Jane E Norman

Summary

Affiliation: University of Edinburgh
Country: UK

Publications

  1. doi Vaginal progesterone prophylaxis for preterm birth (the OPPTIMUM study): a multicentre, randomised, double-blind trial
    Jane Elizabeth Norman
    Tommy s Centre for Maternal and Fetal Health, MRC Centre for Maternal and Fetal Health, University of Edinburgh, Edinburgh, UK Electronic address
    Lancet 387:2106-16. 2016
  2. pmc Leukocytes are primed in peripheral blood for activation during term and preterm labour
    M Yuan
    Centre for Reproductive Biology, The Queen s Medical Research Centre, University of Edinburgh, Edinburgh EH16 4TY, UK
    Mol Hum Reprod 15:713-24. 2009
  3. pmc Trial protocol OPPTIMUM-- does progesterone prophylaxis for the prevention of preterm labour improve outcome?
    Jane E Norman
    University of Edinburgh MRC Centre for Reproductive Health, The Queen s Medical Research Institute, 47 Little France Crescent, Edinburgh, EH16 4TY, UK
    BMC Pregnancy Childbirth 12:79. 2012
  4. pmc Progestogens to prevent preterm birth in twin pregnancies: an individual participant data meta-analysis of randomized trials
    Ewoud Schuit
    Julius Centre for Health Sciences and Primary Care, University Medical Centre Utrecht, Utrecht, The Netherlands
    BMC Pregnancy Childbirth 12:13. 2012
  5. doi Progesterone for the prevention of preterm birth in twin pregnancy (STOPPIT): a randomised, double-blind, placebo-controlled study and meta-analysis
    Jane E Norman
    Reproductive and Developmental Sciences, University of Edinburgh, Edinburgh, UK
    Lancet 373:2034-40. 2009
  6. pmc The effect of changing patterns of obstetric care in Scotland (1980-2004) on rates of preterm birth and its neonatal consequences: perinatal database study
    Jane E Norman
    University of Edinburgh Centre for Reproductive Biology, Edinburgh, UK
    PLoS Med 6:e1000153. 2009
  7. doi Effect of prolonged in vivo administration of progesterone in pregnancy on myometrial gene expression, peripheral blood leukocyte activation, and circulating steroid hormone levels
    Jane E Norman
    Centre for Reproductive Biology, Queen s Medical Research Centre, University of Edinburgh, Edinburgh, United Kingdom
    Reprod Sci 18:435-46. 2011
  8. doi The consequences of obesity and excess weight gain in pregnancy
    Jane E Norman
    Tommy s Centre for Maternal and Fetal Health, MRC Centre for Reproductive Health, Queen s Medical Research Institute, University of Edinburgh, 47 Little France Crescent, Edinburgh EH16 4TY, UK
    Proc Nutr Soc 70:450-6. 2011
  9. pmc Outcomes of induction of labour in women with previous caesarean delivery: a retrospective cohort study using a population database
    Sarah J Stock
    MRC Centre for Reproductive Health, University of Edinburgh, Edinburgh, United Kingdom
    PLoS ONE 8:e60404. 2013
  10. pmc Effect of metformin on maternal and fetal outcomes in obese pregnant women (EMPOWaR): a randomised, double-blind, placebo-controlled trial
    Carolyn Chiswick
    Tommy s Centre for Maternal and Fetal Health, Medical Research Council MRC Centre for Reproductive Health, Queen s Medical Research Institute, Edinburgh, UK
    Lancet Diabetes Endocrinol 3:778-86. 2015

Collaborators

Detail Information

Publications47

  1. doi Vaginal progesterone prophylaxis for preterm birth (the OPPTIMUM study): a multicentre, randomised, double-blind trial
    Jane Elizabeth Norman
    Tommy s Centre for Maternal and Fetal Health, MRC Centre for Maternal and Fetal Health, University of Edinburgh, Edinburgh, UK Electronic address
    Lancet 387:2106-16. 2016
    ..Progesterone administration has been shown to reduce the risk of preterm birth and neonatal morbidity in women at high risk, but there is uncertainty about longer term effects on the child...
