Charles M Marson

Summary

Affiliation: University College London
Country: UK

Publications

  1. ncbi request reprint A catalytic asymmetric protocol for the enantioselective synthesis of 3(2H)-furanones
    Charles M Marson
    Department of Chemistry, University College London, Christopher Ingold Laboratories, 20 Gordon Street, London, UK
    Chem Commun (Camb) . 2007
  2. doi request reprint Discovery of potent, isoform-selective inhibitors of histone deacetylase containing chiral heterocyclic capping groups and a N-(2-aminophenyl)benzamide binding unit
    Charles M Marson
    Department of Chemistry, University College London, Christopher Ingold Laboratories, 20 Gordon Street, London WC1H OAJ, UK
    J Med Chem 56:6156-74. 2013
  3. doi request reprint Multicomponent and sequential organocatalytic reactions: diversity with atom-economy and enantiocontrol
    Charles M Marson
    Department of Chemistry, University College London, Christopher Ingold Laboratories, UK
    Chem Soc Rev 41:7712-22. 2012
  4. ncbi request reprint Histone deacetylase inhibitors: design, structure-activity relationships and therapeutic implications for cancer
    Charles M Marson
    Department of Chemistry, University College London, Christopher Ingold Laboratories, 20 Gordon Street, London WC1HOAJ, UK
    Anticancer Agents Med Chem 9:661-92. 2009
  5. ncbi request reprint Cyclic acid anhydrides as a new class of potent, selective and non-peptidic inhibitors of geranylgeranyl transferase
    Charles M Marson
    Department of Chemistry, University College London, Christopher Ingold Laboratories, 20 Gordon Street, London WC1H OAJ, UK
    Bioorg Med Chem Lett 12:255-9. 2002
  6. ncbi request reprint Synthesis of the penta-oxazole core of telomestatin in a convergent approach to poly-oxazole macrocycles
    Charles M Marson
    Department of Chemistry, University College London, Christopher Ingold Laboratories, 20 Gordon Street, London, WC1H 0AJ, UK
    Org Biomol Chem 4:3892-3. 2006
  7. ncbi request reprint Structure-activity relationships of aryloxyalkanoic acid hydroxyamides as potent inhibitors of histone deacetylase
    Charles M Marson
    Department of Chemistry, University College London, Christopher Ingold Laboratories, 20 Gordon Street, London WC1H OAJ, UK
    Bioorg Med Chem Lett 17:136-41. 2007
  8. ncbi request reprint Aromatic sulfide inhibitors of histone deacetylase based on arylsulfinyl-2,4-hexadienoic acid hydroxyamides
    Charles M Marson
    Department of Chemistry, University College London, Christopher Ingold Laboratories, London WC1H OAJ, UK
    J Med Chem 49:800-5. 2006
  9. ncbi request reprint Enantioselective syntheses of trans-3,4-difluoropyrrolidines and investigation of their applications in catalytic asymmetric synthesis
    Charles M Marson
    Department of Chemistry, University College London, Christopher Ingold Laboratories, 20 Gordon Street, London WC1H 0AJ, UK
    J Org Chem 70:9771-9. 2005
  10. ncbi request reprint Stereodefined and polyunsaturated inhibitors of histone deacetylase based on (2E,4E)-5-arylpenta-2,4-dienoic acid hydroxyamides
    Charles M Marson
    Department of Chemistry, University College London, Christopher Ingold Laboratories, 20 Gordon Street, London WC1H OAJ, UK
    Bioorg Med Chem Lett 14:2477-81. 2004

