Claudia Mauri

Summary

Affiliation: University College London
Country: UK

Publications

  1. doi request reprint Regulatory B cells in autoimmunity: developments and controversies
    Claudia Mauri
    Centre for Rheumatology Research, Department of Medicine, University College London, 46 Cleveland Street, London W1T 4JF, UK
    Nat Rev Rheumatol 6:636-43. 2010
  2. pmc Prevention of arthritis by interleukin 10-producing B cells
    Claudia Mauri
    The Kennedy Institute of Rheumatology Division, Faculty of Medicine, Imperial College of Science Technology and Medicine, London W6 8 LH, United Kingdom
    J Exp Med 197:489-501. 2003
  3. pmc The expanding family of regulatory B cells
    Claudia Mauri
    Centre for Rheumatology, Division of Medicine, University College London, 5 University Street, London WC1E 6JF, UK
    Int Immunol 27:479-86. 2015
  4. doi request reprint The incognito journey of a regulatory B cell
    Claudia Mauri
    Centre for Rheumatology, Division of Medicine, University College London, London WC1E 6JF, UK Electronic address
    Immunity 41:878-80. 2014
  5. pmc Anti-TNF-alpha therapy induces a distinct regulatory T cell population in patients with rheumatoid arthritis via TGF-beta
    Suchita Nadkarni
    Centre for Rheumatology, Department of Medicine, Windeyer Institute, University College London, London W1T 4JF, England, UK
    J Exp Med 204:33-9. 2007
  6. doi request reprint Immune regulatory function of B cells
    Claudia Mauri
    Center for Rheumatology Research, Division of Medicine, University College London, London WC1E 6JF, United Kingdom
    Annu Rev Immunol 30:221-41. 2012
  7. pmc Is there a feudal hierarchy amongst regulatory immune cells? More than just Tregs
    Claudia Mauri
    Centre for Rheumatology Research, University College London, Department of Medicine, Cleveland Street, London, UK
    Arthritis Res Ther 11:237. 2009
  8. doi request reprint Regulation of immunity and autoimmunity by B cells
    Claudia Mauri
    Centre for Rheumatology Research, Division of Medicine, University College London, 46 Cleveland Street, London W1T4JF, United Kingdom
    Curr Opin Immunol 22:761-7. 2010
  9. doi request reprint The 'short' history of regulatory B cells
    Claudia Mauri
    Department of Medicine, University College London, 46 Cleveland Street, London W1T 4JF, UK
    Trends Immunol 29:34-40. 2008
  10. ncbi request reprint Down-regulation of Th1-mediated pathology in experimental arthritis by stimulation of the Th2 arm of the immune response
    Claudia Mauri
    Center for Rheumatology Research, Windeyer Institute of Medical Sciences, University College London, London, UK
    Arthritis Rheum 48:839-45. 2003

