Genomes and Genes
R M Lewis
Affiliation: University of Southampton
- Effects of maternal iron restriction in the rat on hypoxia-induced gene expression and fetal metabolite levelsR M Lewis
Department of Clinical Biochemistry, Addenbrooke s Hospital, University of Cambridge, UK
Br J Nutr 85:193-201. 2001..These changes in fetal metabolism may contribute to fetal growth retardation in this model. This study does not support the hypothesis that the Fe-restricted fetus is hypoxic...
- Umbilical venous-arterial plasma composition differences suggest differential incorporation of fatty acids in NEFA and cholesteryl ester poolsRohan M Lewis
Institute of Developmental Sciences, Faculty of Medicine, University of Southampton, UK
Br J Nutr 106:463-7. 2011..The present study demonstrates differential enrichment across the placenta of fatty acids into specific lipid pools in the fetal circulation. Such partitioning may facilitate supply of individual fatty acids to specific fetal tissues...
- L-serine uptake by human placental microvillous membrane vesiclesR M Lewis
Centre for Developmental Origins of Health and Disease, University of Southampton, Level F MP887, Princess Anne Hospital, Coxford Road, Southampton SO16 5YA, UK
Placenta 28:445-52. 2007..Further studies are now required to define the fate of L-serine taken up by the placenta and its importance for the fetus...
- Low serine hydroxymethyltransferase activity in the human placenta has important implications for fetal glycine supplyRohan M Lewis
Centre for the Developmental Origins of Health and Disease, University of Southampton, Princess Anne Hospital, SO16 5YA Southampton, United Kingdom
J Clin Endocrinol Metab 90:1594-8. 2005..The low activity of SHMT in the human and rat placenta suggests that, unlike in the sheep, placental conversion of serine to glycine is not a major source of fetal glycine in these species...
- Long-term programming of blood pressure by maternal dietary iron restriction in the ratRohan M Lewis
Department of Clinical Biochemistry, University of Cambridge, Addenbrooke s Hospital, CB2 2QR, UK
Br J Nutr 88:283-90. 2002..Both cardiac hypertrophy and decreased serum triacylglycerol have also been observed in Fe-restricted fetuses, suggesting that these changes may be initiated in utero...
- Effects of maternal iron restriction on placental vascularization in the ratR M Lewis
Department of Clinical Biochemistry, University of Cambridge, Box 232 Addenbrooke s Hospital, Hills Road, Cambridge, UK
Placenta 22:534-9. 2001..These changes in placental vascularization may contribute to the fetal growth retardation observed in iron-restricted litters...
- Effects of maternal iron restriction in the rat on blood pressure, glucose tolerance, and serum lipids in the 3-month-old offspringR M Lewis
Department of Clinical Biochemistry, Addenbrooke's Hospital, University of Cambridge, Cambridge, UK
Metabolism 50:562-7. 2001..It is thus speculated that the long-term effects of maternal dietary restriction may result from common fetal metabolic responses to this restriction...
- Relationship between placental expression of the imprinted PHLDA2 gene, intrauterine skeletal growth and childhood bone massR M Lewis
Institute of Developmental Sciences, University of Southampton and Southampton University Hospitals NHS Trust, UK
Bone 50:337-42. 2012..The results suggest that placental PHLDA2 may provide a biomarker for suboptimal skeletal growth in pregnancies uncomplicated by overt fetal growth restriction...
- Partitioning of glutamine synthesised by the isolated perfused human placenta between the maternal and fetal circulationsP E L Day
University of Southampton, Faculty of Medicine, Human Development and Health, United Kingdom
Placenta 34:1223-31. 2013..The objective of this study was to investigate the role of glutamate/glutamine metabolism by the isolated perfused human placenta in the provision of glutamine to the fetus...
- Facilitated transporters mediate net efflux of amino acids to the fetus across the basal membrane of the placental syncytiotrophoblastJ K Cleal
Institute of Developmental Sciences, University of Southampton, Mail point 887, Southampton General Hospital, Tremona Road, Southampton SO16 6YD, UK
J Physiol 589:987-97. 2011..Consistent with a role in placental amino acid transfer capacity and fetal growth TAT1 and LAT3 mRNA expression showed positive associations with infant size at birth...
- Computational modelling of amino acid exchange and facilitated transport in placental membrane vesiclesN Panitchob
Bioengineering Science Research Group, Faculty of Engineering and the Environment, University of Southampton, Southampton, UK
J Theor Biol 365:352-64. 2015..Analysis of the results indicated the presence of a facilitated transport component, while based on the model no evidence for substantial levels of endogenous amino acids within the vesicle was found. ..
- Comparison of L-serine uptake by human placental microvillous membrane vesicles and placental villous fragmentsA P Brand
Institute of Developmental Sciences, University of Southampton, School of Medicine, UK
Placenta 31:456-9. 2010..This study suggests that uptake of L-serine into MVM vesicles and villous fragments via Systems A and L is comparable, but that this is not true for all components of L-serine uptake...
- Phenylalanine transfer across the isolated perfused human placenta: an experimental and modeling investigationE M Lofthouse
Faculty of Medicine, University of Southampton, Southampton, United Kingdom Institute for Life Sciences, University of Southampton, Southampton, United Kingdom
Am J Physiol Regul Integr Comp Physiol 310:R828-36. 2016..We suggest that amino acid metabolism, primarily incorporation into protein, is controlling free amino acid levels and, thus, placental transfer. ..