Collaborators

Detail Information

Publications16

  1. ncbi request reprint A catalytic asymmetric protocol for the enantioselective synthesis of 3(2H)-furanones
    Charles M Marson
    Department of Chemistry, University College London, Christopher Ingold Laboratories, 20 Gordon Street, London, UK
    Chem Commun (Camb) . 2007
    ..3(2H)-Furanones can be prepared by a catalytic asymmetric protocol from enynones, which, if electron-rich, require only one reagent and involve two reactions in a single operation--a domino process...
  2. doi request reprint Discovery of potent, isoform-selective inhibitors of histone deacetylase containing chiral heterocyclic capping groups and a N-(2-aminophenyl)benzamide binding unit
    Charles M Marson
    Department of Chemistry, University College London, Christopher Ingold Laboratories, 20 Gordon Street, London WC1H OAJ, UK
    J Med Chem 56:6156-74. 2013
    ..Inhibition of the growth of MCF-7, A549, DU145, and HCT116 cell lines by 24a was observed, with respective IC50 values of 5.4, 5.8, 6.4, and 2.2 mM. ..
  3. doi request reprint Multicomponent and sequential organocatalytic reactions: diversity with atom-economy and enantiocontrol
    Charles M Marson
    Department of Chemistry, University College London, Christopher Ingold Laboratories, UK
    Chem Soc Rev 41:7712-22. 2012
    ....
  4. ncbi request reprint Histone deacetylase inhibitors: design, structure-activity relationships and therapeutic implications for cancer
    Charles M Marson
    Department of Chemistry, University College London, Christopher Ingold Laboratories, 20 Gordon Street, London WC1HOAJ, UK
    Anticancer Agents Med Chem 9:661-92. 2009
    ..This review highlights recent developments in the design, synthesis and biological properties of HDAC inhibitors in the context of potential cancer therapy...
  5. ncbi request reprint Cyclic acid anhydrides as a new class of potent, selective and non-peptidic inhibitors of geranylgeranyl transferase
    Charles M Marson
    Department of Chemistry, University College London, Christopher Ingold Laboratories, 20 Gordon Street, London WC1H OAJ, UK
    Bioorg Med Chem Lett 12:255-9. 2002
    ..Cyclic acid anhydrides possessing a lipid chain have been shown to be a new class of non-peptidic inhibitors of geranylgeranyl protein-transferase type I (GGPTase-I)...
  6. ncbi request reprint Synthesis of the penta-oxazole core of telomestatin in a convergent approach to poly-oxazole macrocycles
    Charles M Marson
    Department of Chemistry, University College London, Christopher Ingold Laboratories, 20 Gordon Street, London, WC1H 0AJ, UK
    Org Biomol Chem 4:3892-3. 2006
    ..A protocol for the construction of poly-oxazoles with consecutive 2,4'-linkages is described, and has afforded an efficient route to a penta-oxazole which demarcates a route to telomestatin and related macrocyclic poly-oxazole systems...
  7. ncbi request reprint Structure-activity relationships of aryloxyalkanoic acid hydroxyamides as potent inhibitors of histone deacetylase
    Charles M Marson
    Department of Chemistry, University College London, Christopher Ingold Laboratories, 20 Gordon Street, London WC1H OAJ, UK
    Bioorg Med Chem Lett 17:136-41. 2007
    ..Variation of the substituents on the benzene ring as well as fusion of a second ring have marked effects on potency, in vitro IC(50) values down to 1 nM being obtained...
  8. ncbi request reprint Aromatic sulfide inhibitors of histone deacetylase based on arylsulfinyl-2,4-hexadienoic acid hydroxyamides
    Charles M Marson
    Department of Chemistry, University College London, Christopher Ingold Laboratories, London WC1H OAJ, UK
    J Med Chem 49:800-5. 2006
    ..5 microM, comparable to or better than that of suberoylanilide hydroxamic acid, an inhibitor of histone deacetylase currently in clinical trials...
  9. ncbi request reprint Enantioselective syntheses of trans-3,4-difluoropyrrolidines and investigation of their applications in catalytic asymmetric synthesis
    Charles M Marson
    Department of Chemistry, University College London, Christopher Ingold Laboratories, 20 Gordon Street, London WC1H 0AJ, UK
    J Org Chem 70:9771-9. 2005
    ....
  10. ncbi request reprint Stereodefined and polyunsaturated inhibitors of histone deacetylase based on (2E,4E)-5-arylpenta-2,4-dienoic acid hydroxyamides
    Charles M Marson
    Department of Chemistry, University College London, Christopher Ingold Laboratories, 20 Gordon Street, London WC1H OAJ, UK
    Bioorg Med Chem Lett 14:2477-81. 2004
    ..Variation of substituents on the aromatic ring has a marked effect on potency, in vitro IC(50) values down to 50 nM being obtained...
  11. doi request reprint Potent and Selective Inhibitors of Histone Deacetylase-3 Containing Chiral Oxazoline Capping Groups and a N-(2-Aminophenyl)-benzamide Binding Unit
    Charles M Marson
    Department of Chemistry, University College London, Christopher Ingold Laboratories, 20 Gordon Street, London WC1H OAJ, U K
    J Med Chem 58:6803-18. 2015
    ....
  12. doi request reprint Effects of a selection of histone deacetylase inhibitors on mast cell activation and airway and colonic smooth muscle contraction
    El Sayed K Assem
    Department of Pharmacology, University College London, Gower Street, London WC1E 6BT, UK
    Int Immunopharmacol 8:1793-801. 2008
    ..Those various effects appear to involve modulation of cell signaling, probably involving G-protein coupled pathways, and further support the development of HDAC inhibitors as anti-inflammatory agents...
  13. doi request reprint New and unusual scaffolds in medicinal chemistry
    Charles M Marson
    Department of Chemistry, University College London, Christopher Ingold Laboratories, 20 Gordon Street, London, WC1H OAJ, UK
    Chem Soc Rev 40:5514-33. 2011
    ....
  14. ncbi request reprint Production of malodorous steroids from androsta-5,16-dienes and androsta-4,16-dienes by Corynebacteria and other human axillary bacteria
    Richard A Decreau
    Christopher Ingold Laboratories, Department of Chemistry, University College London, 20 Gordon Street, WC1H 0AJ London, UK
    J Steroid Biochem Mol Biol 87:327-36. 2003
    ..Pre-incubation with a 3beta-fluoro-steroid inhibited the formation of the odorous androsta-4,16-dien-3-one...
  15. doi request reprint Thiostrepton selectively targets breast cancer cells through inhibition of forkhead box M1 expression
    Jimmy M M Kwok
    Cancer Research UK Labs, Department of Oncology, MRC Cyclotron Building, Imperial College London, Hammersmith Hospital Campus, Du Cane Road, London W12 0NN, United Kingdom
    Mol Cancer Ther 7:2022-32. 2008
    ....
  16. ncbi request reprint An asymmetric synthesis of aza analogues of the tricyclic skeleton of daphnane and the ABC ring system of phorbol
    Charles M Marson
    Rhone Poulenc Rorer Ltd, Rainham Road South, Dagenham, Essex RM10 7XS, UK
    J Org Chem 68:792-8. 2003
    ..Subsequent demethylation and oxidative dearomatization of ring C afforded an enantiopure dienone 20 with the same relative and absolute configuration at the 9- and 10-positions of the phorbol skeleton...