Werner Muller

Summary

Publications

  1. pmc Interleukin 10 but not interleukin 4 is a natural suppressant of cutaneous inflammatory responses
    D J Berg
    Department of Immunology, DNAX Research Institute of Cellular and Molecular Biology, Palo Alto, California 94304, USA
    J Exp Med 182:99-108. 1995
  2. ncbi request reprint Keratin 14 Cre transgenic mice authenticate keratin 14 as an oocyte-expressed protein
    Martin Hafner
    Genesis 38:176-81. 2004
  3. doi request reprint Intestinal tolerance requires gut homing and expansion of FoxP3+ regulatory T cells in the lamina propria
    Usriansyah Hadis
    Institute of Immunology, Hannover Medical School, Hannover, Germany
    Immunity 34:237-46. 2011
  4. ncbi request reprint Gp130 signaling promotes development of acute experimental colitis by facilitating early neutrophil/macrophage recruitment and activation
    Leif E Sander
    Department of Medicine III, RWTH University Hospital Aachen, Aachen, Germany
    J Immunol 181:3586-94. 2008
  5. ncbi request reprint Mice with neonatally induced inactivation of the vascular cell adhesion molecule-1 fail to control the parasite in Toxoplasma encephalitis
    Martina Deckert
    Abteilung für Neuropathologie, Universitat zu Koln, Cologne, Germany
    Eur J Immunol 33:1418-28. 2003
  6. ncbi request reprint Early B-cell development in the mouse: insights from mutations introduced by gene targeting
    D Loffert
    Institute for Genetics, University of Cologne, FRG
    Immunol Rev 137:135-53. 1994
  7. ncbi request reprint Somatic hypermutation occurs in B cells of terminal deoxynucleotidyl transferase-, CD23-, interleukin-4-, IgD- and CD30-deficient mouse mutants
    G Texido
    Institute for Genetics, University of Cologne, Germany
    Eur J Immunol 26:1966-9. 1996
  8. ncbi request reprint Critical role for beta7 integrins in formation of the gut-associated lymphoid tissue
    N Wagner
    Institute for Genetics, University of Cologne, Germany
    Nature 382:366-70. 1996
  9. pmc IFN-γ-mediated induction of an apical IL-10 receptor on polarized intestinal epithelia
    Douglas J Kominsky
    Department of Anesthesiology and Perioperative Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO 80045
    J Immunol 192:1267-76. 2014
  10. ncbi request reprint The roles of L-selectin, beta 7 integrins, and P-selectin in leukocyte rolling and adhesion in high endothelial venules of Peyer's patches
    E J Kunkel
    Department of Biomedical Engineering, University of Virginia School of Medicine, Charlottesville 22908, USA
    J Immunol 161:2449-56. 1998

Detail Information

Publications144 found, 100 shown here

  1. pmc Interleukin 10 but not interleukin 4 is a natural suppressant of cutaneous inflammatory responses
    D J Berg
    Department of Immunology, DNAX Research Institute of Cellular and Molecular Biology, Palo Alto, California 94304, USA
    J Exp Med 182:99-108. 1995
    ..Based on these studies, we have concluded that IL-10, but not IL-4, is a natural suppressant of irritant responses and of CH, and it limits immunopathologic damage in the skin...
  2. ncbi request reprint Keratin 14 Cre transgenic mice authenticate keratin 14 as an oocyte-expressed protein
    Martin Hafner
    Genesis 38:176-81. 2004
    ....
  3. doi request reprint Intestinal tolerance requires gut homing and expansion of FoxP3+ regulatory T cells in the lamina propria
    Usriansyah Hadis
    Institute of Immunology, Hannover Medical School, Hannover, Germany
    Immunity 34:237-46. 2011
    ..We propose a model of stepwise oral tolerance induction comprising the generation of Treg cells in the gut-draining lymph nodes, followed by migration into the gut and subsequent expansion of Treg cells driven by intestinal macrophages...
  4. ncbi request reprint Gp130 signaling promotes development of acute experimental colitis by facilitating early neutrophil/macrophage recruitment and activation
    Leif E Sander
    Department of Medicine III, RWTH University Hospital Aachen, Aachen, Germany
    J Immunol 181:3586-94. 2008
    ..We provide evidence that IL-6 cytokines acting via gp130 are required in the acute stages of intestinal inflammation by modulating the dynamics of innate immune cell recruitment and activation...
