Affiliation: University of Oxford
- HIV-1 infection is characterized by profound depletion of CD161+ Th17 cells and gradual decline in regulatory T cellsAndrew Prendergast
Department of Paediatrics, University of Oxford, South Parks Road, Oxford, UK
AIDS 24:491-502. 2010..The balance between pro-inflammatory Th17 and immunoregulatory Tregs may be critical in HIV pathogenesis. This study addressed changes in CD161, Th17 and Treg subsets during untreated HIV infection...
- Replicative capacity of human immunodeficiency virus type 1 transmitted from mother to child is associated with pediatric disease progression rateJulia G Prado
Department of Pediatrics, University of Oxford, Oxford OX1 3SY, UK
J Virol 84:492-502. 2010..These data underline the importance of virus-host interactions and highlight the contribution of viral attenuation through Gag-specific CD8(+) T-cell escape mutations, among other factors, in the control of pediatric HIV infection...
- Factors influencing T cell activation and programmed death 1 expression in HIV-infected childrenAndrew Prendergast
Department of Paediatrics, University of Oxford, Oxford, United Kingdom
AIDS Res Hum Retroviruses 28:465-8. 2012..Further understanding of the factors that drive immune activation in children is critical to developing future therapeutic strategies in this population...
- Early virological suppression with three-class antiretroviral therapy in HIV-infected African infantsAndrew Prendergast
Department of Paediatrics, University of Oxford, Oxford, UK
AIDS 22:1333-43. 2008..Data on treatment outcome in sub-Saharan African infants exposed to single-dose nevirapine are urgently required. This feasibility study addresses efficacy of infant antiretroviral therapy in this setting...
- Gag-specific CD4+ T-cell responses are associated with virological control of paediatric HIV-1 infectionAndrew Prendergast
Department of Paediatrics, University of Oxford, UK
AIDS 25:1329-31. 2011..43, P < 0.001), suggesting that preservation of this cell population may be an important goal of therapeutic/vaccine strategies...
- HLA footprints on human immunodeficiency virus type 1 are associated with interclade polymorphisms and intraclade phylogenetic clusteringPhilippa C Matthews
Department of Paediatrics, Nuffield Department of Medicine, Peter Medawar Building for Pathogen Research, Oxford, United Kingdom
J Virol 83:4605-15. 2009..In conclusion, these data highlight the fact that HLA can be a strong selection force for both intra- and interclade HIV evolution at a population level...
- International perspectives, progress, and future challenges of paediatric HIV infectionAndrew Prendergast
Department of Paediatrics, University of Oxford, Peter Medawar Building for Pathogen Research, Oxford OX1 3SY, UK
Lancet 370:68-80. 2007....