Kevin P Moore
Affiliation: University College London
- The management of ascites in cirrhosis: report on the consensus conference of the International Ascites ClubKevin P Moore
Centre for Hepatology, Royal Free and University College Medical School, UCL, London, United Kingdom
Hepatology 38:258-66. 2003..Liver transplantation should be considered for all ascitic patients, and this should preferably be performed prior to the development of renal dysfunction to prevent further compromise of their prognosis...
- Endothelin and vascular function in liver diseaseK Moore
Centre for Hepatology, Royal Free and University College Medical School, University College London, Rowland Hill Street, London NW3 2PF, UK
Gut 53:159-61. 2004..Speculation on the role of endothelin in the pathogenesis of acute renal failure, including hepatorenal syndrome, has also been speculated...
- Isoprostanes and the liverKevin Moore
Centre for Hepatology, Royal Free and University College Medical School, University College London, London, UK
Chem Phys Lipids 128:125-33. 2004..90 (6) (1992b) 2502; J. Lipid Mediat. 6 (1/3) (1993) 417]. This article will cover the measurement of F2-IsoPs as markers of lipid peroxidation in vivo in liver disease, and review their biological activity as mediators of disease...
- Making and working with hydrogen sulfide: The chemistry and generation of hydrogen sulfide in vitro and its measurement in vivo: a reviewMartin N Hughes
Centre for Hepatology, Department of Medicine, University College London Medical School, London NW3 2PF, UK
Free Radic Biol Med 47:1346-53. 2009..We also give a brief overview of knockout animals and inhibition of the enzymes involved in the formation of hydrogen sulfide in vivo...
- Heart rate dynamics in iNOS knockout miceAli R Mani
The UCL Institute of Hepatology, Department of Medicine, Royal Free and University College Medical School, UCL, London, Rowland Hill Street London NW3 2PF, UK
Life Sci 79:1593-9. 2006..We conclude that disruption of iNOS gene leads to an increase in the low frequency power of HRV consistent with increased cardiac sympathetic activity. These data also demonstrate that LPS-induced decrease of HRV is independent of iNOS...
- Decreased heart rate variability in patients with cirrhosis relates to the presence and degree of hepatic encephalopathyAli R Mani
Centre for Hepatology, Royal Free Campus, University College London Medical School, London, UK
Am J Physiol Gastrointest Liver Physiol 296:G330-8. 2009..The changes observed in HRV and in neuropsychiatric status in patients with cirrhosis are significantly correlated, most likely reflecting a common pathogenic mechanism mediated by inflammatory cytokines...
- Endotoxemia produces coma and brain swelling in bile duct ligated ratsGavin Wright
Liver Failure Group, Institute of Hepatology, Division of Medicine, University College London, 69 75 Chenies Mews, London, UK
Hepatology 45:1517-26. 2007..Although the exact mechanism of how hyperammonemia and LPS facilitate cytotoxic edema and pre-coma in cirrhosis is not clear, our data support an important role for the nitrosation of brain proteins...
- pH-dependent nitration of para-hydroxyphenylacetic acid in the stomachAnanth S Pannala
Centre for Age Related Diseases, GKT School of Biomedical Sciences, King s College London, London, UK
Free Radic Biol Med 41:896-901. 2006....
- Nitration of cardiac proteins is associated with abnormal cardiac chronotropic responses in rats with biliary cirrhosisAli R Mani
The UCL Institute of Hepatology, Department of Medicine, Royal Free and University College Medical School, University College London, London, UK
Hepatology 43:847-56. 2006..Two independent treatments (N-acetylcysteine and L-NAME) that decrease nitration of cardiac proteins led to normalization of cardiac responses. Nitration of critical proteins in cardiac tissue may lead to abnormal cardiac function...
- Nitration of endogenous para-hydroxyphenylacetic acid and the metabolism of nitrotyrosineAli R Mani
Centre for Hepatology, Department of Medicine, Royal Free and University College Medical School, University College London, Rowland Hill Street, London NW3 2PF, UK
Biochem J 374:521-7. 2003..This is the first study to demonstrate that NHPA can be formed by nitration of PHPA in vivo, and that this is the major route for its formation...
- Peroxynitrite-induced oxidation of plasma lipids is enhanced in stable hemodialysis patientsBarbara Ferraro
Centre for Hepatology, Royal Free and University College Medical School, London, United Kingdom
Kidney Int 63:2207-13. 2003....
- Metalloprotein-dependent decomposition of S-nitrosothiols: studies on the stabilization and measurement of S-nitrosothiols in tissuesAli R Mani
The UCL Institute of Hepatology, Department of Medicine, Royal Free and University College Medical School, University College London, London NW3 2PF, UK
Free Radic Biol Med 40:1654-63. 2006....
- Xanthine oxidoreductase is present in bile ducts of normal and cirrhotic liverHannah M Martin
Department of Biology and Biochemistry, University of Bath, Bath, BA2 7AY, UK
Free Radic Biol Med 37:1214-23. 2004..We conclude that XOR is expressed primarily in hepatocytes, but is also present in bile duct epithelial cells and is secreted into bile. Its role in bile is unknown but it may be involved in innate immunity of the bowel muscosa...
- Urinary excretion of the nitrotyrosine metabolite 3-nitro-4-hydroxyphenylacetic acid in preterm and term infantsThomas Hoehn
Neonatology and Paediatric Intensive Care Medicine, Department of General Paediatrics, Heinrich Heine University, Dusseldorf, Germany
Neonatology 93:73-6. 2008..Nitrative stress is predominantly caused following synthesis of peroxynitrite. Particularly preterm infants with immature defense mechanisms against free radical injury appear at risk...
- Discovery of lipid peroxidation products formed in vivo with a substituted tetrahydrofuran ring (isofurans) that are favored by increased oxygen tensionJoshua P Fessel
Departments of Pharmacology, Vanderbilt University, Nashville, TN 37232, USA
Proc Natl Acad Sci U S A 99:16713-8. 2002....
- The metabolic fate of dietary polyphenols in humansAndreas R Rechner
Antioxidant Research Group, Wolfson Centre for Age Related Diseases, School of Biomedical Sciences, King s College London, UK
Free Radic Biol Med 33:220-35. 2002..The results suggest that consideration should be given to the cleavage products as having a putative role as physiologically relevant bioactive components in vivo...