Isla S Mackenzie

Summary

Affiliation: University of Dundee
Country: UK

Publications

  1. pmc Incidence and prevalence of multiple sclerosis in the UK 1990-2010: a descriptive study in the General Practice Research Database
    I S Mackenzie
    Medicines Monitoring Unit MEMO, University of Dundee, Dundee, UK
    J Neurol Neurosurg Psychiatry 85:76-84. 2014
  2. pmc Cardiovascular safety of lumiracoxib: a meta-analysis of randomised controlled trials in patients with osteoarthritis
    Isla S Mackenzie
    Medicines Monitoring Unit MEMO and Hypertension Research Centre HRC, Division of Medical Sciences, University of Dundee, Ninewells Hospital and Medical School, Dundee DD1 9SY, UK
    Eur J Clin Pharmacol 69:133-41. 2013
  3. pmc Spironolactone and risk of incident breast cancer in women older than 55 years: retrospective, matched cohort study
    Isla S Mackenzie
    Medicines Monitoring Unit, University of Dundee, Dundee DD1 9SY, UK
    BMJ 345:e4447. 2012
  4. pmc Cluster randomized trials of prescription medicines or prescribing policy: public and general practitioner opinions in Scotland
    Isla S Mackenzie
    Medicines Monitoring Unit MEMO, University of Dundee, Dundee, UK
    Br J Clin Pharmacol 74:354-61. 2012
  5. pmc Influenza H1N1 (swine flu) vaccination: a safety surveillance feasibility study using self-reporting of serious adverse events and pregnancy outcomes
    Isla S Mackenzie
    Medicines Monitoring Unit, Division of Medical Sciences, University of Dundee, Ninewells Hospital and Medical School, Dundee, UK
    Br J Clin Pharmacol 73:801-11. 2012
  6. doi request reprint Managing security and privacy concerns over data storage in healthcare research
    Isla S Mackenzie
    Medicines Monitoring Unit MEMO, University of Dundee, Dundee, UK
    Pharmacoepidemiol Drug Saf 20:885-93. 2011
  7. pmc Promoting public awareness of randomised clinical trials using the media: the 'Get Randomised' campaign
    Isla S Mackenzie
    Medicines Monitoring Unit MEMO, University of Dundee, Dundee and Health Services Research Unit, University of Aberdeen, Aberdeen, UK
    Br J Clin Pharmacol 69:128-35. 2010
  8. doi request reprint Treatment of osteoarthritis in hypertensive patients
    Isla S Mackenzie
    University of Dundee, Ninewells Hospital, Hypertension Research Centre and Medicines Monitoring Unit, Level 7, Dundee DD1 9SY, UK
    Expert Opin Pharmacother 11:393-403. 2010
  9. pmc Nitric oxide and cardiovascular effects: new insights in the role of nitric oxide for the management of osteoarthritis
    Isla S Mackenzie
    Hypertension Research Centre, Division of Medicine and Therapeutics, University of Dundee, Dundee DD1 9SY, UK
    Arthritis Res Ther 10:S3. 2008
  10. doi request reprint Molecular and clinical investigations in patients with low-renin hypertension
    Isla S Mackenzie
    Hypertension Research Centre, Ninewells Hospital, University of Dundee, Level 7, Dundee, DD1 9SY, UK
    Clin Exp Nephrol 13:1-8. 2009