Collaborators

Detail Information

Publications40

  1. doi request reprint Regulatory B cells in autoimmunity: developments and controversies
    Claudia Mauri
    Centre for Rheumatology Research, Department of Medicine, University College London, 46 Cleveland Street, London W1T 4JF, UK
    Nat Rev Rheumatol 6:636-43. 2010
    ..A particular emphasis is placed on B(REG)-cell function in rheumatic diseases...
  2. pmc Prevention of arthritis by interleukin 10-producing B cells
    Claudia Mauri
    The Kennedy Institute of Rheumatology Division, Faculty of Medicine, Imperial College of Science Technology and Medicine, London W6 8 LH, United Kingdom
    J Exp Med 197:489-501. 2003
    ..Our results suggest a new role of a subset of B cells in controlling T cell differentiation and autoimmune disorders...
  3. pmc The expanding family of regulatory B cells
    Claudia Mauri
    Centre for Rheumatology, Division of Medicine, University College London, 5 University Street, London WC1E 6JF, UK
    Int Immunol 27:479-86. 2015
    ..In this review, we describe the different Breg subsets identified in mice and humans, and their diverse mechanisms of suppression in different disease settings. ..
  4. doi request reprint The incognito journey of a regulatory B cell
    Claudia Mauri
    Centre for Rheumatology, Division of Medicine, University College London, London WC1E 6JF, UK Electronic address
    Immunity 41:878-80. 2014
    ..Matsumoto et al. (2014) report that IL-10(+) plasmablasts restrain autoimmune inflammation and suggest an ontological connection between immature B cells and regulatory plasmablasts. ..
  5. pmc Anti-TNF-alpha therapy induces a distinct regulatory T cell population in patients with rheumatoid arthritis via TGF-beta
    Suchita Nadkarni
    Centre for Rheumatology, Department of Medicine, Windeyer Institute, University College London, London W1T 4JF, England, UK
    J Exp Med 204:33-9. 2007
    ..Therefore, manipulation of a proinflammatory environment could represent a therapeutic strategy for the induction of T reg cells and the restoration of tolerance...
  6. doi request reprint Immune regulatory function of B cells
    Claudia Mauri
    Center for Rheumatology Research, Division of Medicine, University College London, London WC1E 6JF, United Kingdom
    Annu Rev Immunol 30:221-41. 2012
    ..This review reports and discusses the factors that are important for Breg differentiation and for their effector function in both mouse and human...
  7. pmc Is there a feudal hierarchy amongst regulatory immune cells? More than just Tregs
    Claudia Mauri
    Centre for Rheumatology Research, University College London, Department of Medicine, Cleveland Street, London, UK
    Arthritis Res Ther 11:237. 2009
    ..However, it has become clearer that other immune suppressive cells inhibit auto-reactivity as effectively as Tregs. The function of Tregs and other regulatory cells in rheumatoid arthritis will be discussed in this review...
  8. doi request reprint Regulation of immunity and autoimmunity by B cells
    Claudia Mauri
    Centre for Rheumatology Research, Division of Medicine, University College London, 46 Cleveland Street, London W1T4JF, United Kingdom
    Curr Opin Immunol 22:761-7. 2010
    ..A complete analysis of their function in immune-mediated diseases is required for possible future use of B(regs) as a part of new clinical strategies for treating autoimmune diseases and in the induction of transplant tolerance...
  9. doi request reprint The 'short' history of regulatory B cells
    Claudia Mauri
    Department of Medicine, University College London, 46 Cleveland Street, London W1T 4JF, UK
    Trends Immunol 29:34-40. 2008
    ..The identification of their existence is of great relevance to the understanding of autoimmune diseases and to the development of new therapeutic strategies...
  10. ncbi request reprint Down-regulation of Th1-mediated pathology in experimental arthritis by stimulation of the Th2 arm of the immune response
    Claudia Mauri
    Center for Rheumatology Research, Windeyer Institute of Medical Sciences, University College London, London, UK
    Arthritis Rheum 48:839-45. 2003
    ....
  11. pmc Cells of the synovium in rheumatoid arthritis. B cells
    Claudia Mauri
    Centre for Rheumatology Research, Department of Medicine, University College London, Cleveland Street, London, W1T 4JF, UK
    Arthritis Res Ther 9:205. 2007
    ..In this review we analyze the multifaceted role that B cells play in the pathogenesis of rheumatoid arthritis and discuss how this information can be used to guide more specific targeting of B cells for the therapy of this disease...
  12. ncbi request reprint Novel suppressive function of transitional 2 B cells in experimental arthritis
    Jamie G Evans
    Centre for Rheumatology Research, Department of Medicine, University College London, 46 Cleveland Street, London, United Kingdom
    J Immunol 178:7868-78. 2007
    ..The ability to regulate an established immune response by T2-MZP B cells endows this subset of B cells with a striking and previously unrecognized immunoregulatory potential...
  13. doi request reprint Abnormal CTLA-4 function in T cells from patients with systemic lupus erythematosus
    Elizabeth C Jury
    Department of Medicine, Centre for Rheumatology, University College London, London, UK
    Eur J Immunol 40:569-78. 2010
    ..Collectively our data identify CTLA-4 dysfunction as a potential cause for abnormal T-cell activation in patients with SLE, which could be targeted for therapy...
