Ulrich F O Luhmann

Summary

Affiliation: University College London
Country: UK

Publications

  1. pmc The severity of retinal pathology in homozygous Crb1rd8/rd8 mice is dependent on additional genetic factors
    Ulrich F O Luhmann
    Department of Genetics and
    Hum Mol Genet 24:128-41. 2015
  2. doi request reprint The relevance of chemokine signalling in modulating inherited and age-related retinal degenerations
    Ulrich Fo Luhmann
    Department of Genetics, UCL Institute of Ophthalmology, 11 43 Bath Street, EC1V 9EL, London, UK
    Adv Exp Med Biol 801:427-33. 2014
  3. pmc Ccl2, Cx3cr1 and Ccl2/Cx3cr1 chemokine deficiencies are not sufficient to cause age-related retinal degeneration
    Ulrich F O Luhmann
    Department of Genetics, UCL Institute of Ophthalmology, 11 43 Bath Street, EC1V9EL London, United Kingdom
    Exp Eye Res 107:80-7. 2013
  4. pmc Differential modulation of retinal degeneration by Ccl2 and Cx3cr1 chemokine signalling
    Ulrich F O Luhmann
    Department of Genetics, UCL Institute of Ophthalmology, London, United Kingdom
    PLoS ONE 7:e35551. 2012
  5. pmc The drusenlike phenotype in aging Ccl2-knockout mice is caused by an accelerated accumulation of swollen autofluorescent subretinal macrophages
    Ulrich F O Luhmann
    Department of Genetics, UCL Institute of Ophthalmology, London, United Kingdom
    Invest Ophthalmol Vis Sci 50:5934-43. 2009
  6. pmc Endogenous erythropoietin protects neuroretinal function in ischemic retinopathy
    Freya M Mowat
    Department of Genetics, University College London Institute of Ophthalmology, London, United Kingdom
    Am J Pathol 180:1726-39. 2012
  7. pmc Repair of the degenerate retina by photoreceptor transplantation
    Amanda C Barber
    Department of Genetics, University College London Institute of Ophthalmology, London EC1V 9EL, United Kingdom
    Proc Natl Acad Sci U S A 110:354-9. 2013
  8. doi request reprint Cd59a deficiency in mice leads to preferential innate immune activation in the retinal pigment epithelium-choroid with age
    Philipp Herrmann
    Department of Genetics, UCL Institute of Ophthalmology, London, UK
    Neurobiol Aging 36:2637-48. 2015
  9. pmc Von Hippel-Lindau protein in the RPE is essential for normal ocular growth and vascular development
    Clemens A K Lange
    Department of Genetics, Institute of Ophthalmology, NIHR Biomedical Research Centre for Ophthalmology, University College London, London EC1V 9EL, UK
    Development 139:2340-50. 2012
  10. doi request reprint Enhanced Ccl2-Ccr2 signaling drives more severe choroidal neovascularization with aging
    Scott J Robbie
    Department of Genetics, UCL Institute of Ophthalmology, London, UK NIHR Biomedical Research Centre at Moorfields Eye Hospital NHS Foundation Trust and UCL Institute of Ophthalmology, London, UK
    Neurobiol Aging 40:110-9. 2016