Collaborators

Detail Information

Publications27

  1. pmc Incidence and prevalence of multiple sclerosis in the UK 1990-2010: a descriptive study in the General Practice Research Database
    I S Mackenzie
    Medicines Monitoring Unit MEMO, University of Dundee, Dundee, UK
    J Neurol Neurosurg Psychiatry 85:76-84. 2014
    ....
  2. pmc Cardiovascular safety of lumiracoxib: a meta-analysis of randomised controlled trials in patients with osteoarthritis
    Isla S Mackenzie
    Medicines Monitoring Unit MEMO and Hypertension Research Centre HRC, Division of Medical Sciences, University of Dundee, Ninewells Hospital and Medical School, Dundee DD1 9SY, UK
    Eur J Clin Pharmacol 69:133-41. 2013
    ..To re-evaluate the cardiovascular risk of lumiracoxib compared with other non-steroidal anti-inflammatory drugs (NSAIDs) or placebo in patients with osteoarthritis...
  3. pmc Spironolactone and risk of incident breast cancer in women older than 55 years: retrospective, matched cohort study
    Isla S Mackenzie
    Medicines Monitoring Unit, University of Dundee, Dundee DD1 9SY, UK
    BMJ 345:e4447. 2012
    ..To investigate whether exposure to spironolactone treatment affects the risk of incident breast cancer in women over 55 years of age...
  4. pmc Cluster randomized trials of prescription medicines or prescribing policy: public and general practitioner opinions in Scotland
    Isla S Mackenzie
    Medicines Monitoring Unit MEMO, University of Dundee, Dundee, UK
    Br J Clin Pharmacol 74:354-61. 2012
    ..To understand public and general practitioner (GP) opinion on the acceptability of randomized policy design (RPD) studies (cluster randomized trials) of prescription medicines in Scotland...
  5. pmc Influenza H1N1 (swine flu) vaccination: a safety surveillance feasibility study using self-reporting of serious adverse events and pregnancy outcomes
    Isla S Mackenzie
    Medicines Monitoring Unit, Division of Medical Sciences, University of Dundee, Ninewells Hospital and Medical School, Dundee, UK
    Br J Clin Pharmacol 73:801-11. 2012
    ....
  6. doi request reprint Managing security and privacy concerns over data storage in healthcare research
    Isla S Mackenzie
    Medicines Monitoring Unit MEMO, University of Dundee, Dundee, UK
    Pharmacoepidemiol Drug Saf 20:885-93. 2011
    ..We discuss holistic measures, involving both information technology and people, taken to improve the security and privacy of data storage...
  7. pmc Promoting public awareness of randomised clinical trials using the media: the 'Get Randomised' campaign
    Isla S Mackenzie
    Medicines Monitoring Unit MEMO, University of Dundee, Dundee and Health Services Research Unit, University of Aberdeen, Aberdeen, UK
    Br J Clin Pharmacol 69:128-35. 2010
    ..8, 3.1%; P= 0.92]. CONCLUSIONS It is possible to raise public awareness of clinical research using the media, but further efforts may be required to influence individuals' decisions to take part in clinical research...
  8. doi request reprint Treatment of osteoarthritis in hypertensive patients
    Isla S Mackenzie
    University of Dundee, Ninewells Hospital, Hypertension Research Centre and Medicines Monitoring Unit, Level 7, Dundee DD1 9SY, UK
    Expert Opin Pharmacother 11:393-403. 2010
    ..NSAIDs may also increase cardiovascular risk due to mechanisms other than by raising blood pressure...
  9. pmc Nitric oxide and cardiovascular effects: new insights in the role of nitric oxide for the management of osteoarthritis
    Isla S Mackenzie
    Hypertension Research Centre, Division of Medicine and Therapeutics, University of Dundee, Dundee DD1 9SY, UK
    Arthritis Res Ther 10:S3. 2008
    ..Further studies of the effects of CINODs in humans are required, but these agents represent a potential exciting advance in the management of osteoarthritis...
  10. doi request reprint Molecular and clinical investigations in patients with low-renin hypertension
    Isla S Mackenzie
    Hypertension Research Centre, Ninewells Hospital, University of Dundee, Level 7, Dundee, DD1 9SY, UK
    Clin Exp Nephrol 13:1-8. 2009
