David I Phillips

Summary

Affiliation: University of Southampton
Country: UK

Publications

  1. ncbi request reprint Air pollution in early life and adult mortality from chronic rheumatic heart disease
    David I W Phillips
    MRC Lifecourse Epidemiology Unit, Southampton General Hospital, Southampton, UK
    Int J Epidemiol . 2016
  2. ncbi request reprint Elevated plasma cortisol concentrations: a link between low birth weight and the insulin resistance syndrome?
    D I Phillips
    Medical Research Council Environmental Epidemiology Unit, University of Southampton, United Kingdom
    J Clin Endocrinol Metab 83:757-60. 1998
  3. ncbi request reprint Fetal and infant growth and glucose tolerance in the Hertfordshire Cohort Study: a study of men and women born between 1931 and 1939
    David I W Phillips
    Medical Research Ccouncil Epidemiology Resource Centre, University of Southampton, Southampton General Hospital, Tremona Rd, Southampton, SO16 6YD, U K
    Diabetes 54:S145-50. 2005
  4. pmc Fetal programming of autonomic and HPA function: do people who were small babies have enhanced stress responses?
    David I W Phillips
    Developmental Origins of Health and Disease Division University of Southampton, MRC Mailpoint 95, Southampton General Hospital, Tremona Road, Southampton SO16 6YD, UK
    J Physiol 572:45-50. 2006
  5. ncbi request reprint Maternal body composition, offspring blood pressure and the hypothalamic-pituitary-adrenal axis
    David I W Phillips
    MRC Environmental Epidemiology Unit, University of Southampton, Southampton General Hospital, Southampton, UK
    Paediatr Perinat Epidemiol 19:294-302. 2005
  6. ncbi request reprint Birth weight, stress, and the metabolic syndrome in adult life
    David I W Phillips
    Developmental Origins of Health and Disease Division, University of Southampton, Level F, Southampton General Hospital, Tremona Road, Southampton SO16 6YD, UK
    Ann N Y Acad Sci 1083:28-36. 2006
  7. ncbi request reprint External influences on the fetus and their long-term consequences
    D I W Phillips
    MRC Resource Centre, Southampton General Hospital, Southampton, UK
    Lupus 15:794-800. 2006
  8. doi request reprint Association of adult height and leg length with fasting plasma cortisol concentrations: evidence for an effect of normal variation in adrenocortical activity on growth
    D I W Phillips
    MRC Epidemiology Resource Centre, Mpt 95, Southampton General Hospital, Southampton, United Kingdom
    Am J Hum Biol 20:712-5. 2008
  9. ncbi request reprint Programming of the stress response: a fundamental mechanism underlying the long-term effects of the fetal environment?
    D I W Phillips
    MRC Resource Centre, Southampton General Hospital, University of Southampton, Southampton, UK
    J Intern Med 261:453-60. 2007
  10. ncbi request reprint Birth weight and the future development of diabetes. A review of the evidence
    D I Phillips
    Medical Research Council Metabolic Programming Group, Southampton General Hospital, U K
    Diabetes Care 21:B150-5. 1998

Research Grants

Collaborators

Detail Information

Publications56

  1. ncbi request reprint Air pollution in early life and adult mortality from chronic rheumatic heart disease
    David I W Phillips
    MRC Lifecourse Epidemiology Unit, Southampton General Hospital, Southampton, UK
    Int J Epidemiol . 2016
    ..They raised the possibility that early air pollution, which is known to be strongly linked with chest infection during infancy, may predispose to RHD...
  2. ncbi request reprint Elevated plasma cortisol concentrations: a link between low birth weight and the insulin resistance syndrome?
    D I Phillips
    Medical Research Council Environmental Epidemiology Unit, University of Southampton, United Kingdom
    J Clin Endocrinol Metab 83:757-60. 1998
    ..Moreover, this study provides the first evidence that intrauterine programming of the HPAA may be a mechanism underlying the association between low birth weight and the insulin resistance syndrome in adult life...
