Bethan Lang

Summary

Affiliation: University of Oxford
Country: UK

Publications

  1. ncbi request reprint Pathogenic autoantibodies in the lambert-eaton myasthenic syndrome
    Bethan Lang
    Neurosciences Group and Department of Clinical Neurology, Oxford University, Oxford, United Kingdom
    Ann N Y Acad Sci 998:187-95. 2003
  2. ncbi request reprint Antibodies to voltage-gated calcium channels in children with falciparum malaria
    Bethan Lang
    Neurosciences, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, Oxford OX3 9DS, UK
    J Infect Dis 191:117-21. 2005
  3. doi request reprint Autoimmune disorders of the neuromuscular junction
    Bethan Lang
    Department of Clinical Neurology, University of Oxford, Oxford OX3 9DS, UK
    Curr Opin Pharmacol 9:336-40. 2009
  4. ncbi request reprint Autoantibodies to ion channels at the neuromuscular junction
    Bethan Lang
    Neurosciences Group, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, Headington, Oxford OX3 9DS, UK
    Autoimmun Rev 2:94-100. 2003
  5. ncbi request reprint New autoantibody mediated disorders of the central nervous system
    Bethan Lang
    Neurosciences Group, Department of Clinical Neurology, Weatherall Institute of Molecular Medicine, University of Oxford, UK
    Curr Opin Neurol 16:351-7. 2003
  6. doi request reprint Autoantibodies in neuromuscular autoimmune disorders
    Bethan Lang
    Neuroscience Group, Weatherall Institute for Molecular Medicine, University of Oxford, OX3 9DS Oxford, UK
    Expert Rev Clin Immunol 2:293-307. 2006
  7. pmc Antibodies to Kv1 potassium channel-complex proteins leucine-rich, glioma inactivated 1 protein and contactin-associated protein-2 in limbic encephalitis, Morvan's syndrome and acquired neuromyotonia
    Sarosh R Irani
    Neurosciences Group, Department of Clinical Neurology, University of Oxford, John Radcliffe Hospital, Oxford, UK
    Brain 133:2734-48. 2010
  8. doi request reprint Morvan syndrome: clinical and serological observations in 29 cases
    Sarosh R Irani
    Neurosciences Group, Nuffield Department of Clinical Neurosciences, John Radcliffe Hospital, Oxford, United Kingdom
    Ann Neurol 72:241-55. 2012
  9. doi request reprint Faciobrachial dystonic seizures: the influence of immunotherapy on seizure control and prevention of cognitive impairment in a broadening phenotype
    Sarosh R Irani
    1 Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, UK
    Brain 136:3151-62. 2013
  10. doi request reprint Faciobrachial dystonic seizures precede Lgi1 antibody limbic encephalitis
    Sarosh R Irani
    Department of Clinical Neurology, Oxford University, Oxford, UK
    Ann Neurol 69:892-900. 2011

Detail Information

Publications47

  1. ncbi request reprint Pathogenic autoantibodies in the lambert-eaton myasthenic syndrome
    Bethan Lang
    Neurosciences Group and Department of Clinical Neurology, Oxford University, Oxford, United Kingdom
    Ann N Y Acad Sci 998:187-95. 2003
    ..These results demonstrate an unexpected plasticity in the expression of VGCCs in mammalian neurons and may represent a mechanism by which the pathogenic effects of LEMS IgG are reduced...
  2. ncbi request reprint Antibodies to voltage-gated calcium channels in children with falciparum malaria
    Bethan Lang
    Neurosciences, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, Oxford OX3 9DS, UK
    J Infect Dis 191:117-21. 2005
    ..Here, we show that, in a cohort of Kenyan children, levels of antibodies to the voltage-gated calcium channels, but not to other ion channels, increased with the severity of malaria infection...
  3. doi request reprint Autoimmune disorders of the neuromuscular junction
    Bethan Lang
    Department of Clinical Neurology, University of Oxford, Oxford OX3 9DS, UK
    Curr Opin Pharmacol 9:336-40. 2009
    ..General immunosuppression is still the main treatment, but novel treatments that reduce complement-mediated damage or inhibit the binding of pathogenic antibodies are beginning to look promising...
  4. ncbi request reprint Autoantibodies to ion channels at the neuromuscular junction
    Bethan Lang
    Neurosciences Group, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, Headington, Oxford OX3 9DS, UK
    Autoimmun Rev 2:94-100. 2003
    ....