    ..The importance of investigation, factors determining renin and aldosterone levels, and drug therapies in low-renin hypertension are reviewed...
  11. pmc Association between cardiovascular events and sodium-containing effervescent, dispersible, and soluble drugs: nested case-control study
    Jacob George
    Division of Medical Science, Ninewells Hospital and Medical School, Dundee DD1 9SY, UK
    BMJ 347:f6954. 2013
    ..To determine whether patients taking formulations of drugs that contain sodium have a higher incidence of cardiovascular events compared with patients on non-sodium formulations of the same drugs...
  12. pmc Does offering an incentive payment improve recruitment to clinical trials and increase the proportion of socially deprived and elderly participants?
    Claudine G Jennings
    Medicines Monitoring Unit MEMO, University of Dundee, Ninewells Hospital, Dundee, DD1 9SY, UK
    Trials 16:80. 2015
    ..The idea of paying patients an incentive to participate in research is controversial, and evidence is needed to evaluate this as a recruitment strategy...
  13. ncbi request reprint Randomized trial of switching from prescribed non-selective non-steroidal anti-inflammatory drugs to prescribed celecoxib: the Standard care vs. Celecoxib Outcome Trial (SCOT)
    Thomas M MacDonald
    Medicines Monitoring Unit MEMO, Division of Molecular and Clinical Medicine, University of Dundee, Ninewells Hospital and Medical School Dundee, Dundee DD1 9SY, UK
    Eur Heart J . 2016
    ..We compared the CV safety of switching to celecoxib vs. continuing nsNSAID therapy in a European setting...
  14. pmc Multicentre, prospective, randomised, open-label, blinded end point trial of the efficacy of allopurinol therapy in improving cardiovascular outcomes in patients with ischaemic heart disease: protocol of the ALL-HEART study
    Isla S Mackenzie
    Medicines Monitoring Unit MEMO and Hypertension Research Centre, Division of Molecular and Clinical Medicine, University of Dundee and Ninewells Hospital, Dundee, UK
    BMJ Open 6:e013774. 2016
    ..The ALL-HEART study aims to determine whether allopurinol improves cardiovascular outcomes in patients with IHD...
  15. pmc Methods of a large prospective, randomised, open-label, blinded end-point study comparing morning versus evening dosing in hypertensive patients: the Treatment In Morning versus Evening (TIME) study
    David A Rorie
    University of Dundee, Ninewells Hospital and Medical School, Dundee, UK
    BMJ Open 6:e010313. 2016
    ..The Treatment In Morning versus Evening (TIME) study aims to establish whether evening dosing is more cardioprotective than morning dosing...
  16. doi request reprint Does offering an incentive payment improve recruitment to clinical trials and increase the proportion of socially deprived and elderly participants?
    Claudine G Jennings
    Medicines Monitoring Unit MEMO, University of Dundee, Ninewells Hospital, Dundee, DD1 9SY, UK
    Trials 16:582. 2015
    ..The idea of paying patients an incentive to participate in research is controversial, and evidence is needed to evaluate this as a recruitment strategy...
  17. pmc Impact of allopurinol use on urate concentration and cardiovascular outcome
    Li Wei
    Medicines Monitoring Unit MEMO, Division of Medical Sciences, Ninewells Hospital and Medical School, Dundee DD1 9SY, UK
    Br J Clin Pharmacol 71:600-7. 2011
    ..To characterize patients with urate measurements by urate-lowering therapy (ULT) use and to study the impact of allopurinol treatment on cardiovascular and mortality outcomes...
  18. pmc Protocol of the Febuxostat versus Allopurinol Streamlined Trial (FAST): a large prospective, randomised, open, blinded endpoint study comparing the cardiovascular safety of allopurinol and febuxostat in the management of symptomatic hyperuricaemia
    Thomas M MacDonald
    Medicines Monitoring Unit MEMO, Ninewells Hospital, University of Dundee, Dundee, UK
    BMJ Open 4:e005354. 2014
    ..The European Medicines Agency requested a postlicensing cardiovascular safety study of febuxostat versus allopurinol, which has been named the Febuxostat versus Allopurinol Streamlined trial (FAST)...
