
    Andrew J Wright
    Department of Molecular Biology and Biotechnology, University of Sheffield, Sheffield S10 2TN, UK
    Mol Immunol 44:2507-17. 2007
    ..We conclude that CHIPS is likely to be too immunogenic to be used as an anti-inflammatory treatment but that some antibodies against CHIPS may be useful in the treatment of S. aureus infections...
  55. pmc Analysis of histone post translational modifications in primary monocyte derived macrophages using reverse phase√óreverse phase chromatography in conjunction with porous graphitic carbon stationary phase
    Thomas C Minshull
    Department of Chemical and Biological Engineering, ChELSI Institute, University of Sheffield, Mappin Street, Sheffield S1 3JD, United Kingdom Department of Infection, Immunity and Cardiovascular Disease, University of Sheffield Medical School, United Kingdom Sheffield Teaching Hospitals, United Kingdom
    J Chromatogr A 1453:43-53. 2016
    ..The automation of a section of the downstream analysis pipeline increased the throughput of the 2D-LC-MS/MS approach for the quantification of histone post translational modifications. ..
  56. doi request reprint Anti-adhesion methods as novel therapeutics for bacterial infections
    Daniel Cozens
    Department of Infection and Immunity, K Floor, Royal Hallamshire Hospital, Sheffield School of Medicine and Biomedical Science, University of Sheffield, Sheffield, S10 3JF, UK
    Expert Rev Anti Infect Ther 10:1457-68. 2012
    ..Once developed, these drugs will contribute to the arsenal for fighting infectious disease in the future, potentially subverting antibiotic resistance...
  57. doi request reprint Genetic susceptibility to meningococcal infection
    Adam P Dale
    Department of Infection and Immunity, University of Sheffield, Medical School, Beech Hill Road, Sheffield, South Yorkshire, S10 2RX, UK
    Expert Rev Anti Infect Ther 11:187-99. 2013
    ....
  58. ncbi request reprint Variation within genes encoding interleukin-1 and the interleukin-1 receptor antagonist influence the severity of meningococcal disease
    Robert C Read
    Division of Genomic Medicine, University of Sheffield Medical School, Beech Hill Road, Sheffield S10 2RX, United Kingdom
    Ann Intern Med 138:534-41. 2003
    ..Genetically determined variation in proinflammatory cytokine release influences severity of meningococcal disease and other serious infections...
  59. doi request reprint Oseltamivir, zanamivir and amantadine in the prevention of influenza: a systematic review
    Rachel J Jackson
    Health Economics and Decision Science, School of Health and Related Research, University of Sheffield, Regent Court, 30 Regent Street, Sheffield, UK
    J Infect 62:14-25. 2011
    ..To systematically review evidence relating to the clinical efficacy of oseltamivir, zanamivir and amantadine in the prevention of influenza...
  60. ncbi request reprint Streptococcus pneumoniae-associated human macrophage apoptosis after bacterial internalization via complement and Fcgamma receptors correlates with intracellular bacterial load
    Farzana Ali
    Division of Genomic Medicine, University of Sheffield School of Medicine and Biomedical Sciences, Sheffield, United Kingdom
    J Infect Dis 188:1119-31. 2003
    ..A dynamic interaction between live intracellular bacteria and the host cell is necessary for induction of apoptosis in MDMs, and induction of apoptosis contributes to the host defense against S. pneumoniae...
  61. ncbi request reprint An interleukin-1 genotype is associated with fatal outcome of meningococcal disease
    R C Read
    1Division of Genomic Medicine, University of Sheffield Medical School, Sheffield, and 2Meningococcal Reference Unit, Manchester Public Health Laboratory, Withington Hospital, Manchester, United Kingdom
    J Infect Dis 182:1557-60. 2000
    ..018; OR, 7.78 [95% CI, 1. 05-59.05]). There was no association between TNF genotype and fatal outcome. These data suggest that IL-1 genotype influences the severity of meningococcal disease...
  62. ncbi request reprint Post-transcriptional regulation of bacterial motility by aconitase proteins
    Yue Tang
    Krebs Institute for Biomolecular Research, Department of Molecular Biology and Biotechnology, University of Sheffield, Sheffield S10 2TN, UK
    Mol Microbiol 51:1817-26. 2004
    ..The lower levels of FtsH protease activity then influence sigma32, DnaK and, ultimately, FliC production...
  63. ncbi request reprint Management of meningitis
    Anne Tunbridge
    Division of Genomic Medicine, School of Medicine and Biomedical Sciences, University of Sheffield
    Clin Med 4:499-505. 2004
  64. pmc Evidence of a functional B-cell immunodeficiency in adults who experience serogroup C meningococcal disease
    Rachel A Foster
    Unit of Infection and Immunity, University of Sheffield School of Medicine and Biomedical Science, Sheffield, United Kingdom
    Clin Vaccine Immunol 16:692-8. 2009
    ..This defect is manifested as an impaired B-cell response to T-cell-independent type 2 antigens analogous to bacterial capsular polysaccharide...