  5. ncbi request reprint New autoantibody mediated disorders of the central nervous system
    Bethan Lang
    Neurosciences Group, Department of Clinical Neurology, Weatherall Institute of Molecular Medicine, University of Oxford, UK
    Curr Opin Neurol 16:351-7. 2003
    ..This review summarizes the recent findings and assesses the evidence that these conditions are caused by the antibodies, using the criteria established for peripheral nervous system autoimmune diseases...
  6. doi request reprint Autoantibodies in neuromuscular autoimmune disorders
    Bethan Lang
    Neuroscience Group, Weatherall Institute for Molecular Medicine, University of Oxford, OX3 9DS Oxford, UK
    Expert Rev Clin Immunol 2:293-307. 2006
    ..Moreover, it is hoped that the distinct patient subgroups and the characteristic tumor associations therein will hold valuable clues to pathways of autoimmunization...
  7. pmc Antibodies to Kv1 potassium channel-complex proteins leucine-rich, glioma inactivated 1 protein and contactin-associated protein-2 in limbic encephalitis, Morvan's syndrome and acquired neuromyotonia
    Sarosh R Irani
    Neurosciences Group, Department of Clinical Neurology, University of Oxford, John Radcliffe Hospital, Oxford, UK
    Brain 133:2734-48. 2010
    ....
  8. doi request reprint Morvan syndrome: clinical and serological observations in 29 cases
    Sarosh R Irani
    Neurosciences Group, Nuffield Department of Clinical Neurosciences, John Radcliffe Hospital, Oxford, United Kingdom
    Ann Neurol 72:241-55. 2012
    ....
  9. doi request reprint Faciobrachial dystonic seizures: the influence of immunotherapy on seizure control and prevention of cognitive impairment in a broadening phenotype
    Sarosh R Irani
    1 Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, UK
    Brain 136:3151-62. 2013
    ..Immunotherapy is associated with excellent control of the frequently anti-epileptic drug refractory seizures, hastens time to recovery, and may prevent the subsequent development of cognitive impairment observed in this study. ..
  10. doi request reprint Faciobrachial dystonic seizures precede Lgi1 antibody limbic encephalitis
    Sarosh R Irani
    Department of Clinical Neurology, Oxford University, Oxford, UK
    Ann Neurol 69:892-900. 2011
    ..To describe a distinctive seizure semiology that closely associates with voltage-gated potassium channel (VGKC)-complex/Lgi1 antibodies and commonly precedes the onset of limbic encephalitis (LE)...
  11. doi request reprint Autoimmune epilepsies
    Sarosh R Irani
    Department of Clinical Neurosciences Clinical Neurology, Oxford University, Oxford, UK
    Curr Opin Neurol 24:146-53. 2011
    ..To review the recent literature describing the detection and clinical importance of serum antibodies in patients with various epilepsies and other seizure-related disorders...
  12. doi request reprint IgG and complement deposition and neuronal loss in cats and humans with epilepsy and voltage-gated potassium channel complex antibodies
    Andrea Klang
    From the Institute of Pathology and Forensic Veterinary Medicine, Department for Pathobiology AK, PS, Clinic for Internal Medicine and Infectious Diseases AP, Diagnostic Imaging SK, Department for Companion Animals and Horses, University of Veterinary Medicine Vienna, Vienna, Austria Department of Neuroimmunology JB, Center for Brain Research, Medical University of Vienna, Vienna, Austria Austrian Agency for Health and Food Safety ZB, Institute for Veterinary Disease Control, Mödling, Austria Department of Clinical Neurology AV, BL, TM, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, Oxford, England Hospital Mara CGB, Epilepsy Center Bethel, Bielefeld, Germany Institute of Experimental Medicine PH, Budapest, Hungary
    J Neuropathol Exp Neurol 73:403-13. 2014
    ..These findings provide further evidence that FEPSO is a feline form of VGKC-complex-Ab limbic encephalitis and provide a model for increasing understanding of the human disease. ..
  13. doi request reprint Autoantibody-mediated disorders of the central nervous system
    Sarosh Irani
    Neurosciences Group, Department of Clinical Neurology, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, Headington, Oxford, UK
    Autoimmunity 41:55-65. 2008
    ....
  14. doi request reprint Prevalence of neurologic autoantibodies in cohorts of patients with new and established epilepsy
    Tanja Brenner
    Nuffield Department of Clinical Neurosciences, John Radcliffe Hospital, Oxford, United Kingdom
    Epilepsia 54:1028-35. 2013
    ..Previous cross-sectional studies have found specific neurologic antibodies in a small proportion of people with established epilepsy, but these investigations have seldom included patients with recent diagnosis...
