P G Murray

Summary

Affiliation: University of Birmingham
Country: UK

Publications

  1. ncbi request reprint Interleukin 6 expression by Hodgkin/Reed-Sternberg cells is associated with the presence of 'B' symptoms and failure to achieve complete remission in patients with advanced Hodgkin's disease
    Gary M Reynolds
    The Liver Research Laboratories, CRC Institute for Cancer Studies, Department of Pathology, University of Birmingham, Edgbaston, UK
    Br J Haematol 118:195-201. 2002
  2. pmc Novel markers for differentiation of lobular and ductal invasive breast carcinomas by laser microdissection and microarray analysis
    Gulisa Turashvili
    Laboratory of Molecular Pathology, Institute of Pathology, Palacky University, Olomouc, Czech Republic
    BMC Cancer 7:55. 2007
  3. ncbi request reprint Down-regulation of the TGF-beta target gene, PTPRK, by the Epstein-Barr virus encoded EBNA1 contributes to the growth and survival of Hodgkin lymphoma cells
    Joanne R Flavell
    Cancer Research UK Institute for Cancer Studies, The Medical School, University of Birmingham, Vincent Drive, Edgbaston, Birmingham, B15 2TT, United Kingdom
    Blood 111:292-301. 2008
  4. ncbi request reprint Epstein-Barr virus infection: basis of malignancy and potential for therapy
    P G Murray
    Department of Pathology, Division of Cancer Studies, Medical School, University of Birmingham, Birmingham, B15 2TT, UK
    Expert Rev Mol Med 3:1-20. 2001
  5. doi request reprint Contribution of the Epstein-Barr Virus to the Pathogenesis of Hodgkin Lymphoma
    Paul Murray
    School of Cancer Sciences and Centre for Human Virology, College of Medical and Dental Sciences, University of Birmingham, Birmingham, Edgbaston, B15 2TT, UK
    Curr Top Microbiol Immunol 390:287-313. 2015
  6. pmc Epstein-Barr virus and the origin of Hodgkin lymphoma
    Martina Vockerodt
    School of Cancer Sciences, University of Birmingham, Birmingham, B15 2TT, The United Kingdom
    Chin J Cancer 33:591-7. 2014
  7. pmc Low prevalence of Epstein-Barr virus in incident gastric adenocarcinomas from the United Kingdom
    D E Burgess
    Department of Pathology, Division of Cancer Studies, The Medical School, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK
    Br J Cancer 86:702-4. 2002
  8. pmc Seasonal differences in the onset of the EBV-positive and -negative forms of paediatric Hodgkin's lymphoma
    A Reiman
    Department of Pathology, The Medical School, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK
    Br J Cancer 89:1200-1. 2003
  9. pmc Epigenetic silencing of the 3p22 tumor suppressor DLEC1 by promoter CpG methylation in non-Hodgkin and Hodgkin lymphomas
    Zhaohui Wang
    Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences CUHK, Shenzhen, China
    J Transl Med 10:209. 2012
  10. ncbi request reprint Epstein-Barr virus in breast cancer: artefact or aetiological agent?
    P G Murray
    Medical School University of Birmingham, UK
    J Pathol 209:427-9. 2006

Collaborators

Detail Information

Publications46

  1. ncbi request reprint Interleukin 6 expression by Hodgkin/Reed-Sternberg cells is associated with the presence of 'B' symptoms and failure to achieve complete remission in patients with advanced Hodgkin's disease
    Gary M Reynolds
    The Liver Research Laboratories, CRC Institute for Cancer Studies, Department of Pathology, University of Birmingham, Edgbaston, UK
    Br J Haematol 118:195-201. 2002
    ..57). In summary, the results suggest that IL-6 expression by HRS cells may contribute to the presence of 'B' symptoms and to a decreased likelihood to achieve a complete remission in HD patients...
  2. pmc Novel markers for differentiation of lobular and ductal invasive breast carcinomas by laser microdissection and microarray analysis
    Gulisa Turashvili
    Laboratory of Molecular Pathology, Institute of Pathology, Palacky University, Olomouc, Czech Republic
    BMC Cancer 7:55. 2007
    ..The aim of our study was to identify gene expression profiles of IDC and ILC in relation to normal breast epithelial cells...
