A G Marson

Summary

Affiliation: University of Liverpool
Country: UK

Publications

  1. doi request reprint Interpreting regulatory trials in epilepsy
    A G Marson
    The University of Liverpool, Liverpool, UK
    Curr Opin Neurol 22:167-73. 2009
  2. ncbi request reprint Efficacy of carbamazepine and valproate as monotherapy for early epilepsy and single seizures
    A G Marson
    Division of Neurological Science, Clinical Sciences Centre for Research and Education, University of Liverpool, Liverpool, L9 7LJ, UK
    Neurology 67:1872-5. 2006
  3. pmc The SANAD study of effectiveness of carbamazepine, gabapentin, lamotrigine, oxcarbazepine, or topiramate for treatment of partial epilepsy: an unblinded randomised controlled trial
    Anthony G Marson
    Division of Neurological Science, University of Liverpool, UK
    Lancet 369:1000-15. 2007
  4. pmc The SANAD study of effectiveness of valproate, lamotrigine, or topiramate for generalised and unclassifiable epilepsy: an unblinded randomised controlled trial
    Anthony G Marson
    Division of Neurological Science, University of Liverpool, UK
    Lancet 369:1016-26. 2007
  5. doi request reprint When to start antiepileptic drug treatment and with what evidence?
    Anthony G Marson
    The University of Liverpool, The Walton Centre, Liverpool, UK
    Epilepsia 49:3-6. 2008
  6. ncbi request reprint Levetiracetam, oxcarbazepine, remacemide and zonisamide for drug resistant localization-related epilepsy: a systematic review
    A G Marson
    Department of Neurological Science, Clinical Sciences Centre for Research and Education, University of Liverpool, Lower Lane, Fazakerley, Liverpool L9 7LJ, UK
    Epilepsy Res 46:259-70. 2001
  7. ncbi request reprint Carbamazepine versus valproate monotherapy for epilepsy: a meta-analysis
    Anthony G Marson
    Department of Neurological Science, Faculty of Medicine, University of Liverpool, Liverpool, England, UK
    Epilepsia 43:505-13. 2002
  8. doi request reprint Reporting and analysis of open-label extension studies of anti-epileptic drugs
    M J Maguire
    Department of Neuroscience, University of Liverpool, Liverpool, UK
    Epilepsy Res 81:24-9. 2008
  9. pmc New antiepileptic drugs: a systematic review of their efficacy and tolerability
    A G Marson
    Department of Neurological Science, University of Liverpool
    BMJ 313:1169-74. 1996
  10. ncbi request reprint A randomised controlled trial examining the longer-term outcomes of standard versus new antiepileptic drugs. The SANAD trial
    A G Marson
    Division of Neurological Science, University of Liverpool, UK
    Health Technol Assess 11:iii-iv, ix-x, 1-134. 2007

Collaborators

Detail Information

Publications38

  1. doi request reprint Interpreting regulatory trials in epilepsy
    A G Marson
    The University of Liverpool, Liverpool, UK
    Curr Opin Neurol 22:167-73. 2009
    ....
  2. ncbi request reprint Efficacy of carbamazepine and valproate as monotherapy for early epilepsy and single seizures
    A G Marson
    Division of Neurological Science, Clinical Sciences Centre for Research and Education, University of Liverpool, Liverpool, L9 7LJ, UK
    Neurology 67:1872-5. 2006
    ..For time to first seizure recurrence, MESS provides strong evidence of an effect for carbamazepine as monotherapy but mixed evidence of an effect for valproate...
  3. pmc The SANAD study of effectiveness of carbamazepine, gabapentin, lamotrigine, oxcarbazepine, or topiramate for treatment of partial epilepsy: an unblinded randomised controlled trial
    Anthony G Marson
    Division of Neurological Science, University of Liverpool, UK
    Lancet 369:1000-15. 2007
    ..We aimed to assess efficacy with regards to longer-term outcomes, quality of life, and health economic outcomes...
