Andrew C Povey

Summary

Affiliation: University of Manchester
Country: UK

Publications

  1. ncbi Association between lung cancer risk and single nucleotide polymorphisms in the first intron and codon 178 of the DNA repair gene, O6-alkylguanine-DNA alkyltransferase
    Philip A J Crosbie
    Cancer Research UK Carcinogenesis Group, Paterson Institute for Cancer Research, Christie Hospital NHS Trust, Manchester, United Kingdom
    Int J Cancer 122:791-5. 2008
  2. doi Pesticide exposure and screen-positive neuropsychiatric disease in British sheep farmers
    Andrew C Povey
    Centre for Occupational and Environmental Health, Centre for Epidemiology, Institute of Population Health, Faculty of Medical and Human Sciences, University of Manchester, Manchester M13 9PL, United Kingdom Electronic address
    Environ Res 135:262-70. 2014
  3. doi Acute ill-health in sheep farmers following use of pesticides
    A C Povey
    Centre for Occupational and Environmental Health, Faculty of Medical and Human Sciences, University of Manchester Manchester, UK
    Occup Med (Lond) 62:541-8. 2012
  4. ncbi Smoking is associated with a decrease of O6-alkylguanine-DNA alkyltransferase activity in bronchial epithelial cells
    Andrew C Povey
    Centre for Occupational and Environmental Health, University of Manchester, Manchester, United Kingdom
    Int J Cancer 119:463-6. 2006
  5. ncbi Lung cancer risk and variation in MGMT activity and sequence
    Andrew C Povey
    Centre for Occupational and Environmental Health, University of Manchester, United Kingdom
    DNA Repair (Amst) 6:1134-44. 2007
  6. pmc The nitrosated bile acid DNA lesion O6-carboxymethylguanine is a substrate for the human DNA repair protein O6-methylguanine-DNA methyltransferase
    Pattama Senthong
    Centre for Occupational and Environmental Health, Faculty of Medical and Human Sciences, University of Manchester, Manchester M13 9PL, UK
    Nucleic Acids Res 41:3047-55. 2013
  7. ncbi Quantitative trait locus analysis reveals two intragenic sites that influence O6-alkylguanine-DNA alkyltransferase activity in peripheral blood mononuclear cells
    Geoffrey P Margison
    Cancer Research UK Carcinogenesis Group, Paterson Institute for Cancer Research, Christie Hospital NHS Trust, Manchester, UK
    Carcinogenesis 26:1473-80. 2005
  8. doi Topographical study of O(6)-alkylguanine DNA alkyltransferase repair activity and N7-methylguanine levels in resected lung tissue
    Philip A J Crosbie
    Cancer Research UK Carcinogenesis Group, Paterson Institute for Cancer Research, University of Manchester, Manchester M20 4BX, UK
    Chem Biol Interact 204:98-104. 2013
  9. doi GSTM1 copy number and lung cancer risk
    Philip A J Crosbie
    Cancer Research UK Carcinogenesis Group, Paterson Institute for Cancer Research, Christie Hospital NHS Trust, Manchester, United Kingdom
    Mutat Res 664:1-5. 2009
  10. ncbi Associations between tissue-specific DNA alkylation, DNA repair and cell proliferation in the colon and colon tumour yield in mice treated with 1,2-dimethylhydrazine
    Peta E Jackson
    Cancer Research UK Carcinogenesis Group, Paterson Institute for Cancer Research, Manchester, M20 9BX, UK
    Carcinogenesis 24:527-33. 2003