- Computational modelling of placental amino acid transfer as an integrated systemN Panitchob
Bioengineering Science Research Group, Faculty of Engineering and the Environment, University of Southampton, UK
Biochim Biophys Acta 1858:1451-61. 2016....
- Placental amino acid transport may be regulated by maternal vitamin D and vitamin D-binding protein: results from the Southampton Women's SurveyJ K Cleal
Faculty of Medicine, Institute of Developmental Sciences, University of Southampton, Tremona Road, SouthamptonSO16 6YD, UK
Br J Nutr 113:1903-10. 2015..This exploratory study identifies placental amino acid transporters which may be altered in response to modifiable maternal factors and provides a basis for further studies. ..
- What factors determine placental glucose transfer kinetics?P E Day
Institute of Developmental Sciences, University of Southampton, Faculty of Medicine, Southampton SO16 6YD, United Kingdom
Placenta 34:953-8. 2013..This study investigates the relationship between maternal and fetal glucose concentrations and transfer across the placenta...
- Review: Modelling placental amino acid transfer--from transporters to placental functionR M Lewis
University of Southampton, Southampton General Hospital, Faculty of Medicine, MP 887, Tremona Road, Southampton SO14 6BD, UK
Placenta 34:S46-51. 2013..This model may also allow the development of strategies to optimise placental transfer in pathologies associated with impaired amino acid transfer such as fetal growth restriction...
- Maternal muscle mass may influence system A activity in human placentaR M Lewis
Institute of Developmental Sciences, School of Medicine, University of Southampton, UK
Placenta 31:418-22. 2010..This alteration may affect fetal development, altering fetal body composition, with long-term consequences...
- Placental composition and surface area but not vascularization are altered by maternal protein restriction in the ratC B Doherty
Department of Clinical Biochemistry, University of Cambridge, Box 232 Addenbrooke s Hospital, Hills Rd, UK
Placenta 24:34-8. 2003..This study found that maternal protein restriction is associated with an increase in placental size, and that this enlargement is accompanied by increases in some, but not all, structural correlates of function...
- Computational modelling of amino acid transfer interactions in the placentaB G Sengers
University of Southampton, UK
Exp Physiol 95:829-40. 2010..Ultimately, this approach will allow physiological simulations of amino acid transfer. This will enhance our understanding of these complex systems and placental function in health and disease...
- Relation of FTO gene variants to fetal growth trajectories: Findings from the Southampton Women's surveyS J Barton
MRC Lifecourse Epidemiology Unit, Faculty of Medicine, University of Southampton, Southampton SO16 6YD, UK Electronic address
Placenta 38:100-6. 2016..Here we investigated how FTO and MC4R gene variants linked with obesity relate to patterns of fetal growth and to placental FTO expression...
- The placental exposome: placental determinants of fetal adiposity and postnatal body compositionR M Lewis
University of Southampton, Southampton, UK
Ann Nutr Metab 63:208-15. 2013....
- Effect of maternal iron restriction during pregnancy on renal morphology in the adult rat offspringS J M Lisle
Department of Physiology, University of Cambridge, Downing Street, Cambridge CB2 3EG, UK
Br J Nutr 90:33-9. 2003..42, n 28, P<0.05) and 16 months of age (r-0.64, n 28, P<0.05). Therefore, in rats, maternal Fe restriction causes hypertension in the adult offspring that may be due, in part, to a deficit in nephron number...
- The mechanisms and regulation of placental amino acid transport to the human foetusJ K Cleal
The Institute of Developmental Sciences, University of Southampton, Southampton, UK
J Neuroendocrinol 20:419-26. 2008..Understanding the mechanisms and regulation of amino acid transport is necessary to understand the causes of intrauterine growth restriction in human pregnancy...
- Review: Placenta, evolution and lifelong healthR M Lewis
University of Southampton, Faculty of Medicine, Southampton, UK
Placenta 33:S28-32. 2012....
- Maternal dietary iron restriction modulates hepatic lipid metabolism in the fetusesJunlong Zhang
Endocrinology and Metabolism Unit, Developmental Origins of Health and Disease Division, School of Medicine, University of Southampton, Southampton General Hospital, Southampton SO16 6YD, UK
Am J Physiol Regul Integr Comp Physiol 288:R104-11. 2005....
- Modification of fetal plasma amino acid composition by placental amino acid exchangers in vitroJane K Cleal
DOHaD Division, University of Southampton, Southampton, UK
J Physiol 582:871-82. 2007..This study demonstrates that these transporters have the capacity to exchange micromolar amounts of specific amino acids, and suggests that they play an important role in regulating fetal plasma amino acid composition...
- Quantitated transcript haplotypes (QTH) of AGTR1, reduced abundance of mRNA haplotypes containing 1166C (rs5186:A>C), and relevance to metabolic syndrome traitsMohammad R Abdollahi
Human Genetics Division, Southampton General Hospital, University of Southampton, Southampton, United Kingdom
Hum Mutat 28:365-73. 2007..Differential abundance of AGTR1 mRNA haplotypes may mediate clinical phenotypic observations of the AGTR1 genotype...