  3. ncbi request reprint Fetal and infant growth and glucose tolerance in the Hertfordshire Cohort Study: a study of men and women born between 1931 and 1939
    David I W Phillips
    Medical Research Ccouncil Epidemiology Resource Centre, University of Southampton, Southampton General Hospital, Tremona Rd, Southampton, SO16 6YD, U K
    Diabetes 54:S145-50. 2005
    ....
  4. pmc Fetal programming of autonomic and HPA function: do people who were small babies have enhanced stress responses?
    David I W Phillips
    Developmental Origins of Health and Disease Division University of Southampton, MRC Mailpoint 95, Southampton General Hospital, Tremona Road, Southampton SO16 6YD, UK
    J Physiol 572:45-50. 2006
    ..Thus the combination of enhanced stress susceptibility and the psychosocial stressors to which people are exposed may be an important component of the disease risk in human populations...
  5. ncbi request reprint Maternal body composition, offspring blood pressure and the hypothalamic-pituitary-adrenal axis
    David I W Phillips
    MRC Environmental Epidemiology Unit, University of Southampton, Southampton General Hospital, Southampton, UK
    Paediatr Perinat Epidemiol 19:294-302. 2005
    ..These findings suggest that maternal truncal obesity rather than thinness is associated with raised blood pressure in the offspring, and that this link may be mediated by increased cortisol secretion...
  6. ncbi request reprint Birth weight, stress, and the metabolic syndrome in adult life
    David I W Phillips
    Developmental Origins of Health and Disease Division, University of Southampton, Level F, Southampton General Hospital, Tremona Road, Southampton SO16 6YD, UK
    Ann N Y Acad Sci 1083:28-36. 2006
    ....
  7. ncbi request reprint External influences on the fetus and their long-term consequences
    D I W Phillips
    MRC Resource Centre, Southampton General Hospital, Southampton, UK
    Lupus 15:794-800. 2006
    ..The corresponding human evidence, though preliminary, suggests that birth weight or other markers of the early environment are associated with a range of autoimmune diseases...
  8. doi request reprint Association of adult height and leg length with fasting plasma cortisol concentrations: evidence for an effect of normal variation in adrenocortical activity on growth
    D I W Phillips
    MRC Epidemiology Resource Centre, Mpt 95, Southampton General Hospital, Southampton, United Kingdom
    Am J Hum Biol 20:712-5. 2008
    ..They also raise the possibility that the HPA axis may be involved in mediating resource allocation decisions and trade-offs during development perhaps by limiting physical growth to enable other competing processes...
  9. ncbi request reprint Programming of the stress response: a fundamental mechanism underlying the long-term effects of the fetal environment?
    D I W Phillips
    MRC Resource Centre, Southampton General Hospital, University of Southampton, Southampton, UK
    J Intern Med 261:453-60. 2007
    ..This has biological advantages if the actual adult environment turns out to be appropriate for the phenotype. However, ill health may occur if the phenotype is not well matched to the actual environment encountered in adult life...
  10. ncbi request reprint Birth weight and the future development of diabetes. A review of the evidence
    D I Phillips
    Medical Research Council Metabolic Programming Group, Southampton General Hospital, U K
    Diabetes Care 21:B150-5. 1998
    ..These hormonal alterations may contribute to the predisposition to diabetes and the metabolic syndrome in people who were small at birth...
  11. ncbi request reprint Size at birth and plasma leptin concentrations in adult life
    D I Phillips
    MRC Environmental Epidemiology Unit, University of Southampton, Southampton General Hospital, Southampton, UK
    Int J Obes Relat Metab Disord 23:1025-9. 1999
    ..To determine whether low birthweight is associated with higher plasma leptin concentrations in adult life and whether leptin contributes to the metabolic alterations in adults that are associated with reduced foetal growth...
  12. ncbi request reprint Low birth weight predicts elevated plasma cortisol concentrations in adults from 3 populations
    D I Phillips
    Medical Research Council Environmental Epidemiology Unit, University of Southampton, UK
    Hypertension 35:1301-6. 2000
    ..These results show that low birth weight is associated with raised fasting plasma cortisol concentrations. Increased activity of the hypothalamic-pituitary-adrenal axis may link low birth weight with raised blood pressure in adult life...
