Genomes and Genes
Affiliation: University of Leeds
- Evidence-based medicine: the time has come to set standards for stagingPhil Quirke
Pathology and Tumour Biology, Leeds Institute of Molecular Medicine, St James s University Hospital, University of Leeds, Leeds, UK
J Pathol 221:357-60. 2010..TNM is central to the management of cancer patients and we must protect and enhance its reputation...
- EURECCA consensus conference highlights about colorectal cancer clinical management: the pathologists expert reviewP Quirke
Department of Pathology, Anatomy and Tumour Biology, Leeds Institute of Cancer and Pathology, School of Medicine, University of Leeds, Leeds, UK
Virchows Arch 464:129-34. 2014..The expert panel consisted of representatives of European scientific organizations involved in cancer care of patients with colon and rectal cancer and representatives of national colorectal registries. ..
- EnROL: a multicentre randomised trial of conventional versus laparoscopic surgery for colorectal cancer within an enhanced recovery programmeRobin H Kennedy
St Mark s Hospital, Harrow, UK
BMC Cancer 12:181. 2012....
- Histopathological work-up of resection specimens, local excisions and biopsies in colorectal cancerPhilip Quirke
Department of Histopathology, Pathology and Tumour Biology, Leeds Institute of Molecular Medicine, University of Leeds, Leeds, UK
Dig Dis 30:2-8. 2012..The widespread introduction of bowel cancer screening is changing the stage of presentation of colorectal cancer leading to increasing numbers of local excisions and polyp cancers...
- European guidelines for quality assurance in colorectal cancer screening and diagnosis. First Edition--Quality assurance in pathology in colorectal cancer screening and diagnosisP Quirke
Pathology and Tumour Biology, Leeds Institute of Molecular Medicine, University of Leeds, Leeds, United Kingdom
Endoscopy 44:SE116-30. 2012....
- Association of molecular markers with toxicity outcomes in a randomized trial of chemotherapy for advanced colorectal cancer: the FOCUS trialMichael S Braun
Oncology and Clinical Research and Pathology and Tumour Biology Sections, Leeds Institute of Molecular Medicine, University of Leeds, Leeds, United Kingdom
J Clin Oncol 27:5519-28. 2009..Predicting efficacy and toxicity could potentially allow individualization of cancer therapy. We investigated putative pharmacogenetic markers of chemotherapy toxicity in a large randomized trial...
- KRAS and BRAF mutations in advanced colorectal cancer are associated with poor prognosis but do not preclude benefit from oxaliplatin or irinotecan: results from the MRC FOCUS trialSusan D Richman
Leeds Institute of Molecular Medicine, St James s Institute of Oncology, Cancer Research UK Genomic Services, University of Leeds, Leeds, UK
J Clin Oncol 27:5931-7. 2009..We wanted to determine whether KRAS and/or BRAF mutation is also a predictive biomarker for other aCRC therapies...
- Value of mismatch repair, KRAS, and BRAF mutations in predicting recurrence and benefits from chemotherapy in colorectal cancerGordon Hutchins
Leeds Institute of Molecular Medicine, Leeds University, United Kingdom
J Clin Oncol 29:1261-70. 2011..We investigated the usefulness of defective mismatch repair (dMMR), BRAF, and KRAS mutations in predicting tumor recurrence and sensitivity to chemotherapy...
- Understanding optimal colonic cancer surgery: comparison of Japanese D3 resection and European complete mesocolic excision with central vascular ligationNicholas P West
Leeds Institute of Molecular Medicine, Leeds, United Kingdom
J Clin Oncol 30:1763-9. 2012..We aimed to independently compare the physical appearances and quality of specimens resected using both techniques in major institutions in Japan and Germany...
- Intra-tumoral heterogeneity of KRAS and BRAF mutation status in patients with advanced colorectal cancer (aCRC) and cost-effectiveness of multiple sample testingSusan D Richman
The Section of Pathology, Leeds Institute of Molecular Medicine, University of Leeds, UK
Anal Cell Pathol (Amst) 34:61-6. 2011..Testing more than one block, or preferably preparation of a 'DNA cocktail' from two or more tumor blocks, improves mutation detection at minimal extra cost...
- Randomized trial of laparoscopic-assisted resection of colorectal carcinoma: 3-year results of the UK MRC CLASICC Trial GroupDavid G Jayne
Academic Unit of Surgery, St James s University Hospital, Leeds, United Kingdom
J Clin Oncol 25:3061-8. 2007..Few data are available on rectal cancer, and long-term data on survival and recurrence are now required...
