Affiliation: University College London
- Neural responses in the inferior colliculus to binaural masking level differences created by inverting the noise in one earA R Palmer
Medical Research Council Institute of Hearing Research, University of Nottingham, Nottingham NG7 2RD, United Kingdom
J Neurophysiol 84:844-52. 2000..6 dB (NoSo vs. NpiSo) compared with 6.6 dB for the NoSo versus NoSpi BMLD we had previously reported. This lower magnitude is consistent with the hierarchy of human psychophysical BMLDs...
- GABAergic inhibition controls neural gain in inferior colliculus neurons sensitive to interaural time differencesNeil J Ingham
The Ear Institute and Department of Physiology, University College London, London WC1E 6BT, United Kingdom
J Neurosci 25:6187-98. 2005..This gain control appears to arise from a combination of additive and multiplicative processes, and may involve mechanisms such as shunting inhibition or changes in the efficacy of inhibitory and excitatory inputs...
- Creating a sense of auditory spaceDavid McAlpine
Department of Physiology and The Ear Institute, University College London, Gower Street, London WC1E 6BT, UK
J Physiol 566:21-8. 2005....
- Optimal neural population coding of an auditory spatial cueNicol S Harper
Department of Physiology and UCL Ear Institute, University College London, London WC1E 6BT, UK
Nature 430:682-6. 2004..For humans, the optimal strategy to code ITDs from an acoustically measured distribution depends on frequency; above 400 Hz a homogeneous distribution is optimal, and below 400 Hz distinct sub-populations are optimal...
- Neural sensitivity to periodicity in the inferior colliculus: evidence for the role of cochlear distortionsDavid McAlpine
Dept of Physiology, University College London, Gower Street, London WC1E 6BT, UK
J Neurophysiol 92:1295-311. 2004..The auditory midbrain appears to show a robust representation of cochlear distortions generated by amplitude-modulated sounds...
- Objective Measures of Neural Processing of Interaural Time DifferencesDavid McAlpine
UCL Ear Institute, 332 Gray s Inn Road, WC1X 8EE, London, UK
Adv Exp Med Biol 894:197-205. 2016..High-frequency neurons in the LSO receive excitatory and inhibitory input from the two ears receptively--as such maximum activity occurs when the sounds at the two ears are presented out of phase...
- Evaluation of the acoustic coordinated reset (CR®) neuromodulation therapy for tinnitus: study protocol for a double-blind randomized placebo-controlled trialDerek J Hoare
National Institute for Health Research NIHR Nottingham Hearing Biomedical Research Unit, University of Nottingham, Ropewalk House, Nottingham, UK
Trials 14:207. 2013..The most effective stimulation paradigm is now in clinical use as a sound therapy device, the acoustic coordinated reset (CR®) neuromodulation (Adaptive Neuromodulation GmbH (ANM), Köln, Germany)...
- A neural code for low-frequency sound localization in mammalsD McAlpine
MRC Institute of Hearing Research, Science Road, University of Nottingham, Nottingham NG7 2RD, UK
Nat Neurosci 4:396-401. 2001....
- Blocking GABAergic inhibition increases sensitivity to sound motion cues in the inferior colliculusDavid McAlpine
Department of Physiology, University College London, London, WC1E 6BT, United Kingdom
J Neurosci 22:1443-53. 2002..These results indicate that GABAergic inhibition strongly influences the context-dependent processing of low-frequency binaural signals in the IC...
- Sound localization and delay lines--do mammals fit the model?David McAlpine
Department of Physiology, University College London, London WC1E 6BT, UK
Trends Neurosci 26:347-50. 2003....
- Spike-frequency adaptation in the inferior colliculusNeil J Ingham
Department of Physiology, University College London, Gower Street, London, WC1E 6BT, United Kingdom
J Neurophysiol 91:632-45. 2004..We conclude that such binaurally derived measures of adaptation reflect processes that occur above the level of exclusively monaural pathways, and subsequent to the site of primary binaural interaction...
- Spatial receptive fields of inferior colliculus neurons to auditory apparent motion in free fieldN J Ingham
Department of Physiology, University College London, London WC1E 6BT, United Kingdom
J Neurophysiol 85:23-33. 2001..In addition, the data indicate that the sequential activation of an array of speakers to produce apparent auditory motion may not be an optimal stimulus paradigm to separate the temporal and spatial aspects of auditory motion processing...
- Adaptive coding is constrained to midline locations in a spatial listening taskJ K Maier
UCL Ear Institute, London, United Kingdom
J Neurophysiol 108:1856-68. 2012..The data support the notion that adaptive coding in the midbrain is a key element of behaviorally efficient sound localization in dynamic acoustic environments...
- Modelling convergent input onto interaural-delay-sensitive inferior colliculus neuronesT M Shackleton
MRC Institute of Hearing Research, University of Nottingham, University Park, Nottingham, UK
Hear Res 149:199-215. 2000..Non-zero characteristic phases arise if the characteristic frequencies of the AN fibres feeding into a single superior olive cell are mismatched...
- Precise inhibition is essential for microsecond interaural time difference codingAntje Brand
Max Planck Institute of Neurobiology, Am Klopferspitz 18a, 82152 Martinsried, Germany
Nature 417:543-7. 2002..A computer model, simulating the response of a coincidence-detector neuron with bilateral excitatory inputs and a temporally precise contralateral inhibitory input, supports this conclusion...
- Rapid neural adaptation to sound level statisticsIsabel Dean
University College London Ear Institute, London WC1X 8EE, United Kingdom
J Neurosci 28:6430-8. 2008..Our findings provide constraints in the search for mechanisms underlying adaptation to sound level. They also have functional implications for the role of adaptation in the representation of natural sounds...
- Representation of interaural time delay in the human auditory midbrainSarah K Thompson
Department of Physiology and UCL Ear Institute, University College London, 332 Gray s Inn Road, London WC1X 8EE, UK
Nat Neurosci 9:1096-8. 2006..The data require a new model for human ITD processing...
- Neural population coding of sound level adapts to stimulus statisticsIsabel Dean
Department of Physiology and University College London Ear Institute, UK
Nat Neurosci 8:1684-9. 2005..This extends the range of sound levels that can be accurately encoded, fine-tuning hearing to the local acoustic environment...
- Neural sensitivity to interaural envelope delays in the inferior colliculus of the guinea pigSarah J Griffin
Department of Physiology, University College London, Gower Street, London, WC1E 6BT, UK
J Neurophysiol 93:3463-78. 2005..This suggests that the neural mechanisms that mediate sensitivity to ITDs at high and low frequencies are functionally equivalent, provided that the stimuli result in appropriate temporal patterns of action potentials in ANFs...