  2. pmc Leukocytes are primed in peripheral blood for activation during term and preterm labour
    M Yuan
    Centre for Reproductive Biology, The Queen s Medical Research Centre, University of Edinburgh, Edinburgh EH16 4TY, UK
    Mol Hum Reprod 15:713-24. 2009
    ..These data may lead to novel therapies and diagnostic tools for the prevention and/or diagnosis of preterm birth...
  3. pmc Trial protocol OPPTIMUM-- does progesterone prophylaxis for the prevention of preterm labour improve outcome?
    Jane E Norman
    University of Edinburgh MRC Centre for Reproductive Health, The Queen s Medical Research Institute, 47 Little France Crescent, Edinburgh, EH16 4TY, UK
    BMC Pregnancy Childbirth 12:79. 2012
    ....
  4. pmc Progestogens to prevent preterm birth in twin pregnancies: an individual participant data meta-analysis of randomized trials
    Ewoud Schuit
    Julius Centre for Health Sciences and Primary Care, University Medical Centre Utrecht, Utrecht, The Netherlands
    BMC Pregnancy Childbirth 12:13. 2012
    ....
  5. doi Progesterone for the prevention of preterm birth in twin pregnancy (STOPPIT): a randomised, double-blind, placebo-controlled study and meta-analysis
    Jane E Norman
    Reproductive and Developmental Sciences, University of Edinburgh, Edinburgh, UK
    Lancet 373:2034-40. 2009
    ..We investigated the use of progesterone for prevention of preterm birth in twin pregnancy...
  6. pmc The effect of changing patterns of obstetric care in Scotland (1980-2004) on rates of preterm birth and its neonatal consequences: perinatal database study
    Jane E Norman
    University of Edinburgh Centre for Reproductive Biology, Edinburgh, UK
    PLoS Med 6:e1000153. 2009
    ..We aimed, in a population-based database of 5 million people, to determine the temporal trends and obstetric antecedents of singleton preterm birth and its associated neonatal mortality and morbidity for the period 1980-2004...
  7. doi Effect of prolonged in vivo administration of progesterone in pregnancy on myometrial gene expression, peripheral blood leukocyte activation, and circulating steroid hormone levels
    Jane E Norman
    Centre for Reproductive Biology, Queen s Medical Research Centre, University of Edinburgh, Edinburgh, United Kingdom
    Reprod Sci 18:435-46. 2011
    ..We aimed to investigate the effects of progesterone on gene expression and function of both myometrium and circulating leukocytes...
  8. doi The consequences of obesity and excess weight gain in pregnancy
    Jane E Norman
    Tommy s Centre for Maternal and Fetal Health, MRC Centre for Reproductive Health, Queen s Medical Research Institute, University of Edinburgh, 47 Little France Crescent, Edinburgh EH16 4TY, UK
    Proc Nutr Soc 70:450-6. 2011
    ..Lastly, we discuss the nature and rationale for possible intervention strategies in obese pregnant women...
  9. pmc Outcomes of induction of labour in women with previous caesarean delivery: a retrospective cohort study using a population database
    Sarah J Stock
    MRC Centre for Reproductive Health, University of Edinburgh, Edinburgh, United Kingdom
    PLoS ONE 8:e60404. 2013
    ..The aim of this study was to describe outcomes of IOL at 39-41 weeks in women with one previous caesarean delivery and to compare outcomes of IOL or planned caesarean delivery to those of expectant management...
  10. pmc Effect of metformin on maternal and fetal outcomes in obese pregnant women (EMPOWaR): a randomised, double-blind, placebo-controlled trial
    Carolyn Chiswick
    Tommy s Centre for Maternal and Fetal Health, Medical Research Council MRC Centre for Reproductive Health, Queen s Medical Research Institute, Edinburgh, UK
    Lancet Diabetes Endocrinol 3:778-86. 2015
    ..We aimed to establish whether the insulin sensitising drug metformin improves maternal and fetal outcomes in obese pregnant women without diabetes...