  5. ncbi request reprint Mice with neonatally induced inactivation of the vascular cell adhesion molecule-1 fail to control the parasite in Toxoplasma encephalitis
    Martina Deckert
    Abteilung für Neuropathologie, Universitat zu Koln, Cologne, Germany
    Eur J Immunol 33:1418-28. 2003
    ....
  6. ncbi request reprint Early B-cell development in the mouse: insights from mutations introduced by gene targeting
    D Loffert
    Institute for Genetics, University of Cologne, FRG
    Immunol Rev 137:135-53. 1994
  7. ncbi request reprint Somatic hypermutation occurs in B cells of terminal deoxynucleotidyl transferase-, CD23-, interleukin-4-, IgD- and CD30-deficient mouse mutants
    G Texido
    Institute for Genetics, University of Cologne, Germany
    Eur J Immunol 26:1966-9. 1996
  8. ncbi request reprint Critical role for beta7 integrins in formation of the gut-associated lymphoid tissue
    N Wagner
    Institute for Genetics, University of Cologne, Germany
    Nature 382:366-70. 1996
    ..This is probably due to a failure of beta7-/- lymphocytes to arrest and adhere to the vasculature at the site of transmigration into the GALT...
  9. pmc IFN-γ-mediated induction of an apical IL-10 receptor on polarized intestinal epithelia
    Douglas J Kominsky
    Department of Anesthesiology and Perioperative Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO 80045
    J Immunol 192:1267-76. 2014
    ..Together, these results provide novel insight into the crucial and underappreciated role of epithelial IL-10 signaling in the maintenance and restitution of epithelial barrier and of the temporal regulation of these pathways by IFN-γ. ..
  10. ncbi request reprint The roles of L-selectin, beta 7 integrins, and P-selectin in leukocyte rolling and adhesion in high endothelial venules of Peyer's patches
    E J Kunkel
    Department of Biomedical Engineering, University of Virginia School of Medicine, Charlottesville 22908, USA
    J Immunol 161:2449-56. 1998
    ..In situ, beta 7 integrins and L-selectin account for all lymphocyte homing to Peyer's patches, but P-selectin-dependent rolling, as induced by minimal trauma, may support trafficking of effector T lymphocytes to Peyer's patches...
  11. pmc T cell-derived IL-10 determines leishmaniasis disease outcome and is suppressed by a dendritic cell based vaccine
    Tobias Schwarz
    Institute for Molecular Infection Biology, University of Wurzburg, Wurzburg, Germany
    PLoS Pathog 9:e1003476. 2013
    ..Taken together, IL-10 secretion by T cells has an influence on immune activation early after infection and is sufficient to render BALB/c mice susceptible to an uncontrolled Leishmania major infection. ..
  12. pmc Mouse SAMHD1 has antiretroviral activity and suppresses a spontaneous cell-intrinsic antiviral response
    Rayk Behrendt
    Institute for Immunology, Medical Faculty Carl Gustav Carus, University of Technology Dresden, Fetscherstrasse 74, 01307 Dresden, Germany
    Cell Rep 4:689-96. 2013
    ..SAMHD1-deficient mice may be instrumental for elucidating the mechanisms that trigger pathogenic type I IFN responses in AGS and SLE. ..
  13. ncbi request reprint Chronic colitis in IL-10-/- mice: insufficient counter regulation of a Th1 response
    N J Davidson
    DNAX Research Institute of Cellular and Molecular Biology, Palo Alto, CA 94304, USA
    Int Rev Immunol 19:91-121. 2000
    ..The findings of these mechanistic studies as they relate to our understanding of progressive inflammatory disease and the role of IL-10 in controlling the acute and chronic stages are discussed...
  14. pmc Constitutive CD40 signaling in B cells selectively activates the noncanonical NF-kappaB pathway and promotes lymphomagenesis
    Cornelia Hömig-Hölzel
    Institute of Clinical Molecular Biology and Tumor Genetics, Helmholtz Center Munich, German Research Center for Environment and Health, D 81377 Munich, Germany
    J Exp Med 205:1317-29. 2008
    ....
  15. ncbi request reprint Protective intestinal anti-rotavirus B cell immunity is dependent on alpha 4 beta 7 integrin expression but does not require IgA antibody production
    N A Kuklin
    Department of Microbiology and Immunology, Palo Alto Health Care System, Palo Alto, CA 94305, USA
    J Immunol 166:1894-902. 2001
    ..Our findings suggest that alpha(4)beta(7) integrin expression is necessary for B cell-mediated immunity to RV independent of the presence of IgA...
