Robert F Miller

Summary

Affiliation: University College London
Country: UK

Publications

  1. ncbi Human immunodeficiency virus type 1-related pulmonary Mycobacterium xenopi infection: a need to treat?
    L Kerbiriou
    Department of Respiratory Medicine, Royal Free Hospital, London, United Kingdom
    Clin Infect Dis 37:1250-4. 2003
  2. ncbi Pneumocystis carinii infection in non-AIDS patients
    R F Miller
    Windeyer Institute of Medical Sciences, Royal Free and University College Medical School, London, UK
    Curr Opin Infect Dis 12:371-7. 1999
  3. ncbi Pneumonia complicating Shigella sonnei dysentery in an HIV-infected adult male
    R F Miller
    Centre for Sexual Health and HIV Research, Department of Population Sciences and Primary Care, Royal Free and University College Medical School, University College London
    Int J STD AIDS 16:763-5. 2005
  4. pmc Genotypes of Pneumocystis jiroveci isolates obtained in Harare, Zimbabwe, and London, United Kingdom
    Robert F Miller
    Department of Sexually Transmitted Diseases, Windeyer Institute of Medical Sciences, Royal Free and University College Medical School, University College London, London WC1E 6AU, United Kingdom
    Antimicrob Agents Chemother 47:3979-81. 2003
  5. ncbi Multilocus genotyping of Pneumocystis jirovecii from adult HIV-infected patients with Pneumocystis pneumonia
    Robert F Miller
    Department of Sexually Transmitted Diseases, Windeyer Institute of Medical Sciences, Royal Free and University College Medical School, University College London, United Kingdom
    J Eukaryot Microbiol 50:654-5. 2003
  6. doi Seasonal variation in mortality of Pneumocystis jirovecii pneumonia in HIV-infected patients
    R F Miller
    Centre for Sexual Health and HIV Research, Research Department of Infection and Population Health, Division of Population Health, University College London, UK
    Int J STD AIDS 21:497-503. 2010
  7. ncbi Polyphenotypic expression of mitochondrial toxicity caused by nucleoside reverse transcriptase inhibitors
    Robert F Miller
    Department of Sexually Transmitted Diseases, Royal Free and University College Medical School, University College London and Camden Primary Care Trust, London, UK
    Antivir Ther 8:253-7. 2003
  8. ncbi Isolates of Pneumocystis jirovecii from Harare show high genotypic similarity to isolates from London at the superoxide dismutase locus
    Robert F Miller
    Centre for Sexual Health and HIV Research, Department of Primary Care and Population Sciences, Royal Free and University College Medical School, University College London, London WC1E 6AU, UK
    Trans R Soc Trop Med Hyg 99:202-6. 2005
  9. doi Focal Salmonella enteritidis infection in a patient with HIV infection and other multiple causes of immunodeficiency
    Dimitra Peppa
    T8, University College London Hospitals, London NW1 2BU
    Int J STD AIDS 19:491-2. 2008
  10. pmc Peripheral neuropathy in patients with HIV infection: consider dual pathology
    R F Miller
    Department of Sexually Transmitted Diseases, Royal Free and University College Medical School, Camden Primary Care Trust, London WC1E 6AU, UK
    Sex Transm Infect 78:462-3. 2002

Detail Information

Publications99

  1. ncbi Human immunodeficiency virus type 1-related pulmonary Mycobacterium xenopi infection: a need to treat?
    L Kerbiriou
    Department of Respiratory Medicine, Royal Free Hospital, London, United Kingdom
    Clin Infect Dis 37:1250-4. 2003
    ..xenopi infection, both showing clinical improvement. We conclude that pulmonary M. xenopi isolation in HIV-1 patients receiving HAART does not usually require specific treatment...
  2. ncbi Pneumocystis carinii infection in non-AIDS patients
    R F Miller
    Windeyer Institute of Medical Sciences, Royal Free and University College Medical School, London, UK
    Curr Opin Infect Dis 12:371-7. 1999
    ..A diagnosis of Pneumocystis carinii pneumonia may be achieved in the majority of cases by DNA detection using polymerase chain reaction on oropharyngeal mouth washes...
  3. ncbi Pneumonia complicating Shigella sonnei dysentery in an HIV-infected adult male
    R F Miller
    Centre for Sexual Health and HIV Research, Department of Population Sciences and Primary Care, Royal Free and University College Medical School, University College London
    Int J STD AIDS 16:763-5. 2005
    ..Culture of sputum and blood was negative. The patient recovered with fluid resuscitation and ciprofloxacin monotherapy. This is the first reported case of pneumonia complicating S. sonnei dysentery in an HIV-infected adult...
  4. pmc Genotypes of Pneumocystis jiroveci isolates obtained in Harare, Zimbabwe, and London, United Kingdom
    Robert F Miller
    Department of Sexually Transmitted Diseases, Windeyer Institute of Medical Sciences, Royal Free and University College Medical School, University College London, London WC1E 6AU, United Kingdom
    Antimicrob Agents Chemother 47:3979-81. 2003
    ..At the dihydropteroate synthase (DHPS) locus, there was evidence of selection pressure from sulfa drug exposure, and reversal of DHPS genotype ratios occurred when selection pressure was absent or was removed...