  11. pmc Maternal obesity during pregnancy and premature mortality from cardiovascular event in adult offspring: follow-up of 1 323 275 person years
    Rebecca M Reynolds
    Endocrinology Unit, BHF University Centre for Cardiovascular Science, University of Edinburgh, Queen s Medical Research Institute, Edinburgh EH14 6TJ, UK
    BMJ 347:f4539. 2013
    ..To determine whether maternal obesity during pregnancy is associated with increased mortality from cardiovascular events in adult offspring...
  12. pmc Health Behaviours during Pregnancy in Women with Very Severe Obesity
    Nor A Mohd-Shukri
    Endocrinology Unit, University BHF Centre for Cardiovascular Science, Queen s Medical Research Institute, University of Edinburgh, Edinburgh EH16 4TJ, UK
    Nutrients 7:8431-43. 2015
    ..These high-risk women represent a group to target for education about health behaviours prior to and during pregnancy...
  13. doi Maternal Obesity During Pregnancy Associates With Premature Mortality and Major Cardiovascular Events in Later Life
    Kuan Ken Lee
    From the Endocrinology Unit, BHF University Centre for Cardiovascular Science K K L, R M R and Tommy s Centre for Fetal and Maternal Health, Medical Research Council Centre for Reproductive Health J E N, R M R, Queen s Medical Research Institute, University of Edinburgh, Edinburgh, United Kingdom and Institute of Applied Health Sciences, University of Aberdeen, Aberdeen, United Kingdom E A R, A J L, Sohinee Bhattacharya, Siladitya Bhattacharya
    Hypertension 66:938-44. 2015
    ..Pregnancy and early postpartum could represent an opportunity for interventions to identify obesity and reduce its adverse consequences...
  14. pmc Ultrasound-guided intrauterine injection of lipopolysaccharide as a novel model of preterm birth in the mouse
    Sara F Rinaldi
    Tommy s Centre for Maternal and Fetal Health at the Medical Research Council Centre for Reproductive Health, University of Edinburgh, Queen s Medical Research Institute, Edinburgh, United Kingdom
    Am J Pathol 185:1201-6. 2015
    ..Ultrasound-guided intrauterine LPS injection is a useful novel model of PTB for future studies and concords with the principles of reduction, replacement, and refinement...
  15. pmc Decidual neutrophil infiltration is not required for preterm birth in a mouse model of infection-induced preterm labor
    Sara F Rinaldi
    Medical Research Council Centre for Reproductive Health, University of Edinburgh, Queen s Medical Research Institute, Edinburgh EH16 4TJ, United Kingdom
    J Immunol 192:2315-25. 2014
    ....
  16. doi Maternal obesity has little effect on the immediate offspring but impacts on the next generation
    Vicky King
    Medical Research Council University of Edinburgh Centre for Reproductive Health, University British Heart Foundation Centre for Cardiovascular Science, University of Edinburgh, The Queen s Medical Research Institute, Edinburgh EH16 4TJ, United Kingdom
    Endocrinology 154:2514-24. 2013
    ..This suggests that the consequences of the current dietary obesity epidemic may also have an impact on the descendants of obese individuals, even when the phenotype of the F1 appears largely unaffected. ..
  17. doi A novel antiinflammatory role for the short-chain fatty acids in human labor
    Chiara Voltolini
    Medical Research Council Human Reproductive Sciences Unit, The Queen s Medical Research Institute, Edinburgh EH16 4TJ, United Kingdom
    Endocrinology 153:395-403. 2012
    ..Suppression of inflammatory pathways by SCFA may be therapeutically beneficial for pregnant women at risk of pathogen-induced preterm delivery...