  16. ncbi request reprint Common cytokine receptor gamma chain (gammac)-deficient B cells persist in T cell-deficient gammac-mice and respond to a T-independent antigen
    C A Vosshenrich
    Institute for Genetics, Cologne, Germany
    Eur J Immunol 30:1614-22. 2000
    ..The gammac-/nude and gammac-/TCRbeta-/- mice provide new models to dissect the role of gammac-dependent receptors during murine B cell differentiation...
  17. ncbi request reprint Interleukin-10-deficient mice develop chronic enterocolitis
    R Kuhn
    Institute for Genetics, University of Cologne, Federal Republic of Germany
    Cell 75:263-74. 1993
    ..These results indicate that the bowel inflammation in the mutants originates from uncontrolled immune responses stimulated by enteric antigens and that IL-10 is an essential immunoregulator in the intestinal tract...
  18. pmc Rearrangement and expression of immunoglobulin light chain genes can precede heavy chain expression during normal B cell development in mice
    T I Novobrantseva
    Institute for Genetics, University of Cologne, Weyertal 121, 50931 Cologne, Germany
    J Exp Med 189:75-88. 1999
    ..In addition, we show that in B cell progenitors VkappaJkappa joining rapidly initiates kappa chain expression, irrespective of the presence of a mu chain...
  19. doi request reprint Gp130-dependent astrocytic survival is critical for the control of autoimmune central nervous system inflammation
    Fahad Haroon
    Institut fur Medizinische Mikrobiologie, Otto von Guericke Universitat Magdeburg, 39120 Magdeburg, Germany
    J Immunol 186:6521-31. 2011
    ....
  20. doi request reprint IL-10 acts as a developmental switch guiding monocyte differentiation to macrophages during a murine peritoneal infection
    Huu Hung Nguyen
    Department of Immunology, University of Greifswald, 17487 Greifswald, Germany
    J Immunol 189:3112-20. 2012
    ..Finally, high numbers of wild-type monocytes injected into IL-10R1-deficient animals develop into MHC II(lo) macrophages and were able by a bystander effect to induce the differentiation of the endogenous monocytes to the same fate...
  21. doi request reprint T-cell-specific deletion of gp130 renders the highly susceptible IL-10-deficient mouse resistant to intestinal nematode infection
    Nicolas Fasnacht
    Department of Experimental Immunology, Helmholtz Centre for Infection Research, Braunschweig, Germany
    Eur J Immunol 39:2173-83. 2009
    ..Taken together, the data demonstrate that gp130 signalling in T cells is a positive regulator of inflammatory processes, favouring the Th1/Th17 axis...
  22. ncbi request reprint Cre-loxP-mediated gene replacement: a mouse strain producing humanized antibodies
    Y R Zou
    Institute of Genetics, University of Cologne, Germany
    Curr Biol 4:1099-103. 1994
    ..In principle, Cre-loxP-mediated recombination should also allow gene replacement, and thus the introduction of virtually any kind of mutation into the genome...
  23. ncbi request reprint Tolerance without clonal expansion: self-antigen-expressing B cells program self-reactive T cells for future deletion
    Friederike Frommer
    I Medical Department, Johannes Gutenberg University Mainz, Obere Zahlbacher Str 63, Mainz, Germany
    J Immunol 181:5748-59. 2008
    ..In contrast, the T cells became sensitive to Ag-induced cell death. Our results demonstrate that B cells participate in the homeostasis of the immune system by ablation of conventional self-reactive T cells...
  24. ncbi request reprint Interleukin 6/gp130-dependent pathways are protective during chronic liver diseases
    Konrad L Streetz
    Department of Gastroenterology, Hepatology and Endocrinology, Medizinische Hochschule Hannover, Hannover, Germany
    Hepatology 38:218-29. 2003
    ..Hepatology 2003;38:218-229)...
  25. pmc Conditional deletion of the MHC class I-related receptor FcRn reveals the sites of IgG homeostasis in mice
    Héctor Pérez Montoyo
    Department of Immunology, University of Texas Southwestern Medical Center, 6000 Harry Hines Boulevard, Dallas, TX 75390 9093, USA
    Proc Natl Acad Sci U S A 106:2788-93. 2009
    ..The primary sites for the maintenance of endogenous IgGs in mice are therefore endothelial and hematopoietic cells...
  26. ncbi request reprint Beta7 integrin-deficient mice: delayed leukocyte recruitment and attenuated protective immunity in the small intestine during enteric helminth infection
    D Artis
    Immunology Group, School of Biological Sciences, University of Manchester, GB
    Eur J Immunol 30:1656-64. 2000
    ..Furthermore, these results suggest that beta7 integrin-independent adhesion molecule interactions are deployed in the large but not small intestine during intestinal inflammation...