  5. ncbi Multilocus genotyping of Pneumocystis jirovecii from adult HIV-infected patients with Pneumocystis pneumonia
    Robert F Miller
    Department of Sexually Transmitted Diseases, Windeyer Institute of Medical Sciences, Royal Free and University College Medical School, University College London, United Kingdom
    J Eukaryot Microbiol 50:654-5. 2003
  6. doi Seasonal variation in mortality of Pneumocystis jirovecii pneumonia in HIV-infected patients
    R F Miller
    Centre for Sexual Health and HIV Research, Research Department of Infection and Population Health, Division of Population Health, University College London, UK
    Int J STD AIDS 21:497-503. 2010
    ..67; DHPS mutations were identified with equal frequency in each season and the mortality rate for February and August (when junior medical staff arrive in new posts) was 16.7%, only slightly greater than for other months (13.0%)...
  7. ncbi Polyphenotypic expression of mitochondrial toxicity caused by nucleoside reverse transcriptase inhibitors
    Robert F Miller
    Department of Sexually Transmitted Diseases, Royal Free and University College Medical School, University College London and Camden Primary Care Trust, London, UK
    Antivir Ther 8:253-7. 2003
    ..At this stage, dual protease inhibitors and nevirapine were started. A repeat muscle biopsy 14 months after presentation showed normal morphology and respiratory chain biochemistry was almost normal...
  8. ncbi Isolates of Pneumocystis jirovecii from Harare show high genotypic similarity to isolates from London at the superoxide dismutase locus
    Robert F Miller
    Centre for Sexual Health and HIV Research, Department of Primary Care and Population Sciences, Royal Free and University College Medical School, University College London, London WC1E 6AU, UK
    Trans R Soc Trop Med Hyg 99:202-6. 2005
    ..jirovecii obtained from patients in London, UK was observed. These data provide additional support for the hypothesis that P. jirovecii is genetically indistinguishable in isolates from geographically diverse locations...
  9. doi Focal Salmonella enteritidis infection in a patient with HIV infection and other multiple causes of immunodeficiency
    Dimitra Peppa
    T8, University College London Hospitals, London NW1 2BU
    Int J STD AIDS 19:491-2. 2008
    ....
  10. pmc Peripheral neuropathy in patients with HIV infection: consider dual pathology
    R F Miller
    Department of Sexually Transmitted Diseases, Royal Free and University College Medical School, Camden Primary Care Trust, London WC1E 6AU, UK
    Sex Transm Infect 78:462-3. 2002
    ....
  11. pmc Progressive neuropsychiatric problems following institution of highly active antiretroviral therapy
    R F Miller
    Patrick Manson Unit, University College London Hospital, and Mortimer Market Centre, London WC1E 6AU, UK
    Sex Transm Infect 81:351-7. 2005
    ..Despite modifying and subsequently stopping HAART her condition progressively worsened. Cranial magnetic resonance imaging revealed multiple areas of abnormal signal suggestive of either a vasculitis or demyelination...
  12. pmc Genotypic variation in Pneumocystis jirovecii isolates in Britain
    R F Miller
    Centre for Sexual Health and HIV Research, Department of Primary Care and Population Sciences, Royal Free and University College Medical School, University College London, Mortimer Market Centre, London WC1E 6AU, UK
    Thorax 60:679-82. 2005
    ..The aim of this study was to describe the molecular epidemiology of P jirovecii in Britain over a period of 12.5 years...
  13. pmc Progressive symptoms and signs following institution of highly active antiretroviral therapy and subsequent antituberculosis therapy: immune reconstitution syndrome or infection?
    R F Miller
    Centre for Sexual Health and HIV Research, Royal Free and University College Medical School, University College London, Mortimer Market Centre, off Capper Street, London WC1E 6AU, UK
    Sex Transm Infect 82:111-6. 2006
    ..An eventual diagnosis was established but multiple problems occurred throughout the treatment period. Differentiation between immune reconstitution inflammatory syndrome and an infective cause was problematic...
  14. pmc Improved survival for HIV infected patients with severe Pneumocystis jirovecii pneumonia is independent of highly active antiretroviral therapy
    R F Miller
    Centre for Sexual Health and HIV Research, University College London, Mortimer Market Centre, London WC1E 6AU, UK
    Thorax 61:716-21. 2006
    ..A study was undertaken to examine the outcome from intensive care for patients with PCP and to identify prognostic factors...
  15. pmc Herpesvirus infection of eye and brain in HIV infected patients
    R F Miller
    Department of Sexually Transmitted Diseases, Windeyer Institute of Medical Sciences, Royal Free and University College Medical School, Mortimer Market Centre, London
    Sex Transm Infect 76:282-6. 2000
    ....
  16. pmc Pleural effusions in patients with AIDS
    R F Miller
    Department of Sexually Transmitted Diseases, Windeyer Institute of Medical Sciences, Royal Free and University College Medical School, London
    Sex Transm Infect 76:122-5. 2000
    ..To describe the range of pathology causing pleural effusions in HIV infected patients with acute respiratory episodes and to attempt to identify whether any associated radiological abnormalities enabled aetiological discrimination...
  17. ncbi Clinical presentation and significance of emerging opportunistic infections
    R F Miller
    Windeyer Institute of Medical Sciences, Royal Free and University College Medical School, London, UK
    J Eukaryot Microbiol 47:21-3. 2000
    ..Despite treatment, prognosis is often poor. Clinicians should be aware of these opportunistic pathogens in order that a timely diagnosis may be made and appropriate therapy given...
  18. ncbi Central pontine myelinolysis in AIDS
    R F Miller
    Division of Pathology and Infectious Diseases, University College London Medical School, UK
    Acta Neuropathol 96:537-40. 1998
    ..At post mortem there was a close correlation between the MR abnormalities and the anatomic changes in the pons...
