Affiliation: University of Manchester
- Resilience to adult psychopathology following childhood maltreatment: evidence from a community sampleStephan Collishaw
King s College London, MRC Social, Genetic, and Developmental Psychiatry Centre, Institute of Psychiatry, London, UK
Child Abuse Negl 31:211-29. 2007..The aims of the present study were to address the extent of resilience to adult psychopathology in a representative community sample, and to explore predictors of a good prognosis...
- Variable expression of the autism broader phenotype: findings from extended pedigreesA Pickles
MRC Child Psychiatry Unit and the Institute of Psychiatry, King s College, London, UK
J Child Psychol Psychiatry 41:491-502. 2000..Patterns of expression within the families did not support a simple X-linked nor an imprinted X-linked mode of inheritance. The basis for sex differences in rates of expression is discussed...
- Child psychiatric symptoms and psychosocial impairment: relationship and prognostic significanceA Pickles
School of Epidemiology and Health Science, University of Manchester, Manchester, UK
Br J Psychiatry 179:230-5. 2001..Relatively little is known about the relationships between psychiatric symptoms, diagnosis and psychosocial impairment...
- Natural categories or fundamental dimensions: on carving nature at the joints and the rearticulation of psychopathologyAndrew Pickles
Biostatistics Group, School of Epidemiology and Health Science, University of Manchester, UK
Dev Psychopathol 15:529-51. 2003..We suggest replacing Meehl's analogy involving qualitatively distinct species with an alternative analogy with the "duality" of light, a phenomenon with both wave- and particle-like properties...
- Parent-mediated communication-focused treatment in children with autism (PACT): a randomised controlled trialJonathan Green
Psychiatry Research Group, University of Manchester, Manchester, UK
Lancet 375:2152-60. 2010..Results of small trials suggest that early interventions for social communication are effective for the treatment of autism in children. We therefore investigated the efficacy of such an intervention in a larger trial...
- Validation of the social communication questionnaire in a population cohort of children with autism spectrum disordersSusie Chandler
Guy s and Thomas NHS Foundation Trust, London, UK
J Am Acad Child Adolesc Psychiatry 46:1324-32. 2007..To examine the properties of the Social Communication Questionnaire (SCQ) in a population cohort of children with autism spectrum disorders (ASDs) and in the general population...
- 'Everyday memory' impairments in autism spectrum disordersCatherine R G Jones
Centre for Research in Autism and Education, Department of Psychology and Human Development, Institute of Education, London, WC1H 0AL, UK
J Autism Dev Disord 41:455-64. 2011..Social and communication ability was significantly associated with prospective remembering in an everyday memory context but not with the CAVLT-2. The complex nature of everyday memory and its relevance to ASD is discussed...
- The persistence and stability of psychiatric problems in adolescents with autism spectrum disordersEmily Simonoff
Department of Child and Adolescent Psychiatry, King s College London, Institute of Psychiatry and NIHR Biomedical Research Centre for Mental Health, London, UK
J Child Psychol Psychiatry 54:186-94. 2013..We use a longitudinal population-representative cohort to examine for the first time the persistence of psychiatric problems and to identify risk factors for their occurrence and stability...
- Severe mood problems in adolescents with autism spectrum disorderEmily Simonoff
Department of Child and Adolescent Psychiatry, King s College London, Institute of Psychiatry and NIHR Biomedical Research Centre for Mental Health, De Crespigny Park, London, UK
J Child Psychol Psychiatry 53:1157-66. 2012..SMP in people with autism spectrum disorders (ASDs) have not previously been explored...
- Pathways from adolescent deliberate self-poisoning to early adult outcomes: a six-year follow-upAzza Aglan
Division of Psychiatry, University of Manchester, UK
J Child Psychol Psychiatry 49:508-15. 2008..The goal of this study was to identify pathways linking childhood risk factors to early adult outcomes of suicidal adolescents...
- Reading and arithmetic in adolescents with autism spectrum disorders: peaks and dips in attainmentCatherine R G Jones
Department of Psychology and Human Development, Institute of Education, London, UK
Neuropsychology 23:718-28. 2009..The high rate of uneven academic attainment in ASD has implications for educational practice...