  3. ncbi request reprint Down-regulation of the TGF-beta target gene, PTPRK, by the Epstein-Barr virus encoded EBNA1 contributes to the growth and survival of Hodgkin lymphoma cells
    Joanne R Flavell
    Cancer Research UK Institute for Cancer Studies, The Medical School, University of Birmingham, Vincent Drive, Edgbaston, Birmingham, B15 2TT, United Kingdom
    Blood 111:292-301. 2008
    ..We speculate that loss of the phosphatase function of PTPRK may activate as-yet-unidentified growth-promoting protein tyrosine kinases, which in turn contribute to the pathogenesis of EBV-positive HL...
  4. ncbi request reprint Epstein-Barr virus infection: basis of malignancy and potential for therapy
    P G Murray
    Department of Pathology, Division of Cancer Studies, Medical School, University of Birmingham, Birmingham, B15 2TT, UK
    Expert Rev Mol Med 3:1-20. 2001
    ..Strategies to target EBV in tumours, potentially providing alternative therapeutic approaches, are also discussed...
  5. doi request reprint Contribution of the Epstein-Barr Virus to the Pathogenesis of Hodgkin Lymphoma
    Paul Murray
    School of Cancer Sciences and Centre for Human Virology, College of Medical and Dental Sciences, University of Birmingham, Birmingham, Edgbaston, B15 2TT, UK
    Curr Top Microbiol Immunol 390:287-313. 2015
    ..This review summarises current knowledge of the pathogenesis of Hodgkin lymphoma with a particular emphasis on the contribution of EBV. ..
  6. pmc Epstein-Barr virus and the origin of Hodgkin lymphoma
    Martina Vockerodt
    School of Cancer Sciences, University of Birmingham, Birmingham, B15 2TT, The United Kingdom
    Chin J Cancer 33:591-7. 2014
    ..This article reviews what is known about the contribution of EBV to the pathogenesis of cHL and focuses on emerging evidence implicating chronic inflammation as a potential oncogenic co-factor in this malignancy. ..
  7. pmc Low prevalence of Epstein-Barr virus in incident gastric adenocarcinomas from the United Kingdom
    D E Burgess
    Department of Pathology, Division of Cancer Studies, The Medical School, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK
    Br J Cancer 86:702-4. 2002
    ..Gastric adenocarcinoma is another tumour whose association with Epstein-Barr virus varies with the population studied...
  8. pmc Seasonal differences in the onset of the EBV-positive and -negative forms of paediatric Hodgkin's lymphoma
    A Reiman
    Department of Pathology, The Medical School, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK
    Br J Cancer 89:1200-1. 2003
    ..This suggests aetiological differences between the two forms of this disease. EBV-positive HL might be a rare consequence of primary EBV infection...
  9. pmc Epigenetic silencing of the 3p22 tumor suppressor DLEC1 by promoter CpG methylation in non-Hodgkin and Hodgkin lymphomas
    Zhaohui Wang
    Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences CUHK, Shenzhen, China
    J Transl Med 10:209. 2012
    ..Deleted in lung and esophageal cancer 1 (DLEC1), located at the 3p22-21.3 TSG cluster, has been identified frequently silenced by promoter CpG methylation in multiple carcinomas, however, no study has been performed for lymphomas yet...
  10. ncbi request reprint Epstein-Barr virus in breast cancer: artefact or aetiological agent?
    P G Murray
    Medical School University of Birmingham, UK
    J Pathol 209:427-9. 2006
    ..Their observation suggests that reports documenting an EBV association on the basis of reactivity with this antibody must be considered unreliable. It also re-opens the debate about whether breast cancer is an EBV-associated disease...
  11. ncbi request reprint Expression of the tumour necrosis factor receptor-associated factors 1 and 2 in Hodgkin's disease
    P G Murray
    Department of Pathology, Division of Cancer Studies, University of Birmingham, Birmingham, B15 2TT, UK
    J Pathol 194:158-64. 2001
    ..In contrast, TRAF2 expression by HRS cells appeared to be independent of EBV status. Using a sequential labelling approach, co-localization of LMP1 with either TRAF1 or TRAF2 was also demonstrated in HRS cells from EBV-positive tumours...
