Olivier Namy

Summary

Affiliation: University of Cambridge
Country: UK

Publications

  1. pmc Identification of stop codon readthrough genes in Saccharomyces cerevisiae
    Olivier Namy
    Laboratoire de Génétique Moléculaire de la Traduction, Institut de Genetique et Microbiologie, Universite Paris Sud, 91405 Orsay Cedex, France
    Nucleic Acids Res 31:2289-96. 2003
  2. ncbi request reprint Reprogrammed genetic decoding in cellular gene expression
    Olivier Namy
    Division of Virology, Department of Pathology, University of Cambridge, Tennis Court Road, Cambridge, CB2 1QP, United Kingdom
    Mol Cell 13:157-68. 2004
  3. pmc Fine-tuning of translation termination efficiency in Saccharomyces cerevisiae involves two factors in close proximity to the exit tunnel of the ribosome
    Isabelle Hatin
    IGM, Universite Paris Sud, UMR 8621, F91405 Orsay, France
    Genetics 177:1527-37. 2007
  4. ncbi request reprint Translational readthrough of the PDE2 stop codon modulates cAMP levels in Saccharomyces cerevisiae
    Olivier Namy
    Laboratoire de Génétique Moléculaire de la Traduction, Institut de Genetique et Microbiologie, Universite Paris Sud, Orsay, France
    Mol Microbiol 43:641-52. 2002
  5. ncbi request reprint Adding pyrrolysine to the Escherichia coli genetic code
    Olivier Namy
    Institut de Genetique et Microbiologie, Universite Paris Sud, CNRS UMR8621, Orsay F 91405, France
    FEBS Lett 581:5282-8. 2007
  6. pmc Gene overexpression as a tool for identifying new trans-acting factors involved in translation termination in Saccharomyces cerevisiae
    Olivier Namy
    Laboratoire de Génétique Moléculaire de la Traduction, Institut de Genetique et Microbiologie, CNRS UMR8621, Universite Paris Sud, 91405 Orsay Cedex, France
    Genetics 161:585-94. 2002
  7. pmc Prokaryotic-style frameshifting in a plant translation system: conservation of an unusual single-tRNA slippage event
    Sawsan Napthine
    Division of Virology, Department of Pathology, University of Cambridge, Tennis Court Road, Cambridge CB2 1QP, UK
    EMBO J 22:3941-50. 2003
  8. ncbi request reprint A mechanical explanation of RNA pseudoknot function in programmed ribosomal frameshifting
    Olivier Namy
    Division of Virology, Department of Pathology, University of Cambridge, Tennis Court Road, Cambridge CB2 1QP, UK
    Nature 441:244-7. 2006
  9. doi request reprint Translational errors: from yeast to new therapeutic targets
    Laure Bidou
    Universite Paris Sud, IGM CNRS UMR 8621, Orsay, France
    FEMS Yeast Res 10:1070-82. 2010
  10. doi request reprint Translation Analysis at the Genome Scale by Ribosome Profiling
    Agnes Baudin-Baillieu
    Institute for Integrative Biology of the Cell I2BC, UMR 9198 CEA, CNRS, Universite Paris Sud, Batiment 400, 91405, Orsay, France
    Methods Mol Biol 1361:105-24. 2016