  19. ncbi Clinical aspects of Pneumocystis carinii pneumonia in HIV-infected patients: 1997
    R Miller
    Department of Sexually Transmitted Diseases, University College London Medical School, UK
    FEMS Immunol Med Microbiol 22:103-5. 1998
    ..Given the high frequency of ADR to co-trimoxazole when used as treatment for P. carinii pneumonia, there is also a need for effective, non-toxic alternative therapies...
  20. ncbi A need for standardized definitions for clinical studies of Pneumocystis
    Robert F Miller
    Centre for Sexual Health and HIV Research, Department of Population Sciences and Primary Care, Royal Free and University College Medical School, University College London, London, United Kingdom
    J Eukaryot Microbiol 53:S87-8. 2006
  21. ncbi Climate and genotypes of Pneumocystis jirovecii
    R F Miller
    Centre for Sexual Health and HIV Research, Department of Population Sciences and Primary Care, Royal Free and University College Medical School, University College London, London, UK
    Clin Microbiol Infect 13:445-8. 2007
    ..018 and p 0.031, respectively) and genotype 2 (p 0.029 and p 0.086, respectively). There was no association between month/season and genotypes 1, 3 and 4, or between monthly temperature or rainfall and any genotype...
  22. pmc Adherent human alveolar macrophages exhibit a transient pro-inflammatory profile that confounds responses to innate immune stimulation
    Gillian S Tomlinson
    Infection and Immunity, University College London, London, United Kingdom
    PLoS ONE 7:e40348. 2012
    ..Moreover, despite the prevailing view that AM have an anti-inflammatory bias, our data clearly show that they can adopt a striking pro-inflammatory phenotype, and may have greater capacity for presentation of exogenous antigens than MDM...
  23. pmc Different screening strategies (single or dual) for the diagnosis of suspected latent tuberculosis: a cost effectiveness analysis
    Anil Pooran
    Division of Infection and Immunity, Centre for Infectious Diseases and International Health, University College London Medical School, University College London, 43 Cleveland Street, London W1T 4JF, UK
    BMC Pulm Med 10:7. 2010
    ..tb...
  24. pmc Genome-wide innate immune responses in HIV-1-infected macrophages are preserved despite attenuation of the NF-kappa B activation pathway
    Mahdad Noursadeghi
    Infection and Immunity, University College London, London, United Kingdom
    J Immunol 182:319-28. 2009
    ..Unexpectedly, our data suggest innate immune responses are broadly preserved with limited exceptions, and pave the way for further study of the complex relationship between HIV-1 and immunological pathways within macrophages...
  25. pmc HIV-1 infection of macrophages is dependent on evasion of innate immune cellular activation
    Jhen Tsang
    Division of Infection and Immunity, University College London, London, UK
    AIDS 23:2255-63. 2009
    ..In view of HIV-1 tropism for macrophages, which can be activated via pattern recognition receptors to trigger antimicrobial defences, we investigated innate immune responses to HIV-1 by monocyte-derived macrophages...
  26. pmc Transcriptional profiling of innate and adaptive human immune responses to mycobacteria in the tuberculin skin test
    Gillian S Tomlinson
    Infection and Immunity, University College London, London, UK
    Eur J Immunol 41:3253-60. 2011
    ..These data provide new insights into complex multifaceted responses within the TST, with much greater sensitivity than previous clinical or histological assessments...
  27. doi High rate of lymphoma among a UK cohort of adolescents with vertically acquired HIV-1 infection transitioning to adult care in the era of antiretroviral therapy
    Chris P Eades
    aDepartment of Sexual Health, Mortimer Market Centre, Central and North West London NHS Foundation TrustbCentre for Sexual Health and HIV Research, Research Department of Infection and Population Health, University College London, London, UK
    AIDS 30:153-6. 2016
    ..These data suggest that careful surveillance and a low threshold for investigating relevant symptoms continue to be essential for such patients. ..
  28. doi Pneumocystis pneumonia associated with human immunodeficiency virus
    Robert F Miller
    Research Department of Infection and Population Health, University College London, London WC1E 6JB, UK
    Clin Chest Med 34:229-41. 2013
    ..Trimethoprim-sulfamethoxazole remains the preferred first-line treatment regimen. In the era of ART, mortality from PCP is approximately 10% to 12%. The optimal time to start ART in a patient with PCP remains uncertain...
  29. ncbi HIV infection presenting in older children and adolescents: a case series from Harare, Zimbabwe
    Rashida A Ferrand
    Mortimer Market Centre, Camden Primary Care Trust, London WC1E 6AU, UK
    Clin Infect Dis 44:874-8. 2007
    ..We investigated social and clinical features in patients of this age group presenting to a HIV treatment clinic with special adolescent services in Harare, Zimbabwe...
  30. pmc Probable mother-to-infant transmission of Pneumocystis carinii f. sp. hominis infection
    Robert F Miller
    Department of Sexually Transmitted Diseases, Windeyer Institute of Medical Sciences, Royal Free and University College Medical School, University College, London, United Kingdom
    J Clin Microbiol 40:1555-7. 2002
    ..Genotyping of P. carinii f. sp. hominis DNA at three independent loci showed the same genotype in samples from mother and infant. These data suggest transmission of P. carinii organisms from the mother to her infant...
  31. ncbi Monocyte derived dendritic cells from HIV-1 infected individuals partially reconstitute CD4 T-cell responses
    Philippa J Newton
    Department of Immunology and Molecular Pathology, University College London, UK
    AIDS 20:171-80. 2006
    ..The study tests the hypothesis that monocyte derived dendritic cells from HIV-1 infected individuals are normal and can restore impaired CD4 T-cell antigen specific responses...