  12. ncbi request reprint Reactivity with A monoclonal antibody to Epstein-Barr virus (EBV) nuclear antigen 1 defines a subset of aggressive breast cancers in the absence of the EBV genome
    Paul G Murray
    Department of Pathology, University of Birmingham, Edgbaston, United Kingdom
    Cancer Res 63:2338-43. 2003
    ..Additional studies should be directed to the identification of this protein and to elucidation of its role in breast cancer...
  13. ncbi request reprint Frequent expression of the tumor necrosis factor receptor-associated factor 1 in latent membrane protein 1-positive posttransplant lymphoproliferative disease and HIV-associated lymphomas
    P G Murray
    Division of Cancer Studies, University of Birmingham, Edgbaston, Birmingham, England
    Hum Pathol 32:963-9. 2001
    ....
  14. ncbi request reprint Effect of Epstein-Barr virus infection on response to chemotherapy and survival in Hodgkin's disease
    P G Murray
    CRC Institute for Cancer Studies, University of Birmingham, Birmingham, UK
    Blood 94:442-7. 1999
    ..40, respectively). In conclusion, the results confirm the favorable prognostic value of EBV in the tumor cells of HD patients and suggest important differences in response to chemotherapy between EBV-positive and EBV-negative patients...
  15. ncbi request reprint Antigen presenting phenotype of Hodgkin Reed-Sternberg cells: analysis of the HLA class I processing pathway and the effects of interleukin-10 on epstein-barr virus-specific cytotoxic T-cell recognition
    S P Lee
    CRC Institute for Cancer Studies, University of Birmingham, Birmingham, UK
    Blood 92:1020-30. 1998
    ..However, IL-10 pretreatment of the H-RS lines or of the EBV-specific CTLs had no such effect in this system. These results support the possibility that EBV-specific CTLs may be used to treat virus-positive HD...
  16. doi request reprint The Epstein-Barr virus oncoprotein, latent membrane protein-1, reprograms germinal centre B cells towards a Hodgkin's Reed-Sternberg-like phenotype
    M Vockerodt
    Cancer Research UK Institute for Cancer Studies, The Medical School, University of Birmingham, UK
    J Pathol 216:83-92. 2008
    ..Our data suggest that in EBV-positive cases, LMP1 is likely to be a major contributor to the altered transcriptional pattern characteristic of Hodgkin/Reed-Sternberg cells, including the loss of B-cell identity...
  17. doi request reprint The H3K27me3 demethylase, KDM6B, is induced by Epstein-Barr virus and over-expressed in Hodgkin's Lymphoma
    J A Anderton
    School of Cancer Sciences, College of Medical and Dental Sciences, University of Birmingham, Edgbaston, Birmingham, UK
    Oncogene 30:2037-43. 2011
    ..Consistent with these observations, we found that KDM6B transcriptional targets in GC B cells are enriched for genes differentially expressed in HL, and that KDM6B depletion can restore the tri-methylation of H3K27 on these genes...
  18. pmc Expression of the cellular FLICE-inhibitory protein (c-FLIP) protects Hodgkin's lymphoma cells from autonomous Fas-mediated death
    A Dutton
    Department of Pathology, University of Birmingham, Birmingham B15 2TT, United Kingdom
    Proc Natl Acad Sci U S A 101:6611-6. 2004
    ..Our results provide a mechanism whereby HRS cells are protected from autonomous FasL-mediated cell death while preserving their ability to evade immunosurveillance. Targeting c-FLIP could provide a novel approach to the treatment of HL...
  19. ncbi request reprint The Role of the Epstein-Barr virus in human disease
    P G Murray
    Department of Pathology, Division of Cancer Studies, Medical School, University of Birmingham, Birmingham, B15 2TT, UK
    Front Biosci 7:d519-40. 2002
    ..Finally, therapeutic strategies that target EBV in tumours are discussed...
