D I Phillips

Summary

Affiliation: University of Southampton
Country: UK

Publications

  1. ncbi request reprint Fetal growth and programming of the hypothalamic-pituitary-adrenal axis
    D I Phillips
    MRC Metabolic Programming Group, Southampton General Hospital, Southampton, UK
    Clin Exp Pharmacol Physiol 28:967-70. 2001
  2. ncbi request reprint Testing the fetal origins hypothesis in twins: the Birmingham twin study
    J Baird
    MRC Environmental Epidemiology Unit, Southampton General Hospital, UK
    Diabetologia 44:33-9. 2001
  3. ncbi request reprint Cortisol clearance and associations with insulin sensitivity, body fat and fatty liver in middle-aged men
    H B Holt
    Endocrinology and Metabolism, DOHaD Division, University of Southampton, Southampton, UK
    Diabetologia 50:1024-32. 2007
  4. ncbi request reprint Elevated plasma cortisol concentrations: a link between low birth weight and the insulin resistance syndrome?
    D I Phillips
    Medical Research Council Environmental Epidemiology Unit, University of Southampton, United Kingdom
    J Clin Endocrinol Metab 83:757-60. 1998
  5. ncbi request reprint Fetal growth and the fetal origins hypothesis in twins--problems and perspectives
    D I Phillips
    MRC Unit University of Southampton, Southampton General Hospital, UK
    Twin Res 4:327-31. 2001
  6. ncbi request reprint Regulation of glucocorticoid receptor alpha and beta isoforms and type I 11beta-hydroxysteroid dehydrogenase expression in human skeletal muscle cells: a key role in the pathogenesis of insulin resistance?
    C B Whorwood
    Endocrinology and Metabolism Unit, Southampton General Hospital School of Medicine, Southampton General Hospital, United Kingdom
    J Clin Endocrinol Metab 86:2296-308. 2001
  7. ncbi request reprint Relation between size at birth and age-related cataract
    N F Hall
    MRC Environmental Epidemiology Unit, University of Southampton General Hospital, Tremona Road, Southampton, Hampshire SO16 6YD, UK
    Invest Ophthalmol Vis Sci 42:614-9. 2001
  8. pmc Fetal origins of adult disease: epidemiology and mechanisms
    C D Byrne
    University of Southampton, School of Medicine, Endocrine and Metabolism Unit, South Academic Block, Southampton General Hospital, Southampton SO16 6YD, UK
    J Clin Pathol 53:822-8. 2000
  9. ncbi request reprint Low birth weight predicts elevated plasma cortisol concentrations in adults from 3 populations
    D I Phillips
    Medical Research Council Environmental Epidemiology Unit, University of Southampton, UK
    Hypertension 35:1301-6. 2000
  10. ncbi request reprint Size at birth and plasma leptin concentrations in adult life
    D I Phillips
    MRC Environmental Epidemiology Unit, University of Southampton, Southampton General Hospital, Southampton, UK
    Int J Obes Relat Metab Disord 23:1025-9. 1999

