Affiliation: University of Leicester
- Dried blood spots, pharmacokinetic studies and better medicines for childrenHitesh C Pandya
Department of Infection, Immunity and Inflammation, University of Leicester, Robert Kilpatrick Clinical Sciences Building, Infirmary Square, Leicester, UK
Bioanalysis 3:779-86. 2011..This article discusses the potential for dried blood spot sampling to offer a solution to this issue...
- Facilitating pharmacokinetic studies in children: a new use of dried blood spotsParul Patel
School of Pharmacy, De Montfort University, Leicester, UK
Arch Dis Child 95:484-7. 2010..In this article, we review the DBS technique for performing pharmacokinetic studies and highlight issues that still need to be addressed to establish DBS as a method for performing pharmacokinetic studies in children...
- Essential medicines containing ethanol elevate blood acetaldehyde concentrations in neonatesH C Pandya
Department of Infection, Immunity and Inflammation, University of Leicester, University Road, Leicester, LE1 9HN, UK
Eur J Pediatr 175:841-7. 2016..89) mg/L, 0.21 (range = 0-2.43) mg/L and in control group infants were 0.01 (range = 0-0.14) mg/L. There was no discernible relationship between blood ethanol or acetaldehyde concentrations and time after medication dose...
- Toxic additives in medication for preterm infantsA Whittaker
Department of Infection, Immunity and Inflammation, University of Leicester Robert Kilpatrick Clinical Sciences Building, Leicester Royal Infirmary, Leicester LE2 7LX, UK
Arch Dis Child Fetal Neonatal Ed 94:F236-40. 2009..Little is known about exposure of preterm infants to excipients during routine clinical care...
- Dexamethasone quantification in dried blood spot samples using LC-MS: The potential for application to neonatal pharmacokinetic studiesParul Patel
Leicester School of Pharmacy, De Montfort University, Leicester, LE1 9BH, UK
J Chromatogr B Analyt Technol Biomed Life Sci 878:3277-82. 2010..Requiring only a microvolume (30μl) blood sample for analysis, the developed assay is particularly suited to pharmacokinetic studies involving paediatric populations...
- How does the changing profile of infants who are referred for extracorporeal membrane oxygenation affect their overall respiratory outcome?Caroline S Beardsmore
Department of Infection, Immunity and Inflammation Child Health, University of Leicester, Robert Kilpatrick Clinical Sciences Building, Leicester Royal Infirmary, PO Box 65, Leicester LE2 7LX, United Kingdom
Pediatrics 120:e762-8. 2007....
- Specific antibody deficiency in children with chronic wet coughMichael Teik Chung Lim
Department of Paediatrics, University Hospitals of Leicester, Leicester, UK
Arch Dis Child 97:478-80. 2012..029). The authors conclude that SAD is present in a significant number of children with chronic wet cough. The clinical significance and long-term outcome of SAD warrant further investigation in prospective studies...
- Pneumococcal sepsis: should we look for asplenia?Mohammed Fadel
Children s Intensive Care Unit, Leicester Royal Infirmary, Leicester LE1 5WW, UK
J R Soc Med 97:582-3. 2004