  27. ncbi request reprint Beta7 integrins contribute to skin graft rejection
    Xueying Sun
    Department of Molecular Medicine and Pathology, Faculty of Medicine and Health Science, University of Auckland, 85 Park Road, Grafton, New Zealand
    Transplantation 74:1202-3. 2002
    ..Because integrins alpha4beta7 and alphaEbeta7 contribute to epidermotropism of T-cells during skin inflammation, we sought to study their role in skin allograft rejection...
  28. doi request reprint Monocyte-derived dendritic cells perform hemophagocytosis to fine-tune excessive immune responses
    Hideaki Ohyagi
    Department of Hematology, Nephrology and Rheumatology, Akita University Graduate School of Medicine, Akita 010 8543, Japan
    Immunity 39:584-98. 2013
    ..This sheds light on the physiological relevance of hemophagocytosis in severe inflammatory and infectious diseases. ..
  29. doi request reprint Regulatory T cell-derived interleukin-10 limits inflammation at environmental interfaces
    Yuri P Rubtsov
    Department of Immunology, University of Washington School of Medicine, Seattle, WA 98195, USA
    Immunity 28:546-58. 2008
    ..Furthermore, these mechanisms are likely to be nonredundant, in that a distinct suppressor mechanism most likely plays a prominent and identifiable role at a particular tissue and inflammatory setting...
  30. doi request reprint Role of beta7 integrin and the chemokine/chemokine receptor pair CCL25/CCR9 in modeled TNF-dependent Crohn's disease
    Maria Apostolaki
    Institute of Immunology, Biomedical Sciences Research Center Alexander Fleming, Vari, Greece
    Gastroenterology 134:2025-35. 2008
    ....
  31. ncbi request reprint Nine fluorescence parameter analysis on a four-color fluorescence activated flow cytometer
    Ursula Frischmann
    German Research Centre for Biotechnology, Department of Experimental Immunology, Mascheroder Weg 1, D 38124 Braunschweig
    Cytometry A 69:124-6. 2006
    ..In many cases a frequent monitoring of blood is important, e.g. during an infection. Often the availability of blood is the limiting factor...
  32. ncbi request reprint Lack of gp130 expression in hepatocytes promotes liver injury
    Konrad L Streetz
    Department of Gastroenterology, Hepatology and Endocrinology, Medizinische Hochschule Hannover, Hannover, Germany
    Gastroenterology 125:532-43. 2003
    ..To define the IL-6-dependent intracellular pathways more specifically, we generated a hepatocyte-specific gp130 knockout mouse...
  33. doi request reprint A key role for gp130 expressed on peripheral sensory nerves in pathological pain
    Manfred Andratsch
    Department of Physiology and Medical Physics, Division of Physiology, Innsbruck Medical University, Innsbruck, Austria
    J Neurosci 29:13473-83. 2009
    ..Our results uncover the significance of gp130 expressed in peripheral pain sensing neurons in the pathophysiology of major clinical pain disorders and suggest their use as novel pain relieving agents in inflammatory and tumor pain...
  34. doi request reprint β7 integrin controls immunogenic and tolerogenic mucosal B cell responses
    Angela Schippers
    Department of Pediatrics, Medical Faculty, RWTH Aachen University, Aachen D 52074, Germany
    Clin Immunol 144:87-97. 2012
    ..These observations suggest that β7 integrin expression on cells of the innate immune system contributes to the critical role of β7 integrin in the process of B cell tolerance...
  35. ncbi request reprint IL-15 is an essential mediator of peripheral NK-cell homeostasis
    Thomas Ranson
    Unité des Cytokines et Développement Lymphoide, Institut Pasteur, Paris, France
    Blood 101:4887-93. 2003
    ..Finally, although NK cells bear functional inhibitory Ly49 receptors for MHC class I molecules, the presence or absence of specific ligands on host cells did not influence the survival or homeostatic expansion of donor NK cells...
  36. pmc Langerhans cells suppress contact hypersensitivity responses via cognate CD4 interaction and langerhans cell-derived IL-10
    Botond Z Igyarto
    Department of Dermatology, Center for Immunology, University of Minnesota, Minneapolis, MN 55455, USA
    J Immunol 183:5085-93. 2009
    ..These data support a model in which cognate interaction of LC with CD4 T cells enables LC to inhibit expansion of Ag-specific responses via elaboration of IL-10...
