Affiliation: University College London
- Sodium accumulation is associated with disability and a progressive course in multiple sclerosisDavid Paling
NMR Research Unit, Department of Neuroinflammation, Queen Square Multiple Sclerosis Centre, UCL Institute of Neurology, Queen Square, London, WC1N 3BG, UK
Brain 136:2305-17. 2013..Increased total sodium concentration is likely to reflect neuroaxonal pathophysiology leading to clinical progression and increased disability...
- Reduced R2' in multiple sclerosis normal appearing white matter and lesions may reflect decreased myelin and iron contentDavid Paling
NMR Research Unit, Department of Neuroinflammation, UCL Institute of Neurology, Queen Square, London, UK
J Neurol Neurosurg Psychiatry 83:785-92. 2012..R(2)' may detect features of multiple sclerosis (MS) not evident with conventional MRI...
- Energy failure in multiple sclerosis and its investigation using MR techniquesDavid Paling
NMR Research Unit, UCL Institute of Neurology, Queen Square, London, WC1N 3BG, UK
J Neurol 258:2113-27. 2011....
- Cerebral arterial bolus arrival time is prolonged in multiple sclerosis and associated with disabilityDavid Paling
Department of Neuroinflammation, UCL Institute of Neurology, Queen Square MS Centre, London, UK
J Cereb Blood Flow Metab 34:34-42. 2014..Bolus arrival time was longer in patients with greater disability independent of atrophy and T2 lesion load, suggesting alterations in cerebral arterial hemodynamics may be a marker of clinically relevant pathology. ..
- Phenytoin for neuroprotection in patients with acute optic neuritis: a randomised, placebo-controlled, phase 2 trialRhian Raftopoulos
National Hospital for Neurology and Neurosurgery, London, UK University College London Institute of Neurology, London, UK Queen Square Multiple Sclerosis Centre, London, UK
Lancet Neurol 15:259-69. 2016..Inhibition of voltage-gated sodium channels is neuroprotective in preclinical models. In this study we aimed to establish whether sodium-channel inhibition with phenytoin is neuroprotective in patient with acute optic neuritis...