Collaborators

Detail Information

Publications17

  1. pmc Identification of stop codon readthrough genes in Saccharomyces cerevisiae
    Olivier Namy
    Laboratoire de Génétique Moléculaire de la Traduction, Institut de Genetique et Microbiologie, Universite Paris Sud, 91405 Orsay Cedex, France
    Nucleic Acids Res 31:2289-96. 2003
    ..This emphasizes that genome annotation should take into account the fact that recoding signals could be more frequently used than previously expected...
  2. ncbi request reprint Reprogrammed genetic decoding in cellular gene expression
    Olivier Namy
    Division of Virology, Department of Pathology, University of Cambridge, Tennis Court Road, Cambridge, CB2 1QP, United Kingdom
    Mol Cell 13:157-68. 2004
    ..This review summarizes current knowledge of the structure and function of recoding signals in cellular genes, the biological importance of recoding in gene regulation, and ways to identify new recoded genes...
  3. pmc Fine-tuning of translation termination efficiency in Saccharomyces cerevisiae involves two factors in close proximity to the exit tunnel of the ribosome
    Isabelle Hatin
    IGM, Universite Paris Sud, UMR 8621, F91405 Orsay, France
    Genetics 177:1527-37. 2007
    ..Among them, SSB1 and snR18, two factors close to the exit tunnel of the ribosome, directed the strongest antisuppression effects when overexpressed, showing that they may be involved in fine-tuning of the translation termination level...
  4. ncbi request reprint Translational readthrough of the PDE2 stop codon modulates cAMP levels in Saccharomyces cerevisiae
    Olivier Namy
    Laboratoire de Génétique Moléculaire de la Traduction, Institut de Genetique et Microbiologie, Universite Paris Sud, Orsay, France
    Mol Microbiol 43:641-52. 2002
    ..These results provide a molecular explanation for at least some of the secondary phenotypes associated with suppressor backgrounds...
  5. ncbi request reprint Adding pyrrolysine to the Escherichia coli genetic code
    Olivier Namy
    Institut de Genetique et Microbiologie, Universite Paris Sud, CNRS UMR8621, Orsay F 91405, France
    FEBS Lett 581:5282-8. 2007
    ..Exogenously supplying our reporter system with d-ornithine significantly increases suppression efficiency, indicating that d-ornithine is a direct precursor to Pyl...
  6. pmc Gene overexpression as a tool for identifying new trans-acting factors involved in translation termination in Saccharomyces cerevisiae
    Olivier Namy
    Laboratoire de Génétique Moléculaire de la Traduction, Institut de Genetique et Microbiologie, CNRS UMR8621, Universite Paris Sud, 91405 Orsay Cedex, France
    Genetics 161:585-94. 2002
    ..Interestingly, among these candidates, we identified two genes, SSO1 and STU2, involved in protein transport and spindle pole body formation, respectively, suggesting puzzling connections with the translation termination process...
  7. pmc Prokaryotic-style frameshifting in a plant translation system: conservation of an unusual single-tRNA slippage event
    Sawsan Napthine
    Division of Virology, Department of Pathology, University of Cambridge, Tennis Court Road, Cambridge CB2 1QP, UK
    EMBO J 22:3941-50. 2003
    ..We also show for the first time that prokaryotic tRNA(Asn) is not inherently 'unslippery' and induces efficient frameshifting when in the context of a eukaryotic translation system...
  8. ncbi request reprint A mechanical explanation of RNA pseudoknot function in programmed ribosomal frameshifting
    Olivier Namy
    Division of Virology, Department of Pathology, University of Cambridge, Tennis Court Road, Cambridge CB2 1QP, UK
    Nature 441:244-7. 2006
    ..Together, the structural changes provide a mechanical explanation of how the pseudoknot manipulates the ribosome into a different reading frame...
  9. doi request reprint Translational errors: from yeast to new therapeutic targets
    Laure Bidou
    Universite Paris Sud, IGM CNRS UMR 8621, Orsay, France
    FEMS Yeast Res 10:1070-82. 2010
    ..We explore these two aspects of the contribution of yeast studies to human medicine in this review...
  10. doi request reprint Translation Analysis at the Genome Scale by Ribosome Profiling
    Agnes Baudin-Baillieu
    Institute for Integrative Biology of the Cell I2BC, UMR 9198 CEA, CNRS, Universite Paris Sud, Batiment 400, 91405, Orsay, France
    Methods Mol Biol 1361:105-24. 2016
    ..This approach provides new insights into gene regulation at the translational level. In this review we describe the protocol to prepare polysomes and extract ribosome protected fragments before to deep sequence them. ..
  11. pmc Rab-GDI complex dissociation factor expressed through translational frameshifting in filamentous ascomycetes
    Fabienne Malagnac
    Univ Paris Sud, Institut de Genetique et Microbiologie, UMR8621, Orsay, France Univ Paris Diderot, Sorbonne Paris Cité, Institut des Energies de Demain IED, Paris, France
    PLoS ONE 8:e73772. 2013
    ..The frameshift has been conserved over the evolution of the Pezizomycotina, lasting for over 400 million years, suggesting that it has an important role in the wild. ..
  12. doi request reprint Sense from nonsense: therapies for premature stop codon diseases
    Laure Bidou
    Universite Paris Sud, Orsay, France
    Trends Mol Med 18:679-88. 2012
    ..Here, we review the molecular basis for PTC readthrough in eukaryotes and describe currently available compounds with significant therapeutic potential for treating genetic disorders and cancer...
  13. pmc Are prions part of the dark matter of the cell?
    Agnes Baudin-Baillieu
    Institut de Genetique et Microbiologie, University Paris Sud, CNRS, Orsay, France
    Prion 5:299-304. 2011
    ..The [PSI+] prion might generate diverse modifications not only at the translational, but also at the transcriptional levels, and the phenotypic heterogeneity is the result of these complex combinations of the genotypic expression...
  14. doi request reprint RiboTools: a Galaxy toolbox for qualitative ribosome profiling analysis
    Rachel Legendre
    Institute for Integrative Biology of the Cell I2BC, CEA, CNRS, Universite Paris Sud, Bat 400, 91400 Orsay, France
    Bioinformatics 31:2586-8. 2015
    ..It can be used to detect translational ambiguities, stop codon readthrough events and codon occupancy. It provides a large number of plots for the visualisation of these events...
  15. pmc New insights into stop codon recognition by eRF1
    Sandra Blanchet
    Institute for Integrative Biology of the Cell I2BC, CEA, CNRS, Universite Paris Sud, Batiment 400, 91400 Orsay, France
    Nucleic Acids Res 43:3298-308. 2015
    ..By combining our genetic data with a structural analysis of eRF1 mutants, we were able to formulate a new model in which the stop codon interacts with eRF1 through the P1 pocket...
  16. doi request reprint The mechanics of translocation: a molecular "spring-and-ratchet" system
    Stephen J Moran
    Division of Structural Biology, Henry Wellcome Building for Genomic Medicine, University of Oxford, Roosevelt Drive, Oxford OX3 7BN, United Kingdom
    Structure 16:664-72. 2008
    ..The tRNA can thus be considered a molecular spring and EF-2 a Brownian ratchet in a "spring-and-ratchet" system within the translocation process...
  17. ncbi request reprint Lack of pseudouridine 38/39 in the anticodon arm of yeast cytoplasmic tRNA decreases in vivo recoding efficiency
    François Lecointe
    Laboratoire d Enzymologie et de Biochimie Structurales, CNRS, Avenue de la Terrasse, Bat 34, F 91198 Gif sur Yvette, France
    J Biol Chem 277:30445-53. 2002
    ..Therefore, the presence of pseudouridine 38 or 39 in the tRNA anticodon arm enhances misreading of certain codons by natural nonsense tRNAs as well as promotes frameshifting on slippery sequences in yeast...