Collaborators

Detail Information

Publications24

  1. ncbi Association between lung cancer risk and single nucleotide polymorphisms in the first intron and codon 178 of the DNA repair gene, O6-alkylguanine-DNA alkyltransferase
    Philip A J Crosbie
    Cancer Research UK Carcinogenesis Group, Paterson Institute for Cancer Research, Christie Hospital NHS Trust, Manchester, United Kingdom
    Int J Cancer 122:791-5. 2008
    ..These results suggest that the R allele may protect against lung cancer, specifically in heavy smokers, an effect that may result from this polymorphism affecting the function of the MGMT protein and/or levels in MGMT activity...
  2. doi Pesticide exposure and screen-positive neuropsychiatric disease in British sheep farmers
    Andrew C Povey
    Centre for Occupational and Environmental Health, Centre for Epidemiology, Institute of Population Health, Faculty of Medical and Human Sciences, University of Manchester, Manchester M13 9PL, United Kingdom Electronic address
    Environ Res 135:262-70. 2014
    ..Our aim was to examine whether neuropsychiatric disorders were associated with low dose chronic and/or more acute pesticide exposure in sheep farmers...
  3. doi Acute ill-health in sheep farmers following use of pesticides
    A C Povey
    Centre for Occupational and Environmental Health, Faculty of Medical and Human Sciences, University of Manchester Manchester, UK
    Occup Med (Lond) 62:541-8. 2012
    ..There have been few prospective epidemiological studies to determine it's nature and incidence. Aims To determine the nature and frequency of symptoms occurring in farmers treating sheep for ectoparasites...
  4. ncbi Smoking is associated with a decrease of O6-alkylguanine-DNA alkyltransferase activity in bronchial epithelial cells
    Andrew C Povey
    Centre for Occupational and Environmental Health, University of Manchester, Manchester, United Kingdom
    Int J Cancer 119:463-6. 2006
    ..71; 0.54-0.93 fmol/microg DNA) compared to nonsmokers (1.25; 1.03-1.51 fmol/microg DNA; p = 0.002). This could represent an important contribution to the carcinogenicity of tobacco smoke...
  5. ncbi Lung cancer risk and variation in MGMT activity and sequence
    Andrew C Povey
    Centre for Occupational and Environmental Health, University of Manchester, United Kingdom
    DNA Repair (Amst) 6:1134-44. 2007
    ..We have recently analysed a consecutive series of case-control studies and found evidence that lung cancer risk was lower in subjects with the R178 allele...
  6. pmc The nitrosated bile acid DNA lesion O6-carboxymethylguanine is a substrate for the human DNA repair protein O6-methylguanine-DNA methyltransferase
    Pattama Senthong
    Centre for Occupational and Environmental Health, Faculty of Medical and Human Sciences, University of Manchester, Manchester M13 9PL, UK
    Nucleic Acids Res 41:3047-55. 2013
    ..O(6)-CMG is therefore an MGMT substrate, and hence MGMT is likely to be a protective factor in CRC under conditions where O(6)-CMG is a potential causative agent...
  7. ncbi Quantitative trait locus analysis reveals two intragenic sites that influence O6-alkylguanine-DNA alkyltransferase activity in peripheral blood mononuclear cells
    Geoffrey P Margison
    Cancer Research UK Carcinogenesis Group, Paterson Institute for Cancer Research, Christie Hospital NHS Trust, Manchester, UK
    Carcinogenesis 26:1473-80. 2005
    ..These findings suggest that further investigations of the potential epidemiological and clinical significance of inherited differences in MGMT expression and activity are warranted...
  8. doi Topographical study of O(6)-alkylguanine DNA alkyltransferase repair activity and N7-methylguanine levels in resected lung tissue
    Philip A J Crosbie
    Cancer Research UK Carcinogenesis Group, Paterson Institute for Cancer Research, University of Manchester, Manchester M20 4BX, UK
    Chem Biol Interact 204:98-104. 2013
    ....
  9. doi GSTM1 copy number and lung cancer risk
    Philip A J Crosbie
    Cancer Research UK Carcinogenesis Group, Paterson Institute for Cancer Research, Christie Hospital NHS Trust, Manchester, United Kingdom
    Mutat Res 664:1-5. 2009
    ..07). Results then confirm that the presence of GSTM1 provides protection against the risk of lung cancer. In addition there is equivocal evidence that this protection varies with the number of gene copies...
  10. ncbi Associations between tissue-specific DNA alkylation, DNA repair and cell proliferation in the colon and colon tumour yield in mice treated with 1,2-dimethylhydrazine
    Peta E Jackson
    Cancer Research UK Carcinogenesis Group, Paterson Institute for Cancer Research, Manchester, M20 9BX, UK
    Carcinogenesis 24:527-33. 2003
    ....
  11. ncbi No association between N7-methyldeoxyguanosine and 8-oxodeoxyguanosine levels in human lymphocyte DNA
    Kathryn L Harrison
    Centre for Occupational and Environmental Health, Division of Epidemiology and Health Sciences, Medical School, University of Manchester, Oxford Road, Manchester, M13 9PT, UK
    Mutat Res 600:125-30. 2006
    ..01) suggesting that there is no association between alkylating agent and reactive oxygen species exposure, their metabolism and/or the DNA repair processes that can remove this DNA damage...
  12. doi Elevated N3-methylpurine-DNA glycosylase DNA repair activity is associated with lung cancer
    Philip A J Crosbie