Collaborators

  • Alexander J Smith
  • Susie E Barker
  • Patrick H Maxwell
  • Robert E MacLaren
  • Rachael A Pearson
  • Stephen E Moss
  • John Greenwood
  • J Bainbridge
  • Robin R Ali
  • Yanai Duran
  • Clemens A K Lange
  • Freya M Mowat
  • Emma L West
  • Livia S Carvalho
  • Philipp Herrmann
  • Amanda C Barber
  • Jane C Sowden
  • Scott J Robbie
  • Koji M Nishiguchi
  • Joana Ribeiro
  • Sidath E Liyanage
  • Anastasios Georgiadis
  • Xiaomeng Wang
  • Colin J Chu
  • Laura Abelleira Hervas
  • Sophia Martha Kleine Holthaus
  • Jill A Cowing
  • Matteo Rizzi
  • Kate Powell
  • Enrico Cristante
  • Selina A Azam
  • Claire Hippert
  • Natasha Jeffs
  • Helen M Arthur
  • Vineeta B Tripathi
  • Zhenhua Zhai
  • Andrew D Dick
  • Katherine Warre-Cornish
  • Matthew Swire
  • Jorn Lakowski
  • Sabu Abraham
  • Jenny A G McKenzie
  • Marcus Fruttiger
  • Sabu Abrahams
  • Francisco Gonzalez
  • Michael B Powner
  • Clemens A Lange
  • Haroon Sayed
  • Zdenek J Gregor
  • Panagiotis Stavrakas
  • Don Julian De Silva
  • Sarah Harten
  • Deepa Shukla
  • Clemens Lange