  4. pmc The SANAD study of effectiveness of valproate, lamotrigine, or topiramate for generalised and unclassifiable epilepsy: an unblinded randomised controlled trial
    Anthony G Marson
    Division of Neurological Science, University of Liverpool, UK
    Lancet 369:1016-26. 2007
    ..The SANAD study aimed to compare the longer-term effects of these drugs in patients with generalised onset seizures or seizures that are difficult to classify...
  5. doi request reprint When to start antiepileptic drug treatment and with what evidence?
    Anthony G Marson
    The University of Liverpool, The Walton Centre, Liverpool, UK
    Epilepsia 49:3-6. 2008
    ..They may wish to start antiepileptic drug treatment if they are in a medium or high recurrence risk group as defined by a prognostic model...
  6. ncbi request reprint Levetiracetam, oxcarbazepine, remacemide and zonisamide for drug resistant localization-related epilepsy: a systematic review
    A G Marson
    Department of Neurological Science, Clinical Sciences Centre for Research and Education, University of Liverpool, Lower Lane, Fazakerley, Liverpool L9 7LJ, UK
    Epilepsy Res 46:259-70. 2001
    ..To undertake a systematic review and meta-analysis of placebo controlled add-on trials of levetiracetam, oxcarbazepine, remacemide and zonisamide for patients with drug resistant localization related epilepsy...
  7. ncbi request reprint Carbamazepine versus valproate monotherapy for epilepsy: a meta-analysis
    Anthony G Marson
    Department of Neurological Science, Faculty of Medicine, University of Liverpool, Liverpool, England, UK
    Epilepsia 43:505-13. 2002
    ....
  8. doi request reprint Reporting and analysis of open-label extension studies of anti-epileptic drugs
    M J Maguire
    Department of Neuroscience, University of Liverpool, Liverpool, UK
    Epilepsy Res 81:24-9. 2008
    ..We propose an alternative method of analysis, in line with that recommended in the analysis of RCTs, the intention to treat (ITT) approach, in which it is assumed that all patients who discontinue treatment are non-responders...
  9. pmc New antiepileptic drugs: a systematic review of their efficacy and tolerability
    A G Marson
    Department of Neurological Science, University of Liverpool
    BMJ 313:1169-74. 1996
    ..To evaluate the efficacy and tolerability of the newly developed antiepileptic drugs gabapentin, lamotrigine, tiagabine, topiramate, vigabatrin, and zonisamide in patients with refractory partial epilepsy...
  10. ncbi request reprint A randomised controlled trial examining the longer-term outcomes of standard versus new antiepileptic drugs. The SANAD trial
    A G Marson
    Division of Neurological Science, University of Liverpool, UK
    Health Technol Assess 11:iii-iv, ix-x, 1-134. 2007
    ..To compare clinicians' choice of one of the standard epilepsy drug treatments (carbamazepine or valproate) versus appropriate comparator new drugs...
  11. ncbi request reprint A meta-analysis of individual patient responses to lamotrigine or carbamazepine monotherapy
    C Gamble
    Centre for Medical Statistics and Health Evaluation, University of Liverpool, Liverpool, UK
    Neurology 66:1310-7. 2006
    ..To compare the effects of carbamazepine and lamotrigine monotherapy for people with partial onset seizures or generalized onset tonic-clonic seizures...
  12. doi request reprint Overwhelming heterogeneity in systematic reviews of observational anti-epileptic studies
    M J Maguire
    The Department of Neuroscience, University of Liverpool, Liverpool, UK
    Epilepsy Res 80:201-12. 2008
    ..These issues were investigated in a systematic review of non-randomised add-on anti-epileptic drug studies...
  13. ncbi request reprint Quality-of-life and behavioral outcome measures in randomized controlled trials of antiepileptic drugs: a systematic review of methodology and reporting standards
    G A Baker
    Department of Neurological Science, The Walton Centre, Liverpool, United Kingdom
    Epilepsia 41:1357-63. 2000
    ..To review the methodology and use of quality-of-life and behavioral measures used in randomized controlled trials (RCTs) of antiepileptic drugs in patients with epilepsy...