  19. doi request reprint Vitamin D therapy to reduce blood pressure and left ventricular hypertrophy in resistant hypertension: randomized, controlled trial
    Miles D Witham
    Ageing and Health, Ninewells Hospital, University of Dundee, Dundee DD1 9SY, United Kingdom
    Hypertension 63:706-12. 2014
    ..04). There was no significant change in cholesterol or glucose levels. Thus, 6 months of intermittent, high-dose oral vitamin D3 did not reduce blood pressure or left ventricular mass in patients with resistant hypertension. ..
  20. pmc Pioglitazone and bladder cancer: a propensity score matched cohort study
    Li Wei
    Medicines Monitoring Unit, Division of Medicine and Therapeutics, Ninewells Hospital and Medical School, Dundee, Scotland, UK
    Br J Clin Pharmacol 75:254-9. 2013
    ..To examine whether exposure to pioglitazone use is associated with increased incidence of bladder cancer in patients with type 2 diabetes mellitus...
  21. ncbi request reprint A novel drug management system in the Febuxostat versus Allopurinol Streamlined Trial: A description of a pharmacy system designed to supply medications directly to patients within a prospective multicenter randomised clinical trial
    Amy Rogers
    Medicines Monitoring Unit MEMO and Hypertension Research Centre, Division of Cardiovascular and Diabetes Medicine, University of Dundee, Ninewells Hospital and Medical School, Dundee, UK
    Clin Trials 13:665-670. 2016
    ..This report summarises a novel pharmacy system designed to supply trial medications directly to patients by post in the Febuxostat versus Allopurinol Streamlined Trial...
  22. pmc Effectiveness of newspaper advertising for patient recruitment into a clinical trial
    Adrian Hapca
    Medicines Monitoring Unit, University of Dundee, Ninewells Hospital, Dundee, DD1 9SY, UK
    Br J Clin Pharmacol 77:1064-72. 2014
    ..Celecoxib Outcome Trial (SCOT), a clinical trial investigating the cardiovascular safety of non-steroidal anti-inflammatory drugs in patients with osteoarthritis or rheumatoid arthritis...
  23. doi request reprint Spironolactone use and risk of incident cancers: a retrospective, matched cohort study
    Isla S Mackenzie
    Medicines Monitoring Unit MEMO, Division of Molecular and Clinical Medicine, University of Dundee, Dundee, DD1 9SY, UK
    Br J Clin Pharmacol . 2016
    ..The aim of this study was to assess the effect of spironolactone exposure on cancer incidence...
  24. pmc Monotherapy versus dual therapy for the initial treatment of hypertension (PATHWAY-1): a randomised double-blind controlled trial
    Thomas M MacDonald
    Medicines Monitoring Unit, Medical Research Institute, University of Dundee, Ninewells Hospital and Medical School, Dundee, UK
    BMJ Open 5:e007645. 2015
    ..We test this hypothesis comparing initial monotherapy with dual therapy in the management of essential hypertension...
  25. pmc Quantifying the real life risk profile of inhaled corticosteroids in COPD by record linkage analysis
    Rob W Flynn
    Tayside Respiratory Research Group, East Block, Ninewells Hospital, Dundee DD1 9SY, UK
    Respir Res 15:141. 2014
    ..We investigated this using record linkage in a Dundee COPD population...
  26. doi request reprint Up-titration of allopurinol in patients with gout
    Claudine G Jennings
    Medicines Monitoring Unit MEMO, University of Dundee, Ninewells Hospital, Dundee DD1 9SY, UK Electronic address
    Semin Arthritis Rheum 44:25-30. 2014
    ..The objective of this analysis was to review the efficacy and tolerability of allopurinol up-titration in achieving the EULAR target levels...
  27. pmc Renal artery stenosis-when to screen, what to stent?
    Claudine G Jennings
    Medicines Monitoring Unit and Hypertension Research Centre, Ninewells Hospital and University of Dundee, Dundee, DD1 9SY, UK
    Curr Atheroscler Rep 16:416. 2014
    ..The potential benefits in terms of improving hard cardiovascular outcomes may outweigh the risks of intervention in this group, and further research is needed. ..