- The Croydon Assessment of Learning Study: prevalence and educational identification of mild mental retardationEmily Simonoff
Department of Child and Adolescent Psychiatry, King s College London, Institute of Psychiatry, London, UK
J Child Psychol Psychiatry 47:828-39. 2006..The current study estimates the prevalence of low IQ in the mental retardation range (intellectual disability) in a population sample and examines the factors that relate to educational identification...
- Treatment mechanism in the MRC preschool autism communication trial: implications for study design and parent-focussed therapy for childrenAndrew Pickles
Department of Biostatistics, Institute of Psychiatry, Kings College London, London, UK
J Child Psychol Psychiatry 56:162-70. 2015..This study aimed to better understand the mechanism by which the PACT treatment influenced changes in child behaviour though the targeted parent behaviour...
- Parent-reported gastro-intestinal symptoms in children with autism spectrum disordersSusie Chandler
Children s Neurosciences Department, Newcomen Child Development Centre, Guy s and St Thomas NHS Foundation Trust, Staircase D, St Thomas Hospital, Westminster Bridge Road, London, SE1 7EH, UK
J Autism Dev Disord 43:2737-47. 2013..Parents report more GI symptoms in children with ASD than children with either SEN or TD children but the frequency of reported symptoms is greater in the past than currently in all groups. ..
- An emerging income differential for adolescent emotional problemsEmma Gore Langton
King s College London Institute of Psychiatry, London, UK
J Child Psychol Psychiatry 52:1081-8. 2011..Older studies reported no income differentials, while recent reports suggest that adolescents from low-income families are more likely to experience emotional difficulties than their more affluent peers...
- Regression, developmental trajectory and associated problems in disorders in the autism spectrum: the SNAP studyGillian Baird
Newcomen Centre, Guy s and St Thomas NHS Foundation Trust, London, SE1 9RT, UK
J Autism Dev Disord 38:1827-36. 2008..Regression was associated with higher rates of autistic symptoms and a deviation in developmental trajectory. Regression was not associated with epilepsy or gastrointestinal problems...
- A multimodal approach to emotion recognition ability in autism spectrum disordersCatherine R G Jones
Centre for Research in Autism and Education, Department of Psychology and Human Development, Institute of Education, London, UK
J Child Psychol Psychiatry 52:275-85. 2011..However, experimental investigations of emotion recognition ability in ASD have been equivocal, hampered by small sample sizes, narrow IQ range and over-focus on the visual modality...
- Impairment in movement skills of children with autistic spectrum disordersDido Green
Newcomen Centre, Guy s and St Thomas NHS Foundation Trust, Great Maze Pond, London, UK
Dev Med Child Neurol 51:311-6. 2009..We undertook this study to explore the degree of impairment in movement skills in children with autistic spectrum disorders (ASD) and a wide IQ range...
- A longitudinal study of behavioral, emotional and social difficulties in individuals with a history of specific language impairment (SLI)Michelle C St Clair
School of Psychological Sciences, Ellen Wilkinson Building, University of Manchester, Oxford Road, Manchester M13 9PL, UK
J Commun Disord 44:186-99. 2011..Different aspects of early language abilities and reading skills exert different types and degrees of influence on behavioral, emotional and social difficulties...
- Parent-mediated intervention versus no intervention for infants at high risk of autism: a parallel, single-blind, randomised trialJonathan Green
Institute of Brain, Behaviour and Mental Health, University of Manchester, Manchester, UK Electronic address
Lancet Psychiatry 2:133-40. 2015..We aimed to assess the effect of a parent-mediated intervention for infants at high risk of autism on these markers...
- Cost-effectiveness analysis of a communication-focused therapy for pre-school children with autism: results from a randomised controlled trialSarah Byford
King s Health Economics, Box P024, King s College London, De Crespigny Park, London, SE5 8AF, UK
BMC Psychiatry 15:316. 2015..This study reports an economic evaluation of a parent-mediated, communication-focused therapy carried out within the Pre-School Autism Communication Trial (PACT)...