  18. pmc Prokineticin 1 induces inflammatory response in human myometrium: a potential role in initiating term and preterm parturition
    Marta R Gorowiec
    Medical Research Council Human Reproductive Sciences Unit, The Queen s Medical Research Institute, Edinburgh, United Kingdom
    Am J Pathol 179:2709-19. 2011
    ..We propose that PROK1 is a novel inflammatory mediator that can contribute to the onset of human parturition at term and partially mediate premature onset of inflammatory pathways during bacterial infection...
  19. pmc Outcomes of elective induction of labour compared with expectant management: population based study
    Sarah J Stock
    Tommy s Centre for Maternal and Fetal Health, MRC Centre for Reproductive Health, University of Edinburgh, Queen s Medical Research Institute, UK
    BMJ 344:e2838. 2012
    ..To determine neonatal outcomes (perinatal mortality and special care unit admission) and maternal outcomes (mode of delivery, delivery complications) of elective induction of labour compared with expectant management...
  20. pmc Convergence in insulin resistance between very severely obese and lean women at the end of pregnancy
    Shareen Forbes
    Tommy s Centre for Fetal and Maternal Health, MRC Centre for Reproductive Health, University of Edinburgh, Queen s Medical Research Institute, Edinburgh, UK
    Diabetologia 58:2615-26. 2015
    ..Disrupted intermediary metabolism may contribute to the adverse pregnancy outcomes in women with very severe obesity. Our aim was to study metabolism in such pregnancies...
  21. doi Androgen-Induced Relaxation of Uterine Myocytes Is Mediated by Blockade of Both Ca(2+) Flux and MLC Phosphorylation
    Sofia Makieva
    Medical Research Council MRC Centre for Reproductive Health S M, L J H, S P R, S F R, P B, J E N, The University of Edinburgh, The Queen s Medical Research Institute, Edinburgh EH16 4TJ, United Kingdom Tommy s Centre for Maternal and Fetal Health at the University of Edinburgh S M, L J H, S P R, S F R, J E N, The Queen s Medical Research Institute, Edinburgh EH16 4TJ, United Kingdom MRC Centre for Inflammation Research P T K S, The University of Edinburgh, The Queen s Medical Research Institute, Edinburgh EH16 4TJ, United Kingdom School of Physiology and Pharmacology L J H, University of Bristol, Bristol, BS8 1TD, United Kingdom and Biomolecular Core Facility at The University of Edinburgh P B, The Queen s Medical Research Institute, Edinburgh EH16 4TJ, United Kingdom
    J Clin Endocrinol Metab 101:1055-65. 2016
    ..Uterine quiescence must be maintained until pregnancy reaches term. Premature activation of myometrial contractility leads to preterm labor and delivery...
  22. doi Evaluation of an FFQ to assess total energy and nutrient intakes in severely obese pregnant women
    Nor A Mohd-Shukri
    Endocrinology Unit, University BHF Centre for Cardiovascular Science, University of Edinburgh, The Queen s Medical Research Institute, 47 Little France Crescent, Edinburgh EH16 4TJ, UK
    Public Health Nutr 16:1427-35. 2013
    ..The aim of the present study was to compare nutrient intakes assessed by an FFQ with those obtained from a food diary among severely obese pregnant women...
  23. doi Maternal and neonatal outcomes of successful Kielland's rotational forceps delivery
    Sarah J Stock
    University of Edinburgh MRC Centre for Reproductive Health, Queen s Medical Royal, the Infirmary of Edinburgh, Little France, Edinburgh, UK
    Obstet Gynecol 121:1032-9. 2013
    ..To estimate the rates of early neonatal and maternal complications in a consecutive series of successful Kielland's rotational forceps deliveries...
  24. pmc Novel use of proton magnetic resonance spectroscopy (1HMRS) to non-invasively assess placental metabolism
    Fiona C Denison
    MRC Centre for Reproductive Health, University of Edinburgh, Queen s Medical Research Institute, Edinburgh, Lothian, United Kingdom
    PLoS ONE 7:e42926. 2012
    ..We hypothesised that abnormal placental (1)H MRS may be an earlier biomarker of intrauterine hypoxia, affording the opportunity to optimise timing of delivery in at-risk fetuses...
