A H Mirnezami
Affiliation: University of Southampton
- Role of the unique N-terminal domain of CtBP2 in determining the subcellular localisation of CtBP family proteinsLee M Bergman
Cancer Sciences Division, School of Medicine, University of Southampton, Southampton SO16 6YD, UK
BMC Cell Biol 7:35. 2006..CtBP2s from diverse species contain a unique N-terminus, absent in CtBP1 that plays a key role in controlling the nuclear-cytoplasmic distribution of the protein...
- MicroRNAs: key players in carcinogenesis and novel therapeutic targetsA H F Mirnezami
University Surgical Unit, Level F Centre Block, Southampton General Hospital, Southampton, UK
Eur J Surg Oncol 35:339-47. 2009..The purpose of this review is to summarise these findings in relation to the most common human malignancies, and to analyse the clinical and therapeutic opportunities they provide...
- Robotic colorectal surgery: hype or new hope? A systematic review of robotics in colorectal surgeryA H Mirnezami
Department of Colorectal Surgery, Southampton University Hospital NHS Trust, Southampton, UK
Colorectal Dis 12:1084-93. 2010..The aim of this review is to provide a comprehensive and critical analysis of the available literature on the use of robotic technology in colorectal surgery...
- Increased local recurrence and reduced survival from colorectal cancer following anastomotic leak: systematic review and meta-analysisAlexander Mirnezami
Somers Cancer Research Building, University of Southampton Cancer Sciences Division, Southampton University Hospital NHS Trust, Tremona Road, Southampton, United Kingdom
Ann Surg 253:890-9. 2011..To examine the long-term oncological impact of anastomotic leakage (AL) after restorative surgery for colorectal cancer using meta-analytical methods. Outcomes evaluated were local recurrence, distant recurrence, and survival...
- Pleiotropic actions of miR-21 highlight the critical role of deregulated stromal microRNAs during colorectal cancer progressionM D Bullock
Cancer Sciences Division, University of Southampton, Southampton General Hospital, Southampton, UK
Cell Death Dis 4:e684. 2013....
- Translational aspects in targeting the stromal tumour microenvironment: from bench to bedsideR Bhome
Cancer Sciences, Faculty of Medicine, University of Southampton, Somers Building, Southampton General Hospital, Tremona Road, Southampton, SO16 6YD UK University Surgery, South Academic Block, Southampton General Hospital, Tremona Road, Southampton, SO16 6YD UK
New Horiz Transl Med 3:9-21. 2016..This review outlines key players in the stromal tumour microenvironment and discusses potential targeting strategies that may offer therapeutic benefit...
- miR-19-Mediated Inhibition of Transglutaminase-2 Leads to Enhanced Invasion and Metastasis in Colorectal CancerD Cellura
Molecular Mechanisms Research Unit, Cancer Research UK Centre, University of Southampton Cancer Sciences Division, Somers Cancer Research Building, Southampton University Hospital NHS Trust, Southampton, United Kingdom
Mol Cancer Res 13:1095-105. 2015..Finally, miR-19 overexpression and subsequent decreased TG2 expression was linked to chromosome-13 amplification events, leading to altered invasive behavior in colorectal cancer cells...
- FOXO3 expression during colorectal cancer progression: biomarker potential reflects a tumour suppressor roleM D Bullock
Cancer Research UK Centre, University of Southampton, Somers Cancer Sciences Building, Southampton General Hospital, University Hospital Southampton, Tremona Road, Southampton, UK
Br J Cancer 109:387-94. 2013..To clarify its role in human colorectal cancer (CRC) progression, we examined in vivo FOXO3 expression at key points of the metastatic cascade...
- The adaptive immune response to colorectal cancer: from the laboratory to clinical practiceN J Curtis
Department of Surgery, University Hospital Southampton, Tremona Road, Southampton, Hampshire SO16 6YD, UK
Eur J Surg Oncol 38:889-96. 2012..We aimed to review recent findings to investigate the potential for clinical use...