- Communication and social deficits in relatives of individuals with SLI and relatives of individuals with ASDAndrew Pickles
Biostatistics, Institute of Psychiatry, King s College London, London, UK
J Autism Dev Disord 43:156-67. 2013..There was a higher than would be expected rate (4.3 %) of ASD, particularly in siblings of SLI + ASD probands. Communication and social deficits appear to breed true in SLI and ASD...
- Sex differences in the association between infant markers and later autistic traitsRachael Bedford
Biostatistics Department, Institute of Psychiatry, Psychology and Neuroscience, King s College London, London, UK
Mol Autism 7:21. 2016..Sex-specific protective or risk factors have often been invoked to explain these differences, but such factors are yet to be identified...
- Alexithymia in Adolescents with Autism Spectrum Disorder: Its Relationship to Internalising Difficulties, Sensory Modulation and Social CognitionBosiljka Milosavljevic
Department of Psychology, Institute of Psychiatry, Psychology and Neuroscience, King s College London, Box PO77, Henry Wellcome Building, 16 DeCrespigny Park, London, SE5 8AF, UK
J Autism Dev Disord 46:1354-67. 2016..Overall, our results suggest that alexithymia is highly prevalent, and has selective cognitive correlates in young people with ASD...
- Precursors to social and communication difficulties in infants at-risk for autism: gaze following and attentional engagementRachael Bedford
Centre for Research in Autism and Education, Institute of Education, University of London, 25 Woburn Square, London, UK
J Autism Dev Disord 42:2208-18. 2012..The findings suggest that the subtle emergence of difficulties in JA in infancy may be related to ASD and other atypical outcomes...
- How far are associations between child, family and community factors and child psychopathology informant-specific and informant-general?Stephan Collishaw
King s College London Institute of Psychiatry, MRC Social, Genetic, and Developmental Psychiatry Centre, London, UK
J Child Psychol Psychiatry 50:571-80. 2009..However, few studies have systematically tested how far correlates of child psychopathology differ between informants...
- Measurement of urine indolylacroylglycine is not useful in the diagnosis or dietary management of autismNeil R Dalton
WellChild Laboratory, Evelina London Children s Hospital and King s College London, London, UK
Autism Res . 2016..We found measurement of urinary IAG to have no value in the diagnosis of autism or in the dietary management of children with ASD. Autism Res 2016,. © 2016 International Society for Autism Research, Wiley Periodicals, Inc...
- Testing two screening instruments for autism spectrum disorder in UK community child health servicesTony Charman
King s College London, Institute of Psychiatry, Psychology and Neuroscience, London, UK
Dev Med Child Neurol 58:369-75. 2016..A two-stage screening and in-depth assessment procedure, combined with sampling stratification and statistical weighting, allowed the accuracy of the screens to be estimated in the entire population of referred children...
- Evidence for interplay between genes and parenting on infant temperament in the first year of life: monoamine oxidase A polymorphism moderates effects of maternal sensitivity on infant anger pronenessAndrew Pickles
Institute of Psychiatry, King s College London, London, UK
J Child Psychol Psychiatry 54:1308-17. 2013..In contrast to previous studies, we examined MAOA G × E prospectively using an observational measure of a key aspect of the infant environment, maternal sensitivity, at a specified developmental time point...
- Intervention for infants at risk of developing autism: a case seriesJonathan Green
Institute of Brain, Behaviour and Mental Health, University of Manchester, Room 4 308, Jean McFarlane Building, Oxford Rd, Manchester, M13 9PL, UK
J Autism Dev Disord 43:2502-14. 2013..Measurement across domains was successful and on larger samples promise to be an effective test of whether such an intervention in infancy will modify emergent atypical developmental trajectories in infants at risk for autism. ..