  25. pmc Transcription Analysis of the Myometrium of Labouring and Non-Labouring Women
    Gemma C Sharp
    Tommy s Centre for Maternal and Fetal Health and Medical Research Council MRC Centre for Reproductive Health, University of Edinburgh, Edinburgh, United Kingdom
    PLoS ONE 11:e0155413. 2016
    ..We have made all our data available at www.ebi.ac.uk/arrayexpress/ (accession number E-MTAB-3136) to facilitate progression of this work. ..
  26. doi Decreased maternal hypothalamic-pituitary-adrenal axis activity in very severely obese pregnancy: Associations with birthweight and gestation at delivery
    Laura I Stirrat
    MRC Centre for Reproductive Health, University of Edinburgh, United Kingdom Tommy s Centre for Maternal and Fetal Health, University of Edinburgh, United Kingdom
    Psychoneuroendocrinology 63:135-43. 2016
    ..We hypothesized that maternal cortisol levels would be lower in obese pregnancy, and would associate with increased fetal size and length of gestation...
  27. pmc Post-weaning diet determines metabolic risk in mice exposed to overnutrition in early life
    Vicky King
    Endocrinology Unit, University BHF Centre for Cardiovascular Science, University of Edinburgh, QMRI, 47 Little France Crescent, Edinburgh EH16 4TJ, UK
    Reprod Biol Endocrinol 12:73. 2014
    ....
  28. doi Urocortin 2 role in placental and myometrial inflammatory mechanisms at parturition
    Chiara Voltolini
    Department of Molecular and Developmental Medicine C V, R N, M T, F M S, F P, University of Siena, 53100 Siena, Italy and Medical Research Council Centre for Reproductive Health S B, J E N, University of Edinburgh, EH16 4TY Edinburgh, United Kingdom
    Endocrinology 156:670-9. 2015
    ..Placental and myometrial Ucn2 may play a role in the endocrine-inflammatory processes of parturition, representing a potential target for treating inflammation-induced obstetric complications...
  29. pmc Efficacy of metformin in pregnant obese women: a randomised controlled trial
    Carolyn A Chiswick
    Tommy s Centre for Fetal and Maternal Health, Medical Research Council Centre for Reproductive Health, Queen s Medical Research Institute, The University of Edinburgh, Edinburgh, UK
    BMJ Open 5:e006854. 2015
    ..We present a protocol for a study to test the hypothesis that metformin will improve insulin sensitivity in obese pregnant women, thereby reducing the incidence of high birthweight babies and other pregnancy complications...
  30. doi Immediate versus deferred delivery of the preterm baby with suspected fetal compromise for improving outcomes
    Sarah J Stock
    MRC Centre for Reproductive Health, University of Edinburgh Queen s Medical Research Centre, Edinburgh, UK
    Cochrane Database Syst Rev . 2012
    ..Immediate delivery of the preterm fetus with suspected compromise may decrease the risk of damage due to intrauterine hypoxia. However, it may also increase the risks of prematurity...
  31. doi Quantitative fetal fibronectin to predict preterm birth in asymptomatic women at high risk
    Danielle S Abbott
    Division of Women s Health, King s College London, Women s Health Academic Centre Kings Health Partners, St Thomas Hospital, the UCL Institute for Women s Health, the Parturition Research Group, and the Institute for Reproductive and Developmental Biology, Imperial College London, London, the University of Edinburgh MRC Centre for Reproductive Health, Queen s Medical Research Institute, Edinburgh, and West Middlesex University Hospital, Middlesex, United Kingdom and the Division of Maternal Fetal Medicine, Loma Linda University Medical Center, Loma Linda, California
    Obstet Gynecol 125:1168-76. 2015
    ..To evaluate the diagnostic accuracy of cervicovaginal fluid quantitative fetal fibronectin, measured by a bedside analyzer, to predict spontaneous preterm birth before 34 weeks of gestation...