  14. pmc Selective targeting of B cells with agonistic anti-CD40 is an efficacious strategy for the generation of induced regulatory T2-like B cells and for the suppression of lupus in MRL/lpr mice
    Paul A Blair
    Department of Medicine, Centre for Rheumatology Research, University College London, London, United Kingdom
    J Immunol 182:3492-502. 2009
    ..Taken together, our results suggest a novel cellular approach for the amelioration of experimental lupus...
  15. doi request reprint CD19(+)CD24(hi)CD38(hi) B cells exhibit regulatory capacity in healthy individuals but are functionally impaired in systemic Lupus Erythematosus patients
    Paul A Blair
    Centre for Rheumatology Research, Department of Medicine, University College London, 46 Cleveland Street, London W1T4 JF, UK
    Immunity 32:129-40. 2010
    ..Altered cellular function within this compartment may impact effector immune responses in SLE and other autoimmune disorders...
  16. pmc Lipid-antigen presentation by CD1d(+) B cells is essential for the maintenance of invariant natural killer T cells
    Anneleen Bosma
    Centre for Rheumatology Research, Division of Medicine, University College London, London WC1E 6JF, UK
    Immunity 36:477-90. 2012
    ..We propose that healthy B cells are pivotal for iNKT cell homeostasis...
  17. doi request reprint IL-12p35 subunit contributes to autoimmunity by limiting IL-27-driven regulatory responses
    Rita Vasconcellos
    Centre for Rheumatology Research, University College London, London WC1E 6JF, United Kingdom
    J Immunol 187:3402-12. 2011
    ..The restoration of disease phenotype after anti-IL-27 administration indicates that the IL-12p35 subunit acts as negative regulator of the developing IL-27 response in this model of arthritis...
  18. pmc Interleukin-10 produced by B cells is crucial for the suppression of Th17/Th1 responses, induction of T regulatory type 1 cells and reduction of collagen-induced arthritis
    Natalie A Carter
    Centre for Rheumatology Research, Division of Medicine, University College London, Rayne Building, 5 University Street, London, WC1E 6JF, UK
    Arthritis Res Ther 14:R32. 2012
    ..The aim of this study was to identify the role of endogenous IL-10 secreting B cells in vivo in controlling the induction and disease progression of collagen-induced arthritis (CIA)...
  19. doi request reprint Mice lacking endogenous IL-10-producing regulatory B cells develop exacerbated disease and present with an increased frequency of Th1/Th17 but a decrease in regulatory T cells
    Natalie A Carter
    Division of Medicine, Centre for Rheumatology Research, University College London, London W1T 4JF, United Kingdom
    J Immunol 186:5569-79. 2011
    ..Thus, IL-10-producing B cells restrain inflammation by promoting differentiation of immunoregulatory over proinflammatory T cells...
  20. pmc Defects in CTLA-4 are associated with abnormal regulatory T cell function in rheumatoid arthritis
    Fabian Flores-Borja
    Centre for Rheumatology, Division of Medicine, Windeyer Institute of Medical Sciences, University College London, London W1T 4JF, United Kingdom
    Proc Natl Acad Sci U S A 105:19396-401. 2008
    ..Our results suggest that defects in CTLA-4 could contribute to abnormal Treg function in RA and may represent a target for therapy for inducing long-lasting remission...
  21. ncbi request reprint Atorvastatin restores Lck expression and lipid raft-associated signaling in T cells from patients with systemic lupus erythematosus
    Elizabeth C Jury
    Department of Medicine, Centre for Rheumatology, University College London, United Kingdom
    J Immunol 177:7416-22. 2006
    ..These findings demonstrate the potential for atorvastatin to target lipid raft-associated signaling abnormalities in autoreactive T cells and provide a rationale for its use in therapy of autoimmune disease...
  22. doi request reprint Invariant natural killer T cells are enriched at the site of cutaneous inflammation in lupus erythematosus
    Silke C Hofmann
    Centre for Rheumatology Research, University College London, UK
    J Dermatol Sci 71:22-8. 2013
    ..Limited information exists on the role of iNKT cells in the pathogenesis of lupus erythematosus...
  23. doi request reprint CD19+CD24hiCD38hi B cells maintain regulatory T cells while limiting TH1 and TH17 differentiation
    Fabian Flores-Borja
    Centre for Rheumatology, Division of Medicine, University College London, 5 University Street, London WC1E 6JF, UK
    Sci Transl Med 5:173ra23. 2013
    ..These results suggest that in patients with active RA, CD19(+)CD24(hi)CD38(hi) B cells with regulatory function may fail to prevent the development of autoreactive responses and inflammation, leading to autoimmunity...
  24. doi request reprint Regulatory B cells are induced by gut microbiota-driven interleukin-1β and interleukin-6 production
    Elizabeth C Rosser
    Centre for Rheumatology, Division of Medicine, University College London, London, UK
    Nat Med 20:1334-9. 2014
    ..Thus, in response to inflammatory signals induced by both the gut flora and arthritis, Breg cells increase in number and restrain excessive inflammation. ..
  25. pmc Compromised function of regulatory T cells in rheumatoid arthritis and reversal by anti-TNFalpha therapy
    Michael R Ehrenstein
    Dept of Medicine, Centre for Rheumatology, Windeyer Institute, University College London, London W1T 4JF, England, UK
    J Exp Med 200:277-85. 2004
    ....