  15. pmc Contactin-associated protein-2 antibodies in non-paraneoplastic cerebellar ataxia
    Esther B E Becker
    Nuffield Department of Clinical Neurosciences, John Radcliffe Hospital, Oxford University, Oxford, UK
    J Neurol Neurosurg Psychiatry 83:437-40. 2012
    ..Relatively few studies have searched for potentially pathogenic antibodies in non-paraneoplastic patients with cerebellar ataxia...
  16. ncbi request reprint Autoimmune channelopathies and related neurological disorders
    Angela Vincent
    Neurosciences Group, Department of Clinical Neurology, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, Oxford OX3 9DS, United Kingdom
    Neuron 52:123-38. 2006
    ....
  17. doi request reprint Antibodies to AMPA receptors in Rasmussen's encephalitis
    Anjan Nibber
    Nuffield Department of Clinical Neurosciences, University of Oxford, John Radcliffe Hospital, Oxford, UK
    Eur J Paediatr Neurol 20:222-7. 2016
    ..2%) had evidence of antibodies to neuronal antigens. Whether these antibodies play a primary role in RE, or appear secondary to the neuro-inflammatory damage in this highly destructive disease, requires further study. ..
  18. doi request reprint Prospective study into the incidence of Lambert Eaton myasthenic syndrome in small cell lung cancer
    Miranda Payne
    Department of Medical Oncology, University of Oxford Medical Oncology Unit, Oxford, United Kingdom
    J Thorac Oncol 5:34-8. 2010
    ..VGCC can also be found in patients with SCLC and cerebellar ataxia. This was a prospective study to assess the incidence of clinical and subclinical LEMS or other neurologic disease in patients with SCLC...
  19. doi request reprint Potentially pathogenic autoantibodies associated with epilepsy and encephalitis in children and adults
    Angela Vincent
    Nuffield Department of Clinical Neurosciences, University of Oxford, John Radcliffe Hospital, Headley Way, Oxford, United Kingdom
    Epilepsia 52:8-11. 2011
    ..The conditions are often refractory to traditional antiepileptic drugs. Detection of these antibodies can help to identify forms of epilepsy that may respond to immunotherapies...
  20. ncbi request reprint The action of Lambert-Eaton myasthenic syndrome immunoglobulin G on cloned human voltage-gated calcium channels
    Ashwin Pinto
    Neurosciences Group, Institute of Molecular Medicine, Oxford University, John Radcliffe Hospital, Headington, Oxford OX3 9DS, UK
    Muscle Nerve 25:715-24. 2002
    ..Although several LEMS IgGs can be shown to bind to the alpha(1B) (C2D7) cell line, no functional effects were seen on this channel...
  21. doi request reprint The growing recognition of immunotherapy-responsive seizure disorders with autoantibodies to specific neuronal proteins
    Angela Vincent
    Department of Clinical Neurology, John Radcliffe Hospital, Oxford, UK
    Curr Opin Neurol 23:144-50. 2010
    ..The concept of epilepsy and seizure disorders caused by autoantibodies to specific neuronal membrane proteins has developed significantly during the past few years...
  22. pmc Novel Humoral Prognostic Markers in Small-Cell Lung Carcinoma: A Prospective Study
    Paul Gozzard
    Nuffield Department of Clinical Neurosciences, University of Oxford, John Radcliffe Hospital, Oxford, United Kingdom
    PLoS ONE 10:e0143558. 2015
    ..Our aim was to establish whether neuronal antibodies, independent of clinical neurological features, correlate with SCLC survival...
  23. ncbi request reprint Antibodies in myasthenia gravis and related disorders
    Angela Vincent
    Neurosciences Group, Department of Clinical Neurology, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, Oxford OX3 9DS, United Kingdom
    Ann N Y Acad Sci 998:324-35. 2003
    ..These antibodies are not found in AChR antibody-positive MG and are predominantly IgG4. MuSK antibody positivity appears to be associated with more severe bulbar disease that can be difficult to treat effectively...
  24. doi request reprint Autoantibodies to glutamic acid decarboxylase in patients with epilepsy are associated with low cortical GABA levels
    Charlotte J Stagg
    Centre for Functional Magnetic Resonance of the Brain FMRIB, University of Oxford, Oxford, United Kingdom
    Epilepsia 51:1898-901. 2010
    ....
  25. doi request reprint Intracellular and non-neuronal targets of voltage-gated potassium channel complex antibodies
    Bethan Lang
    Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, UK
    J Neurol Neurosurg Psychiatry . 2017
    ..Therefore, the target(s) and clinical associations of double-negative antibodies need to be determined...