- Adolescent emotional and behavioural outcomes of nonparental preschool childcareHolan Liang
Institute of Psychiatry, King s College London, London, UK
Soc Psychiatry Psychiatr Epidemiol 47:399-407. 2012..This study aimed to identify whether nonparental preschool childcare was associated with adolescent mental health outcomes as measured by the strengths and difficulties questionnaire (SDQ)...
- The impact of nonverbal ability on prevalence and clinical presentation of language disorder: evidence from a population studyCourtenay Frazier Norbury
Psychology and Language Sciences, University College London, London, UK
J Child Psychol Psychiatry 57:1247-1257. 2016..This study sought to delineate the impact of varying NVIQ criteria on prevalence, clinical presentation and functional impact of language disorder in the first UK population study of language impairment at school entry...
- Preschoolers with autism show greater impairment in receptive compared with expressive language abilitiesKristelle Hudry
Centre for Research in Autism and Education, Department of Psychology and Human Development, Institute of Education, London, UK
Int J Lang Commun Disord 45:681-90. 2010..However, the relative degree of delay or impairment in each of these sub-domains may also be atypical and remains less well-understood...
- Overgeneral autobiographical memory in women: association with childhood abuse and history of depression in a community sampleAzza Aglan
Division of Clinical Psychology, University of Manchester, UK
Br J Clin Psychol 49:359-72. 2010..No previous study has examined their joint association with overgeneral memory in a community sample, nor examined whether the associations are with both juvenile- and adult-onset depression...
- Latent mixture models for multivariate and longitudinal outcomesAndrew Pickles
Biostatistics, Health Methodology Research Group, University of Manchester, University Place, Oxford Road, Manchester, M13 9PL, UK
Stat Methods Med Res 19:271-89. 2010..We review methods based on discrete random effects distributions and mixture models for application in this field...
- The relationship between DSM-IV oppositional defiant disorder and conduct disorder: findings from the Great Smoky Mountains StudyRichard Rowe
Department of Child and Adolescent Psychiatry, Institute of Psychiatry, London, UK
J Child Psychol Psychiatry 43:365-73. 2002..We examine models of the relationship between oppositional defiant disorder (ODD) and conduct disorder (CD) in a community sample. Particular attention is paid to the generalisability of findings based on clinic-referred boys...
- Dimensions of respiratory symptoms in preschool children: population-based birth cohort studyJaclyn A Smith
1Respiratory Research Group, University of Manchester, Manchester M23 9LT, UK
Am J Respir Crit Care Med 177:1358-63. 2008..However, such collections or components of overall symptomatology need to be valid, and their relationship established with the known risk factors and physiologic measures...
- Linkage analysis of cross-sectional and longitudinally derived phenotypic measures to identify loci influencing blood pressureNeil Shephard
ARC Epidemiology Unit, University of Manchester, Manchester, United Kingdom
BMC Genet 4:S26. 2003....
- Prenatal anxiety, maternal stroking in infancy, and symptoms of emotional and behavioral disorders at 3.5 yearsAndrew Pickles
Biostatistics Department, Institute of Psychiatry, Psychology and Neuroscience, King s College, London, UK
Eur Child Adolesc Psychiatry . 2016..They indicate that there are long-term effects of early maternal stroking, modifying associations between prenatal anxiety and child emotional and behavioral symptoms...
- Dual Cognitive and Biological Correlates of Anxiety in Autism Spectrum DisordersMatthew J Hollocks
Department of Child and Adolescent Psychiatry, Institute of Psychiatry, Psychology and Neuroscience, King s College London, London, UK
J Autism Dev Disord 46:3295-307. 2016..Structural equation modelling was used to reveal that that both attentional biases and physiological responsiveness were significant, but unrelated, predictors of anxiety in ASD. ..
- Assessing the association of early life antibiotic prescription with asthma exacerbations, impaired antiviral immunity, and genetic variants in 17q21: a population-based birth cohort studyAida Semic-Jusufagic
Centre for Respiratory Medicine and Allergy, Institute of Inflammation and Repair, University of Manchester and University Hospital of South Manchester, Manchester, UK
Lancet Respir Med 2:621-30. 2014....
