Daniel S Martin

Summary

Affiliation: University College London
Country: UK

Publications

  1. pmc The human physiological impact of global deoxygenation
    Daniel Martin
    UCLH NIHR Biomedical Research Centre, Institute of Sport and Exercise Health, University College London Centre for Altitude Space and Extreme Environment Medicine, First Floor, 170 Tottenham Court Road, London, W1T 7HA, UK
    J Physiol Sci 67:97-106. 2017
  2. doi Ebola virus disease: the UK critical care perspective
    D Martin
    Critical Care Unit Division of Surgery and Interventional Science, University College London University College London Centre for Altitude Space and Extreme Environment Medicine, UCLH NIHR Biomedical Research Centre, Institute of Sport and Exercise Health, London W1 T 7HA, UK
    Br J Anaesth 116:590-6. 2016
  3. pmc Systemic oxygen extraction during exercise at high altitude
    D S Martin
    UCLH NIHR Biomedical Research Centre, Institute of Sport and Exercise Health, University College London Centre for Altitude Space and Extreme Environment Medicine, 170 Tottenham Court Road, London W1 T 7HA, UK
    Br J Anaesth 114:677-82. 2015
  4. pmc A paradigm of fragile Earth in Priestley's bell jar
    Daniel Martin
    UCL Centre for Altitude, Space and Extreme Environment Medicine, Portex Unit, Institute of Child Health, 30 Guilford Street, London, WC1N 1EH, UK
    Extrem Physiol Med 1:4. 2012
  5. pmc Xtreme Everest 2: unlocking the secrets of the Sherpa phenotype?
    Daniel S Martin
    UCL Centre for Altitude, Space and Extreme Environment Medicine, Portex Unit, Institute of Child Health, 30 Guilford Street, London WC1N 1EH, UK
    Extrem Physiol Med 2:30. 2013
  6. doi Design and conduct of 'Xtreme Alps': a double-blind, randomised controlled study of the effects of dietary nitrate supplementation on acclimatisation to high altitude
    Daniel S Martin
    UCL Centre for Altitude, Space and Extreme Environment Medicine, Portex Unit, Institute of Child Health, 30 Guilford Street, London WC1N 1EH, UK University College London, Division of Surgery and Interventional Science, 9th Floor, Royal Free Hospital, Pond Street, London NW3 2QG, UK Electronic address
    Contemp Clin Trials 36:450-9. 2013
  7. doi Oxygen therapy in critical illness: precise control of arterial oxygenation and permissive hypoxemia
    Daniel Stuart Martin
    UCL Centre for Altitude, Space and Extreme Environment Medicine, Portex Unit, Institute of Child Health, London, United Kingdom
    Crit Care Med 41:423-32. 2013
  8. doi Reduced coagulation at high altitude identified by thromboelastography
    Daniel S Martin
    UCL Centre for Altitude, Space and Extreme Environment Medicine, Portex Unit, Institute of Child Health, London, UK
    Thromb Haemost 107:1066-71. 2012
  9. doi Changes in sublingual microcirculatory flow index and vessel density on ascent to altitude
    Daniel S Martin
    UCL Centre for Altitude, Space and Extreme Environment Medicine, Portex Unit, Institute of Child Health, 30 Guilford Street, London WC1N 1EH, UK
    Exp Physiol 95:880-91. 2010
  10. pmc Abnormal blood flow in the sublingual microcirculation at high altitude
    Daniel S Martin
    Centre for Altitude, Space and Extreme Environment Medicine CASE Medicine, UCL Institute of Human Health and Performance, First Floor, Charterhouse Building, Archway Campus, Highgate Hill, London, N19 5LW, UK
    Eur J Appl Physiol 106:473-8. 2009