  37. ncbi request reprint Immunoglobulin heavy and light chain genes rearrange independently at early stages of B cell development
    A Ehlich
    Institute for Genetics, University of Cologne, Federal Republic of Germany
    Cell 72:695-704. 1993
    ..We show that neither the pre-B cell receptor complex nor any gene rearrangement in the heavy chain locus is required for the induction of kappa light chain gene rearrangement in early B cell progenitors...
  38. ncbi request reprint Dissecting the cytokine network
    Werner Muller
    University of Manchester, Michael Smith Building, Oxford Road, Manchester, M13 9PT, UK
    Cell Immunol 244:162-4. 2006
    ..This increase in complexity leads to fascinating challenges in the future...
  39. ncbi request reprint LMP1 signaling can replace CD40 signaling in B cells in vivo and has unique features of inducing class-switch recombination to IgG1
    Julia Rastelli
    Institute of Clinical Molecular Biology and Tumor Genetics, GSF National Research Center for Environment and Health, Munich, Germany
    Blood 111:1448-55. 2008
    ..Thus, our data indicate that LMP1 has evolved to imitate T-helper cell function allowing activation, proliferation, and differentiation of EBV-infected B cells independent of T cells...
  40. ncbi request reprint Generation and analysis of interleukin-4 deficient mice
    R Kuhn
    Institute for Genetics, University of Cologne, Germany
    Science 254:707-10. 1991
    ..Thus, some but not all of the in vitro properties of IL-4 are critical for the physiology of the immune system in vivo...
  41. pmc Antiviral immune responses in mice deficient for both interleukin-2 and interleukin-4
    M F Bachmann
    Department of Pathology, University of Zurich, Switzerland
    J Virol 69:4842-6. 1995
    ....
  42. pmc Cloning of the murine thymic stromal lymphopoietin (TSLP) receptor: Formation of a functional heteromeric complex requires interleukin 7 receptor
    L S Park
    Department of Biochemistry, Immunex Corporation, Seattle, Washington 98101, USA
    J Exp Med 192:659-70. 2000
    ..TSLP did not activate cells from IL-7Ralpha(-/)- mice, but did activate cells from gammac(-/)- mice. Thus, the functional TSLPR requires the IL-7Ralpha chain, but not the gammac chain for signaling...
  43. pmc Induction of interleukin 4 (IL-4) expression in T helper (Th) cells is not dependent on IL-4 from non-Th cells
    J Schmitz
    Institute for Genetics, University of Cologne, Germany
    J Exp Med 179:1349-53. 1994
    ..No IgE is detectable, however, in mice in which only CD4- cells can express IL-4, suggesting that Th cells are the primary, if not the only source of IL-4 for initial induction of IgE synthesis...
  44. pmc Pro-B cells sense productive immunoglobulin heavy chain rearrangement irrespective of polypeptide production
    Johannes Lutz
    Division of Molecular Immunology, Department of Internal Medicine III, Nikolaus Fiebiger Center of Molecular Medicine, Friedrich Alexander University Erlangen Nurnberg, D 91054 Erlangen, Germany
    Proc Natl Acad Sci U S A 108:10644-9. 2011
    ....
  45. pmc T cell-specific inactivation of the interleukin 10 gene in mice results in enhanced T cell responses but normal innate responses to lipopolysaccharide or skin irritation
    Axel Roers
    Dept of Dermatology, University of Cologne, Josef Stelzmann Str 9, 50931 Cologne, Germany
    J Exp Med 200:1289-97. 2004
    ..Our data highlight the importance of T cell-derived IL-10 in the regulation of T cell responses and demonstrate that endotoxic shock and the irritant response of the skin are controlled by IL-10 from other cell types...
  46. ncbi request reprint In the absence of endogenous IL-10, mice acutely infected with Toxoplasma gondii succumb to a lethal immune response dependent on CD4+ T cells and accompanied by overproduction of IL-12, IFN-gamma and TNF-alpha
    R T Gazzinelli
    Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892, USA
    J Immunol 157:798-805. 1996
    ..Together the data suggest that endogenous IL-10 synthesis plays an important role in vivo in down-regulating monokine and IFN-gamma responses to acute intracellular infection, thereby preventing host immunopathology...
  47. ncbi request reprint CD4+ T cell-associated pathophysiology critically depends on CD18 gene dose effects in a murine model of psoriasis
    Daniel Kess
    Department of Dermatology, University of Cologne, Cologne, Germany
    J Immunol 171:5697-706. 2003
    ..This murine inflammatory skin model may also have relevance for human polygenic inflammatory diseases...