  14. ncbi request reprint Carbamazepine versus valproate monotherapy for epilepsy
    A G Marson
    University Department of Neurological Science, Room 2 30 Clinical Science Centre for Research and Education, Lower Lane, Liverpool, Merseyside, UK, L9 7LJ
    Cochrane Database Syst Rev . 2000
    ..Despite the lack of hard evidence from individual randomized controlled trials, there is strong clinical belief that valproate is the drug of choice for generalized epilepsies and carbamazepine for partial epilepsies...
  15. doi request reprint Joint modelling of longitudinal and competing risks data
    P R Williamson
    Centre for Medical Statistics and Health Evaluation, University of Liverpool, Shelley s Cottage, Brownlow Street, Liverpool L69 3GS, UK
    Stat Med 27:6426-38. 2008
    ..Adjustment for the titration rate of LTG relative to CBZ resulted in an unchanged effect of the former on drug withdrawals due to inadequate seizure control. LTG remains the AED of choice from this analysis...
  16. ncbi request reprint Gabapentin add-on for drug-resistant partial epilepsy
    A G Marson
    University Department of Neurological Science, Room 2 30 Clinical Science Centre for Research and Education, Lower Lane, Liverpool, Merseyside, UK, L9 7LJ
    Cochrane Database Syst Rev . 2000
    ..In this review we summarise the current evidence regarding a new antiepileptic drug, gabapentin, when used as an add-on treatment for drug-resistant partial epilepsy...
  17. ncbi request reprint Gabapentin for drug-resistant partial epilepsy
    A G Marson
    University Department of Neurological Science, The University of Liverpool, The Walton Centre for Neurology and Neurosurgery, Lower Lane, Fazakerley, Liverpool, Merseyside, UK, L9 7LJ
    Cochrane Database Syst Rev . 2000
    ..In this review we summarise the current evidence regarding a new antiepileptic drug, gabapentin, when used as an add-on treatment for drug-resistant partial epilepsy..
  18. pmc Phenobarbitone versus phenytoin monotherapy for partial onset seizures and generalized onset tonic-clonic seizures
    S Taylor
    Division of Statistics and Operational Research, Department of Mathematical Sciences, University of Liverpool, Peach Street, Liverpool, Merseyside, UK, L69 7ZL
    Cochrane Database Syst Rev . 2001
    ..They are more likely to be used in the developing world than the developed world, primarily because they are inexpensive. The aim of this review is to summarise data from existing trials comparing phenytoin and phenobarbitone...
  19. ncbi request reprint Cognitive and behavioural assessments in clinical trials: what type of measure?
    G A Baker
    University Department of Neurosciences, Walton Centre for Neurology and Neurosurgery, Lower Lane, Fazakerley, L9 7LJ, Liverpool, UK
    Epilepsy Res 45:163-7; discussion 169-70. 2001
    ..A much more standardised approach to assessing these effects is necessary...
  20. ncbi request reprint Carbamazepine versus phenytoin monotherapy for epilepsy
    C Tudur Smith
    Division of Statistics and Operational Research, Department of Mathematical Sciences, University of Liverpool, Mathematics and Oceanography Building, Peach Street, Liverpool, UK, L69 7ZL
    Cochrane Database Syst Rev . 2002
    ..Worldwide, carbamazepine and phenytoin are commonly used antiepileptic drugs. This review summarizes evidence from randomized controlled trials in which these two drugs have been compared...
  21. ncbi request reprint Phenytoin versus valproate monotherapy for partial onset seizures and generalized onset tonic-clonic seizures
    C Tudur Smith
    Division of Statistics and Operational Research, Department of Mathematical Sciences, University of Liverpool, Mathematics and Oceanography Building, Peach Street, Liverpool, UK, L69 7ZL
    Cochrane Database Syst Rev . 2001
    ..The use of individual patient data meta-analysis enabled us to examine time to event outcomes which are important in epilepsy monotherapy trials, and also to examine treatment-covariate interactions...