- Complete mesocolic excision with central vascular ligation produces an oncologically superior specimen compared with standard surgery for carcinoma of the colonNicholas P West
Pathology and Tumour Biology, Leeds Institute of Molecular Medicine, Level 4, Wellcome Trust Brenner Building, St James s University Hospital, Beckett St, Leeds, LS9 7TF, United Kingdom
J Clin Oncol 28:272-8. 2010..We aimed to further investigate the importance of CME and CVL surgery for colonic cancer by comparison with a series of standard specimens...
- Role of the oxidative DNA damage repair gene OGG1 in colorectal tumorigenesisChristopher G Smith
Institute of Cancer and Genetics, School of Medicine, Cardiff University, Cardiff, UK
J Natl Cancer Inst 105:1249-53. 2013..These data suggest that OGG1 (Gly308Glu) may act as a low-penetrance allele that contributes to colorectal tumorigenesis. ..
- Pathology grading of colon cancer surgical resection and its association with survival: a retrospective observational studyNicholas P West
Pathology and Tumour Biology, Leeds Institute of Molecular Medicine, University of Leeds, Leeds, UK
Lancet Oncol 9:857-65. 2008..We aimed to assess the quality of colon cancer surgery by studying the extent of variation in the plane of surgical resection, the amount of tissue removed, and its association with survival...
- Lymphatic vessel distribution in the mucosa and submucosa and potential implications for T1 colorectal tumorsKatherine J E Smith
The Leeds Institute of Molecular Medicine, University of Leeds, Leeds, UK
Dis Colon Rectum 54:35-40. 2011..We hypothesized that this might be due to the quantity or characteristics of lymphatic vasculature in this third...
- Thirty-day postoperative mortality after colorectal cancer surgery in EnglandEva J A Morris
Colorectal Cancer Epidemiology Group, Centre for Epidemiology and Biostatistics, University of Leeds, St James s Institute of Oncology, St James s Hospital Leeds, Leeds, UK
Gut 60:806-13. 2011..To assess the variation in risk-adjusted 30-day postoperative mortality for patients with colorectal cancer between hospital trusts within the English NHS...
- HER2 overexpression and amplification as a potential therapeutic target in colorectal cancer: analysis of 3256 patients enrolled in the QUASAR, FOCUS and PICCOLO colorectal cancer trialsSusan D Richman
Section of Pathology and Tumour Biology, Leeds Institute of Cancer and Pathology, University of Leeds, UK
J Pathol 238:562-70. 2016..2015 The Authors. Journal of Pathology published by John Wiley & Sons Ltd on behalf of Pathological Society of Great Britain and Ireland. ..
- Accurately identifying low-allelic fraction variants in single samples with next-generation sequencing: applications in tumor subclone resolutionLucy F Stead
Leeds Institute of Cancer and Pathology, St James s University Hospital, University of Leeds, Leeds, West Yorkshire, LS9 7TF, England
Hum Mutat 34:1432-8. 2013..We found that VarScan2 performed best overall with sequencing depths of 100×, 250×, 500×, and 1,000× required to accurately identify variants present at 10%, 5%, 2.5%, and 1%, respectively. ..
- Detection of somatic mutations in tumors using unaligned clonal sequencing dataKate M Sutton
Section of Pathology and Tumour Biology, Institute of Cancer and Pathology, University of Leeds, St James s University Hospital, Leeds, UK
Lab Invest 94:1173-83. 2014....
- Improving the quality of colon cancer surgery through a surgical education programNicholas P West
Pathology and Tumour Biology, Leeds Institute of Molecular Medicine, Leeds, United Kingdom
Dis Colon Rectum 53:1594-603. 2010..We aimed to assess the effect of surgical education on the oncological quality of the resection specimen produced...
- The future of the TNM staging system in colorectal cancer: time for a debate?Philip Quirke
Pathology and Tumour Biology, Leeds Institute of Molecular Medicine, St James s University Hospital, University of Leeds, Leeds, UK
Lancet Oncol 8:651-7. 2007....
- [Close teamwork between pathologist and surgeon can improve results in colorectal cancer treatment]Nicholas P West
Pathology and Tumour Biology, Leeds Institute of Molecular Medicine, St James University Hospital, Leeds, England
Ugeskr Laeger 173:1037-40. 2011..Specific markers of oncological quality including grading the plane of surgery, tissue morphometry and lymph node yields are discussed...