    Cancer Research UK Carcinogenesis Group, Paterson Institute for Cancer Research, University of Manchester, Manchester, UK North West Lung Centre, University Hospital of South Manchester, Manchester, UK Centre for Occupational and Environmental Health, Faculty of Medical and Human Sciences, University of Manchester, Manchester, UK
    Mutat Res 732:43-6. 2012
    ..00, 95% CI 1.16-7.75) when compared to those patients in the lowest tertile. These results suggest that elevated MPG activity is associated with lung cancer, possibly by creating an imbalance in the base excision repair pathway...
  13. doi Gene-environmental interactions and organophosphate toxicity
    Andrew C Povey
    Centre for Occupational and Environmental Health, School of Community Based Medicine, Faculty of Medical and Human Sciences, University of Manchester, Ellen Wilkinson Building, Devas Street, Manchester M139PT, United Kingdom
    Toxicology 278:294-304. 2010
    ..Hence further work is required not only to better characterise OP exposure in humans populations but also to identify those populations susceptible to OP toxicity...
  14. ncbi Cotinine levels and self-reported smoking status in patients attending a bronchoscopy clinic
    Sarah J Lewis
    School of Epidemiology and Health Sciences, University of Manchester, Manchester, UK
    Biomarkers 8:218-28. 2003
    ..Such differential misclassification may result in bias in studies examining associations between current smoking habits and disease risk...
  15. pmc Atl1 regulates choice between global genome and transcription-coupled repair of O(6)-alkylguanines
    Vitaly F Latypov
    Cancer Research UK Carcinogenesis Group, Paterson Institute for Cancer Research, University of Manchester, Manchester M20 4BX, UK
    Mol Cell 47:50-60. 2012
    ....
  16. ncbi N7-methyldeoxyguanosine levels in DNA isolated from cervical cytology samples are associated with smoking
    Kathryn L Harrison
    Centre for Occupational and Environmental Health, University of Manchester, Oxford Road, Manchester, United Kingdom
    Int J Cancer 119:961-3. 2006
    ..Our study suggests that cervical DNA contains alkylation damage that can arise from exposure to cigarette smoke...
  17. ncbi DNA alkylation and repair in the large bowel: animal and human studies
    Andrew C Povey
    Centre for Occupational and Environmental Health, School of Epidemiology and Health Sciences, University of Manchester, Manchester, M13 9PL, England
    J Nutr 132:3518S-3521S. 2002
    ..Human exposure to endogenous or exogenous alkylating agents may thus be an environmental determinant of colorectal cancer risk...
  18. ncbi GSTM1, GSTT1 and GSTP1 polymorphisms and lung cancer risk
    Sarah J Lewis
    School of Epidemiology and Health Sciences, University of Manchester, Manchester M13 9PT, UK
    Cancer Lett 180:165-71. 2002
    ....
  19. pmc Estimating intervention effects in a complex multi-level smoking prevention study
    Milena Falcaro
    Biostatistics Group, School of Community Based Medicine, University of Manchester, UK
    Int J Environ Res Public Health 6:463-77. 2009
    ....
  20. ncbi Associations between smoking, GST genotypes and N7-methylguanine levels in DNA extracted from bronchial lavage cells
    Sarah J Lewis
    Department of Epidemiology and Public Health, University College London, 1 19 Torrington Place, London WC1E 6BT, UK
    Mutat Res 559:11-8. 2004
    ..1)x10(-7) versus (2.64+/-3.89)x10(-7) N7-MedGp/dGp, P=0.02). N7-MeG adduct levels in DNA isolated from lung tissue thus reflect exposure to cigarette smoke, and genetic variation in carcinogen-metabolising enzymes may modify these levels...
  21. ncbi Mechanisms of carcinogenicity/chemotherapy by O6-methylguanine
    Geoffrey P Margison
    Cancer Research UK Carcinogenesis Group, Paterson Institute for Cancer Research, Manchester M20 4BX, UK
    Mutagenesis 17:483-7. 2002
    ..Some cancer chemotherapeutic agents exploit the cytotoxic effects of O(6)-alkylguanine and an understanding of the processing of this lesion has allowed strategies to be developed that should increase the effectiveness of such agents...
  22. ncbi Reduced MGMT activity in human colorectal adenomas is associated with K-ras GC->AT transition mutations in a population exposed to methylating agents
    Nicholas P Lees
    Department of Gastrointestinal Surgery, Wythenshawe Hospital, Southmoor Road, Wythenshawe, Manchester M23 9LT, UK
    Carcinogenesis 25:1243-7. 2004
    ..These results are consistent with the acquisition of K-ras GC-->AT transition mutations in adenomas with low MGMT activity as a result of unavoidable exposure to methylating agents...
  23. ncbi Metabolic gene polymorphisms and lung cancer risk in non-smokers. An update of the GSEC study
    Sara Raimondi
    Fondazione Policlinico IRCCS, Molecular and Genetic Epidemiology Unit, Via Pace 9, 20122 Milano, Italy
    Mutat Res 592:45-57. 2005
    ..Since genetic factors may play an important role in lung cancer development at low dose carcinogen exposure, non-smokers are a good model to study genetic susceptibility and its interaction with environmental factors...
  24. ncbi Bladder tumor contains higher N7-methylguanine levels in DNA than adjacent normal bladder epithelium
    Abir A Saad
    Cancer Research UK Carcinogenesis Group, Paterson Institute for Cancer Research, Christie Hospital NHS Trust, Manchester
    Cancer Epidemiol Biomarkers Prev 15:740-3. 2006
    ..03) but not the GSTT1 gene or in subjects with the Ile105Val GSTP1 polymorphism. These results show that exposure to methylating agents is widespread and suggest that such exposure may play a role both in tumor initiation and progression...