  13. ncbi request reprint Fetal growth and the fetal origins hypothesis in twins--problems and perspectives
    D I Phillips
    MRC Unit University of Southampton, Southampton General Hospital, UK
    Twin Res 4:327-31. 2001
    ..While, these findings may reflect methodological limitations, it is also argued that they arise as a consequence of the substantially different biology of fetal growth in twins...
  14. ncbi request reprint Is birthweight associated with thyroid autoimmunity? A study in twins
    David I W Phillips
    MRC Unit, Southampton General Hospital, Southampton, United Kingdom
    Thyroid 12:377-80. 2002
    ..01). Our results suggest that both heritable and early environmental components contribute to the susceptibility to thyroid autoimmunity...
  15. ncbi request reprint Birth weight, weight at 1 y of age, and body composition in older men: findings from the Hertfordshire Cohort Study
    Avan Aihie Sayer
    Medical Research Council Environmental Epidemiology Unit, University of Southampton, Southamption, United Kingdom
    Am J Clin Nutr 80:199-203. 2004
    ..However, body mass index also reflects fat-free mass, and few studies have examined the relation between size in early life and direct measures of body composition in older people...
  16. ncbi request reprint Fetal programming of body composition: relation between birth weight and body composition measured with dual-energy X-ray absorptiometry and anthropometric methods in older Englishmen
    Osama A Kensara
    Institute of Human Nutrition, University of Southampton, Southampton General Hospital, Southampton, United Kingdom
    Am J Clin Nutr 82:980-7. 2005
    ..Most published data are based on simple anthropometric measures, which incompletely describe body composition...
  17. pmc Prenatal Undernutrition and Autonomic Function in Adulthood
    Susanne R de Rooij
    Department of Clinical Epidemiology de Rooij, Roseboom, Biostatistics and Bioinformatics, Academic Medical Center at the University of Amsterdam, Amsterdam, the Netherlands Centre for Cardiovascular Imaging Jones, UCL Institute of Cardiovascular Science, London, UK MRC Lifecourse Epidemiology Unit Phillips, Osmond, University of Southampton, Southampton, UK Department of Systems Physiology Karemaker, Heart Failure Research Center, Academic Medical Center at the University of Amsterdam, Amsterdam, the Netherlands and Department of Obstetrics and Gynaecology Roseboom, Painter, Academic Medical Center at the University of Amsterdam, Amsterdam, The Netherlands
    Psychosom Med 78:991-997. 2016
    ..In the present study, we tested the hypothesis that prenatal undernutrition induces alterations in the autonomic nervous system, which may increase the risk of developing heart disease...
  18. ncbi request reprint Size at birth and motor activity during stress in children aged 7 to 9 years
    Wolff Schlotz
    Medical Research Council Epidemiology Resource Centre, University of Southampton, Southampton General Hospital, Southampton SO16 6YD, United Kingdom
    Pediatrics 120:e1237-44. 2007
    ..Therefore, we investigated associations between size at birth and motor activity during psychosocial stress...
  19. ncbi request reprint Body size at birth predicts hypothalamic-pituitary-adrenal axis response to psychosocial stress at age 60 to 70 years
    Eero Kajantie
    National Public Health Institute, Department of Health Promotion and Chronic Disease Prevention, Mannerheimintie 166, 00300 Helsinki, Finland
    J Clin Endocrinol Metab 92:4094-100. 2007
    ..Studies in humans and animals have suggested intrauterine programming of hypothalamic-pituitary-adrenal axis (HPAA) function as an important mechanism in linking fetal life conditions with adult disease...
  20. ncbi request reprint Fetal growth and the adrenocortical response to psychological stress
    Alexander Jones
    Medical Research Council, Southampton General Hospital, Tremona Road, Southampton SO16 6YD, United Kingdom
    J Clin Endocrinol Metab 91:1868-71. 2006
    ..The extent to which such prenatal hypothalamic-pituitary-adrenal axis adaptations occur in humans is unknown...