  20. ncbi request reprint Down-regulation of ATM protein in HRS cells of nodular sclerosis Hodgkin's lymphoma in children occurs in the absence of ATM gene inactivation
    S Bose
    CRUK Institute for Cancer Research, Vincent Drive, Edgbaston, Birmingham B15 2TT, UK
    J Pathol 213:329-36. 2007
    ..Importantly, ATM loss in paediatric cHLs has clinical implications and could be potentially exploited to guide future, less toxic, tumour-specific treatments...
  21. pmc Smoking initiation is followed by the early acquisition of epigenetic change in cervical epithelium: a longitudinal study
    Y T Ma
    Cancer Research UK Institute for Cancer Studies, School of Cancer Sciences, University of Birmingham, Birmingham, Edgbaston, B15 2TT, UK
    Br J Cancer 104:1500-4. 2011
    ....
  22. pmc Hypoxia-regulated carbonic anhydrase IX expression is associated with poor survival in patients with invasive breast cancer
    S A Hussain
    Cancer Research UK, Institute for Cancer Studies, University Hospital Birmingham, Edgbaston, Birmingham B15 2TT, UK
    Br J Cancer 96:104-9. 2007
    ..This study showed in both univariate and multivariate analysis that survival is significantly inferior in patients with tumour expressing CA IX. Prospective studies are underway to investigate this correlation in clinical trial setting...
  23. ncbi request reprint Bmi-1 is induced by the Epstein-Barr virus oncogene LMP1 and regulates the expression of viral target genes in Hodgkin lymphoma cells
    Amanda Dutton
    Cancer Research UK Institute for Cancer Studies, The Medical School, University of Birmingham, Edgbaston, United Kingdom
    Blood 109:2597-603. 2007
    ..We show here that Bmi-1 and LMP1 down-regulate the ataxia telangiectasia-mutated (ATM) tumor suppressor and conclude that Bmi-1 contributes to LMP1-induced oncogenesis in HL...
  24. ncbi request reprint Frequent epigenetic silencing of protocadherin 10 by methylation in multiple haematologic malignancies
    Jianming Ying
    Cancer Epigenetics Laboratory, Department of Clinical Oncology, The Chinese University of Hong Kong, Hong Kong
    Br J Haematol 136:829-32. 2007
    ..Methylation was further detected in 14% of Hodgkin lymphoma sera. Thus, PCDH10 methylation is frequently involved in lymphomagenesis and could serve as a tumour-specific biomarker...
  25. doi request reprint Evidence for a pathophysiological role of cysteinyl leukotrienes in classical Hodgkin lymphoma
    Frida Schain
    Department of Medicine, Division of Hematology, Karolinska University Hospital Solna and Karolinska Institutet, Stockholm, Sweden
    Int J Cancer 123:2285-93. 2008
    ..As these cells are surrounded by CysLT-producing eosinophils, macrophages and mast cells, our results suggest the CysLTs as mediators in the pathogenesis of cHL, contributing to the aberrant cytokine network of this lymphoma...
  26. ncbi request reprint Three-dimensional culturing of the Hodgkin lymphoma cell-line L1236 induces a HL tissue-like gene expression pattern
    Anna Birgersdotter
    Department of Microbiology, Tumor Biology and Cell Biology, Karolinska Institutet, Stockholm, Sweden
    Leuk Lymphoma 48:2042-53. 2007
    ..3D culture affected the expression of 500 genes in L1236, upregulating genes involved in immune response and apoptosis and downregulating genes involved in cell division. It also affected genes involved in actin filament polymerization...
  27. pmc Expression of the Epstein-Barr virus-encoded Epstein-Barr virus nuclear antigen 1 in Hodgkin's lymphoma cells mediates Up-regulation of CCL20 and the migration of regulatory T cells
    Karl R N Baumforth
    Cancer Research United Kingdom Institute for Cancer Studies, University of Birmingham, Birmingham, United Kingdom
    Am J Pathol 173:195-204. 2008
    ....
  28. ncbi request reprint Targeting cellular FLICE-like inhibitory protein as a novel approach to the treatment of Hodgkin's lymphoma
    Amanda Dutton
    Cancer Research UK Institute for Cancer Studies, University of Birmingham, Birmingham, West Midlands, B15 2TT, UK
    Expert Rev Anticancer Ther 6:911-9. 2006
    ....