  48. pmc Gp130-dependent release of acute phase proteins is linked to the activation of innate immune signaling pathways
    Maren Luchtefeld
    Department of Cardiology and Angiology, Hannover Medical School, Hannover, Germany
    PLoS ONE 6:e19427. 2011
    ..In a previous study, we demonstrated the importance of the IL-6-gp130 axis -as a key regulator of inflammatory acute phase signaling in hepatocytes-for the development of atherosclerosis...
  49. doi request reprint Susceptibility of four inbred mouse strains to a low-pathogenic isolate of Yersinia enterocolitica
    Angela Schippers
    Department of Experimental Immunology, Helmholtz Centre for Infection Research, Inhoffenstrasse 7, 38124 Braunschweig, Germany
    Mamm Genome 19:279-91. 2008
    ..It is furthermore an appropriate model to characterize genetic differences in resistance and immunity of inbred and mutant mouse lines...
  50. ncbi request reprint Sphingosine-1 phosphate signaling regulates positioning of dendritic cells within the spleen
    Niklas Czeloth
    Institute of Immunology, Hannover Medical School, Hannover, Germany
    J Immunol 179:5855-63. 2007
    ....
  51. ncbi request reprint Introducing the German Mouse Clinic: open access platform for standardized phenotyping
    Valerie Gailus-Durner
    Nat Methods 2:403-4. 2005
  52. pmc IMGT, the international ImMunoGeneTics database
    M P Lefranc
    Laboratoire d Immunogenetique moleculaire, Universite Montpellier II, UPR CNRS 1142 IGH, 141 rue de la Cardonille, 34396 Montpellier Cedex 5, France
    Nucleic Acids Res 27:209-12. 1999
    ..IMGT is freely available at http://imgt.cnusc. fr:8104..
  53. ncbi request reprint Analysis of granuloma formation in double cytokine-deficient mice reveals a central role for IL-10 in polarizing both T helper cell 1- and T helper cell 2-type cytokine responses in vivo
    T A Wynn
    Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892 0425, USA
    J Immunol 159:5014-23. 1997
    ..Together, these results argue first that IL-10 is an important endogenous down-regulator of type 2 as well as type 1 cytokine synthesis, and second, that its induction is critical for type 2 response polarization in vivo...
  54. ncbi request reprint IL-20 receptor 2 signaling down-regulates antigen-specific T cell responses
    Christian Wahl
    University Medical Center, Center of Internal Medicine, Department of Internal Medicine I, Ulm, Germany
    J Immunol 182:802-10. 2009
    ..For the first time, we provide evidence that IL-19, IL-20, and IL-24 are part of a signaling network that normally down-modulates T cell responses in mice...
  55. doi request reprint Charles River altered Schaedler flora (CRASF) remained stable for four years in a mouse colony housed in individually ventilated cages
    Matthias Stehr
    Department of Genome Analysis, Helmholtz Centre for Infection Research, Inhoffenstrasse 7, 38124 Braunschweig, Germany
    Lab Anim 43:362-70. 2009
    ..CRASF remained stable for seven mouse generations and was efficiently transferred to the imported mouse strains...
  56. pmc Neonatally induced inactivation of the vascular cell adhesion molecule 1 gene impairs B cell localization and T cell-dependent humoral immune response
    C E Leuker
    Institute for Genetics, University of Cologne, Weyertal 121, D 50931 Cologne, Germany
    J Exp Med 193:755-68. 2001
    ..In addition, the humoral immune response to a T cell-dependent antigen is impaired. VCAM-1 serves an important role for B cell localization and the T cell-dependent humoral immune response...
  57. pmc gp130 signaling in proopiomelanocortin neurons mediates the acute anorectic response to centrally applied ciliary neurotrophic factor
    Ruth Janoschek
    Institute for Genetics and Center for Molecular Medicine Cologne, Department of Mouse Genetics and Metabolism, University of Cologne, D 50674 Cologne, Germany
    Proc Natl Acad Sci U S A 103:10707-12. 2006
    ..These data reveal POMC neurons as a critical site of CNTF action in mediating its anorectic effect...
  58. ncbi request reprint Heterozygous deficiency of manganese superoxide dismutase results in severe lipid peroxidation and spontaneous apoptosis in murine myocardium in vivo
    Maria Strassburger
    Department of Dermatology and Allergology, University of Ulm, Maienweg 12, 89081 Ulm, Germany
    Free Radic Biol Med 38:1458-70. 2005
    ..This model may be particularly suited to long-term studies on age-related heart failure as well as other age-related diseases and the polygenic base of tissue-specific responses to oxidative injury...
