Claudia Langenberg

Summary

Affiliation: University of Cambridge
Country: UK

Publications

  1. pmc Associations of common genetic variants with age-related changes in fasting and postload glucose: evidence from 18 years of follow-up of the Whitehall II cohort
    Anders C Jensen
    Steno Diabetes Center, Gentofte, Denmark
    Diabetes 60:1617-23. 2011
  2. pmc Common genetic variation in the melatonin receptor 1B gene (MTNR1B) is associated with decreased early-phase insulin response
    C Langenberg
    MRC Epidemiology Unit, Institute of Metabolic Science, Addenbrooke s Hospital, Cambridge CB2 0QQ, UK
    Diabetologia 52:1537-42. 2009
  3. pmc Design and cohort description of the InterAct Project: an examination of the interaction of genetic and lifestyle factors on the incidence of type 2 diabetes in the EPIC Study
    C Langenberg
    Medical Research Council Epidemiology Unit, Institute of Metabolic Science, Addenbrooke s Hospital, Box 285, Cambridge CB2 0QQ, UK E mail
    Diabetologia 54:2272-82. 2011
  4. pmc Seropositivity and higher immunoglobulin g antibody levels against cytomegalovirus are associated with mortality in the population-based European prospective investigation of Cancer-Norfolk cohort
    Effrossyni Gkrania-Klotsas
    Medical Research Council Epidemiology Unit, Institute of Metabolic Science, Cambridge, United Kingdom
    Clin Infect Dis 56:1421-7. 2013
  5. pmc Dietary intakes of individual flavanols and flavonols are inversely associated with incident type 2 diabetes in European populations
    Raul Zamora-Ros
    MRC Epidemiology Unit, University of Cambridge, Institute of Metabolic Science, Cambridge, UK
    J Nutr 144:335-43. 2014
  6. doi Genetic determinants of glucose homeostasis
    Adam Barker
    Medical Research Council Epidemiology Unit, Addenbrooke s Hospital, Institute of Metabolic Science, Cambridge, UK
    Best Pract Res Clin Endocrinol Metab 26:159-70. 2012
  7. pmc Common genetic variants highlight the role of insulin resistance and body fat distribution in type 2 diabetes, independent of obesity
    Robert A Scott
    MRC Epidemiology Unit, Institute of Metabolic Science, Cambridge Biomedical Campus, University of Cambridge School of Clinical Medicine, Cambridge, U K
    Diabetes 63:4378-87. 2014
  8. pmc Association of genetic Loci with glucose levels in childhood and adolescence: a meta-analysis of over 6,000 children
    Adam Barker
    Medical Research Council Epidemiology Unit, Addenbrooke s Hospital, Institute of Metabolic Science, Cambridge, U K
    Diabetes 60:1805-12. 2011
  9. pmc Association between circulating 25-hydroxyvitamin D and incident type 2 diabetes: a mendelian randomisation study
    Zheng Ye
    MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, Cambridge, UK
    Lancet Diabetes Endocrinol 3:35-42. 2015
  10. pmc No interactions between previously associated 2-hour glucose gene variants and physical activity or BMI on 2-hour glucose levels
    Robert A Scott
    Medical Research Council Epidemiology Unit, Institute of Metabolic Science, Addenbrooke s Hospital, Cambridge, UK
    Diabetes 61:1291-6. 2012

