P D Lewis
Affiliation: University of Wales
- Evaluation of FTIR spectroscopy as a diagnostic tool for lung cancer using sputumPaul D Lewis
Swansea University, UK
BMC Cancer 10:640. 2010..The main objective of this study was to evaluate Fourier transform infrared spectroscopy (FTIR) as a high throughput and cost effective method for identifying biochemical changes in sputum as biomarkers for detection of lung cancer...
- Comparison of induced and cancer-associated mutational spectra using multivariate data analysisP D Lewis
Cancer Informatics Group, Institute of Life Science, Swansea Medical School, Swansea University, Singleton Park, Swansea SA2 8PP, UK
Carcinogenesis 29:772-8. 2008..Specifically, the analysis reveals key differences between smoking- and non-smoking-related lung cancer for TP53 mutations and the mutability of CpG sites between exons in skin cancer...
- A study of mitochondrial DNA D-loop mutations and p53 status in nonmelanoma skin cancerS L Prior
School of Medicine, Institute of Life Science, Swansea University, Singleton Park, Swansea, UK
Br J Dermatol 161:1067-71. 2009..Additionally, they have been observed in SCC and basal cell carcinoma of nonmelanoma skin cancer (NMSC). However, they have not been examined in the SCC precursor lesions, Bowen disease or actinic keratosis...
- Detection of damage to the mitochondrial genome in the oncocytic cells of Warthin's tumourP D Lewis
School of Biological Sciences, University of Wales Swansea, UK
J Pathol 191:274-81. 2000..Whilst the deletion was present in all parotid tissue, its presence was significantly higher in oncocytic tumour cells. In a small number of controls, there was a trend towards higher concentrations of the deletion in smokers...
- Mitochondrial DNA mutations in the parotid gland of cigarette smokers and non-smokersP D Lewis
School of Biological Sciences, University of Wales Swansea, Swansea SA2 8PP, UK
Mutat Res 518:47-54. 2002..These results are evidence of age related increase in the 4977 bp deletion and a higher level of mutations, probably due to oxidative damage, in the parotid gland of smokers...
- Mitochondrial DNA mutations in oral squamous cell carcinomaS L Prior
School of Biological Sciences, University of Wales Swansea, Swansea, SA2 8PP, UK
Carcinogenesis 27:945-50. 2006....
- Spontaneous mutation spectra in supF: comparative analysis of mammalian cell line base substitution spectraP D Lewis
Bioniformatics Laboratory, Centre for Molecular Genetics and Toxicology, School of Biological Sciences, University of Wales Swansea, Swansea SA2 8PP, UK
Mutagenesis 16:503-15. 2001..The spectra presented here will be a useful reference for analysis and re-analysis of chemically induced spectra as well as for use in comparison with the spontaneous spectra of other gene systems...
- The mammalian gene mutation databaseP D Lewis
Centre for Molecular Genetics and Toxicology, School of Biological Sciences, University of Wales Swansea, Swansea SA2 8PP, UK
Mutagenesis 15:411-4. 2000..The structure of the database permits easy retrieval of specific mutation data for further analysis. Thus, the MGMD should become a useful and necessary reference source and provides an analysis tool for genetic toxicologists...
- An exploratory analysis of multiple mutation spectraP D Lewis
Bioinformatics Group, Centre for Molecular and Genetic Toxicology, School of Biological Sciences, University of Wales Swansea, UK
Mutat Res 518:163-80. 2002..The methods clearly demonstrate how different patterns of spontaneous and UV-induced supF mutation spectra can result from variation in plasmid, culture medium, species origin of cell line and whether mutations arose in vivo or in vitro...
- In silico p53 mutation hotspots in lung cancerP D Lewis
School of Biosciences, Cardiff University, Cardiff CF10 3US, UK
Carcinogenesis 25:1099-107. 2004..The algorithm shows how BPDE target sequence specificity and DNA curvature both shape the overall mutation distribution...