  21. ncbi request reprint Length of gestation and depressive symptoms at age 60 years
    Katri Raikkonen
    Department of Psychology, University of Helsinki, PO Box 9, 00014 University of Helsinki, Finland
    Br J Psychiatry 190:469-74. 2007
    ..A non-optimal foetal environment, reflected in smaller birth size and shorter duration of gestation, is a risk factor for compromised health later in life...
  22. ncbi request reprint Substrate-energy metabolism and metabolic risk factors for cardiovascular disease in relation to fetal growth and adult body composition
    Osama A Kensara
    Institute of Human Nutrition, University of Southampton, Southampton General Hospital, Tremona Road, Southampton SO16 6YD, UK
    Am J Physiol Endocrinol Metab 291:E365-71. 2006
    ..BW was found to be a significant predictor of REE that was independent of adult weight plus height...
  23. ncbi request reprint The effects of the Pro12Ala polymorphism of the peroxisome proliferator-activated receptor-gamma2 gene on glucose/insulin metabolism interact with prenatal exposure to famine
    Susanne R de Rooij
    Academic Medical Centre, Department of Clinical Epidemiology and Biostatistics, Room nr J1B 210 1, Meibergdreef 9, P O Box 22660, 1100 DD, Amsterdam, Netherlands
    Diabetes Care 29:1052-7. 2006
    ..In the present study, we assessed a possible interaction of the peroxisome proliferator-activated receptor (PPAR)-gamma2 Pro12Ala polymorphism with prenatal exposure to famine on glucose and insulin metabolism...
  24. ncbi request reprint Hypothalamic-pituitary-adrenal axis activity in adults who were prenatally exposed to the Dutch famine
    Susanne R de Rooij
    Department of Clinical Epidemiology and Biostatistics, Academic Medical Centre, University of Amsterdam, 1100DD Amsterdam, The Netherlands
    Eur J Endocrinol 155:153-60. 2006
    ..In this study, we tested the hypothesis that prenatal exposure to famine during different periods of gestation is associated with increased activity of the HPA axis...
  25. ncbi request reprint Impaired insulin secretion after prenatal exposure to the Dutch famine
    Susanne R de Rooij
    Department of Clinical Epidemiology and Biostatistics, Academic Medical Centre, University of Amsterdam, The
    Diabetes Care 29:1897-901. 2006
    ..We aimed to determine whether this association is mediated through alterations in insulin secretion, insulin sensitivity, or a combination of both...
  26. ncbi request reprint Associations of body size at birth with late-life cortisol concentrations and glucose tolerance are modified by haplotypes of the glucocorticoid receptor gene
    Anna Rautanen
    Department of Medical Genetics, University of Helsinki, FIN 00014 Helsinki, Finland
    J Clin Endocrinol Metab 91:4544-51. 2006
    ..Small body size at birth is associated with cardiovascular disease and type 2 diabetes in adult life. This link may be in part mediated by early-life programming of the hypothalamic-pituitary-adrenal axis (HPAA) function...
  27. ncbi request reprint Predicting cardiovascular risk factors from plasma cortisol measured during oral glucose tolerance tests
    Rebecca M Reynolds
    Medical Research Council Environmental Epidemiology Unit, University of Southampton, Southampton, UK
    Metabolism 52:524-7. 2003
    ..However, the altered HPA response to feeding does not appear to be primarily responsible for HPA activation in subjects with the metabolic syndrome...
  28. ncbi request reprint Stress responsiveness in adult life: influence of mother's diet in late pregnancy
    Rebecca M Reynolds
    Endocrinology Unit, University of Edinburgh, Queen s Medical Research Institute, Edinburgh, UK
    J Clin Endocrinol Metab 92:2208-10. 2007
    ..Because raised fasting cortisol concentrations probably reflect a greater response to the stress of fasting and venesection, we suspected that this diet may have led to increased stress responsiveness in the adult offspring...