Detail Information

Publications26

  1. pmc Associations of common genetic variants with age-related changes in fasting and postload glucose: evidence from 18 years of follow-up of the Whitehall II cohort
    Anders C Jensen
    Steno Diabetes Center, Gentofte, Denmark
    Diabetes 60:1617-23. 2011
    ..The reasons underlying these different age trajectories are unknown. We investigated whether common genetic variants associated with fasting and 2-h glucose contribute to age-related changes of these traits...
  2. pmc Common genetic variation in the melatonin receptor 1B gene (MTNR1B) is associated with decreased early-phase insulin response
    C Langenberg
    MRC Epidemiology Unit, Institute of Metabolic Science, Addenbrooke s Hospital, Cambridge CB2 0QQ, UK
    Diabetologia 52:1537-42. 2009
    ....
  3. pmc Design and cohort description of the InterAct Project: an examination of the interaction of genetic and lifestyle factors on the incidence of type 2 diabetes in the EPIC Study
    C Langenberg
    Medical Research Council Epidemiology Unit, Institute of Metabolic Science, Addenbrooke s Hospital, Box 285, Cambridge CB2 0QQ, UK E mail
    Diabetologia 54:2272-82. 2011
    ..This case-cohort study aims to investigate how genetic and potentially modifiable lifestyle and behavioural factors, particularly diet and physical activity, interact in their influence on the risk of developing type 2 diabetes...
  4. pmc Seropositivity and higher immunoglobulin g antibody levels against cytomegalovirus are associated with mortality in the population-based European prospective investigation of Cancer-Norfolk cohort
    Effrossyni Gkrania-Klotsas
    Medical Research Council Epidemiology Unit, Institute of Metabolic Science, Cambridge, United Kingdom
    Clin Infect Dis 56:1421-7. 2013
    ..We aimed to examine whether seropositivity for CMV and the level of CMV immunoglobulin G (IgG) antibody are associated with all-cause and cause-specific mortality...
  5. pmc Dietary intakes of individual flavanols and flavonols are inversely associated with incident type 2 diabetes in European populations
    Raul Zamora-Ros
    MRC Epidemiology Unit, University of Cambridge, Institute of Metabolic Science, Cambridge, UK
    J Nutr 144:335-43. 2014
    ..These results suggest that individual flavonoids have different roles in the etiology of T2D. ..
  6. doi Genetic determinants of glucose homeostasis
    Adam Barker
    Medical Research Council Epidemiology Unit, Addenbrooke s Hospital, Institute of Metabolic Science, Cambridge, UK
    Best Pract Res Clin Endocrinol Metab 26:159-70. 2012
    ....
  7. pmc Common genetic variants highlight the role of insulin resistance and body fat distribution in type 2 diabetes, independent of obesity
    Robert A Scott
    MRC Epidemiology Unit, Institute of Metabolic Science, Cambridge Biomedical Campus, University of Cambridge School of Clinical Medicine, Cambridge, U K
    Diabetes 63:4378-87. 2014
    ....
  8. pmc Association of genetic Loci with glucose levels in childhood and adolescence: a meta-analysis of over 6,000 children
    Adam Barker
    Medical Research Council Epidemiology Unit, Addenbrooke s Hospital, Institute of Metabolic Science, Cambridge, U K
    Diabetes 60:1805-12. 2011
    ..To investigate whether associations of common genetic variants recently identified for fasting glucose or insulin levels in nondiabetic adults are detectable in healthy children and adolescents...
  9. pmc Association between circulating 25-hydroxyvitamin D and incident type 2 diabetes: a mendelian randomisation study
    Zheng Ye
    MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, Cambridge, UK
    Lancet Diabetes Endocrinol 3:35-42. 2015
    ..We aimed to estimate the unconfounded, causal association between 25(OH)D concentration and risk of type 2 diabetes using a mendelian randomisation approach...
  10. pmc No interactions between previously associated 2-hour glucose gene variants and physical activity or BMI on 2-hour glucose levels
    Robert A Scott
    Medical Research Council Epidemiology Unit, Institute of Metabolic Science, Addenbrooke s Hospital, Cambridge, UK
    Diabetes 61:1291-6. 2012
    ..It is perhaps unlikely that top loci from genome-wide association studies will exhibit strong subgroup-specific effects, and may not, therefore, make the best candidates for the study of interactions...
  11. pmc Genetic markers of adult obesity risk are associated with greater early infancy weight gain and growth
    Cathy E Elks
    MRC Epidemiology Unit, Addenbrooke s Hospital, Cambridge, United Kingdom
    PLoS Med 7:e1000284. 2010
    ..Exploration of these genotype associations in children may provide insights into the timing of weight changes leading to adult obesity...
  12. pmc Common genetic determinants of glucose homeostasis in healthy children: the European Youth Heart Study
    Clara Kelliny
    Medical Research Council Epidemiology Unit, Addenbrooke s Hospital, Institute of Metabolic Science, Cambridge, U K
    Diabetes 58:2939-45. 2009
    ..The goal of this study was to investigate whether the effects of common genetic variants associated with fasting glucose in adults are detectable in healthy children...
  13. pmc Gene-lifestyle interaction and type 2 diabetes: the EPIC interact case-cohort study
    Claudia Langenberg
    Medical Research Council Epidemiology Unit, University of Cambridge, Cambridge, United Kingdom
    PLoS Med 11:e1001647. 2014
    ..Therefore, we aimed to quantify the combined effects of genetic and lifestyle factors on risk of T2D in order to inform strategies for prevention...
  14. doi Higher immunoglobulin G antibody levels against cytomegalovirus are associated with incident ischemic heart disease in the population-based EPIC-Norfolk cohort
    Effrossyni Gkrania-Klotsas
    Medical Research Council Epidemiology Unit, Institute of Metabolic Science, Addenbrooke s Hospital, Cambridge CB2 0QQ, United Kingdom
    J Infect Dis 206:1897-903. 2012