  29. ncbi request reprint The role of cellular FLICE inhibitory protein (c-FLIP) in the pathogenesis and treatment of cancer
    Amanda Dutton
    Cancer Research UK Institute for Cancer Studies, Division of Cancer Studies, Department of Pathology, The Medical School, University of Birmingham, Edgbaston, Birmingham, B15 2TT, UK
    Expert Opin Ther Targets 10:27-35. 2006
    ..The possibility of targeting c-FLIP as an approach to the treatment of cancer and, in particular, Hodgkin's lymphoma is discussed...
  30. ncbi request reprint HIF activation identifies early lesions in VHL kidneys: evidence for site-specific tumor suppressor function in the nephron
    Stefano J Mandriota
    Wellcome Trust Centre for Human Genetics, Oxford OX3 7BN, United Kingdom
    Cancer Cell 1:459-68. 2002
    ..In proximal tubules these were almost entirely unicellular, whereas multicellular foci were almost exclusively seen in the distal nephron...
  31. ncbi request reprint Absence of Epstein-Barr virus DNA in the tumor cells of European hepatocellular carcinoma
    Jia Junying
    Department of Pathology, University of Birmingham, B15 2TT, Edgbaston, Birmingham, UK
    Virology 306:236-43. 2003
    ..Furthermore, none of the German or U.K. HCC tumors tested positive for EBER or EBNAI expression in tumor cells. Our results provide strong evidence that HCCs from the U.K. or Germany are not associated with EBV...
  32. pmc Variations in ATM protein expression during normal lymphoid differentiation and among B-cell-derived neoplasias
    Jane Starczynski
    Department of Histopathology, Birmingham Heartland s Hospital, Birmingham, United Kingdom
    Am J Pathol 163:423-32. 2003
    ..As a result, immunostaining to identify lymphoid neoplasias with ATM inactivation might only be feasible for tumors derived from the stages where ATM is constitutively highly expressed...
  33. ncbi request reprint Epstein-Barr virus and oncogenesis: from latent genes to tumours
    Lawrence S Young
    Cancer Research UK Institute for Cancer Studies, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK
    Oncogene 22:5108-21. 2003
    ..This review summarises our current knowledge of EBV latent gene function and how this relates to the role of the virus in the aetiology of different tumours...
  34. ncbi request reprint Epstein-Barr virus-encoded latent infection membrane protein 1 regulates the processing of p100 NF-kappaB2 to p52 via an IKKgamma/NEMO-independent signalling pathway
    Aristides G Eliopoulos
    Cancer Research UK Institute for Cancer Studies, The University of Birmingham Medical School, Birmingham B15 2TA, UK
    Oncogene 22:7557-69. 2003
    ..These data point to the existence of a novel signalling pathway that regulates NF-kappaB in LMP1-expressing cells, and may thereby play a role in both oncogenic transformation and the establishment of persistent EBV infection...
  35. ncbi request reprint Epstein-Barr virus-associated cancers: aetiology and treatment
    Victor Lopes
    Cancer Research UK Institute for Cancer Studies, University of Birmingham, Birmingham, UK
    Herpes 10:78-82. 2003
    ..Understanding the functions of EBV latent proteins will improve our knowledge of the role of the virus in transformation, and may help to identify novel therapies...
  36. ncbi request reprint Epstein-Barr virus (EBV) and its associated human cancers--genetics, epigenetics, pathobiology and novel therapeutics
    Qian Tao
    Sir YK Pao Cancer Center, Department of Clinical Oncology, The Chinese University of Hong Kong, Hong Kong
    Front Biosci 11:2672-713. 2006
    ..Finally, therapeutic strategies targeting EBV in tumors are discussed...
  37. ncbi request reprint Carbonic anhydrase IX, a marker of hypoxia: correlation with clinical outcome in transitional cell carcinoma of the bladder
    Syed A Hussain
    Cancer Research UK Institute for Cancer Studies, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK
    Oncol Rep 11:1005-10. 2004
    ..94). There was a trend towards longer survival for tumour expressing CA IX strongly. This is likely to be a reflection of the significantly higher rate of strong CA IX expression in non-invasive cancers influencing these survival data...