  32. doi Immunosuppression among HIV-1-positive patients attending for care: experience from two large HIV centres in the United Kingdom
    Derval Harte
    Department of Genitourinary Medicine, Mortimer Market Centre, Camden Provider Services PCT, London, UK
    HIV Med 11:114-20. 2010
    ..The aim of the study was to describe the prevalence of and examine the factors associated with immunosuppression (CD4 < 200 cells/microL) among HIV-infected patients attending two large inner London treatment centres...
  33. pmc Cardiac disease in adolescents with delayed diagnosis of vertically acquired HIV infection
    Robert F Miller
    Research Department of Infection and Population Health, Institute of Epidemiology and Healthcare, University College London, Mortimer Market Centre, London WC1E 6JB, United Kingdom
    Clin Infect Dis 56:576-82. 2013
    ..We investigated the characteristics of cardiac disease among adolescents with HIV infection diagnosed in late childhood who were receiving ambulatory HIV care in Harare, Zimbabwe...
  34. pmc In Vivo Molecular Dissection of the Effects of HIV-1 in Active Tuberculosis
    Lucy C K Bell
    Division of Infection and Immunity, University College London, London, United Kingdom
    PLoS Pathog 12:e1005469. 2016
    ..TST molecular profiling categorised different mechanisms of immunological dysfunction in HIV-1 infection beyond the effects on CD4 T cells, each associated with increased risk of TB disease and amenable to host-directed therapies. ..
  35. pmc A declining CD4 count and diagnosis of HIV-associated Hodgkin lymphoma: do prior clinical symptoms and laboratory abnormalities aid diagnosis?
    Ravindra K Gupta
    Division of Infection and Immunity, University College London, London, United Kingdom University College London Hospitals NHS Foundation Trust, London, United Kingdom
    PLoS ONE 9:e87442. 2014
    ..In an era of economic austerity monitoring the efficacy of cART by CD4 counts may no longer be required where CD4 count>350 cells/┬Ál and viral load is suppressed (<50 copies/ml)...
  36. ncbi Clinical value of C-reactive protein measurements in HIV-positive patients
    Mahdad Noursadeghi
    Patrick Manson Unit, University College London Hospitals Trust, London, UK
    Int J STD AIDS 16:438-41. 2005
    ..In HIV-1 antibody-positive patients without intercurrent infection, CRP values higher than in the general population possibly reflect a sustained acute-phase response as a consequence of HIV infection per se...
  37. pmc Early predictors of mortality from Pneumocystis jirovecii pneumonia in HIV-infected patients: 1985-2006
    Peter D Walzer
    Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, University College London, London, United Kingdom
    Clin Infect Dis 46:625-33. 2008
    ..Previous studies of PCP that identified case-fatality risk factors involved small numbers of patients, were performed over few years, and often focused on patients who were admitted to the intensive care unit...
  38. ncbi Problems of developing molecular diagnostic tests for opportunistic pathogens: the example of Pneumocystis jirovecii
    Jim F Huggett
    Centre for Infectious Diseases and International Health, University College London, London, United Kingdom
    J Eukaryot Microbiol 53:S85-6. 2006
  39. ncbi Performance of a T-cell-based diagnostic test for tuberculosis infection in HIV-infected individuals is independent of CD4 cell count
    Keertan Dheda
    Centre for Infectious Diseases and International Health, Department of Population Sciences and Primary Care, Royal Free and University College Medical School, University College London, London, UK
    AIDS 19:2038-41. 2005
    ..ELISPOT test performance appears to be independent of HIV-associated immunosuppression...
  40. ncbi HIV-1 infection of mononuclear phagocytic cells: the case for bacterial innate immune deficiency in AIDS
    Mahdad Noursadeghi
    Department of Immunology and Molecular Pathology, University College London, UK
    Lancet Infect Dis 6:794-804. 2006
    ..HIV-mediated injury to bacterial innate immunity provides an experimental paradigm that could broaden our overall understanding of innate immunity and be used to study responses to pathogens other than bacteria...
  41. ncbi Efficacy of boosted protease inhibitor monotherapy in patients with complex medical problems
    Nigel J Garrett
    Mortimer Market Centre, London, UK
    AIDS 21:1821-3. 2007
    ..During follow-up, at median (range) = 50 (8-156) weeks, no patient had an opportunistic illness; one patient developed new PI mutations after 48 weeks. These very preliminary data need further confirmation on a larger scale...
  42. ncbi The measurement of R2, R2* and R2' in HIV-infected patients using the prime sequence as a measure of brain iron deposition
    K A Miszkiel
    Department of Radiology at UCL Hospitals NHS Trust, London, UK
    Magn Reson Imaging 15:1113-9. 1997
    ..The relationship between iron deposition in the brain and various parameters of severity of HIV infection remains uncertain...
  43. ncbi Immune reconstitution inflammatory syndrome in HIV-infected patients with mycobacterial infections starting highly active anti-retroviral therapy
    S J Buckingham
    Department of Imaging, University College London Hospitals NHS Trust, London, UK
    Clin Radiol 59:505-13. 2004
    ..To describe the radiological appearances of immune reconstitution inflammatory syndrome (IRIS) in human immunodeficiency virus (HIV)-infected patients with mycobacterial infections starting highly active anti-retroviral therapy (HAART)...
  44. ncbi Elevated cerebrospinal fluid and serum nitrate and nitrite levels in patients with central nervous system complications of HIV-1 infection: a correlation with blood-brain-barrier dysfunction
    G Giovannoni
    Department of Neuroimmunology, The Natioinal Hospital for Neurology and Neurosurgery, London, UK
    J Neurol Sci 156:53-8. 1998
    ..CSF nitrate and nitrite levels correlated with the albumin quotient. This study supports the evidence that .NO is a potential mediator of blood-brain-barrier breakdown in inflammatory diseases of the central nervous system...