    ..Cytomegalovirus (CMV) is associated with ischemic heart disease (IHD) among organ transplant recipients. The relationship between the levels of antibody for CMV with IHD in immunocompetent individuals is uncertain...
  15. pmc Large-scale association analyses identify new loci influencing glycemic traits and provide insight into the underlying biological pathways
    Robert A Scott
    Medical Research Council Epidemiology Unit, Institute of Metabolic Science, Addenbrooke s Hospital, Cambridge, UK
    Nat Genet 44:991-1005. 2012
    ..Functional analysis of these newly discovered loci will further improve our understanding of glycemic control...
  16. pmc Genetic variation near IRS1 associates with reduced adiposity and an impaired metabolic profile
    Tuomas O Kilpeläinen
    Medical Research Council MRC Epidemiology Unit, Institute of Metabolic Science, Cambridge, UK
    Nat Genet 43:753-60. 2011
    ..Our findings provide new insights into adiposity and insulin resistance...
  17. pmc Association of Multiple Biomarkers of Iron Metabolism and Type 2 Diabetes: The EPIC-InterAct Study
    Clara Podmore
    MRC Epidemiology Unit, Institute of Metabolic Science, University of Cambridge School of Clinical Medicine, Cambridge, U K
    Diabetes Care 39:572-81. 2016
    ..We investigated associations of ferritin, transferrin saturation (TSAT), serum iron, and transferrin with T2D incidence to clarify the role of iron in the pathogenesis of T2D...
  18. pmc A genomic approach to therapeutic target validation identifies a glucose-lowering GLP1R variant protective for coronary heart disease
    Robert A Scott
    Medical Research Council MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, Cambridge Biomedical Campus, Cambridge CB2 0QQ, UK
    Sci Transl Med 8:341ra76. 2016
    ..Genetic variants associated with metabolic traits and multiple disease outcomes can be used to validate therapeutic targets at an early stage in the drug development process. ..
  19. pmc Definitions of Metabolic Health and Risk of Future Type 2 Diabetes in BMI Categories: A Systematic Review and Network Meta-analysis
    Luca A Lotta
    MRC Epidemiology Unit, Institute of Metabolic Science, University of Cambridge School of Clinical Medicine, Cambridge Biomedical Campus, Addenbrooke s Hospital, Cambridge, U K
    Diabetes Care 38:2177-87. 2015
    ..Various definitions of metabolic health have been proposed to explain differences in the risk of type 2 diabetes within BMI categories. The goal of this study was to assess their predictive relevance...
  20. pmc The association of the mitochondrial DNA OriB variant (16184-16193 polycytosine tract) with type 2 diabetes in Europid populations
    Zheng Ye
    Medical Research Council Epidemiology Unit, Institute of Metabolic Science, Addenbrooke s Hospital, PO Box 285, Hills Road, Cambridge CB2 0QQ, UK
    Diabetologia 56:1907-13. 2013
    ..We report a systematic review of published literature in Europid populations, new data from the Norfolk Diabetes Case-Control Study and a meta-analysis to help quantify this association...
  21. pmc Mendelian randomization study of B-type natriuretic peptide and type 2 diabetes: evidence of causal association from population studies
    Roman Pfister
    Medical Research Council Epidemiology Unit, Institute of Metabolic Science, University of Cambridge, Cambridge, United Kingdom
    PLoS Med 8:e1001112. 2011
    ....
  22. doi Integrative genomic analysis implicates limited peripheral adipose storage capacity in the pathogenesis of human insulin resistance
    Luca A Lotta
    MRC Epidemiology Unit, University of Cambridge, Cambridge, UK
    Nat Genet . 2016
    ..Our findings support the notion that limited storage capacity of peripheral adipose tissue is an important etiological component in insulin-resistant cardiometabolic disease and highlight genes and mechanisms underpinning this link...
  23. pmc Identification of heart rate-associated loci and their effects on cardiac conduction and rhythm disorders
    Marcel den Hoed
    Medical Research Council MRC Epidemiology Unit, Institute of Metabolic Science, Addenbrooke s Hospital, Cambridge, UK
    Nat Genet 45:621-31. 2013
    ..Our findings provide fresh insights into the mechanisms regulating heart rate and identify new therapeutic targets...
  24. doi Genetic markers of insulin sensitivity and insulin secretion are associated with spontaneous postnatal growth and response to growth hormone treatment in short SGA children: the North European SGA Study (NESGAS)
    Rikke Beck Jensen
    Department of Growth and Reproduction R B J, A J, Rigshospitalet, University of Copenhagen, DK 2100 Copenhagen, Denmark Department of Pediatrics R B J, A T, D B D, Addenbrooke s Hospital, University of Cambridge, Cambridge CB2 0QQ, United Kingdom Medical Research Council, Epidemiology Unit F D, R A S, C L, K K O, Institute of Metabolic Science, Addenbrooke s Hospital, University of Cambridge, Cambridge CB2 0QQ, United Kingdom Department of Endocrinology J K, Birmingham Children s Hospital, Birmingham B4 6NH, United Kingdom Department of Endocrinology M D, Royal Hospital for Sick Children, Glasgow G3 8SJ, United Kingdom Department of Clinical Sciences S I, Endocrine and Diabetes Unit, University of Lund, SE 205 02 Malmo, Sweden Pediatric Endocrinology Unit O S, Department of Women s and Children s Health, Karolinska Institutet and University Hospital, 171 76 Stockholm, Sweden and Department of Pediatrics E R, H H, Toronto Hospital
    J Clin Endocrinol Metab 100:E503-7. 2015
    ..The wide heterogeneity in the early growth and metabolism of children born small for gestational age (SGA), both before and during GH therapy, may reflect common genetic variations related to insulin secretion or sensitivity...
  25. pmc The prospective association between total and type of fish intake and type 2 diabetes in 8 European countries: EPIC-InterAct Study
    Pinal S Patel
    MRC Epidemiology Unit, Cambridge, UK
    Am J Clin Nutr 95:1445-53. 2012
    ..Epidemiologic evidence of an association between fish intake and type 2 diabetes (T2D) is inconsistent and unresolved...