  26. ncbi request reprint Natural serum IgM maintains immunological homeostasis and prevents autoimmunity
    Jessica J Manson
    Department of Rheumatology, University College London, London, UK
    Springer Semin Immunopathol 26:425-32. 2005
    ..This review focuses on these new areas of research, which also show that many pathologies not normally recognised as having an immunological basis are modulated by serum IgM...
  27. doi request reprint Biosprayed spleen cells integrate and function in mouse models
    Natalie A Carter
    Centre for Rheumatology Research, Division of Medicine, University College London, 46 Cleveland Street, London, W1T 4JF, UK
    Analyst 136:3434-7. 2011
    ..Hence these biotechniques hold great potential for use in the development of three-dimensional cultures, tracking and monitoring cell-interactions and in vitro modelling of disease-states and therapeutics...
  28. ncbi request reprint Atorvastatin inhibits autoreactive B cell activation and delays lupus development in New Zealand black/white F1 mice
    Sarah Lawman
    Department of Medicine, University College London, London, United Kingdom
    J Immunol 173:7641-6. 2004
    ..This is the first demonstration that atorvastatin can delay the progression of a spontaneous autoimmune disease and may specifically benefit patients with systemic lupus erythematosus...
  29. doi request reprint Restoring the balance: harnessing regulatory T cells for therapy in rheumatoid arthritis
    Fabian Flores-Borja
    Department of Medicine, University College London, London, UK
    Eur J Immunol 38:934-7. 2008
    ..Here we discuss strategies aimed at enhancing Treg function in patients with rheumatoid arthritis with the ultimate aim of restoring lasting tolerance but without increasing the risk of infections or cancer...
  30. pmc A Regulatory Feedback between Plasmacytoid Dendritic Cells and Regulatory B Cells Is Aberrant in Systemic Lupus Erythematosus
    Madhvi Menon
    Centre for Rheumatology, Division of Medicine, University College London, 5 University Street, London WC1E 6JF, UK
    Immunity 44:683-97. 2016
    ..We propose that alteration in pDC-CD24(+)CD38(hi) Breg cell interaction contributes to the pathogenesis of SLE...
  31. doi request reprint Cellular targets of regulatory B cell-mediated suppression
    Elizabeth C Rosser
    Centre for Rheumatology, Division of Medicine, University College London, 5 University Street, London WC1E 6JF, United Kingdom
    Mol Immunol 62:296-304. 2014
    ..Here, we summarize the multiplicity of cellular targets of Breg-mediated suppression and describe the mechanisms employed by Bregs to suppress chronic inflammatory responses. ..
  32. doi request reprint Th17 cells are restrained by Treg cells via the inhibition of interleukin-6 in patients with rheumatoid arthritis responding to anti-tumor necrosis factor antibody therapy
    Jenny L McGovern
    University College London, London, UK
    Arthritis Rheum 64:3129-38. 2012
    ..This study sought to address whether Th17 cells are inhibited by Treg cells in rheumatoid arthritis (RA) patients responding to anti-tumor necrosis factor (anti-TNF) therapy, and if so defining the underlying mechanisms of suppression...
  33. doi request reprint A clinical update on the significance of the gut microbiota in systemic autoimmunity
    Elizabeth C Rosser
    University College London Institute of Child Health, London, UK Electronic address
    J Autoimmun 74:85-93. 2016
    ....
  34. doi request reprint Regulatory B cells: origin, phenotype, and function
    Elizabeth C Rosser
    Centre for Rheumatology Research, Division of Medicine, University College London, 5 University Street, London WC1E 6JF, UK
    Immunity 42:607-12. 2015
    ....
  35. pmc Exacerbated experimental arthritis in Wiskott-Aldrich syndrome protein deficiency: modulatory role of regulatory B cells
    Gerben Bouma
    Molecular Immunology Unit, UCL Institute of Child Health, London, UK
    Eur J Immunol 44:2692-702. 2014
    ..A properly regulated cytoskeleton is therefore important for normal Breg-cell activity and complementation of defects in this lineage is likely to have important therapeutic benefits. ..
  36. doi request reprint Regulatory B cells in experimental mouse models of arthritis
    Elizabeth C Rosser
    Centre for Rheumatology, Division of Medicine, University College London, 5 University Street, London, WC1E 6JF, UK
    Methods Mol Biol 1190:183-94. 2014
    ..We will specifically focus on how to induce arthritis as well as methods for the isolation and functional study of Bregs both in vitro and in vivo...
  37. pmc If the treatment works, do we need to know why?: the promise of immunotherapy for experimental medicine
    Michael R Ehrenstein
    Department of Medicine, University College London, London W1T 4JF, UK
    J Exp Med 204:2249-52. 2007
    ..Studies aimed at understanding the mechanism of action of biologic agents will yield significant benefits for experimental medicine...
  38. ncbi request reprint Type I IFN protects permissive macrophages from Legionella pneumophila infection through an IFN-gamma-independent pathway
    Giovanna Schiavoni
    Laboratory of Virology, Istituto Superiore di Sanita, Rome, Italy
    J Immunol 173:1266-75. 2004
    ..pneumophila infection in mouse models of susceptible macrophages and suggest the existence of different pathways for the control of intracellular bacteria in macrophages...
  39. ncbi request reprint Statins for atherosclerosis--as good as it gets?
    Michael R Ehrenstein
    N Engl J Med 352:73-5. 2005