  45. ncbi Short echo-time proton magnetic resonance spectroscopy in regions of severe HIV-related diffuse white matter abnormality on MRI
    I D Wilkinson
    Department of Medical Physics and Bioengineering, London, England
    J NeuroAIDS 2:55-67. 1998
    ..These data suggest that mobile lipids are only rarely detected by H-MRS in patients with HADC and abnormalities on MRI and that their presence may be transitory...
  46. pmc Adverse events and treatment interruption in tuberculosis patients with and without HIV co-infection
    R A M Breen
    Department of Thoracic and HIV Medicine, Royal Free Hospital, London, UK
    Thorax 61:791-4. 2006
    ..A study was undertaken to assess the frequency of serious (grade III/IV) adverse events and interruption of anti-TB treatment in the era of effective antiretroviral therapy...
  47. ncbi Hypercalcaemia complicating immune reconstitution in an HIV-infected patient with disseminated tuberculosis
    R A Ferrand
    Patrick Manson Unit, University College London Hospitals, London, UK
    Int J STD AIDS 17:349-50. 2006
    ..Hypercalcaemia resolved with stopping HAART and was thought to be due to immune reconstitution inflammatory syndrome...
  48. ncbi Virological response to highly active antiretroviral therapy is unaffected by antituberculosis therapy
    Ronan A M Breen
    Department of HIV Medicine, Royal Free Hospital, and Department of Primary Care and Population Sciences, Royal Free and University College Medical School, London, United Kingdom
    J Infect Dis 193:1437-40. 2006
    ..Tuberculosis recurrence rates were similar to those found in an HIV-uninfected population of 156 subjects (3% and 1%, respectively). Treatment for HIV and tuberculosis does not compromise outcomes for either disease...
  49. doi Adverse events to antituberculosis therapy: influence of HIV and antiretroviral drugs
    D J B Marks
    Centre for Molecular Medicine, University College London, London, UK
    Int J STD AIDS 20:339-45. 2009
    ..008). The treatment completion did not differ significantly between the two groups (76.6% and 84.2%, P = 0.08)...
  50. ncbi Diagnostic utility of bone marrow sampling in HIV-infected patients since the advent of highly active antiretroviral therapy
    M J Llewelyn
    Patrick Manson Unit, University College London Hospitals NHS Trust, London WC1E 6AU, UK
    Int J STD AIDS 16:686-90. 2005
    ..BM sampling had less diagnostic value in the investigation of fever without cytopaenia or cytopaenia without fever...
  51. ncbi BHIVA treatment guidelines for tuberculosis (TB)/HIV infection 2005
    A L Pozniak
    Chelsea and Westminster NHS Healthcare Trust, London, UK
    HIV Med 6:62-83. 2005
  52. pmc Differential susceptibility of PCR reactions to inhibitors: an important and unrecognised phenomenon
    Jim F Huggett
    Centre for Infectious Diseases and International Health, Windeyer Institute for Medical Sciences, 46 Cleveland Street, University College London, London, W1T 4JF, UK
    BMC Res Notes 1:70. 2008
    ..To test this assumption we performed inhibition assessment on DNA extracts from human urine samples, fresh urine and EDTA using different PCR reactions...
  53. pmc Quantitative imaging assay for NF-kappaB nuclear translocation in primary human macrophages
    Mahdad Noursadeghi
    Department of Immunology and Molecular Pathology, University College London, Windeyer Building, 46 Cleveland Street, W1T 4JF London, UK
    J Immunol Methods 329:194-200. 2008
    ....
  54. ncbi Septic shock and multi-organ failure in HIV infection-'sepsis tuberculosa gravissima'
    Rashida A Ferrand
    University College Hospital, London NW1 2BU, UK
    Int J STD AIDS 17:562-4. 2006
    ..With specific anti-tuberculosis therapy the patient rapidly recovered. Although most cases of sepsis syndrome in HIV-infected patients are due to bacteria, tuberculosis should be added to the differential diagnosis of this presentation...
  55. ncbi Pathology of bone marrow in human herpes virus-8 (HHV8)-associated multicentric Castleman disease
    Chris M Bacon
    Department of Histopathology, Royal Free and University College Medical School, London, UK
    Br J Haematol 127:585-91. 2004
    ..Our results suggest that the presence of HHV8+ plasmablasts within lymphoid follicles and/or interstitium of the bone marrow are helpful features for the early diagnosis of MCD...
  56. ncbi Cerebral CD8+ lymphocytosis in HIV-1 infected patients with immune restoration induced by HAART
    Robert F Miller
    Department of Primary Care and Population Sciences, Centre for Sexually Transmitted Diseases, UCL, London, UK
    Acta Neuropathol 108:17-23. 2004
    ..The appearances in patient two further suggest that HIV brain infection, even without encephalitis, is sufficient to trigger this response...
  57. ncbi Cytomegalovirus viral load testing of blood using quantitative polymerase chain reaction in acutely unwell HIV-1-positive patients lacks diagnostic utility
    S G Edwards
    Department of Genitourinary Medicine, Mortimer Market Centre, Camden Primary Care Trust, London WC1E 6JB, UK
    Int J STD AIDS 18:321-3. 2007
    ..In acutely unwell HIV-infected patients, detection of CMV by qPCR is a poor predictor of CMV end-organ disease...
