Alison D Murray
Affiliation: University of Aberdeen
- Brain white matter hyperintensities: relative importance of vascular risk factors in nondemented elderly peopleAlison D Murray
Department of Radiology, University of Aberdeen, Foresterhill, Aberdeen AB25 2ZD, Scotland
Radiology 237:251-7. 2005....
- Brain hyperintensity location determines outcome in the triad of impaired cognition, physical health and depressive symptoms: A cohort study in late lifeAlison Murray
University of Aberdeen, Aberdeen, UK Electronic address
Arch Gerontol Geriatr 63:49-54. 2016..Here we test the hypothesis that the association between hyperintensities and cognitive ability, physical health and depressive symptoms depends on lesion location...
- Imaging approaches for dementiaA D Murray
Aberdeen Biomedical Imaging Centre, Division of Applied Medicine, University of Aberdeen, Aberdeen, UK
AJNR Am J Neuroradiol 33:1836-44. 2012..Whole-body FDG-PET may be helpful in patients with rapidly progressing "autoimmune dementias," and FLAIR and DWI are indicated in suspected CJD. A major role of imaging is in the development of new drugs and less costly biomarkers...
- Depressive symptoms in late life and cerebrovascular disease: the importance of intelligence and lesion locationAlison D Murray
Aberdeen Biomedical Imaging Centre, University of Aberdeen, Aberdeen, Scotland, UK
Depress Anxiety 30:77-84. 2013....
- Brain lesions, hypertension and cognitive ageing in the 1921 and 1936 Aberdeen birth cohortsAlison D Murray
University of Aberdeen, UK
Age (Dordr) 34:451-9. 2012..The positive relationship between childhood and late-life intelligence decreases with age. The negative relationship between WMH and late-life intelligence is linear and increases with age...
- The balance between cognitive reserve and brain imaging biomarkers of cerebrovascular and Alzheimer's diseasesAlison D Murray
Aberdeen Biomedical Imaging Centre, Lilian Sutton Building, Foresterhill, Aberdeen AB25 2ZD, UK
Brain 134:3687-96. 2011..20 for hippocampal atrophy. This study illustrates how education counteracts the deleterious effects of cerebrovascular disease and Alzheimer's disease and highlights the importance of quantifying cognitive reserve in dementia research...
- Anticholinergic drugs in late life: adverse effects on cognition but not on progress to dementiaLawrence J Whalley
The Institute of Applied Health Sciences, Foresterhill, University of Aberdeen, Aberdeen, Scotland, UK
J Alzheimers Dis 30:253-61. 2012..We concluded that anticholinergic drug use in this narrow age range sample was linked to cognitive impairment but not to subsequent dementia...
- Childhood intelligence and brain white matter hyperintensities predict fluid intelligence age 78-81 years: a 1921 Aberdeen birth cohort studySima Salarirad
Biomedical Imaging Centre Radiology, University of Aberdeen, Lilian Sutton Building Foresterhill, Aberdeen AB25 2ZD, UK
Age Ageing 40:562-7. 2011..to evaluate the role of childhood intelligence and white matter hyperintensities (WMH) in the prediction of the trajectory of fluid intelligence in healthy old people from age 78 to 81...
- Brain structural complexity and life course cognitive changeNazahah Mustafa
Aberdeen Biomedical Imaging Centre, Lilian Sutton Building, University of Aberdeen, Foresterhill, AB25 2ZD Aberdeen, Scotland, UK
Neuroimage 61:694-701. 2012....
- Inter-individual differences in fMRI entropy measurements in old ageMoses O Sokunbi
Aberdeen Biomedical Imaging Centre, SINAPSE Collaboration, University of Aberdeen, Aberdeen, Scotland, UK
IEEE Trans Biomed Eng 58:3206-14. 2011..This finding was independent of ability in childhood but not independent of current cognitive ability. ApEn is used for the first time to identify a potential source of individual differences in cognitive ability using fMRI data...
- Is retaining the youthful functional anatomy underlying speed of information processing a signature of successful cognitive ageing? An event-related fMRI study of inspection time performanceGordon D Waiter
Department of Radiology, College of Life Sciences and Medicine, University of Aberdeen, UK
Neuroimage 41:581-95. 2008..The relative preservation of complex reasoning skills in old age may be associated with the preservation of the neural networks that underpin fundamental information processing in youth...
- Generality and specificity in cognitive aging: a volumetric brain analysisRoger T Staff
Department of Bio medical Physics, Aberdeen Royal Infirmary, Foresterhill, Aberdeen AB25 2ZD, UK
Neuroimage 30:1433-40. 2006..To investigate whether, in old age, brain volume differences are associated with age-related change in general mental ability and/or specific cognitive abilities...