  29. ncbi request reprint Size at birth and autonomic function during psychological stress
    Alexander Jones
    Medical Research Council Epidemiology Resource Centre, University of Southampton, Southampton, United Kingdom
    Hypertension 49:548-55. 2007
    ..We also provide the first human evidence of a relationship between size at birth and baroreflex function...
  30. ncbi request reprint Cortisol responses to psychological stress in adults after prenatal exposure to the Dutch famine
    Susanne R de Rooij
    Department of Clinical Epidemiology and Biostatistics, Academic Medical Centre, University of Amsterdam, Meibergdreef 9, 1100 DD Amsterdam, The Netherlands
    Psychoneuroendocrinology 31:1257-65. 2006
    ..However, the stress protocol we have used may have been unsuccessful in inducing a strong enough HPA axis activation to be able to detect famine related differences...
  31. ncbi request reprint Specific associations of insulin resistance with impaired health-related quality of life in the Hertfordshire Cohort Study
    Wolff Schlotz
    MRC Epidemiology Resource Centre, University of Southampton, Southampton General Hospital, Southampton, SO16 6YD, UK
    Qual Life Res 16:429-36. 2007
    ..The results indicate that insulin resistance is associated with poor HRQoL in domains of physical health, but not in domains of mental health...
  32. ncbi request reprint Spontaneous hypothyroidism in adult women is predicted by small body size at birth and during childhood
    Eero Kajantie
    National Public Health Institute, Department of Epidemiology and Health Promotion, Mannerheimintie 166, 00300 Helsinki, Finland
    J Clin Endocrinol Metab 91:4953-6. 2006
    ..The relationships of early growth with coronary heart disease and type 2 diabetes have received considerable attention. It is not known whether fetal or childhood growth is linked with autoimmune disorders...
  33. ncbi request reprint Replication of IGF2-INS-TH*5 haplotype effect on obesity in older men and study of related phenotypes
    Santiago Rodriguez
    Human Genetics Division, University of Southampton, School of Medicine, Southampton General Hospital, Southampton, UK
    Eur J Hum Genet 14:109-16. 2006
    ..Our results, taken together with other data on IGFII levels and TH activity, point to the importance of (*)5 as an integrated polygenic haplotype relevant to obesity and insulin response to glucose in men...
  34. ncbi request reprint Maternal consumption of a high-meat, low-carbohydrate diet in late pregnancy: relation to adult cortisol concentrations in the offspring
    Kirsten Herrick
    Medical Research Council Environmental Epidemiology Unit, University of Southampton, Southampton General Hospital, Southampton SO16 6YD, United Kingdom
    J Clin Endocrinol Metab 88:3554-60. 2003
    ....
  35. ncbi request reprint Lutein and zeaxanthin status and risk of age-related macular degeneration
    Catharine R Gale
    Medical Research Council Environmental Epidemiology Unit, University of Southampton, Southampton General Hospital, Southampton, United Kingdom
    Invest Ophthalmol Vis Sci 44:2461-5. 2003
    ..To investigate the relation between plasma concentrations of lutein and zeaxanthin and age-related macular degeneration in a group of elderly men and women...
  36. pmc Cortisol and the metabolic syndrome in South Asians
    Alexandra M V Ward
    MRC Environmental Epidemiology Unit and Regional Endocrine Laboratory, Southampton General Hospital, UK
    Clin Endocrinol (Oxf) 58:500-5. 2003
    ..South Asians have high rates of cardiovascular disease and its risk factors. We have investigated the relationships between HPAA activity, adiposity and the metabolic syndrome in a South Asian population...
  37. ncbi request reprint Serum insulin-like growth factor (IGF)-I and IGF-binding protein-1 in elderly people: relationships with cardiovascular risk factors, body composition, size at birth, and childhood growth
    Eero Kajantie
    Hospital for Children and Adolescents, Helsinki University Central Hospital, 00029 HUS, Helsinki, Finland
    J Clin Endocrinol Metab 88:1059-65. 2003
    ..Prospective studies should address whether this group is susceptible to type 2 diabetes, coronary heart disease, and osteoporosis...