Collaborators

Detail Information

Publications20

  1. pmc The human physiological impact of global deoxygenation
    Daniel Martin
    UCLH NIHR Biomedical Research Centre, Institute of Sport and Exercise Health, University College London Centre for Altitude Space and Extreme Environment Medicine, First Floor, 170 Tottenham Court Road, London, W1T 7HA, UK
    J Physiol Sci 67:97-106. 2017
    ..Accordingly, without dramatic changes to the way in which we interact with our planet, humans may lose their dominance on Earth during the next few millennia...
  2. doi Ebola virus disease: the UK critical care perspective
    D Martin
    Critical Care Unit Division of Surgery and Interventional Science, University College London University College London Centre for Altitude Space and Extreme Environment Medicine, UCLH NIHR Biomedical Research Centre, Institute of Sport and Exercise Health, London W1 T 7HA, UK
    Br J Anaesth 116:590-6. 2016
    ..We report our recent experiences of managing patients with EVD, with particular focus on those aspects of care pertinent to anaesthesia and critical care medicine. ..
  3. pmc Systemic oxygen extraction during exercise at high altitude
    D S Martin
    UCLH NIHR Biomedical Research Centre, Institute of Sport and Exercise Health, University College London Centre for Altitude Space and Extreme Environment Medicine, 170 Tottenham Court Road, London W1 T 7HA, UK
    Br J Anaesth 114:677-82. 2015
    ..Classic teaching suggests that diminished availability of oxygen leads to increased tissue oxygen extraction yet evidence to support this notion in the context of hypoxaemia, as opposed to anaemia or cardiac failure, is limited...
  4. pmc A paradigm of fragile Earth in Priestley's bell jar
    Daniel Martin
    UCL Centre for Altitude, Space and Extreme Environment Medicine, Portex Unit, Institute of Child Health, 30 Guilford Street, London, WC1N 1EH, UK
    Extrem Physiol Med 1:4. 2012
    ..In order to demonstrate the fragility of life on Earth, Priestley's experiment was recreated using a human subject placed within a modern-day bell jar...
  5. pmc Xtreme Everest 2: unlocking the secrets of the Sherpa phenotype?
    Daniel S Martin
    UCL Centre for Altitude, Space and Extreme Environment Medicine, Portex Unit, Institute of Child Health, 30 Guilford Street, London WC1N 1EH, UK
    Extrem Physiol Med 2:30. 2013
    ..Data generated will also contribute to (and be compared with) the bioresource obtained from our previous observational high-altitude study, Caudwell Xtreme Everest (2007). ..
  6. doi Design and conduct of 'Xtreme Alps': a double-blind, randomised controlled study of the effects of dietary nitrate supplementation on acclimatisation to high altitude
    Daniel S Martin
    UCL Centre for Altitude, Space and Extreme Environment Medicine, Portex Unit, Institute of Child Health, 30 Guilford Street, London WC1N 1EH, UK University College London, Division of Surgery and Interventional Science, 9th Floor, Royal Free Hospital, Pond Street, London NW3 2QG, UK Electronic address
    Contemp Clin Trials 36:450-9. 2013
    ..Improved understanding of hypoxaemia in critical illness may provide new therapeutic avenues for interventions that will improve survival in critically ill patients. ..
  7. doi Oxygen therapy in critical illness: precise control of arterial oxygenation and permissive hypoxemia
    Daniel Stuart Martin
    UCL Centre for Altitude, Space and Extreme Environment Medicine, Portex Unit, Institute of Child Health, London, United Kingdom
    Crit Care Med 41:423-32. 2013
    ..This review sets out to discuss the strengths and limitations of precise control of arterial oxygenation and permissive hypoxemia as candidate management strategies in hypoxemic critically ill patients...
  8. doi Reduced coagulation at high altitude identified by thromboelastography
    Daniel S Martin
    UCL Centre for Altitude, Space and Extreme Environment Medicine, Portex Unit, Institute of Child Health, London, UK
    Thromb Haemost 107:1066-71. 2012
    ..7 (± 8.2) to 51.6 (± 6.4) (p<0.001). There was no change in maximum amplitude (MA) on ascent to altitude. These changes are consistent with an overall pattern of slowed coagulation at high altitude...
  9. doi Changes in sublingual microcirculatory flow index and vessel density on ascent to altitude
    Daniel S Martin
    UCL Centre for Altitude, Space and Extreme Environment Medicine, Portex Unit, Institute of Child Health, 30 Guilford Street, London WC1N 1EH, UK
    Exp Physiol 95:880-91. 2010
    ..Thus, MFI was reduced whilst GX increased in the sublingual mucosa with prolonged exposure to hypoxia and was exaggerated in those exposed to extreme altitude...
  10. pmc Abnormal blood flow in the sublingual microcirculation at high altitude
    Daniel S Martin
    Centre for Altitude, Space and Extreme Environment Medicine CASE Medicine, UCL Institute of Human Health and Performance, First Floor, Charterhouse Building, Archway Campus, Highgate Hill, London, N19 5LW, UK
    Eur J Appl Physiol 106:473-8. 2009
