R M Lewis
Affiliation: University of Southampton
- Relationship between placental expression of the imprinted PHLDA2 gene, intrauterine skeletal growth and childhood bone massR M Lewis
Institute of Developmental Sciences, University of Southampton and Southampton University Hospitals NHS Trust, UK
Bone 50:337-42. 2012..The results suggest that placental PHLDA2 may provide a biomarker for suboptimal skeletal growth in pregnancies uncomplicated by overt fetal growth restriction...
- Maternal muscle mass may influence system A activity in human placentaR M Lewis
Institute of Developmental Sciences, School of Medicine, University of Southampton, UK
Placenta 31:418-22. 2010..This alteration may affect fetal development, altering fetal body composition, with long-term consequences...
- Facilitated transporters mediate net efflux of amino acids to the fetus across the basal membrane of the placental syncytiotrophoblastJ K Cleal
Institute of Developmental Sciences, University of Southampton, Mail point 887, Southampton General Hospital, Tremona Road, Southampton SO16 6YD, UK
J Physiol 589:987-97. 2011..Consistent with a role in placental amino acid transfer capacity and fetal growth TAT1 and LAT3 mRNA expression showed positive associations with infant size at birth...
- Computational modelling of amino acid exchange and facilitated transport in placental membrane vesiclesN Panitchob
Bioengineering Science Research Group, Faculty of Engineering and the Environment, University of Southampton, Southampton, UK
J Theor Biol 365:352-64. 2015..Analysis of the results indicated the presence of a facilitated transport component, while based on the model no evidence for substantial levels of endogenous amino acids within the vesicle was found. ..
- Comparison of L-serine uptake by human placental microvillous membrane vesicles and placental villous fragmentsA P Brand
Institute of Developmental Sciences, University of Southampton, School of Medicine, UK
Placenta 31:456-9. 2010..This study suggests that uptake of L-serine into MVM vesicles and villous fragments via Systems A and L is comparable, but that this is not true for all components of L-serine uptake...
- Placental amino acid transport may be regulated by maternal vitamin D and vitamin D-binding protein: results from the Southampton Women's SurveyJ K Cleal
Faculty of Medicine, Institute of Developmental Sciences, University of Southampton, Tremona Road, SouthamptonSO16 6YD, UK
Br J Nutr 113:1903-10. 2015..This exploratory study identifies placental amino acid transporters which may be altered in response to modifiable maternal factors and provides a basis for further studies. ..
- Review: Modelling placental amino acid transfer--from transporters to placental functionR M Lewis
University of Southampton, Southampton General Hospital, Faculty of Medicine, MP 887, Tremona Road, Southampton SO14 6BD, UK
Placenta 34:S46-51. 2013..This model may also allow the development of strategies to optimise placental transfer in pathologies associated with impaired amino acid transfer such as fetal growth restriction...
- The placental exposome: placental determinants of fetal adiposity and postnatal body compositionR M Lewis
University of Southampton, Southampton, UK
Ann Nutr Metab 63:208-15. 2013....
- What factors determine placental glucose transfer kinetics?P E Day
Institute of Developmental Sciences, University of Southampton, Faculty of Medicine, Southampton SO16 6YD, United Kingdom
Placenta 34:953-8. 2013..This study investigates the relationship between maternal and fetal glucose concentrations and transfer across the placenta...
- L-serine uptake by human placental microvillous membrane vesiclesR M Lewis
Centre for Developmental Origins of Health and Disease, University of Southampton, Level F MP887, Princess Anne Hospital, Coxford Road, Southampton SO16 5YA, UK
Placenta 28:445-52. 2007..Further studies are now required to define the fate of L-serine taken up by the placenta and its importance for the fetus...
- Computational modelling of amino acid transfer interactions in the placentaB G Sengers
University of Southampton, UK
Exp Physiol 95:829-40. 2010..Ultimately, this approach will allow physiological simulations of amino acid transfer. This will enhance our understanding of these complex systems and placental function in health and disease...
- Review: Placenta, evolution and lifelong healthR M Lewis
University of Southampton, Faculty of Medicine, Southampton, UK
Placenta 33:S28-32. 2012....
- The mechanisms and regulation of placental amino acid transport to the human foetusJ K Cleal
The Institute of Developmental Sciences, University of Southampton, Southampton, UK
J Neuroendocrinol 20:419-26. 2008..Understanding the mechanisms and regulation of amino acid transport is necessary to understand the causes of intrauterine growth restriction in human pregnancy...
- Effects of maternal iron restriction on placental vascularization in the ratR M Lewis
Department of Clinical Biochemistry, University of Cambridge, Box 232 Addenbrooke s Hospital, Hills Road, Cambridge, UK
Placenta 22:534-9. 2001..These changes in placental vascularization may contribute to the fetal growth retardation observed in iron-restricted litters...
- Effects of maternal iron restriction in the rat on hypoxia-induced gene expression and fetal metabolite levelsR M Lewis
Department of Clinical Biochemistry, Addenbrooke s Hospital, University of Cambridge, UK
Br J Nutr 85:193-201. 2001..These changes in fetal metabolism may contribute to fetal growth retardation in this model. This study does not support the hypothesis that the Fe-restricted fetus is hypoxic...