  22. doi request reprint HLA genotype and carbamazepine-induced cutaneous adverse drug reactions: a systematic review
    V L Yip
    Department of Molecular and Clinical Pharmacology, University of Liverpool, Liverpool, UK
    Clin Pharmacol Ther 92:757-65. 2012
    ..Our findings suggest that HLA testing before carbamazepine therapy would be effective at identifying individuals at risk of hypersensitivity and applicable to multiple populations providing hope for prevention in the future...
  23. ncbi request reprint Lamotrigine versus carbamazepine monotherapy for epilepsy
    C L Gamble
    University of Liverpool, Centre for Medical Statistics and Health Evaluation, Shelley s Cottage, Brownlow Street, Liverpool, UK, L69 3GS
    Cochrane Database Syst Rev . 2006
    ..Carbamazepine is the usual drug of choice for people with newly-diagnosed partial onset seizures. Lamotrigine is a relatively new AED which is licensed in many countries for use as an initial monotherapy...
  24. ncbi request reprint Zonisamide add-on for drug-resistant partial epilepsy
    D W Chadwick
    Department of Neurological Science, Room 2 26 Clinical Science Centre for Research and Education, Lower Lane, Liverpool, Merseyside, UK L9 7LJ
    Cochrane Database Syst Rev . 2005
    ..In this review we summarize the current evidence regarding zonisamide, when used as an add-on treatment for drug-resistant partial epilepsy...
  25. ncbi request reprint Zonisamide for drug-resistant partial epilepsy
    D W Chadwick
    Department of Neurological Science, The Walton Centre for Neurology and Neurosurgery, Lower Lane, Fazakerley, Liverpool, Merseyside, UK, L9 7LJ
    Cochrane Database Syst Rev . 2000
    ..In this review we summarise the current evidence regarding a new antiepileptic drug, zonisamide, when used as an add-on treatment for drug-resistant partial epilepsy...
  26. ncbi request reprint Zonisamide add-on for drug-resistant partial epilepsy
    D W Chadwick
    Department of Neurological Science, Room 2 26 Clinical Science Centre for Research and Education, Lower Lane, Liverpool, Merseyside, UK, L9 7LJ
    Cochrane Database Syst Rev . 2002
    ..In this review we summarize the current evidence regarding zonisamide, when used as an add-on treatment for drug-resistant partial epilepsy...
  27. ncbi request reprint Carbamazepine versus phenobarbitone monotherapy for epilepsy
    C Tudur Smith
    Division of Statistics and Operational Research, Department of Mathematical Sciences, University of Liverpool, Mathematics and Oceanography Building, Peach Street, Liverpool, UK, L69 7ZL
    Cochrane Database Syst Rev . 2003
    ..We report a review using individual patient data in which carbamazepine and phenobarbitone are compared...
  28. doi request reprint Personalized medicine approaches in epilepsy
    L E Walker
    Department of Molecular and Clinical Pharmacology, University of Liverpool, Liverpool, UK
    J Intern Med 277:218-34. 2015
    ..In this review, we explore the currently available key stratification approaches to address the therapeutic challenges in epilepsy...
  29. doi request reprint A comprehensive functional and clinical analysis of ABCC2 and its impact on treatment response to carbamazepine
    S Rädisch
    Department of Molecular and Clinical Pharmacology, The Wolfson Centre for Personalised Medicine, Institute of Translational Medicine, University of Liverpool, Liverpool, UK
    Pharmacogenomics J 14:481-7. 2014
    ..Clinically, no significant association was observed for the ABCC2 genetic variants and CBZ treatment outcomes. This comprehensive analysis does not support a role for ABCC2 in CBZ treatment efficacy. ..