- Training and quality assurance for rectal cancer: 20 years of data is enoughPhil Quirke
University of Leeds, Leeds, UK
Lancet Oncol 4:695-702. 2003..New developments in radiology and oncology may further increase this benefit...
- Predictive biomarkers of chemotherapy efficacy in colorectal cancer: results from the UK MRC FOCUS trialMichael S Braun
Leeds Institute of Molecular Medicine, University of Leeds, Leeds, United Kingdom
J Clin Oncol 26:2690-8. 2008....
- Mutation detection by clonal sequencing of PCR amplicons and grouped read typing is applicable to clinical diagnosticsPhilip A Chambers
Leeds Institute of Molecular Medicine, Leeds University, Leeds, UK
Hum Mutat 34:248-54. 2013..This novel approach has immediate applicability to clinical testing for disease-associated genetic variants...
- Evidence of the oncologic superiority of cylindrical abdominoperineal excision for low rectal cancerNicholas P West
Pathology and Tumour Biology, Leeds Institute of Molecular Medicine, University of Leeds, United Kingdom
J Clin Oncol 26:3517-22. 2008..Changing to an extended prone perineal dissection results in a more cylindrical specimen and should improve outcomes...
- Identifying stage III colorectal cancer patients: the influence of the patient, surgeon, and pathologistEva Judith Ann Morris
Cancer Epidemiology Group, Centre for Epidemiology and Biostatistics, University of Leeds, United Kingdom
J Clin Oncol 25:2573-9. 2007..This study sought to determine what patient, tumor, and management factors influence the number of nodes retrieved and to determine if the extent of lymphadenectomy affects stage allocation and influences survival...
- Toward routine use of 3D histopathology as a research toolNicholas Roberts
Department of Pathology and Tumor Biology, Leeds Institute of Molecular Medicine, Leeds, United Kingdom
Am J Pathol 180:1835-42. 2012..Both 3D tissue volumes and generated 3D models are presented for four demonstrator cases...
- Prediction of the response of colorectal cancer to systemic therapyJulian W Adlard
Academic Department of Pathology, University of Leeds, UK
Lancet Oncol 3:75-82. 2002..Thus, predictive-factor testing of tumour biopsy samples may allow us to select chemotherapy or immunotherapy treatments with a high likelihood of benefit for the individual patient...
- Prospective Validation of a Low Rectal Cancer Magnetic Resonance Imaging Staging System and Development of a Local Recurrence Risk Stratification Model: The MERCURY II StudyNicholas J Battersby
Pelican Cancer Foundation, Basingstoke, United Kingdom North Hampshire Hospital, Basingstoke, United Kingdom Dresden Friedrichstadt General Hospital, Dresden, Germany Pathology and Tumor Biology, Leeds Institute of Cancer and Pathology, University of Leeds, Leeds, United Kingdom Salisbury District Hospital, Salisbury, United Kingdom Vivantes im Friedrichshain, Berlin, Germany The Royal Marsden NHS Foundation Trust, London, United Kingdom Aarhus University Hospital, Aarhus, Denmark Frimley Park Hospital, Frimley, United Kingdom The Academic Department for Radiology, The Royal Marsden Hospital, Sutton, United Kingdom
Ann Surg 263:751-60. 2016..This study aimed to validate a magnetic resonance imaging (MRI) staging classification that preoperatively assessed the relationship between tumor and the low rectal cancer surgical resection plane (mrLRP)...
- The correlation between endoscopic and histopathological measurements in colorectal polypsYasmin Levene
Pathology and Tumour Biology, Leeds Institute of Cancer and Pathology, University of Leeds, Leeds, UK
Histopathology 66:485-90. 2015..Currently there is no standardized method of assessing polyp size. We aimed to examine the correlation between endoscopic and histopathological measurements to determine the most appropriate method for clinical use...
- A retrospective observational study of the relationship between single nucleotide polymorphisms associated with the risk of developing colorectal cancer and survivalEva J A Morris
Section of Epidemiology and Biostatistics, Leeds Institute of Cancer and Pathology, University of Leeds, Leeds LS9 7TF, United Kingdom
PLoS ONE 10:e0117816. 2015..33 and Xp22 have robustly been shown to be associated with the risk of developing CRC. Since germline variation can also influence patient outcome the relationship between these SNPs and patient survivorship from CRC was examined...