- Longitudinal trajectories of peer relations in children with specific language impairmentPearl L H Mok
The University of Manchester, Manchester, UK
J Child Psychol Psychiatry 55:516-27. 2014..Peer relations is a vulnerable area of functioning in children with specific language impairment (SLI), but little is known about the developmental trajectories of individuals...
- Joint modeling of parentally reported and physician-confirmed wheeze identifies children with persistent troublesome wheezingDanielle C M Belgrave
Centre for Respiratory Medicine and Allergy, Institute of Inflammation and Repair, University of Manchester, United Kingdom
J Allergy Clin Immunol 132:575-583.e12. 2013..Previous studies have suggested the presence of different childhood wheeze phenotypes through statistical modeling based on parentally reported wheezing...
- Psychopathology in children before and after surgery for extratemporal lobe epilepsyM Chiara Colonnelli
Neuroscience Department, UCL Institute of Child Health and Great Ormond Street Hospital for Children NHS Foundation Trust, London, UK
Dev Med Child Neurol 54:521-6. 2012..To establish the rates and types of psychiatric disorder in children before and after surgery for extratemporal epilepsy. Relationships between psychiatric morbidity and demographic/clinical variables were examined...
- Institutional care: associations between overactivity and lack of selectivity in social relationshipsPenny Roy
Department of Language and Communication Science, City University, London, UK
J Child Psychol Psychiatry 45:866-73. 2004....
- Prevalence of disorders of the autism spectrum in a population cohort of children in South Thames: the Special Needs and Autism Project (SNAP)Gillian Baird
Newcomen Centre, Guy s and St Thomas NHS Foundation Trust, London, UK
Lancet 368:210-5. 2006..Recent reports have suggested that the prevalence of autism and related spectrum disorders (ASDs) is substantially higher than previously recognised. We sought to quantify prevalence of ASDs in children in South Thames, UK...
- A flexible model for multivariate interval-censored survival times with complex correlation structureMilena Falcaro
Biostatistics Group, Division of Epidemiology and Health Sciences, The University of Manchester, UK
Stat Med 26:663-80. 2007..The proposed model allows estimation of the genetic and environmental effects that are shared by both of these risk behaviours as well as those that are specific...
- Early adult outcomes of adolescents who deliberately poisoned themselvesRichard Harrington
Royal Manchester Children s Hospital, Manchester, UK
J Am Acad Child Adolesc Psychiatry 45:337-45. 2006..To describe the early adult psychopathological and social outcomes of adolescents who deliberately poisoned themselves...
- Estimating intervention effects in a complex multi-level smoking prevention studyMilena Falcaro
Biostatistics Group, School of Community Based Medicine, University of Manchester, UK
Int J Environ Res Public Health 6:463-77. 2009....
- Attention training for infants at familial risk of ADHD (INTERSTAARS): study protocol for a randomised controlled trialAMY GOODWIN
Department of Child and Adolescent Psychiatry, Institute of Psychiatry, Psychology and Neuroscience IoPPN, King s College London, London, UK
Trials 17:608. 2016..The aim of INTERSTAARS is to train early executive skills, thereby increasing resilience and reducing later ADHD symptoms and associated impairment...
- Depression: an exploratory parallel-group randomised controlled trial of Antenatal guided self help for WomeN (DAWN): study protocol for a randomised controlled trialKylee Trevillion
Institute of Psychiatry, Psychology and Neuroscience, King s College London, London, UK
Trials 17:503. 2016..International guidelines recommend a stepped care approach starting with Guided Self Help, and the aim of this exploratory trial is to investigate Guided Self Help modified for pregnancy...
- Evaluation and validation of social and psychological markers in randomised trials of complex interventions in mental health: a methodological research programmeGraham Dunn
Centre for Biostatistics, Institute of Population Health, University of Manchester and Manchester Academic Health Science Centre, Manchester, UK
Health Technol Assess 19:1-115, v-vi. 2015....