  59. doi request reprint Differential roles of macrophages in diverse phases of skin repair
    Tina Lucas
    Department of Dermatology, University of Cologne, Cologne, Germany
    J Immunol 184:3964-77. 2010
    ..These results demonstrate that macrophages exert distinct functions during the diverse phases of skin repair, which are crucial to control the natural sequence of repair events...
  60. ncbi request reprint A role for CD5 in TCR-mediated signal transduction and thymocyte selection
    A Tarakhovsky
    Institute for Genetics, University of Cologne, Germany
    Science 269:535-7. 1995
    ..These observations indicate that CD5 can influence the fate of developing thymocytes by acting as a negative regulator of TCR-mediated signal transduction...
  61. ncbi request reprint Loss of a gp130 cardiac muscle cell survival pathway is a critical event in the onset of heart failure during biomechanical stress
    H Hirota
    UCSD Salk NHLBI Program in Molecular Medicine, Department of Medicine, La Jolla 920093, USA
    Cell 97:189-98. 1999
    ..Thus, cardiac myocyte apoptosis is a critical point in the transition between compensatory cardiac hypertrophy and heart failure. gp130-dependent cytokines may represent a novel therapeutic strategy for preventing in vivo heart failure...
  62. ncbi request reprint Interleukin-6/glycoprotein 130-dependent pathways are protective during liver regeneration
    Torsten Wuestefeld
    Department of Gastroenterology, Hepatology, and Endocrinology, Medizinische Hochschule Hannover, 30625 Hannover, Germany
    J Biol Chem 278:11281-8. 2003
    ..Thus our results suggest that the role of gp130-dependent signaling is not a direct influence on cell cycle progression after partial hepatectomy but is to activate protective pathways important to enable hepatocyte proliferation...
  63. pmc IL-27 promotes IL-10 production by effector Th1 CD4+ T cells: a critical mechanism for protection from severe immunopathology during malaria infection
    Ana Paula Freitas do Rosario
    Division of Parasitology, Medical Research Council National Institute for Medical Research, London, NW7 1AA, United Kingdom
    J Immunol 188:1178-90. 2012
    ..Finally, in this model of malaria, we demonstrate that the generation of protective IL10(+)IFN-γ(+) Th1 cells is dependent on IL-27 signaling and independent of IL-21...
  64. pmc T helper cell 1-type CD4+ T cells, but not B cells, mediate colitis in interleukin 10-deficient mice
    N J Davidson
    DNAX Research Institute of Molecular and Cellular Biology Inc, Palo Alto, California 94304, USA
    J Exp Med 184:241-51. 1996
    ..We thus conclude that colitis in IL-10-/- mice is predominantly mediated by TH1-type alpha beta TCR+ T cells expressing CD4 alone, or in combination with the CD8 alpha molecule...
  65. ncbi request reprint Serum response factor contributes selectively to lymphocyte development
    Anne Fleige
    Department of Experimental Immunology, Helmholtz Centre for Infection Research, 38124 Braunschweig, Germany
    J Biol Chem 282:24320-8. 2007
    ..We conclude that SRF fulfills essential and distinct functions in the differentiation of different types of lymphocytes...
  66. pmc Interleukin-10 is a central regulator of the response to LPS in murine models of endotoxic shock and the Shwartzman reaction but not endotoxin tolerance
    D J Berg
    Department of Immunology, DNAX Research Institute of Cellular and Molecular Biology, Palo Alto, California 94304, USA
    J Clin Invest 96:2339-47. 1995
    ..These results show that IL-10 is a critical component of the host's natural defense against the development of pathologic responses to LPS although it is not responsible for LPS-induced tolerance...
  67. doi request reprint T-cell-derived, but not B-cell-derived, IL-10 suppresses antigen-specific T-cell responses in Litomosoides sigmodontis-infected mice
    Irma Haben
    Bernhard Nocht Institute for Tropical Medicine, Hamburg, Germany
    Eur J Immunol 43:1799-805. 2013
    ..Our results suggest that the initiation of Ag-specific cellular responses during L. sigmodontis infection is suppressed by T-cell-derived IL-10 and not by B-cell-derived IL-10. ..
  68. doi request reprint Neuronal gp130 expression is crucial to prevent neuronal loss, hyperinflammation, and lethal course of murine Toxoplasma encephalitis
    Ulrike Händel
    Institute of Medical Microbiology, Otto von Guericke University, Magdeburg, Magdeburg, Germany
    Am J Pathol 181:163-73. 2012
    ..Collectively, these findings indicate a crucial protective function of gp130-expressing neurons in a model of chronic encephalitis...