Detail Information

Publications15

  1. ncbi request reprint Fetal growth and programming of the hypothalamic-pituitary-adrenal axis
    D I Phillips
    MRC Metabolic Programming Group, Southampton General Hospital, Southampton, UK
    Clin Exp Pharmacol Physiol 28:967-70. 2001
    ..4. These data raise the possibility that the nature and amplitude of the stress response may be determined by intra-uterine factors...
  2. ncbi request reprint Testing the fetal origins hypothesis in twins: the Birmingham twin study
    J Baird
    MRC Environmental Epidemiology Unit, Southampton General Hospital, UK
    Diabetologia 44:33-9. 2001
    ..We also suggest that shared genetic determinants for fetal growth and adult outcomes are not likely to be prevalent or powerful...
  3. ncbi request reprint Cortisol clearance and associations with insulin sensitivity, body fat and fatty liver in middle-aged men
    H B Holt
    Endocrinology and Metabolism, DOHaD Division, University of Southampton, Southampton, UK
    Diabetologia 50:1024-32. 2007
    ..The regulation of cortisol metabolism in vivo is not well understood. We evaluated the relationship between cortisol metabolism and insulin sensitivity, adjusting for total and regional fat content and for non-alcoholic fatty liver disease...
  4. ncbi request reprint Elevated plasma cortisol concentrations: a link between low birth weight and the insulin resistance syndrome?
    D I Phillips
    Medical Research Council Environmental Epidemiology Unit, University of Southampton, United Kingdom
    J Clin Endocrinol Metab 83:757-60. 1998
    ..Moreover, this study provides the first evidence that intrauterine programming of the HPAA may be a mechanism underlying the association between low birth weight and the insulin resistance syndrome in adult life...
  5. ncbi request reprint Fetal growth and the fetal origins hypothesis in twins--problems and perspectives
    D I Phillips
    MRC Unit University of Southampton, Southampton General Hospital, UK
    Twin Res 4:327-31. 2001
    ..While, these findings may reflect methodological limitations, it is also argued that they arise as a consequence of the substantially different biology of fetal growth in twins...
  6. ncbi request reprint Regulation of glucocorticoid receptor alpha and beta isoforms and type I 11beta-hydroxysteroid dehydrogenase expression in human skeletal muscle cells: a key role in the pathogenesis of insulin resistance?
    C B Whorwood
    Endocrinology and Metabolism Unit, Southampton General Hospital School of Medicine, Southampton General Hospital, United Kingdom
    J Clin Endocrinol Metab 86:2296-308. 2001
    ..Additionally, insulin and insulin-like growth factor I regulation of 11betaHSD1 may represent a novel mechanism that maintains insulin sensitivity in skeletal muscle tissue by diminishing glucocorticoid antagonism of insulin action...
  7. ncbi request reprint Relation between size at birth and age-related cataract
    N F Hall
    MRC Environmental Epidemiology Unit, University of Southampton General Hospital, Tremona Road, Southampton, Hampshire SO16 6YD, UK
    Invest Ophthalmol Vis Sci 42:614-9. 2001
    ..To determine whether poor fetal growth, as determined by size at birth, is associated with an increased risk of age-related cataract...
  8. pmc Fetal origins of adult disease: epidemiology and mechanisms
    C D Byrne
    University of Southampton, School of Medicine, Endocrine and Metabolism Unit, South Academic Block, Southampton General Hospital, Southampton SO16 6YD, UK
    J Clin Pathol 53:822-8. 2000
    ..The purpose of this review is to describe some of the relevant, important, and more recent epidemiological studies, and also to discuss potential mechanisms underpinning the associations...
  9. ncbi request reprint Low birth weight predicts elevated plasma cortisol concentrations in adults from 3 populations
    D I Phillips
    Medical Research Council Environmental Epidemiology Unit, University of Southampton, UK
    Hypertension 35:1301-6. 2000
    ..These results show that low birth weight is associated with raised fasting plasma cortisol concentrations. Increased activity of the hypothalamic-pituitary-adrenal axis may link low birth weight with raised blood pressure in adult life...
  10. ncbi request reprint Size at birth and plasma leptin concentrations in adult life
    D I Phillips
    MRC Environmental Epidemiology Unit, University of Southampton, Southampton General Hospital, Southampton, UK
    Int J Obes Relat Metab Disord 23:1025-9. 1999
    ..To determine whether low birthweight is associated with higher plasma leptin concentrations in adult life and whether leptin contributes to the metabolic alterations in adults that are associated with reduced foetal growth...
  11. ncbi request reprint Reproducibility of the low dose dexamethasone suppression test: comparison between direct plasma and salivary cortisol assays
    R M Reynolds
    Medical Research Council Environmental Epidemiology Unit, University of Southampton, UK
    Clin Endocrinol (Oxf) 49:307-10. 1998
    ..Little is known about the reproducibility of this test, or whether the test can be combined with analysis of salivary cortisol which would offer a significant advantage over plasma in population studies...
  12. ncbi request reprint Birth weight and the future development of diabetes. A review of the evidence
    D I Phillips
    Medical Research Council Metabolic Programming Group, Southampton General Hospital, U K
    Diabetes Care 21:B150-5. 1998
    ..These hormonal alterations may contribute to the predisposition to diabetes and the metabolic syndrome in people who were small at birth...
  13. ncbi request reprint Differential effects of fatness, fitness and physical activity energy expenditure on whole-body, liver and fat insulin sensitivity
    H B Holt
    Endocrinology and Metabolism, DOHaD Division, School of Medicine, University of Southampton, Southampton, UK
    Diabetologia 50:1698-706. 2007
    ..The aim of this study was to determine whether fitness and PAEE are associated with whole-body, liver and fat insulin sensitivity independently of body fat...
  14. ncbi request reprint Plasma antioxidant vitamins and carotenoids and age-related cataract
    C R Gale
    MRC Environmental Epidemiology Unit, University of Southampton, Southampton General Hospital, Southampton, Hants, England
    Ophthalmology 108:1992-8. 2001
    ..CONCLUSIONS: These findings suggest that a diet rich in carotenoids may protect against cataract development, but because they are based on observational data, they need to be confirmed in randomized controlled trials...
  15. ncbi request reprint Non-esterified fatty acid concentrations are independently associated with hepatic steatosis in obese subjects
    H B Holt
    Developmental Origins of Health and Disease Division Endocrinology and Metabolism Unit, Centre Block, Southampton General Hospital, Southampton SO16 6YD, UK
    Diabetologia 49:141-8. 2006
    ..We tested the hypothesis that NEFA concentrations are higher in obese subjects with fatty liver than in obese subjects without fatty liver...