  58. pmc Survival of HIV-infected patients in the intensive care unit in the era of highly active antiretroviral therapy
    S J Dickson
    University College London Hospitals, London, UK
    Thorax 62:964-8. 2007
    ..A study was undertaken to examine the outcome from the ICU for HIV-infected patients and to identify prognostic factors...
  59. pmc Virological efficacy of PI monotherapy for HIV-1 in clinical practice
    Kate El Bouzidi
    Research Department of Infection, Division of Infection and Immunity, University College London, London, UK
    J Antimicrob Chemother 71:3228-3234. 2016
    ..However, outcomes among patients receiving PI monotherapy for clinical reasons, such as toxicity or adherence issues, are less well studied...
  60. pmc Blood transcriptomic diagnosis of pulmonary and extrapulmonary tuberculosis
    Jennifer K Roe
    Division of Infection and Immunity, University College London, London, United Kingdom
    JCI Insight 1:e87238. 2016
    ..b>FUNDING. MRC, Wellcome Trust, Rosetrees Trust, British Lung Foundation, NIHR...
  61. doi The response of HIV-associated lymphadenopathic Kaposi sarcoma to highly active antiretroviral therapy evaluated by 18F-FDG PET/CT
    Satveer K Mankia
    T8, University College London Hospitals, Centre for Sexual Health and HIV Research, Research Department of Infection and Population Health, University College London, London, United Kingdom
    Clin Nucl Med 37:692-3. 2012
    ..Chemotherapy was initiated, and the patient achieved a complete clinical, PET/CT, and virological response. PET/CT enabled monitoring of treatment response and led to changes in management...
  62. ncbi Immune reconstitution sarcoidosis presenting with hypercalcaemia and renal failure in HIV infection
    R A Ferrand
    University College London Hospitals, London NW1 2BU, UK Camden Primary Care Trust, Mortimer Market Centre, London WC1E 6AU, UK
    Int J STD AIDS 18:138-9. 2007
    ..This presentation was thought to be a manifestation of immune reconstitution inflammatory syndrome, and the patient was successfully treated with corticosteroid therapy...
  63. pmc Unusual muscle disease in HIV infected patients
    S Roedling
    Patrick Manson Unit, University College London Hospitals, London WC1E 6AU, UK
    Sex Transm Infect 80:315-7. 2004
    ..These cases illustrate the importance of muscle biopsy in identifying the underlying pathology in HIV infected patients with muscle weakness and little or no abnormality in laboratory investigations...
  64. doi Gastrointestinal histoplasmosis in an HIV-infected patient living in a non-endemic area
    D Peppa
    T8, University College London Hospitals, London, UK
    Int J STD AIDS 19:864-5. 2008
    ..The diagnosis of histoplasmosis was delayed as the presentation was initially ascribed to intercurrent enteric pathogens and the patient's lifetime travel history was not obtained...
  65. doi Outcome from treatment of Pneumocystis jirovecii pneumonia with co-trimoxazole
    M Fisk
    Department of Genitourinary Medicine, Camden Provider Services PCT, Mortimer Market Centre, London, UK
    Int J STD AIDS 20:652-3. 2009
    ..Overall mortality was 13.6% (49/359); mortality among patients who failed co-trimoxazole treatment was 48% (12/25) and by contrast mortality was 4.8% (5/104) among patients with treatment-limiting toxicity...
  66. ncbi Thrombotic thrombocytopaenic purpura in HIV-infected patients
    R F Miller
    Centre for Sexual Health and HIV Research, Department of Primary Care and Population Sciences, Royal Free and University College Medical School, University College London, Mortimer Market Centre, Camden PCT, London WC1E 6AU, UK
    Int J STD AIDS 16:538-42. 2005
    ..Given the clear benefit from HAART in addition to plasma exchange, these data suggest that all patients presenting with TTP should undergo HIV testing...
  67. ncbi Development and evaluation of a real-time PCR assay for detection of Pneumocystis jirovecii DNA in bronchoalveolar lavage fluid of HIV-infected patients
    J F Huggett
    Centre for Infectious Diseases and International Health, Windeyer Institute for Medical Sciences, University College London, London, UK
    Thorax 63:154-9. 2008
    ..Pneumocystis pneumonia (PCP) is conventionally diagnosed by identifying Pneumocystis jirovecii in lower respiratory tract samples using cytochemical stains. Molecular diagnosis of PCP is potentially more sensitive...
  68. pmc Transcriptional Profiling of Endobronchial Ultrasound-Guided Lymph Node Samples Aids Diagnosis of Mediastinal Lymphadenopathy
    Gillian S Tomlinson
    Department of Infection and Immunity, University College London, London, England Electronic address
    Chest 149:535-44. 2016
    ..However, improved methods for discriminating between TB and sarcoidosis and excluding malignancy are still needed. We sought to evaluate the role of genomewide transcriptional profiling to aid diagnostic processes in this setting...
  69. pmc Pneumocystis jirovecii pneumonia in tropical and low and middle income countries: a systematic review and meta-regression
    David M Lowe
    Wellcome Trust Centre for Research in Clinical Tropical Medicine, Department of Medicine, Imperial College London, London, United Kingdom
    PLoS ONE 8:e69969. 2013
    ..We sought to investigate predictors of PCP in these settings...
  70. doi Urinary retention for the neurologist
    Matthew D Smith
    Department of Uro Neurology, National Hospital for Neurology and Neurosurgery, London, UK
    Pract Neurol 13:288-91. 2013
    ..We present a patient with acute urinary retention who was found to have chronic meningitis, and review the neurological causes for urinary retention. ..
