Charles E Massie
Affiliation: University of Cambridge
- Global identification of androgen response elementsCharles E Massie
Cancer Research UK, Cambridge Research Institute, Cambridge, UK
Methods Mol Biol 776:255-73. 2011....
- Mapping protein-DNA interactions using ChIP-sequencingCharles E Massie
CRUK Cambridge Research Institute, Department of Haematology, Cambridge, UK
Methods Mol Biol 809:157-73. 2012..Herein, we provide a comparison of high-throughput sequencing platforms and a survey of ChIP-seq analysis tools, discuss experimental design, and describe a detailed ChIP-seq method...
- HES5 silencing is an early and recurrent change in prostate tumourigenesisCharles E Massie
Cancer Research UK Cambridge InstituteUniversity of Cambridge, Cambridge, CB2 0RE, UKDivision of Genetics and EpidemiologyThe Institute of Cancer Research, Sutton, UKDepartment of Biological Sciences and School of MedicineUniversity of East Anglia, Norwich, UKRoyal Marsden NHS Foundation TrustLondon and Sutton, UKDepartments of PathologyUrologySurgical OncologyAddenbrooke s Hospital, Hills Road, Cambridge, UK
Endocr Relat Cancer 22:131-44. 2015..Finally, we identify and test a transcriptional module involving the AR, ERG, HES1 and HES6 and propose a model for the impact of HES5 silencing on tumourigenesis as a starting point for future functional studies. ..
- Chromatin immunoprecipitation (ChIP) methodology and readoutsCharles E Massie
Uro Oncology Research Group, Cancer Research UK, Cambridge Research Institute, Li Ka Shing Centre, Cambridge, UK
Methods Mol Biol 505:123-37. 2009..The application of ChIP-based approaches has redefined consensus binding motifs for transcription factors and provided important insights into transcription factor biology...
- The androgen receptor fuels prostate cancer by regulating central metabolism and biosynthesisCharles E Massie
CRUK Cambridge Research Institute, Cambridge, UK
EMBO J 30:2719-33. 2011..In conclusion, it is possible to progress from transcriptional studies to a promising therapeutic target by taking an unbiased interdisciplinary approach...