  65. ncbi request reprint Haplotype-specific gene expression profiles in a telomeric major histocompatibility complex gene cluster and susceptibility to autoimmune diseases
    D Mewar
    School of Medicine and Biomedical Sciences, University of Sheffield, Sheffield, UK
    Genes Immun 7:625-31. 2006
    ..The implications of our findings for the understanding of genetic associations with disease susceptibility in this region are discussed...
  66. pmc Coinfection with influenza B virus does not affect association of Neisseria meningitidis with human nasopharyngeal mucosa in organ culture
    R C Read
    Division of Molecular and Genetic Medicine, F Floor, and Division of Surgical and Anaesthetic Sciences, University of Sheffield Medical School, Sheffield S10 2RX, United Kingdom
    Infect Immun 67:3082-6. 1999
    ..In the presence of influenza virus infection, these proteins were gradually lost over the course of 72 h. In conclusion, influenza B virus did not increase association of serogroup B N. meningitidis with human nasopharyngeal mucosa...
  67. ncbi request reprint Experimental therapies for sepsis directed against tumour necrosis factor
    R C Read
    Department of Molecular and Genetic Medicine, University of Sheffield Medical School, UK
    J Antimicrob Chemother 41:65-9. 1998
    ..Drugs that modify TNF in vivo may be a useful component of future management of sepsis, either as monotherapy or as part of a combined strategy of immunomodulation...
  68. ncbi request reprint Invasive pneumococcal disease and the potential for prevention by vaccination in the United Kingdom
    H K Parsons
    Department of Microbiology, Sheffield Teaching Hospitals Trust, Sheffield S10 2RX, UK
    J Infect 54:435-8. 2007
    ..The extent of previous exposure to pneumococcal capsular polysaccharide vaccination prior to an episode of IPD in hospitalised adults in the United Kingdom is unclear...
  69. ncbi request reprint Superantigen recognition by HLA class II on monocytes up-regulates toll-like receptor 4 and enhances proinflammatory responses to endotoxin
    Philip A Hopkins
    Department of Infectious Diseases, Imperial College, Du Cane Rd, London, UK
    Blood 105:3655-62. 2005
    ..Pattern recognition of bacterial superantigens by MHC class II receptors may exacerbate the proinflammatory response of monocytes to Gram-negative infection or endotoxin by up-regulation of TLR4...
  70. pmc Nitric oxide metabolism in Neisseria meningitidis
    Muna F Anjum
    Department of Molecular Biology and Biotechnology, University of Sheffield, Western Bank, Sheffield S10 2TN
    J Bacteriol 184:2987-93. 2002
    ..Expression of these genes by N. meningitidis during colonization and disease may confer protection against exogenous or endogenous nitrosative stress...
  71. ncbi request reprint Invasion by Neisseria meningitidis varies widely between clones and among nasopharyngeal mucosae derived from adult human hosts
    Robert Townsend
    Division of Genomic Medicine, F Floor, Sheffield University Medical School, Beech Hill Road, Sheffield S10 2RX, UK
    Microbiology 148:1467-74. 2002
    ..This is consistent with the unpredictable epidemiology of meningococcal disease...
  72. pmc Neisseria meningitidis lactate permease is required for nasopharyngeal colonization
    Rachel M Exley
    The Centre for Molecular Microbiology and Infection, Flowers Building, Imperial College London, Armstrong Rd, London SW7 2AZ, United Kingdom
    Infect Immun 73:5762-6. 2005
    ..Studies with other strains defective for the uptake of specific nutrients should provide valuable information about the environment in which N. meningitidis persists during carriage...
  73. ncbi request reprint The pathogen Neisseria meningitidis requires oxygen, but supplements growth by denitrification. Nitrite, nitric oxide and oxygen control respiratory flux at genetic and metabolic levels
    Jonathan D Rock
    Department of Biology Area 10, University of York, Heslington, York YO10 5YW, UK
    Mol Microbiol 58:800-9. 2005
    ..meningitidis...
  74. pmc Regulation of denitrification genes in Neisseria meningitidis by nitric oxide and the repressor NsrR
    Jonathan D Rock
    Department of Biology, University of York, Heslington, York YO10 5YW, United Kingdom
    J Bacteriol 189:1138-44. 2007
    ..meningitidis retains considerable activity aerobically...
  75. doi request reprint Moxifloxacin monotherapy is effective in hospitalized patients with community-acquired pneumonia: the MOTIV study--a randomized clinical trial
    Antoni Torres
    Servei de Pneumologia i Allergia Respiratoria, Institut Clinic del Torax, Hospital Clinic de Barcelona, Spain
    Clin Infect Dis 46:1499-509. 2008
    ....