  32. doi Immediate versus deferred delivery of the preterm baby with suspected fetal compromise for improving outcomes
    Sarah J Stock
    MRC Centre for Reproductive Health, University of Edinburgh Queen s Medical Research Centre, Edinburgh, UK, EH16 4TJ
    Cochrane Database Syst Rev 7:CD008968. 2016
    ..Immediate delivery of the preterm fetus with suspected compromise may decrease the risk of damage due to intrauterine hypoxia. However, it may also increase the risks of prematurity...
  33. doi Preterm birth: Inflammation, fetal injury and treatment strategies
    Ashley K Boyle
    Tommy s Centre for Maternal and Fetal Health at the Medical Research Council Centre for Reproductive Health, University of Edinburgh, Queen s Medical Research Institute, 47 Little France Crescent, Edinburgh, EH16 4TJ, United Kingdom Electronic address
    J Reprod Immunol . 2016
    ..Further research is urgently required to develop effective methods for the prevention and treatment of PTB and above all, to reduce fetal injury...
  34. pmc Sex-Differences in the Metabolic Health of Offspring of Parents with Diabetes: A Record-Linkage Study
    Marian C Aldhous
    Tommy s Centre for Maternal and Fetal Health, MRC Centre for Reproductive Health, Queen s Medical Research Institute, University of Edinburgh, Edinburgh, United Kingdom
    PLoS ONE 10:e0134883. 2015
    ..In female offspring, maternal diabetes increased the odds of metabolic syndrome, even after adjusting for BMI. Further investigations are required to determine the mechanisms involved. ..
  35. doi Fetal assessment methods for improving neonatal and maternal outcomes in preterm prelabour rupture of membranes
    Gemma C Sharp
    MRC Centre for Reproductive Health, University of Edinburgh Queen s Medical Research Centre, Edinburgh, UK, EH16 4TJ
    Cochrane Database Syst Rev 10:CD010209. 2014
    ..However, early delivery may not always be in the fetal or maternal interest, and the effectiveness of different fetal assessment methods in improving neonatal and maternal outcomes is uncertain...
  36. pmc Human cathelicidin production by the cervix
    Lorraine Frew
    Tommy s Centre for Maternal and Fetal Health, MRC Centre for Reproductive Health, The University of Edinburgh, Edinburgh, United Kingdom
    PLoS ONE 9:e103434. 2014
    ..Further investigation will elucidate the effects of hCAP18/LL-37 on the physiology and pathophysiology of labour, and may lead to strategies for the prevention of infection-associated preterm birth. ..
  37. doi Home cervical ripening with dinoprostone gel in nulliparous women with singleton pregnancies
    Sarah J Stock
    Tommy s Centre for Maternal and Fetal Health and MRC Centre for Reproductive Health, University of Edinburgh, Queen s Medical Research Institute, and the Departments of Obstetrics and Gynaecology and Neonatology, Simpson Centre for Reproductive Health, Edinburgh Royal Infirmary, Edinburgh, United Kingdom
    Obstet Gynecol 124:354-60. 2014
    ..To evaluate whether home cervical ripening is safe and results in shorter hospital stay...
  38. pmc A computational model of lipopolysaccharide-induced nuclear factor kappa B activation: a key signalling pathway in infection-induced preterm labour
    Gemma C Sharp
    Medical Research Council MRC Centre for Reproductive Health, University of Edinburgh, Edinburgh, United Kingdom
    PLoS ONE 8:e70180. 2013
    ....
  39. doi Intergenerational transmission of postpartum hemorrhage risk: analysis of 2 Scottish birth cohorts
    Gemma C Sharp
    MRC Center for Reproductive Health, University of Edinburgh, Edinburgh, Scotland, UK Electronic address
    Am J Obstet Gynecol 211:51.e1-7. 2014
    ..The purpose of this study was to determine risk factors for postpartum hemorrhage (PPH) that includes intergenerational transmission of risk of postpartum hemorrhage...