  38. ncbi request reprint Constitutive activation of phosphatidyl-inositide 3 kinase contributes to the survival of Hodgkin's lymphoma cells through a mechanism involving Akt kinase and mTOR
    Amanda Dutton
    Department of Pathology, University of Birmingham, Birmingham, UK
    J Pathol 205:498-506. 2005
    ..However, rapamycin and doxorubicin acted synergistically to reduce HL cell survival. A combination of rapamycin and chemotherapy should be investigated in the treatment of HL...
  39. ncbi request reprint Induction of autotaxin by the Epstein-Barr virus promotes the growth and survival of Hodgkin lymphoma cells
    Karl R N Baumforth
    CRUK Institute for Cancer Studies, The Medical School, University of Birmingham, Edgbaston, Birmingham, B15 2TT, United Kingdom
    Blood 106:2138-46. 2005
    ....
  40. ncbi request reprint Role of sexual behavior in the acquisition of asymptomatic Epstein-Barr virus infection: a longitudinal study
    Ciaran B J Woodman
    Cancer Research UK Institute for Cancer Studies, University of Birmingham
    Pediatr Infect Dis J 24:498-502. 2005
    ..We report the prevalence and subsequent incidence of EBV infection in a cohort of sexually active young women and explore the social and sexual determinants of incident infections...
  41. ncbi request reprint Constitutive activation of the CD40 pathway promotes cell transformation and neoplastic growth
    Amanda J Baxendale
    Cancer Research UK Institute for Cancer Studies, The University of Birmingham Medical School, University of Birmingham, Edgbaston, Birmingham B15 2TA, UK
    Oncogene 24:7913-23. 2005
    ..Strategies that neutralize this pathway may therefore be useful in cancer treatment and prevention...
  42. ncbi request reprint Changes in expression of the human homologue of the Drosophila discs large tumour suppressor protein in high-grade premalignant cervical neoplasias
    Richard A Watson
    Cancer Research UK Institute for Cancer Studies, The Medical School, University of Birmingham, UK
    Carcinogenesis 23:1791-6. 2002
    ..In invasive squamous cell carcinomas, total cellular hDlg levels are greatly reduced. Our data suggest that loss of hDlg at sites of intercellular contact may be an important step in the development of epithelial cancers...
  43. ncbi request reprint Target cells of Epstein-Barr-virus (EBV)-positive post-transplant lymphoproliferative disease: similarities to EBV-positive Hodgkin's lymphoma
    Judith M Timms
    Cancer Research UK Institute for Cancer Studies, University of Birmingham, Birmingham, UK
    Lancet 361:217-23. 2003
    ..Identification of the precise cellular origin of these tumours could clarify their pathogenesis...
  44. ncbi request reprint Patterned CpG methylation of silenced B cell gene promoters in classical Hodgkin lymphoma-derived and primary effusion lymphoma cell lines
    Jeanette R Doerr
    Department of Microbiology, David Geffen School of Medicine at the University of California, Los Angeles, CA 90095, USA
    J Mol Biol 350:631-40. 2005
    ....
  45. ncbi request reprint Microarray analysis of bicalutamide action on telomerase activity, p53 pathway and viability of prostate carcinoma cell lines
    Jan Bouchal
    Laboratory of Molecular Pathology and Institute of Pathology, Palacky University, Hnevotinska 3, 775 15 Olomouc, Czech Republic
    J Pharm Pharmacol 57:83-92. 2005
    ..In particular, activation of the p53 pathway after treatment with 80 microM bicalutamide could justify usage of bicalutamide dosages higher than 150 mg daily in androgen-sensitive carcinoma therapy...
  46. ncbi request reprint Frequent epigenetic inactivation of the RASSF1A tumor suppressor gene in Hodgkin's lymphoma
    Paul G Murray
    Department of Pathology, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK
    Oncogene 23:1326-31. 2004
    ..Inactivation of RASSF1A could be one mechanism by which HRS cells escape the apoptosis that should occur following nonproductive immunoglobulin gene rearrangements...