  71. ncbi Methaemoglobinaemia causing progressive dyspnoea and cyanosis during treatment of Pneumocystis jirovecii pneumonia
    Matthew Hamill
    Department of Genito Urinary Medicine, Mortimer Market Centre, Camden Primary Care Trust, London, UK
    Int J STD AIDS 18:577-8. 2007
    ..He was found to have 11.4% methaemoglobinaemia and recovered with conservative management...
  72. pmc Acute meningoencephalitis and meningitis due to primary HIV infection
    P J Newton
    Department of Sexually Transmitted Diseases, Royal Free and University College Medical School, University College London, London WC1E 6AU
    BMJ 325:1225-7. 2002
  73. pmc Kaposi's sarcoma infiltrating skeletal muscle
    L J Haddow
    Patrick Manson Unit, University College London Hospitals, London, UK
    Sex Transm Infect 78:464-5. 2002
    ..In addition, he developed pain and swelling behind the right knee. Histology of an ultrasound guided biopsy showed Kaposi's sarcoma infiltrating the head of gastrocnemius...
  74. doi A comparison of computed tomography and magnetic resonance brain imaging in HIV-positive patients with neurological symptoms
    A J Wilson
    T8, University College London Hospitals, London NW18BU, USA
    Int J STD AIDS 21:198-201. 2010
    ....
  75. pmc Polymyositis masquerading as mitochondrial toxicity
    K P Prime
    Department of Genitourinary Medicine, Camden Primary Care Trust, Mortimer Market Centre, London WC1E 6AU, UK
    Sex Transm Infect 79:417-8. 2003
    ....
  76. ncbi Imaging features of multicentric Castleman's disease in HIV infection
    J C Hillier
    Clinical Radiology, Chelsea and Westminster Hospital, London, UK
    Clin Radiol 59:596-601. 2004
    ..To describe the computed tomography (CT) features of human immunodeficiency virus (HIV)-associated Castleman's disease...
  77. pmc Pneumocystis carinii f. sp. hominis DNA in immunocompetent health care workers in contact with patients with P. carinii pneumonia
    R F Miller
    Department of Sexually Transmitted Diseases, Windeyer Institute of Medical Sciences, Royal Free and University College Medical School, University College London, London, United Kingdom
    J Clin Microbiol 39:3877-82. 2001
    ..The results suggested that HCW in close occupational contact with patients who had P. carinii pneumonia may have become colonized with P. carinii. Carriage was asymptomatic and did not result in the development of clinical disease...
  78. doi Suppurative iliac lymphadenitis masquerading as appendicitis in an HIV-infected patient
    D Peppa
    T8, University College London Hospitals, London NW1 8BU, UK
    Int J STD AIDS 20:431-3. 2009
    ....
  79. ncbi The use of therapeutic drug monitoring in the management of protease inhibitor-related toxicity
    S F Forsyth
    Department of Genitourinary Medicine, Mortimer Market Centre, Camden Primary Care Trust, off Capper Street, London WC1E 6AU, UK
    Int J STD AIDS 16:139-41. 2005
    ..TDM-directed dose modification of PI enables patients to continue effective regimens of highly active antiretroviral therapy, thus avoiding the need to switch the regimen...
  80. doi Diagnostic yield of fine-needle aspiration cytology in HIV-infected patients with lymphadenopathy in the era of highly active antiretroviral therapy
    S M Lowe
    Department of Genitourinary Medicine, Mortimer Market Centre, Camden PCT, London, UK
    Int J STD AIDS 19:553-6. 2008
    ..Difficulties in diagnosis of Castleman disease and Hodgkin's lymphoma by FNA cytology are recognized...
  81. ncbi Diagnosis of Chlamydia trachomatis in North Thames region 2003
    G Sethi
    Jefferiss Wing, St Mary s Hospital, London, W2 1NY, UK
    Int J STD AIDS 15:829-30. 2004
    ....
  82. ncbi Management of HIV infection in adolescents attending inner London HIV services
    R A Ferrand
    Department of Genito Urinary Medicine, Mortimer Market Centre, Camden Primary Care Trust, London, UK
    Int J STD AIDS 18:633-4. 2007
    ..In addition, 45% reported to be sexually active with poor uptake of contraception other than condoms and frequent non-disclosure of their HIV status to a sexual partner...
  83. ncbi Dissemination of Strongyloides stercoralis as an immune restoration phenomenon in an HIV-1-infected man on antiretroviral therapy
    M Brown
    Patrick Manson Unit, University College London Hospitals, London, UK
    Int J STD AIDS 17:560-1. 2006
    ..Recent evidence from studies of strongyloides development supports the concept that strongyloides dissemination in this case is an example of an immune reconstitution inflammatory syndrome...
  84. ncbi Localization of infection in HIV antibody positive patients with fever. Comparison of the efficacy of Ga-67 citrate and radiolabeled human IgG
    J R Buscombe
    Institute of Nuclear Medicine, University College London Medical School, United Kingdom
    Clin Nucl Med 20:334-9. 1995
    ..There was no significant difference between the accuracy of Ga-67 and Tc-99m HIG. From this preliminary study In-111 HIG would seem to be the best agent for identifying infection in HIV antibody positive patients with fever...
  85. pmc Fever in the recently returned HIV infected traveller
    A Birnie
    University College London Hospitals NHS Trust, Centre for Sexual Health and HIV Research, Department of Primary Care and Population Sciences, Royal Free and University College Medical School, University College London and Camden PCT, London, UK
    Sex Transm Infect 80:86-90. 2004
    ..A 41 year old HIV infected man with an extensive travel history developed intermittent fever and weight loss shortly after returning from abroad. Extensive and prolonged investigation identified the cause...