- Homocysteine, antioxidant micronutrients and late onset dementiaLawrence J Whalley
Institute of Applied Health Sciences, University of Aberdeen, Polwarth Building, Foresterhill, Aberdeen, Scotland, AB25 2ZH, UK
Eur J Nutr 53:277-85. 2014..To distinguish between contributions to dementia made by homocysteine, folate, B12 and antioxidant micronutrients...
- How the 1932 and 1947 mental surveys of Aberdeen schoolchildren provide a framework to explore the childhood origins of late onset disease and disabilityLawrence J Whalley
Institute of Applied Health Sciences, University of Aberdeen, Foresterhill, Aberdeen, United Kingdom
Maturitas 69:365-72. 2011..To describe the discovery and development of the Aberdeen 1921 and 1936 birth cohort studies...
- Structural white matter deficits in high-functioning individuals with autistic spectrum disorder: a voxel-based investigationGordon D Waiter
Department of Radiology, University of Aberdeen, Aberdeen, UK
Neuroimage 24:455-61. 2005..No significant areas of increased white matter volume were found. Our findings support the hypothesis that reduced white matter volume in the corpus callosum and right hemisphere may play a role in the pathophysiology of ASD...
- Regional cerebral blood flow and aberrant motor behaviour in Alzheimer's diseaseThomas J Reilly
Aberdeen Biomedical Imaging Centre, School of Medicine and Dentistry, University of Aberdeen, UK
Behav Brain Res 222:375-9. 2011..These finding indicate that AMB in Alzheimer's disease are brought about by the same mechanistic failure...
- What provides cerebral reserve?Roger T Staff
Department of Bio Medical Physics and Bioengineering, University of Aberdeen and Aberdeen Royal Infirmary, Foresterhill, UK
Brain 127:1191-9. 2004..We conclude that the intellectual challenges experienced during life, such as education and occupation, accumulate reserve and allow cognitive function to be maintained in old age...
- Genetic and environmental factors in late onset dementia: possible role for early parental deathLawrence J Whalley
Institute of Applied Health Sciences, University of Aberdeen, UK
Int J Geriatr Psychiatry 28:75-81. 2013....
- Between- and within-scanner variability in the CaliBrain study n-back cognitive taskVictoria Gradin
Department of Mental Health, University of Aberdeen, UK
Psychiatry Res 184:86-95. 2010....
- Neural correlates of fatigue in granulomatosis with polyangiitis: a functional magnetic resonance imaging studyNeil Basu
School of Medicine and Dentistry, University of Aberdeen, Aberdeen, UK
Rheumatology (Oxford) 53:2080-7. 2014..The aim of this study was to investigate the neurophysiological effects of fatigue among patients with granulomatosis with polyangiitis (GPA)...
- Cerebral blood flow and cognitive responses to rivastigmine treatment in Alzheimer's diseaseAnnalena Venneri
Department of Psychology, University of Aberdeen, UK
Neuroreport 13:83-7. 2002..Longitudinal assessment with repeated imaging offers a method of better understanding the effects of cholinesterase inhibition on the AD brain...
- Structural brain complexity and cognitive decline in late life--a longitudinal study in the Aberdeen 1936 Birth CohortAnca Larisa Sandu
Aberdeen Biomedical Imaging Centre, Lilian Sutton Building, University of Aberdeen, Foresterhill, AB25 2ZD Aberdeen, Scotland, UK Electronic address
Neuroimage 100:558-63. 2014..Complexity of white matter is associated with higher fluid cognitive ability and, in a longitudinal study, predicts retention of cognitive ability within late life...
- Nonlinear complexity analysis of brain FMRI signals in schizophreniaMoses O Sokunbi
Aberdeen Biomedical Imaging Centre, University of Aberdeen, Aberdeen, United Kingdom Cardiff University Brain Research Imaging Centre, Cardiff University, Cardiff, United Kingdom Institute of Psychological Medicine and Clinical Neurosciences, Medical Research Council Centre for Neuropsychiatric Genetics and Genomics, Cardiff School of Medicine, Cardiff University, Cardiff, United Kingdom
PLoS ONE 9:e95146. 2014....
- Early life socioeconomic circumstance and late life brain hyperintensities--a population based cohort studyAlison D Murray
Aberdeen Biomedical Imaging Centre, University of Aberdeen, Aberdeen, United Kingdom
PLoS ONE 9:e88969. 2014..Hyperintensities on brain magnetic resonance imaging are associated with vascular risk factors, cognitive decline, dementia and death. However, the relationship between childhood socioeconomic circumstance and these lesions is unclear...