  30. ncbi request reprint Statistical issues in the assessment of the evidence for an interaction between factors in epilepsy trials
    Paula R Williamson
    Division of Statistics and Operational Research, Department of Mathematical Sciences, University of Liverpool, Liverpool, L69 3BX, UK
    Stat Med 21:2613-22. 2002
    ..We suggest that in any context where misclassification is likely, it is worth considering the use of an explicit 'unclassified' group, and investigating whether additional covariates can answer the substantive question...
  31. ncbi request reprint Aggregate data meta-analysis with time-to-event outcomes
    Paula R Williamson
    Department of Mathematical Sciences, University of Liverpool, UK
    Stat Med 21:3337-51. 2002
    ..A cohort study comparing life expectancy of males and females with cerebral palsy and a systematic review of five trials comparing two anti-epileptic drugs, carbamazepine and sodium valproate, are used for illustration...
  32. ncbi request reprint Investigating heterogeneity in an individual patient data meta-analysis of time to event outcomes
    Catrin Tudur Smith
    Centre for Medical Statistics and Health Evaluation, University of Liverpool, Liverpool L69 3BX, UK
    Stat Med 24:1307-19. 2005
    ..The models are further applied to simulated data examples in which the degree of heterogeneity and magnitude of treatment effect are varied. The behaviour of each model in each situation is explored and compared...
  33. ncbi request reprint A systematic review of treatment of typical absence seizures in children and adolescents with ethosuximide, sodium valproate or lamotrigine
    Ewa B Posner
    Sir James Spence Institute of Child Health, The Royal Victoria Infirmary, Queen Victoria Road, Newcastle upon Tyne NE1 4LP, UK
    Seizure 14:117-22. 2005
    ..To evaluate the role of ethosuximide, sodium valproate and lamotrigine in children and adolescents with typical absence seizures (AS)...
  34. ncbi request reprint New statistical method for analyzing time to first seizure: example using data comparing carbamazepine and valproate monotherapy
    Benjamin J Cowling
    Department of Community Medicine and School of Public Health, The University of Hong Kong, Hong Kong Special Administrative Region, People s Republic of China
    Epilepsia 48:1173-8. 2007
    ..We re-analyzed a meta-analysis comparing CBZ and VPS monotherapy with new powerful statistical methods that incorporate baseline seizure rate information...
  35. ncbi request reprint An overview of methods and empirical comparison of aggregate data and individual patient data results for investigating heterogeneity in meta-analysis of time-to-event outcomes
    Catrin Tudur Smith
    Centre for Medical Statistics and Health Evaluation, Shelley s Cottage, University of Liverpool, Liverpool, UK
    J Eval Clin Pract 11:468-78. 2005
    ..Time from first ever seizure to randomization is only identified by some AD models. A more thorough explanation of heterogeneity is obtained from the model using IPD but further empirical evidence comparing IPD and AD results are needed...
  36. ncbi request reprint Clinical factors and ABCB1 polymorphisms in prediction of antiepileptic drug response: a prospective cohort study
    Guy Leschziner
    Division of Neurosciences, Imperial College London, London, UK
    Lancet Neurol 5:668-76. 2006
    ..We aimed to determine the effect of the ABCB1 gene on epilepsy drug response, using a unique large cohort of epilepsy patients with prospectively measured seizure and drug response outcomes...
  37. ncbi request reprint Prediction of risk of seizure recurrence after a single seizure and early epilepsy: further results from the MESS trial
    Lois G Kim
    MRC Biostatistics Unit, Institute of Public Health, Cambridge, UK
    Lancet Neurol 5:317-22. 2006
    ..This will enable decision-making on the basis of the perceived risk of treatment compared with the benefit of reducing the risk of further seizures in the initial years after diagnosis...
  38. ncbi request reprint The association between polymorphisms in RLIP76 and drug response in epilepsy
    Guy D Leschziner
    Imperial College London, Division of Neuroscience, Charing Cross Campus, Room 10E07, St Dunstan s Road, London W6 8RF, UK
    Pharmacogenomics 8:1715-22. 2007
    ..We aimed to look for an association with outcomes reflecting drug response in a larger prospective cohort, with gene-wide coverage...