  86. pmc Progressive intrathoracic lymphadenopathy: EBV associated non-Hodgkin's lymphoma
    R F Miller
    Windeyer Institute of Medical Sciences, Royal Free and University College Medical School, University College London, UK
    Sex Transm Infect 78:13-7. 2002
    ..Later, hepatosplenomegaly and peripheral lymphadenopathy developed. Histology of a cervical lymph node biopsy showed EBV associated diffuse large B cell (non-Hodgkin's) lymphoma...
  87. pmc Multicentric plasma cell variant Castleman's disease mimicking intrapulmonary malignancy
    J Buckley
    Department of Sexually Transmitted Diseases, Royal Free and University College Medical School, Camden and Islington Community Health Services NHS Trust, Mortimer Market Centre, London, UK
    Sex Transm Infect 78:304-5. 2002
  88. ncbi Renal and gastrointestinal amyloidosis in an HIV-infected injection drug user
    C Newey
    T8, University College London Hospitals, London NW1 2BU, UK
    Int J STD AIDS 18:357-8. 2007
    ..After extensive investigation, a diagnosis of reactive systemic AA (amyloid, serum amyloid A protein) amyloidosis was made on the basis of renal, gastric and duodenal biopsies...
  89. ncbi Limited asymptomatic carriage of Pneumocystis jiroveci in human immunodeficiency virus-infected patients
    Ann E Wakefield
    Molecular Infectious Diseases Group, Department of Paediatrics, Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, United Kingdom
    J Infect Dis 187:901-8. 2003
    ..Asymptomatic carriage in HIV-infected patients may play a role in transmission of P. jiroveci and may even supply a reservoir for future infections...
  90. ncbi Pneumocystis jirovecii dihydropteroate synthase gene mutations and human immunodeficiency virus-associated Pneumocystis pneumonia
    Laurence Huang
    HIV AIDS Division, Division of Pulmonary and Critical Care Medicine, San Francisco General Hospital, University of California San Francisco, San Francisco, California 94110, USA
    J Eukaryot Microbiol 53:S114-6. 2006
  91. pmc A new name (Pneumocystis jiroveci) for Pneumocystis from humans
    James R Stringer
    Department of Molecular Genetics, Biochemistry and Microbiology, University of Cincinnati, Cincinnati, Ohio 45267 0524, USA
    Emerg Infect Dis 8:891-6. 2002
    ..DNA sequence variation exists among samples of P. jiroveci, a feature that allows reexamination of the relationships between host and pathogen. Instead of lifelong latency, transient colonization may be the rule...
  92. ncbi On treatment outcomes of patients with HIV and tuberculosis
    Ronan A M Breen
    Am J Respir Crit Care Med 177:121; author reply 121-2. 2008
  93. doi Second-line salvage treatment of AIDS-associated Pneumocystis jirovecii pneumonia: a case series and systematic review
    Thomas Benfield
    Department of Infectious Diseases, Hvidovre University Hospital, University of Copenhagen, Copenhagen, Denmark
    J Acquir Immune Defic Syndr 48:63-7. 2008
    ..Limited clinical data exist to guide the choice of second-line salvage treatment for AIDS-associated Pneumocystis jirovecii pneumonia (PCP)...
  94. ncbi Immune reconstitution disease associated with mycobacterial infections in HIV-infected individuals receiving antiretrovirals
    Stephen D Lawn
    Desmond Tutu HIV Centre, Institute of Infectious Diseases and Molecular Medicine, University of Cape Town, Cape Town, South Africa
    Lancet Infect Dis 5:361-73. 2005
    ..We also discuss the problem of IRD associated with mycobacterial diseases in developing countries where tuberculosis prevalence is high and access to HAART is currently expanding...
  95. ncbi Lack of awareness of HIV post-exposure prophylaxis among HIV-infected and uninfected men attending an inner London clinic
    Shamela de Silva
    Jefferiss Wing Centre for Sexual Health, St Mary s Hospital, London W2 1NY, UK
    Int J STD AIDS 17:629-30. 2006
    ..This audit suggests that strategies for increasing awareness of PEPSE among 'at risk' men are urgently needed...
  96. ncbi Calcium oxalate precipitates in a renomedullary interstitial cell tumor
    Irene Pecorella
    Dipartimento di Medicina Sperimentale e Patologia, Universita degli Studi La Sapienza, Roma, Italy
    Pathol Oncol Res 9:47-8. 2003
    ..The combination of calcium oxalosis and RICT has not been reported before and might possibly be due to systemic biochemical alterations of the glycosaminoglycans as a result of profound metabolic disturbances in AIDS patients...
  97. pmc Neuroectodermal differentiation from mouse multipotent adult progenitor cells
    Yuehua Jiang
    Stem Cell Institute, University of Minnesota Medical School, Minneapolis, MN 55455, USA
    Proc Natl Acad Sci U S A 100:11854-60. 2003
    ..MAPCs therefore may constitute a source of cells for treatment of central nervous system disorders...
  98. ncbi Comment on "Transcription factor FOXO3a mediates apoptosis in HIV-1-infected macrophages"
    Mahdad Noursadeghi
    J Immunol 180:7783; author reply 7783-4. 2008
  99. pmc Mycobacterium tuberculosis Antigen 85A induces Th-1 immune responses in systemic sarcoidosis
    Rana Hajizadeh
    Department of Medicine, Division of Infectious Diseases, Vanderbilt University School of Medicine, 1161 21st Avenue, AA2200 MCN, Nashville, TN 37232, USA
    J Clin Immunol 27:445-54. 2007
    ....