Affiliation: University of Oxford
- Diseases of the neuromuscular junctionJohn McConville
Neurosciences Group, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, Oxford, OX3 9DS, UK
Curr Opin Pharmacol 2:296-301. 2002..This is proving relevant to seronegative myasthenia gravis, with the discovery of anti-MuSK antibodies, and to a type of congenital myasthenic syndrome, in which acetylcholine receptor deficiency is due to mutations in rapsyn...
- Seronegative generalised myasthenia gravis: clinical features, antibodies, and their targetsAngela Vincent
Department of Clinical Neurology, University of Oxford, UK
Lancet Neurol 2:99-106. 2003..Moreover, muscle wasting may be present, which prevents complete response to these therapies...
- Antibodies in myasthenia gravis and related disordersAngela Vincent
Neurosciences Group, Department of Clinical Neurology, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, Oxford OX3 9DS, United Kingdom
Ann N Y Acad Sci 998:324-35. 2003..These antibodies are not found in AChR antibody-positive MG and are predominantly IgG4. MuSK antibody positivity appears to be associated with more severe bulbar disease that can be difficult to treat effectively...
- Detection and characterization of MuSK antibodies in seronegative myasthenia gravisJohn McConville
Weatherall Institute of Molecular Medicine and Department of Clinical Neurology, Oxford, UK
Ann Neurol 55:580-4. 2004..They bind to the extracellular Ig-like domains of soluble or native MuSK. Surprisingly they are predominantly in the IgG4 subclass. MuSK-antibody associated MG may be different in etiological and pathological mechanisms...
- Thymic myoid cells and germinal center formation in myasthenia gravis; possible roles in pathogenesisIoannis Roxanis
Neurosciences Group, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, Headington, Oxford OX3 9DS, UK
J Neuroimmunol 125:185-97. 2002..As autoantibodies became detectable, myoid cell involvement apparently progressed. Our unifying hypothesis--that an early autoantibody attack on myoid cells provokes local GC formation--helps to resolve many puzzles...
- Clinical comparison of muscle-specific tyrosine kinase (MuSK) antibody-positive and -negative myasthenic patientsLan Zhou
Neuromuscular Unit, Department of Neurology, Johns Hopkins School of Medicine, Meyer Building 5 119, 600 North Wolfe Street, Baltimore, Maryland 21287 7519, USA
Muscle Nerve 30:55-60. 2004..Although the distribution of weakness differs somewhat depending on whether MuSK antibodies are present, responses to anticholinesterase and immunosuppressive treatments are similar...
- Seronegative myasthenia gravisAngela Vincent
Department of Clinical Neurology, University of Oxford, Oxford, United Kingdom
Semin Neurol 24:125-33. 2004..MuSK antibody-positive patients may also differ in the distribution of their electrophysiological abnormalities and their responses to treatments...
- Is "seronegative" MG explained by autoantibodies to MuSK?Angela C Vincent
Neurology 64:399; author reply 399. 2005