    ..Disruption of blood flow within microcirculatory may explain persistent abnormal oxygen flux to tissues following the normalisation of systemic oxygen delivery that accompanies acclimatisation to high altitude...
  11. pmc The use of skeletal muscle near infrared spectroscopy and a vascular occlusion test at high altitude
    Daniel S Martin
    1 Centre for Altitude, Space, and Extreme Environment Medicine CASE Medicine, Portex Unit, Institute of Child Health, University College London, London, United Kingdom
    High Alt Med Biol 14:256-62. 2013
    ....
  12. pmc The role of nitrogen oxides in human adaptation to hypoxia
    Denny Z Levett
    Centre for Altitude Space and Extreme Environment Medicine, Portex Unit, UCL Institute of Child Health, 30 Guilford Street, London, WC1N 1EH, UK
    Sci Rep 1:109. 2011
    ....
  13. pmc Design and conduct of Caudwell Xtreme Everest: an observational cohort study of variation in human adaptation to progressive environmental hypoxia
    Denny Z H Levett
    Centre for Altitude Space and Extreme Environment Medicine, UCL Institute of Human Health and Performance, First Floor, Charterhouse Building, UCL Archway Campus, Highgate Hill, London, N19 5LW, UK
    BMC Med Res Methodol 10:98. 2010
    ..The aim of this study was to describe the spectrum of adaptive responses in humans exposed to graded EHH and identify factors (physiological and genetic) associated with inter-individual variation in these responses...
  14. doi Arterial blood gases and oxygen content in climbers on Mount Everest
    Michael P W Grocott
    Centre for Altitude, Space, and Extreme Environment Medicine, University College London Institute of Human Health and Performance, London, United Kingdom
    N Engl J Med 360:140-9. 2009
    ..We performed direct field measurements of arterial blood gases in climbers breathing ambient air on Mount Everest...
  15. doi Acclimatization of skeletal muscle mitochondria to high-altitude hypoxia during an ascent of Everest
    Denny Z Levett
    Centre for Altitude, Space, and Extreme Environment Medicine, University College London UCL Institute of Child Health, University College London, London, UK
    FASEB J 26:1431-41. 2012
    ..However, following sustained exposure, mitochondrial biogenesis is deactivated and uncoupling down-regulated, perhaps to improve the efficiency of ATP production...
  16. pmc Changes in skeletal muscle oxygenation during exercise measured by near-infrared spectroscopy on ascent to altitude
    Daniel S Martin
    Centre for Altitude, Space and Extreme Environment Medicine CASE Medicine, University College London Portex Unit, Institute of Child Health, 30 Guilford Street, London WC1N 1EH, UK
    Crit Care 13:S7. 2009
    ..We sought to quantify changes in skeletal muscle oxygenation during exercise using near-infrared spectroscopy (NIRS) in healthy volunteers ascending to high altitude...
  17. pmc Concepts in hypoxia reborn
    Daniel S Martin
    Centre for Altitude, Space and Extreme Environment Medicine, Portex Unit, University College London Institute of Child Health, 30 Guilford Street, London WC1N 1EH, UK
    Crit Care 14:315. 2010
    ....
  18. doi Effects of dietary nitrate supplementation on symptoms of acute mountain sickness and basic physiological responses in a group of male adolescents during ascent to Mount Everest Base Camp
    Philip J Hennis
    Manchester Metropolitan University, Department of Exercise and Sport Science, Centre for Health, Exercise and Active Living, Crewe, UK University College London, Centre for Altitude Space and Extreme Environment Medicine, UCLH NIHR Biomedical Research Centre, Institute of Sport, Exercise and Health, London, UK Electronic address
    Nitric Oxide 60:24-31. 2016
    ..Mixed modelling revealed no significant between-groups difference in the incidence of AMS (Odds Ratio - nitrate vs...
  19. doi King of the mountains: Tibetan and Sherpa physiological adaptations for life at high altitude
    Edward T Gilbert-Kawai
    University College London Centre for Altitude Space and Extreme Environment Medicine, UCLH NIHR Biomedical Research Centre, Institute of Sport and Exercise Health, London, United Kingdom University College London Division of Surgery and Interventional Science, Royal Free Hospital, London, United Kingdom University College Hospital London NIHR Biomedical Research Centre, London, United Kingdom
    Physiology (Bethesda) 29:388-402. 2014
    ..Furthermore, although many physiological differences between highlanders and lowlanders have been found, it also suggests many more potential avenues of investigation. ..
  20. doi Changes in muscle proteomics in the course of the Caudwell Research Expedition to Mt. Everest
    Denny Z H Levett
    Centre for Altitude, Space, and Extreme Environment Medicine, University College London UCL, Institute of Child Health, University College London, London, UK Anaesthesia and Critical Care Research Unit, University Hospital Southampton, NHS Foundation Trust, Southampton, UK
    Proteomics 15:160-71. 2015
    ....