  38. ncbi request reprint Relation between size at birth and risk of age-related macular degeneration
    Nigel F Hall
    Medical Research Council Environmental Epidemiology Unit, University of Southampton, Southampton General Hospital, United Kingdom
    Invest Ophthalmol Vis Sci 43:3641-5. 2002
    ..To determine whether poor fetal growth, as determined by size at birth, is associated with increased risk of age-related macular degeneration...
  39. ncbi request reprint The influence of maternal BMI and age in twin pregnancies on insulin resistance in the offspring
    Ruth J F Loos
    Center for Human Genetics, Faculty of Medicine, Katholieke Universiteit Leuven, Belgium
    Diabetes Care 25:2191-6. 2002
    ..We have carried out a twin study to distinguish among maternal influences, which affect both twins; fetoplacental influences, which are unique to each twin; and the genetic factors that may underlie this association...
  40. ncbi request reprint Null mutation in human ciliary neurotrophic factor gene confers higher body mass index in males
    Sandra D O'Dell
    Division of Human Genetics, University of Southampton School of Medicine, Duthie Building MP 808, Southampton General Hospital, Tremona Road, Southampton S016 6YD, UK
    Eur J Hum Genet 10:749-52. 2002
    ..03, 2 df) and 3 kg/m(2) greater BMI (P=0.02, 2 df). There was no effect in women. The CNTF G>A null mutation therefore confers a moderate effect on obesity in males of A/A genotype, who represent 1% of the general population...
  41. ncbi request reprint Size at birth, gestational age and cortisol secretion in adult life: foetal programming of both hyper- and hypocortisolism?
    Eero Kajantie
    The Hospital for Children and Adolescents, Helsinki University Central Hospital, Finland
    Clin Endocrinol (Oxf) 57:635-41. 2002
    ..We set out to study reasons for this discrepancy by examining the relationship between adult HPA axis function and birthweight and body proportions at birth in a group of elderly subjects with detailed birth records...
  42. ncbi request reprint Increased glucocorticoid receptor expression in human skeletal muscle cells may contribute to the pathogenesis of the metabolic syndrome
    Christopher B Whorwood
    Endocrine and Metabolism Unit, University Department of Medicine, University of Portsmouth, Portsmouth, UK
    Diabetes 51:1066-75. 2002
    ....
  43. ncbi request reprint Birthsize, gestational age and adrenal function in adult life: studies of dexamethasone suppression and ACTH1-24 stimulation
    Eero Kajantie
    National Public Health Institute, 00300 Helsinki, Finland
    Eur J Endocrinol 149:569-75. 2003
    ..We have now extended these findings by examining the relationship between birthweight, gestational age and tests of adrenal suppression and stimulation...
  44. ncbi request reprint Size at birth, the metabolic syndrome and 24-h salivary cortisol profile
    Eero Kajantie
    National Public Health Institute, Helsinki, Finland
    Clin Endocrinol (Oxf) 60:201-7. 2004
    ..Our aim was to assess whether HPAA activity in everyday living circumstances is related to the metabolic syndrome and size at birth...
  45. ncbi request reprint Type 2 diabetes, muscle strength, and impaired physical function: the tip of the iceberg?
    Avan Aihie Sayer
    Medical Research Council Epidemiology Resource Centre, University of Southampton, Southampton, UK
    Diabetes Care 28:2541-2. 2005
  46. ncbi request reprint The effects of sex and hormonal status on the physiological response to acute psychosocial stress
    Eero Kajantie
    Department of Epidemiology and Health Promotion, The National Public Health Institute, Mannerheimintie 166, 00300 Helsinki, Finland
    Psychoneuroendocrinology 31:151-78. 2006
    ..Studying this hypothesis may have a fundamental impact on our understanding about how adult health is set during early life and how adult disease could be prevented in men and women...