- Annual Research Review: Threats to the validity of child psychiatry and psychologyMichael Rutter
Institute of Psychiatry, Psychology and Neuroscience, Kings College London, London, UK
J Child Psychol Psychiatry 57:398-416. 2016..Suggestions have been made that many claims concern false-positive findings in the field of child psychology and psychiatry...
- Investigation of a functional quinine oxidoreductase (NQO2) polymorphism and cognitive declineAntony Payton
Centre for Integrated Genomic Medical Research, Stopford Building, University of Manchester, Oxford Road, Manchester M13 9PT, UK
Neurobiol Aging 31:351-2. 2010..We observed a nominal significant association between this polymorphism and the trajectory of delayed memory recall over time (p=0.029). No other associations were seen with the decline of other cognitive abilities...
- Seemingly minor changes to a questionnaire can make a big difference to mean scores: a cautionary taleRobert Goodman
King s College London, Institute of Psychiatry, London, UK
Soc Psychiatry Psychiatr Epidemiol 42:322-7. 2007..It is not unusual for researchers to make apparently minor modifications to existing instruments without checking if this alters psychometric properties...
- Predictors of antisocial personality. Continuities from childhood to adult lifeEmily Simonoff
Department of Child and Adolescent Psychiatry, Guy s, King s and St Thomas Medical School and Institute of Psychiatry, London, UK
Br J Psychiatry 184:118-27. 2004..Antisocial behaviour in adult life has its roots in childhood...
- An association analysis of microsatellite markers across the Prader-Willi/Angelman critical region on chromosome 15 (q11-13) and autism spectrum disorderSarah Curran
MRC Social, Genetic and Developmental Pyschiatry Centre, Institute of Pyschiatry, De Crespigny Park, London SE5 8AF, United Kingdom
Am J Med Genet B Neuropsychiatr Genet 137:25-8. 2005..Further more systematic work in larger samples is required and confirmation that GABRB3 is imprinted is desirable...
- Modelling the contribution of changes in family life to time trends in adolescent conduct problemsStephan Collishaw
MRC Social, Genetic, and Developmental Psychiatry Centre, Institute of Psychiatry, King s College London, UK
Soc Sci Med 65:2576-87. 2007....
- Course and short-term outcomes of separation anxiety disorder in a community sample of twinsDebra L Foley
Human Genetics Department, Virginia Commonwealth University, Richmond 23298 0003, USA
J Am Acad Child Adolesc Psychiatry 43:1107-14. 2004..To assess the course and short-term outcomes associated with separation anxiety disorder (SAD) in a community setting...
- Major depression and associated impairment: same or different genetic and environmental risk factors?Debra L Foley
Virginia Institute for Psychiatric and Behavioral Genetics, Departments of Human Genetics and Psychiatry, Virginia Commonwealth University, USA
Am J Psychiatry 160:2128-33. 2003..Impairment was added as a diagnostic criterion for many psychiatric disorders in DSM-IV. Does the addition of impairment influence only prevalence rates, or does it also introduce new etiological factors into psychiatric diagnoses?..
- Juvenile- versus adult-onset depression: multiple differences imply different pathwaysJonathan Hill
Department of Psychiatry, University of Liverpool, UK
Psychol Med 34:1483-93. 2004..These include age of onset, presence of co-morbid disorders, and history of childhood sexual abuse. This study examined these factors in the context of the contrast between onset of depression in young women before and after age 16...
- The relationship between separation anxiety and impairmentDebra L Foley
Virginia Institute for Psychiatric and Behavioral Genetics, Medical College of Virginia Commonwealth University, USA
J Anxiety Disord 22:635-41. 2008..The results indicate that impairment may index current treatment need but symptom levels provide the best information about severity and prognosis...
- Using the autism diagnostic interview--revised to increase phenotypic homogeneity in genetic studies of autismVanessa Hus
University of Michigan Autism and Communication Disorders Center, Ann Arbor, Michigan, USA
Biol Psychiatry 61:438-48. 2007..Group differences in age, gender, IQ, and measures of autism severity are examined as related to Autism Diagnostic Interview-Revised (ADI-R) domains previously used for subsetting or Quantitative Trait Analysis (QTL)...