- Multicenter randomized controlled trial of conventional versus laparoscopic surgery for colorectal cancer within an enhanced recovery programme: EnROLRobin H Kennedy
Robin H Kennedy, St Mark s Hospital, Harrow E Anne Francis, Rose Wharton, and Susan J Dutton, University of Oxford, Oxford Jane M Blazeby, University of Bristol and University Hospitals Bristol National Health Service Foundation Trust, Bristol and Philip Quirke and Nicholas P West, University of Leeds, Leeds, United Kingdom
J Clin Oncol 32:1804-11. 2014..EnROL (Enhanced Recovery Open Versus Laparoscopic) is a multicenter randomized controlled trial examining whether the benefits of laparoscopy still exist when open surgery is optimized within an ERP...
- The modern abdominoperineal excision: the next challenge after total mesorectal excisionRoger Marr
Department of Histopathology, Leeds Teaching Hospitals NHS Trust, University of Leeds, Leeds, UK
Ann Surg 242:74-82. 2005..Examine the cause of local recurrence (LR) and patient survival (S) following abdominoperineal resection (APR) and anterior resection (AR) for rectal carcinoma and the effect of introduction of total mesorectal excision (TME) on APR...
- Expression of the CUB domain containing protein 1 (CDCP1) gene in colorectal tumour cellsSara E Perry
Institute of Molecular and Cellular Biology, Faculty of Biological Sciences, Garstang Building, Room 8 10a, University of Leeds, Leeds LS2 9JT, United Kingdom
FEBS Lett 581:1137-42. 2007..However, intracellular localisation studies revealed that only one of these transcripts encodes a protein that is localised to the cell surface...
- Molecular markers of chemotherapeutic response and toxicity in colorectal cancerMichael S Braun
University of Leeds, UK
Expert Rev Anticancer Ther 7:489-501. 2007..Here we review the evidence for using molecular markers to individualize chemotherapy treatment in colorectal cancer...
- The tissue microarray data exchange specification: Extending TMA DES to provide flexible scoring and incorporate virtual slidesAlexander Wright
Department of Pathology and Tumour Biology, Leeds Institute of Molecular Medicine, University of Leeds, Leeds, LS9 7TF, U K
J Pathol Inform 2:15. 2011....
- Experiences from the front-line routine consenting of surplus surgically removed tissue: without investment by the National Health Service fully informed consent for all is not availableJanet Wheeler
Leeds Teaching Hospitals NHS Trust University of Leeds Pathology and Tumour Biology, Leeds, UK
J Clin Pathol 60:351-4. 2007....
- Expression of DNA double-strand break repair proteins ATM and BRCA1 predicts survival in colorectal cancerHeike Grabsch
Academic Unit of Pathology, University of Leeds, UK
Clin Cancer Res 12:1494-500. 2006..To address this issue, we examined the expression pattern of DSB repair key proteins ATM, BRCA1, BRCA2, Ku70, and Ku80 and their putative role in patients survival in a large series of colorectal cancer...
- DNA methylation, a biomarker for colorectal cancer: implications for screening and pathological utilityAdrian M Jubb
Academic Unit of Pathology, Leeds University, Leeds, UK
Ann N Y Acad Sci 983:251-67. 2003..In addition, the authors consider the pathological utility of epigenetic testing in refining tumor staging and predicting disease recurrence...
- Virtual reality Powerwall versus conventional microscope for viewing pathology slides: an experimental comparisonDarren Treanor
Pathology and Tumour Biology, Leeds Institute of Molecular Medicine, University of Leeds, Leeds LS9 7TF, UK
Histopathology 55:294-300. 2009..The aim was to create and test a virtual reality (VR) microscope using a Powerwall (a high-resolution array of 28 computer screens) for viewing virtual slides more efficiently...
- Preoperative radiotherapy versus selective postoperative chemoradiotherapy in patients with rectal cancer (MRC CR07 and NCIC-CTG C016): a multicentre, randomised trialDavid Sebag-Montefiore
St James s University Hospital, Leeds, UK
Lancet 373:811-20. 2009..We compared short-course preoperative radiotherapy versus initial surgery with selective postoperative chemoradiotherapy...
- Effect of the plane of surgery achieved on local recurrence in patients with operable rectal cancer: a prospective study using data from the MRC CR07 and NCIC-CTG CO16 randomised clinical trialPhil Quirke
Leeds University, Leeds, UK
Lancet 373:821-8. 2009..However, the contributions of surgery and radiotherapy to outcomes are unclear. We assessed the effect of the involvement of the circumferential resection margin and the plane of surgery achieved...