Eva Petermann

Summary

Affiliation: University of Sussex
Country: UK

Publications

  1. pmc Chk1 requirement for high global rates of replication fork progression during normal vertebrate S phase
    Eva Petermann
    Genome Damage and Stability Centre, University of Sussex, Science Park Road, Falmer, Brighton BN1 9RQ, UK
    Mol Cell Biol 26:3319-26. 2006
  2. ncbi Evidence that the ATR/Chk1 pathway maintains normal replication fork progression during unperturbed S phase
    Eva Petermann
    Genome Damage and Stability Centre, University of Sussex, Falmer, Brighton, UK
    Cell Cycle 5:2203-9. 2006
  3. pmc Claspin promotes normal replication fork rates in human cells
    Eva Petermann
    Genome Damage and Stability Centre, University of Sussex, Falmer, Brighton BN1 9RQ, United Kingdom
    Mol Biol Cell 19:2373-8. 2008
  4. pmc ATR-dependent phosphorylation and activation of ATM in response to UV treatment or replication fork stalling
    Thomas Stiff
    Genome Damage and Stability Centre, University of Sussex, Falmer, Brighton, East Sussex, UK
    EMBO J 25:5775-82. 2006
  5. pmc Diminished origin-licensing capacity specifically sensitizes tumor cells to replication stress
    Kristin M Zimmerman
    University of Sussex, Falmer, Brighton BN1 9RQ, United Kingdom
    Mol Cancer Res 11:370-80. 2013
  6. ncbi Measurement of chromosomal DNA single-strand breaks and replication fork progression rates
    Claire Breslin
    Genome Damage and Stability Center, University of Sussex, Brighton, United Kingdom
    Methods Enzymol 409:410-25. 2006
  7. pmc Chk1 regulates the density of active replication origins during the vertebrate S phase
    Apolinar Maya-Mendoza
    Faculty of Life Sciences, University of Manchester, MIB, Manchester, UK
    EMBO J 26:2719-31. 2007
  8. doi DNA repair pathways as targets for cancer therapy
    Thomas Helleday
    Radiation Oncology and Biology, University of Oxford, Old Road Campus Research Building, off Roosevelt Drive, Headington, Oxford, OX3 7DQ, UK
    Nat Rev Cancer 8:193-204. 2008
  9. ncbi Roles of DNA ligase III and XRCC1 in regulating the switch between short patch and long patch BER
    Eva Petermann
    Institut fur Biochemie, Freie Universitat Berlin, Thielallee 63, 14195 Berlin, Federal Republic of Germany
    DNA Repair (Amst) 5:544-55. 2006
  10. ncbi ATP-dependent selection between single nucleotide and long patch base excision repair
    Eva Petermann
    Institut fur Biochemie, Freie Universitat Berlin, Thielallee 63, 14195, Berlin, Germany
    DNA Repair (Amst) 2:1101-14. 2003

Collaborators

Detail Information

Publications10

  1. pmc Chk1 requirement for high global rates of replication fork progression during normal vertebrate S phase
    Eva Petermann
    Genome Damage and Stability Centre, University of Sussex, Science Park Road, Falmer, Brighton BN1 9RQ, UK
    Mol Cell Biol 26:3319-26. 2006
    ....
  2. ncbi Evidence that the ATR/Chk1 pathway maintains normal replication fork progression during unperturbed S phase
    Eva Petermann
    Genome Damage and Stability Centre, University of Sussex, Falmer, Brighton, UK
    Cell Cycle 5:2203-9. 2006
    ..Here we give an overview of how the ATR/Chk1 pathway responds to exogenously blocked replication and then describe evidence for roles of this pathway during replication in an unperturbed S phase...
  3. pmc Claspin promotes normal replication fork rates in human cells
    Eva Petermann
    Genome Damage and Stability Centre, University of Sussex, Falmer, Brighton BN1 9RQ, United Kingdom
    Mol Biol Cell 19:2373-8. 2008
    ..Consistent with this possibility, depletion of Chk1 and Claspin together doubled the percentage of very slow forks, compared with depletion of either protein alone...
  4. pmc ATR-dependent phosphorylation and activation of ATM in response to UV treatment or replication fork stalling
    Thomas Stiff
    Genome Damage and Stability Centre, University of Sussex, Falmer, Brighton, East Sussex, UK
    EMBO J 25:5775-82. 2006
    ..Our findings provide insight into the interplay between the PIKK damage response pathways...
  5. pmc Diminished origin-licensing capacity specifically sensitizes tumor cells to replication stress
    Kristin M Zimmerman
    University of Sussex, Falmer, Brighton BN1 9RQ, United Kingdom
    Mol Cancer Res 11:370-80. 2013
    ..Collectively, these findings suggest that tumor cells may have a reliance on origin-licensing capacity, suggesting that licensing factors could represent a target for drug-based cancer therapy...
  6. ncbi Measurement of chromosomal DNA single-strand breaks and replication fork progression rates
    Claire Breslin
    Genome Damage and Stability Center, University of Sussex, Brighton, United Kingdom
    Methods Enzymol 409:410-25. 2006
    ..We also describe an assay we employ to measure the rate of replication fork progression in mammalian/vertebrate cells in the presence or absence of DNA damage...
  7. pmc Chk1 regulates the density of active replication origins during the vertebrate S phase
    Apolinar Maya-Mendoza
    Faculty of Life Sciences, University of Manchester, MIB, Manchester, UK
    EMBO J 26:2719-31. 2007
    ..The same phenotype is induced in wild-type avian cells when Chk1 or ATM/ATR is inhibited. These observations show that Chk1 regulates replication origin activation and contributes to S-phase progression in somatic vertebrate cells...
  8. doi DNA repair pathways as targets for cancer therapy
    Thomas Helleday
    Radiation Oncology and Biology, University of Oxford, Old Road Campus Research Building, off Roosevelt Drive, Headington, Oxford, OX3 7DQ, UK
    Nat Rev Cancer 8:193-204. 2008
    ....
  9. ncbi Roles of DNA ligase III and XRCC1 in regulating the switch between short patch and long patch BER
    Eva Petermann
    Institut fur Biochemie, Freie Universitat Berlin, Thielallee 63, 14195 Berlin, Federal Republic of Germany
    DNA Repair (Amst) 5:544-55. 2006
    ..Accordingly, lowering the levels of the XRCC1/Lig III complex in HeLa cells using siRNA decreases ligation capacity but enhances Pol beta-dependent DNA synthesis...
  10. ncbi ATP-dependent selection between single nucleotide and long patch base excision repair
    Eva Petermann
    Institut fur Biochemie, Freie Universitat Berlin, Thielallee 63, 14195, Berlin, Germany
    DNA Repair (Amst) 2:1101-14. 2003
    ..It is proposed that long patch BER is required for ATP generation from poly(ADP-ribose) and, therefore, predominant under conditions of ATP shortage...