  26. pmc Paraneoplastic neurologic disorders in small cell lung carcinoma: A prospective study
    Paul Gozzard
    From the Nuffield Department of Clinical Neurosciences P G, M W, A N, P W, A V, B L, University of Oxford, John Radcliffe Hospital, Oxford, United Kingdom Division of Medical Sciences and Graduate Entry Medicine C C, University of Nottingham, Royal Derby Hospital, Derby, United Kingdom and Division of Neurology P M, Queen s Medical Centre, Nottingham, United Kingdom
    Neurology 85:235-9. 2015
    ..To determine the frequency and range of paraneoplastic neurologic disorders (PNDs) and neuronal antibodies in small cell lung carcinoma (SCLC)...
  27. ncbi request reprint Potassium channel antibody-associated encephalopathy: a potentially immunotherapy-responsive form of limbic encephalitis
    Angela Vincent
    Neurosciences Group, Weatherall Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital, Oxford OX3 9DS, UK
    Brain 127:701-12. 2004
    ..Establishing the frequency of this new syndrome, the full range of clinical presentations and means of early recognition, and optimal immunotherapy, should now be the aim...
  28. ncbi request reprint Antibodies to neuronal targets in neurological and psychiatric diseases
    Angela Vincent
    Neurosciences Group, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, Oxford, UK
    Ann N Y Acad Sci 992:48-55. 2003
    ..This review highlights features of these conditions, preliminary investigations into neurodevelopmental disorders, and areas for further study...
  29. pmc N-methyl-D-aspartate antibody encephalitis: temporal progression of clinical and paraclinical observations in a predominantly non-paraneoplastic disorder of both sexes
    Sarosh R Irani
    Department of Clinical Neurology, L6 West Wing, John Radcliffe Hospital, University of Oxford, Oxford OX3 9DU, UK
    Brain 133:1655-67. 2010
    ..Four patients, who only had temporal lobe epilepsy without oligoclonal bands, may represent restriction to the first stage...
  30. doi request reprint Paediatric brainstem encephalitis associated with glial and neuronal autoantibodies
    Yael Hacohen
    Nuffield Department of Clinical Neurosciences, John Radcliffe Hospital, University of Oxford, Oxford, UK
    Dev Med Child Neurol 58:836-41. 2016
    ..Central nervous system (CNS) autoantibodies have been reported in a range of neuroimmune diseases, but there has not been a systematic evaluation of autoantibodies in paediatric patients with brainstem encephalitis...
  31. pmc Neuronal antibodies in pediatric epilepsy: Clinical features and long-term outcomes of a historical cohort not treated with immunotherapy
    Sukhvir Wright
    Nuffield Department of Clinical Neurosciences, John Radcliffe University Hospital, University of Oxford, Oxford, United Kingdom
    Epilepsia 57:823-31. 2016
    ..Neuronal antibodies have also been described in patients with pediatric epilepsy without encephalitis. The aim was to assess whether antibody presence had any effect on long-term outcomes in these patients...
  32. doi request reprint Detection methods for neural autoantibodies
    Patrick Waters
    Neuroimmunology Group, Nuffield Department of Clinical Neurosciences, John Radcliffe Hospital, Oxford, UK Electronic address
    Handb Clin Neurol 133:147-63. 2016
    ..In this chapter we describe the methods used to detect both antibody types, and discuss assay cut-offs, sample handling, and which biologic fluid to test. ..
  33. pmc Glycine receptor antibodies in PERM and related syndromes: characteristics, clinical features and outcomes
    Alexander Carvajal-González
    1 Nuffield Department of Clinical Neurosciences, John Radcliffe Hospital, Oxford OX3 9DU, UK
    Brain 137:2178-92. 2014
    ..The presence of glycine receptor antibodies should help to identify a disease that responds to immunotherapies, but these treatments may need to be sustained, relapses can occur and maintenance immunosuppression may be required. ..
  34. pmc Acute measles encephalitis in partially vaccinated adults
    Annette Fox
    Oxford University Clinical Research Unit, Wellcome Trust Major Overseas Programme, Ho Chi Minh City and Ha Noi, Viet Nam
    PLoS ONE 8:e71671. 2013
    ..Treatment with immune-modulators is based on theories that post-infectious autoimmune responses cause demyelination. The clinical course and immunological parameters of AME were examined during an outbreak in Vietnam...