  40. doi Lipopolysaccharide promotes contraction of uterine myocytes via activation of Rho/ROCK signaling pathways
    James L Hutchinson
    1MRC Centre for Reproductive Health, University of Edinburgh, The Queen s Medical Research Institute, 47 Little France Crescent, Edinburgh EH16 4TJ, UK
    FASEB J 28:94-105. 2014
    ....
  41. doi Anti-inflammatory mediators as physiological and pharmacological regulators of parturition
    Sara F Rinaldi
    MRC Centre for Reproductive Health, University of Edinburgh, Queen s Medical Research Institute, Edinburgh, EH16 4TJ, UK
    Expert Rev Clin Immunol 7:675-96. 2011
    ....
  42. pmc Recruiting and consenting into a peripartum trial in an emergency setting: a qualitative study of the experiences and views of women and healthcare professionals
    Julia Lawton
    Centre for Population Health Sciences, University of Edinburgh, Edinburgh, UK
    Trials 17:195. 2016
    ....
  43. pmc Prescribing Exercise and Lifestyle Training for High Risk Women in Pregnancy and Early Post-partum-Is It Worth It?
    Jane E Norman
    Tommy s Centre for Maternal and Fetal Health, MRC Centre for Reproductive Health, University of Edinburgh, Edinburgh, United Kingdom
    PLoS Med 13:e1002093. 2016
    ..In a Perspective, Jane Norman and Rebecca Reynolds discuss two randomized controlled trials aimed at testing behavioral interventions for women at risk of gestational diabetes. ..
  44. doi Maternal distress associates with placental genes regulating fetal glucocorticoid exposure and IGF2: Role of obesity and sex
    Theresia H Mina
    University BHF Centre for Cardiovascular Sciences, Queen s Medical Research Institute, University of Edinburgh, 47 Little France Crescent, Edinburgh EH16 4TJ, Scotland, UK Tommy s Centre for Maternal and Fetal Health, Queen s Medical Research Institute, University of Edinburgh, Edinburgh EH16 4TJ, Scotland, UK
    Psychoneuroendocrinology 59:112-22. 2015
    ..Further studies are needed to replicate these findings and to test whether this translates to potentially greater negative outcomes of maternal distress in female offspring in early childhood. ..
  45. pmc Androgens in pregnancy: roles in parturition
    Sofia Makieva
    Medical Research Council Centre for Reproductive Health, The University of Edinburgh, Queen s Medical Research Institute, Edinburgh EH16 4TJ, United Kingdom and Tommy s Centre for Maternal and Fetal Health, University of Edinburgh, Queen s Medical Research Institute, Edinburgh EH16 4TJ, United Kingdom
    Hum Reprod Update 20:542-59. 2014
    ..The aim of this review is to highlight potential roles of androgens in the biology of pregnancy and parturition...
  46. pmc Pregnancy in obese mice protects selectively against visceral adiposity and is associated with increased adipocyte estrogen signalling
    Silvia M A Pedroni
    Tommy s Centre for Maternal and Fetal Health, The University of Edinburgh, Queen s Medical Research Institute, Edinburgh, United Kingdom MRC Centre for Reproductive Health, The University of Edinburgh, Queen s Medical Research Institute, Edinburgh, United Kingdom
    PLoS ONE 9:e94680. 2014
    ....
  47. doi A role for lipoxin A4 as anti-inflammatory and proresolution mediator in human parturition
    David Maldonado-Pérez
    Division of Reproductive and Developmental Sciences, University of Edinburgh, Centre for Reproductive Biology, 47 Little France Crescent, Edinburgh EH16 4TJ, UK
    FASEB J 25:569-75. 2011
    ..05), compared to vehicle-treated controls. We demonstrate for the first time a potential role for lipoxin A(4) and its receptor in the resolution of the inflammatory events of both physiological and pathological labor...