  47. ncbi request reprint Size at birth as a predictor of mortality in adulthood: a follow-up of 350 000 person-years
    Eero Kajantie
    National Public Health Institute, Helsinki, Finland
    Int J Epidemiol 34:655-63. 2005
    ..Our aim was to study the relationship between small size at birth and all-cause and non-cardiovascular mortality, which has been poorly documented...
  48. ncbi request reprint Is there a gender difference in the associations of birthweight and adult hypothalamic-pituitary-adrenal axis activity?
    Rebecca M Reynolds
    Endocrinology Unit, School of Molecular and Clinical Medicine, University of Edinburgh, Western General Hospital, Edinburgh EH4 2XU, UK
    Eur J Endocrinol 152:249-53. 2005
    ..In animal models females are more sensitive than males to HPA axis programming, but whether gender influences susceptibility in humans is unknown...
  49. ncbi request reprint Fetal programming of the neuroendocrine response to stress: links between low birth weight and the metabolic syndrome
    David I W Phillips
    Medical Research Council, Southampton General Hospital, Southampton, UK
    Endocr Res 30:819-26. 2004
    ....
  50. ncbi request reprint Size at birth and cardiovascular responses to psychological stressors: evidence for prenatal programming in women
    Alexandra M V Ward
    MRC Environmental Epidemiology Unit, University of Southampton, Southampton General Hospital, UK
    J Hypertens 22:2295-301. 2004
    ..There is some evidence to suggest that exaggerated blood pressure responses to psychological stressors are a forerunner of sustained hypertension...
  51. ncbi request reprint Late life metabolic syndrome, early growth, and common polymorphism in the growth hormone and placental lactogen gene cluster
    Ian N M Day
    Human Genetics Division, Duthie Building Mp808, Tremona Road, School of Medicine, Southampton University Hospital, Southampton, United Kingdom SO16 6YD
    J Clin Endocrinol Metab 89:5569-76. 2004
    ..GH-CSH genotype adds substantially to, but does not account for, the associations between low body weight, at birth and in infancy, and the metabolic syndrome...
  52. ncbi request reprint Central hypothalamic-pituitary-adrenal activity and the metabolic syndrome: Studies using the corticotrophin-releasing hormone test
    Alexandra M V Ward
    MRC Environmental Epidemiology Unit, University of Southampton, Southampton General Hospital, Southhampton, UK
    Metabolism 53:720-6. 2004
    ..We therefore found no evidence to suggest that exaggerated pituitary responsiveness or increased central drive to the pituitary, as determined by CRH testing, plays a part in the development of the metabolic syndrome...
  53. ncbi request reprint Fetal programming of the hypothalamic-pituitary-adrenal (HPA) axis: low birth weight and central HPA regulation
    Alexandra M V Ward
    Medical Research Council Environmental Epidemiology Unit, Southampton General Hospital, Southampton, SO16 6YD, United Kingdom
    J Clin Endocrinol Metab 89:1227-33. 2004
    ..Although these findings do not explain the HPA abnormalities associated with LBW in previous studies, they provide further evidence of dysregulation of the HPA axis in people who were small at birth...
  54. ncbi request reprint Heart-rate and blood-pressure variability during psychophysiological tasks involving speech: influence of respiration
    Alessandro Beda
    Biomedical Engineering Programme COPPE, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil
    Psychophysiology 44:767-78. 2007
    ..Furthermore, a number of subjects with long respiratory period at rest were identified, whose presence in the sample can bias the estimation of baseline rest values...
  55. ncbi request reprint Insulin-like growth factor-I genotype and birthweight
    Ian N M Day
    Lancet 360:945; author reply 945-6. 2002
  56. ncbi request reprint Prevalence and functionality of paucimorphic and private MC4R mutations in a large, unselected European British population, scanned by meltMADGE
    Khalid K Alharbi
    Human Genetics Division, School of Medicine, University of Southampton, Southampton General Hospital, Southampton, United Kingdom
    Hum Mutat 28:294-302. 2007
    ....

Research Grants1

  1. PROGRAMMING GLUCOCORTICOID SECRETION DURING FETAL LIFE
    David Phillips; Fiscal Year: 2003
    ..g. obesity reduction). ..