- Neural mechanisms of imitation and 'mirror neuron' functioning in autistic spectrum disorderJustin H G Williams
Department of Child Health, University of Aberdeen Medical School, Royal Aberdeen Children s Hospital, Aberdeen AB25 2ZG, UK
Neuropsychologia 44:610-21. 2006..Such poor integration is likely to adversely affect the development of ToM through imitation as well as other aspects of social cognitive function in ASD...
- Spatial channels of visual processing in cortical blindnessArash Sahraie
Department of Psychology, University of Aberdeen, Aberdeen AB24 2UB, UK
Eur J Neurosci 18:1189-96. 2003..The findings are discussed in relation to previous reports on the incidence of blindsight and performance on tasks involving spatial processing...
- Late-life deficits in cognitive, physical and emotional functions, childhood intelligence and occupational profile: a life-course examination of the Aberdeen 1936 Birth Cohort (ABC1936)Dorota Chapko
Aberdeen Biomedical Imaging Centre, University of Aberdeen, Aberdeen, UK
Age Ageing 45:486-93. 2016..We investigated how occupational profile and childhood intelligence contribute to the triad of impairment in late life...
- Cerebral correlates of cognitive reserveLawrence J Whalley
Aberdeen Biomedical Imaging Centre, College of Life Sciences and Medicine, University of Aberdeen, Aberdeen AB25 2ZD, UK Institute of Applied Health Sciences, University of Aberdeen, Aberdeen, UK Electronic address
Psychiatry Res 247:65-70. 2016..Cognitive reserve is considered in the context of choice of interventions to prevent dementia and the opposing effects of cerebrovascular disease and Alzheimer like brain appearances. ..
- Tau aggregation inhibitor therapy: an exploratory phase 2 study in mild or moderate Alzheimer's diseaseClaude M Wischik
School of Medicine and Dentistry, University of Aberdeen, Aberdeen, UK
J Alzheimers Dis 44:705-20. 2015..Methylthioninium (MT) acts as a selective TAI in vitro and reduces tau pathology in transgenic mouse models...
- Shape analysis of 123I-N-omega-fluoropropyl-2-beta-carbomethoxy-3beta-(4-iodophenyl) nortropane single-photon emission computed tomography images in the assessment of patients with parkinsonian syndromesRoger T Staff
Medical Physics, Aberdeen Royal Infirmary, NHS Grampian, University of Aberdeen, UK
Nucl Med Commun 30:194-201. 2009....
- Fatigue-related brain white matter changes in granulomatosis with polyangiitisNeil Basu
Musculoskeletal Collaboration Epidemiology Group, School of Medicine and Dentistry, University of Aberdeen Polwarth Building, Foresterhill, Aberdeen AB25 2ZD, UK
Rheumatology (Oxford) 52:1429-34. 2013..To determine the association between brain white matter (WM) damage and persistent fatigue among patients with granulomatosis with polyangiitis (GPA)...
- Hypoplastic internal carotid artery stenosis with a low-lying carotid bifurcation causing cerebral ischemiaAlan G Dawson
Department of Vascular Surgery, Aberdeen Royal Infirmary, Foresterhill, Aberdeen, Scotland, United Kingdom
J Vasc Surg 56:1416-8. 2012..This patient was commenced on aggressive medical therapy and at 7-month follow-up was symptom-free. This case report highlights the need for a centralized registry with long-term follow-up data in order to identify optimal management...
- A voxel-based investigation of brain structure in male adolescents with autistic spectrum disorderGordon D Waiter
Department of Radiology, University of Aberdeen, Aberdeen, UK
Neuroimage 22:619-25. 2004..The picture as a whole may reflect an abnormally functioning social cognitive neural network. We suggest that increased grey matter volume may play a pivotal role in the aetiology of the autistic syndrome...
- Increased sensitivity after repeated stimulation of residual spatial channels in blindsightArash Sahraie
Vision Research Laboratories, School of Psychology, University of Aberdeen, Aberdeen AB24 2UB, United Kingdom
Proc Natl Acad Sci U S A 103:14971-6. 2006..The results show that repeated stimulation by appropriate visual stimuli can result in improvements in visual sensitivities in the very depths of the field defect...
- Cerebral white matter abnormalities and lifetime cognitive change: a 67-year follow-up of the Scottish Mental Survey of 1932Ian J Deary
Department of Psychology, University of Edinburgh, Scotland
Psychol Aging 18:140-8. 2003..Some of this effect might be due to hypertension. This contribution is independent of mental function in early life and is associated with general cognitive ability...