  69. pmc Preconditioning-induced protection of photoreceptors requires activation of the signal-transducing receptor gp130 in photoreceptors
    Yumi Ueki
    Department of Cell Biology, Oklahoma Center for Neuroscience, University of Oklahoma Health Sciences Center, Oklahoma City, OK73104, USA
    Proc Natl Acad Sci U S A 106:21389-94. 2009
    ....
  70. ncbi request reprint VH replacement rescues progenitor B cells with two nonproductive VDJ alleles
    Johannes Lutz
    Division of Molecular Immunology, Department of Internal Medicine III, Nikolaus Fiebiger Center of Molecular Medicine, Friedrich Alexander University Erlangen Nurnberg, Erlangen, Germany
    J Immunol 177:7007-14. 2006
    ..In conclusion, VH replacement can occur in the absence of a muH chain signal and provides a potential rescue mechanism for pro-B cells with two nonproductive IgH alleles...
  71. ncbi request reprint Monoclonal antibody against beta7 integrins, but not beta7 deficiency, attenuates intestinal allograft rejection in mice
    Richard Kellersmann
    Department of Surgery, University of Wurzburg, Wurzburg, Germany
    Transplantation 74:1327-34. 2002
    ..In the present study, we investigated the expression of beta7 integrins after small bowel transplantation (SBT) and tested the effects of blocking beta7-mediated pathways by using monoclonal antibody (mAb) or knockout mice...
  72. ncbi request reprint Altered immune responses in mice lacking inducible nitric oxide synthase
    X Q Wei
    Department of Immunology, University of Glasgow, UK
    Nature 375:408-11. 1995
    ..The mutant mice showed reduced nonspecific inflammatory response to carrageenin, and were resistant to lipopolysaccharide-induced mortality...
  73. pmc Mice reconstituted with DNA polymerase beta-deficient fetal liver cells are able to mount a T cell-dependent immune response and mutate their Ig genes normally
    G Esposito
    Institute for Genetics, University of Cologne, D 50931 Cologne, Germany
    Proc Natl Acad Sci U S A 97:1166-71. 2000
    ....
  74. pmc Neuroprotective intervention by interferon-γ blockade prevents CD8+ T cell-mediated dendrite and synapse loss
    Mario Kreutzfeldt
    Department of Pathology and Immunology and 2 World Health Organization Collaborating Centre for Vaccine Immunology, University of Geneva, 1211 Geneva, Switzerland
    J Exp Med 210:2087-103. 2013
    ..These findings identify neuronal IFN-γ signaling as a novel target for neuroprotective interventions in CTL-mediated CNS disease. ..
  75. pmc The p53-dependent effects of macrophage migration inhibitory factor revealed by gene targeting
    G Fingerle-Rowson
    The Picower Institute for Medical Research, Manhasset, NY 11030, USA
    Proc Natl Acad Sci U S A 100:9354-9. 2003
    ..The data provide direct genetic evidence for a functional link between MIF and the p53 tumor suppressor and indicate an important and previously unappreciated role for MIF in carcinogenesis...
  76. doi request reprint Synthetic mimetics of the gp130 binding site for viral interleukin-6 as inhibitors of the vIL-6-gp130 interaction
    Enge Sudarman
    Chem Biol Drug Des 71:494-500. 2008
    ..These results validate the concept of synthetic mimicry of discontinuous protein-binding sites through assembled peptides, and the use of such molecules as modulators of protein-ligand interactions...
  77. doi request reprint Mucosal addressin cell-adhesion molecule-1 controls plasma-cell migration and function in the small intestine of mice
    Angela Schippers
    Department of Pediatrics, Medical Faculty, RWTH Aachen University, Germany
    Gastroenterology 137:924-33. 2009
    ..We aimed to elucidate the in vivo role of the mucosal addressin cell-adhesion molecule-1 (MAdCAM-1), which is constitutively expressed in the GI-associated lymphoid tissue, in B-cell migration...
  78. pmc Signal transducer of inflammation gp130 modulates atherosclerosis in mice and man
    Maren Luchtefeld
    Abteilung fur Kardiologie und Angiologie, Medizinische Hochschule Hannover, 30625 Hannover, Germany
    J Exp Med 204:1935-44. 2007
    ..Thus, the acute phase reaction should be considered an important target for future drug development in the management of CAD...