  35. doi request reprint Epileptogenic effects of NMDAR antibodies in a passive transfer mouse model
    Sukhvir Wright
    1 Nuffield Department of Clinical Neurosciences, John Radcliffe Hospital, University of Oxford, Oxford, OX3 9DU, UK
    Brain 138:3159-67. 2015
    ....
  36. ncbi request reprint SOX1 autoantibodies: tumor markers in LEMS patients?
    Bethan Lang
    Neurology 70:906-7. 2008
  37. ncbi request reprint P/Q-type calcium channel antibodies, Lambert-Eaton myasthenic syndrome and survival in small cell lung cancer
    Paul W Wirtz
    Department of Neurology, Leiden University Medical Center, P O Box 9600, 2300 RC Leiden, The Netherlands
    J Neuroimmunol 164:161-5. 2005
    ..In both series, only patients with LEMS had a remarkably long survival, whereas presence of the antibodies without LEMS did not result in a better prognosis...
  38. ncbi request reprint Paraneoplastic cerebellar degeneration and antibodies to P/Q-type calcium channels
    Ashwin Pinto
    Ann Neurol 54:277; author reply 277-8. 2003
  39. ncbi request reprint LEMS IgG binds to extracellular determinants on N-type voltage-gated calcium channels, but does not reduce VGCC expression
    Kazuo Iwasa
    Department of Neurology, Kanazawa University School of Medicine, Takara machi, Kanazawa 920 8641, Japan
    Ann N Y Acad Sci 998:196-9. 2003
  40. doi request reprint Cerebellar ataxia in non-paraneoplastic Lambert-Eaton myasthenic syndrome
    Paulo J Lorenzoni
    Department of Internal Medicine, Universidade Federal do Parana, Curitiba, Brazil
    J Neurol Sci 270:194-6. 2008
    ..We suggest that LEMS should be considered in the differential diagnosis of patients with CA...
  41. ncbi request reprint Antibodies to voltage-gated potassium and calcium channels in epilepsy
    H J Marian Majoie
    Epilepsy Centre Kempenhaeghe, Heeze, The Netherlands
    Epilepsy Res 71:135-41. 2006
    ..To determine the prevalence of antibodies to ion channels in patients with long standing epilepsy...
  42. ncbi request reprint GAD antibodies in stiff-person syndrome
    Thashi Chang
    Neurology 63:1999-2000. 2004
  43. ncbi request reprint Autoantibodies in patients with gut motility disorders and enteric neuropathy
    Hans Tornblom
    Karolinska Institutet, Department of Medicine, Karolinska University Hospital, Huddinge, Stockholm, Sweden
    Scand J Gastroenterol 42:1289-93. 2007
    ..The purpose of this study was to test the hypothesis that autoantibodies directed against specific neural antigens including ion channels may be associated with this finding...
  44. ncbi request reprint Neuromyotonia and limbic encephalitis sera target mature Shaker-type K+ channels: subunit specificity correlates with clinical manifestations
    Kleopas A Kleopa
    Department of Clinical Neurosciences, Cyprus Institute of Neurology and Genetics, Nicosia, Cyprus, PA, USA
    Brain 129:1570-84. 2006
    ..Although more than one type of antibody is often detectable in individual sera, higher affinity for certain subunits or subunit combinations may determine the range of clinical manifestations...
  45. pmc Clinical and serological study of myasthenia gravis in HuBei Province, China
    Xiaofan Zhang
    Department of Neurology, Tongji Hospital, Huazhong University of Science and Technology, Wuhan, China
    J Neurol Neurosurg Psychiatry 78:386-90. 2007
    ..Ocular and childhood myasthenia gravis (MG) cases seem relatively more common in Oriental than in Caucasian populations, but there have been no comprehensive serological studies on patients from mainland China...
  46. ncbi request reprint HLA-B8 in patients with the Lambert-Eaton myasthenic syndrome reduces likelihood of associated small cell lung carcinoma
    Paul W Wirtz
    Department of Neurology, Leiden University Medical Center, Leiden, The Netherlands
    Ann N Y Acad Sci 998:200-1. 2003
  47. ncbi request reprint HLA and smoking in prediction and prognosis of small cell lung cancer in autoimmune Lambert-Eaton myasthenic syndrome
    Paul W Wirtz
    Department of Neurology, Leiden University Medical Center, P O Box 9600, 2300 RC Leiden, The Netherlands
    J Neuroimmunol 159:230-7. 2005
    ..Moreover, negativity for HLA-B8 combined with smoking behavior points more strongly to an underlying SCLC and predicts a worse prognosis in SCLC-LEMS patients...