Detail Information

Publications16

  1. pmc The severity of retinal pathology in homozygous Crb1rd8/rd8 mice is dependent on additional genetic factors
    Ulrich F O Luhmann
    Department of Genetics and
    Hum Mol Genet 24:128-41. 2015
    ....
  2. doi request reprint The relevance of chemokine signalling in modulating inherited and age-related retinal degenerations
    Ulrich Fo Luhmann
    Department of Genetics, UCL Institute of Ophthalmology, 11 43 Bath Street, EC1V 9EL, London, UK
    Adv Exp Med Biol 801:427-33. 2014
    ....
  3. pmc Ccl2, Cx3cr1 and Ccl2/Cx3cr1 chemokine deficiencies are not sufficient to cause age-related retinal degeneration
    Ulrich F O Luhmann
    Department of Genetics, UCL Institute of Ophthalmology, 11 43 Bath Street, EC1V9EL London, United Kingdom
    Exp Eye Res 107:80-7. 2013
    ..In conclusion, CCL2-CCR2 and/or CX3CL1-CX3CR1 signalling defects may differentially affect the trafficking of microglia and macrophages in the retina during ageing, but do not appear to cause age-related retinal degeneration in mice...
  4. pmc Differential modulation of retinal degeneration by Ccl2 and Cx3cr1 chemokine signalling
    Ulrich F O Luhmann
    Department of Genetics, UCL Institute of Ophthalmology, London, United Kingdom
    PLoS ONE 7:e35551. 2012
    ..These findings indicate that CCDKO mice are not a model of AMD, but a model for an inherited retinal degeneration that is differentially modulated by Ccl2-Ccr2 and Cx3cl1-Cx3cr1 chemokine signalling...
  5. pmc The drusenlike phenotype in aging Ccl2-knockout mice is caused by an accelerated accumulation of swollen autofluorescent subretinal macrophages
    Ulrich F O Luhmann
    Department of Genetics, UCL Institute of Ophthalmology, London, United Kingdom
    Invest Ophthalmol Vis Sci 50:5934-43. 2009
    ..This study was conducted to investigate the nature of the drusenlike lesions in vivo and further evaluate the Ccl2(-/-) mouse as a model of AMD...
  6. pmc Endogenous erythropoietin protects neuroretinal function in ischemic retinopathy
    Freya M Mowat
    Department of Genetics, University College London Institute of Ophthalmology, London, United Kingdom
    Am J Pathol 180:1726-39. 2012
    ..Endogenous EPO can protect neuroretinal function in ischemic retinopathy...
  7. pmc Repair of the degenerate retina by photoreceptor transplantation
    Amanda C Barber
    Department of Genetics, University College London Institute of Ophthalmology, London EC1V 9EL, United Kingdom
    Proc Natl Acad Sci U S A 110:354-9. 2013
    ..Thus, it is possible to achieve robust integration across a broad range of inherited retinopathies. Moreover, transplantation outcome can be improved by administering appropriate, tailored manipulations of the recipient environment...
  8. doi request reprint Cd59a deficiency in mice leads to preferential innate immune activation in the retinal pigment epithelium-choroid with age
    Philipp Herrmann
    Department of Genetics, UCL Institute of Ophthalmology, London, UK
    Neurobiol Aging 36:2637-48. 2015
    ..This data emphasizes the particular vulnerability of the RPE-choroidal complex to dysregulation of the alternative complement pathway during aging...
  9. pmc Von Hippel-Lindau protein in the RPE is essential for normal ocular growth and vascular development
    Clemens A K Lange
    Department of Genetics, Institute of Ophthalmology, NIHR Biomedical Research Centre for Ophthalmology, University College London, London EC1V 9EL, UK
    Development 139:2340-50. 2012
    ....
  10. doi request reprint Enhanced Ccl2-Ccr2 signaling drives more severe choroidal neovascularization with aging
    Scott J Robbie
    Department of Genetics, UCL Institute of Ophthalmology, London, UK NIHR Biomedical Research Centre at Moorfields Eye Hospital NHS Foundation Trust and UCL Institute of Ophthalmology, London, UK
    Neurobiol Aging 40:110-9. 2016
    ..These findings indicate that CCL2-driven recruitment of myeloid cells contributes to increased severity of CNV with age. Similar mechanisms may be involved in other age-related inflammatory diseases. ..
  11. pmc Assessment and in vivo scoring of murine experimental autoimmune uveoretinitis using optical coherence tomography
    Colin J Chu
    Department of Genetics, UCL Institute of Ophthalmology, London, United Kingdom
    PLoS ONE 8:e63002. 2013
    ..By relating OCT signals with immunohistochemistry in EAU, our findings offer the opportunity to inform the interpretation of OCT changes in human uveitis...
  12. pmc Long-term survival of photoreceptors transplanted into the adult murine neural retina requires immune modulation
    Emma L West
    Department of Genetics, University College London Institute of Ophthalmology, London, United Kingdom
    Stem Cells 28:1997-2007. 2010
    ..These findings suggest that autologous donor cells are optimal for therapeutic approaches to repair the neural retina, though with immune suppression nonautologous donors may be effective...
  13. doi request reprint Intraocular oxygen distribution in advanced proliferative diabetic retinopathy
    Clemens A K Lange
    University College London, Institute of Ophthalmology and Moorfields Eye Hospital, National Institute for Health Research and Biomedical Research Centre, London, United Kingdom
    Am J Ophthalmol 152:406-412.e3. 2011
    ..To determine the preretinal distribution of oxygen in advanced proliferative diabetic retinopathy, and to investigate the relationship between intraocular oxygen tensions and vitreous cytokine concentrations...
  14. pmc Gene therapy restores vision in rd1 mice after removal of a confounding mutation in Gpr179
    Koji M Nishiguchi
    Department of Genetics, UCL Institute of Ophthalmology, 11 43 Bath Street, London, EC1V 9EL, UK
    Nat Commun 6:6006. 2015
    ..Our discovery may explain the failure of previous gene therapy attempts in rd1 mice, and we propose that Grp179 mutation status should be taken into account in future studies involving rd1 mice. ..
  15. pmc HIF-1alpha and HIF-2alpha are differentially activated in distinct cell populations in retinal ischaemia
    Freya M Mowat
    Department of Genetics, University College London Institute of Ophthalmology, London, United Kingdom
    PLoS ONE 5:e11103. 2010
    ....
  16. pmc LRG1 promotes angiogenesis by modulating endothelial TGF-β signalling
    Xiaomeng Wang
    Department of Cell Biology, UCL Institute of Ophthalmology, London EC1V 9EL, UK
    Nature 499:306-11. 2013
    ..LRG1 antibody blockade inhibits this switch and attenuates angiogenesis. These studies reveal a new regulator of angiogenesis that mediates its effect by modulating TGF-β signalling. ..